G. Wen

发表

Tyrosine Hydroxylase, the Rate-Limiting Enzyme in Catecholamine Biosynthesis: Discovery of Common Human Genetic Variants Governing Transcription, Autonomic Activity, and Blood Pressure In Vivo

Douglas W. Smith, N. Schork, D. O'Connor, 2007, Circulation.

Human dopamine β-hydroxylase promoter variant alters transcription in chromaffin cells, enzyme secretion, and blood pressure.

D. O'Connor, J. Rodriguez-Flores, S. Mahata, 2011, American journal of hypertension.

Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure

N. Schork, D. O'Connor, B. Tayo, 2010, Journal of hypertension.

Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion.

N. Schork, D. O'Connor, R. Salem, 2008, Journal of the American College of Cardiology.

Pancreastatin: multiple actions on human intermediary metabolism in vivo, variation in disease, and naturally occurring functional genetic polymorphism.

D. O'Connor, R. Salem, R. Henry, 2005, The Journal of clinical endocrinology and metabolism.

Proteomic Analysis Yields an Unexpected Trans-Acting Point in Control of the Human Sympathochromaffin Phenotype

D. O'Connor, W. Fischer, S. Mahata, 2011, Circulation. Cardiovascular genetics.

Naturally Occurring Genetic Variants in Human Chromogranin A (CHGA) Associated with Hypertension as well as Hypertensive Renal Disease

C. Nievergelt, D. O'Connor, R. Salem, 2010, Cellular and Molecular Neurobiology.

Chapter 72 – Catecholamines, Pheochromocytoma, and Hypertension: Genomic Insights

N. Schork, D. O'Connor, S. Mahata, 2007 .

Catecholamine storage vesicles and the metabolic syndrome: the role of the chromogranin A fragment pancreastatin

D. O'Connor, R. Salem, S. Mahata, 2006, Diabetes, obesity & metabolism.

Biogenesis of the secretory granule: chromogranin A coiled-coil structure results in unusual physical properties and suggests a mechanism for granule core condensation.

N. Schork, D. O'Connor, N. Olson, 2007, Biochemistry.

Biomarker Genes Discovery of Alzheimer’s Disease by Multi-Omics-Based Gene Regulatory Network Construction of Microglia

Wei Kong, Shuaiqun Wang, G. Wen, 2022, Brain sciences.

Genetic Variation at the Human &agr;2B-Adrenergic Receptor Locus: Role in Blood Pressure Variation and Yohimbine Response

N. Schork, D. O'Connor, P. Insel, 2005, Hypertension.

Renal Albumin Excretion: Twin Studies Identify Influences of Heredity, Environment, and Adrenergic Pathway Polymorphism

Douglas W. Smith, N. Schork, D. O'Connor, 2007, Hypertension.

An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension.

N. Schork, A. Chakravarti, D. O'Connor, 2007, Human molecular genetics.

Analyses of coding region polymorphisms in apical and basolateral human organic anion transporter (OAT) genes [OAT1 (NKT), OAT2, OAT3, OAT4, URAT (RST)].

G. Wen, S. Nigam, V. Bhatnagar, 2005, Kidney international.

Chromogranin A polymorphisms are associated with hypertensive renal disease.

Douglas W. Smith, N. Schork, D. O'Connor, 2008, Journal of the American Society of Nephrology : JASN.

Mutation Rate and Predicted Phenotypic Target Sizes in Ethylnitrosourea-Treated Mice

W. Frankel, G. Wen, K. Seburn, 2004, Genetics.

C-reactive protein, an ‘intermediate phenotype’ for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/β-adrenergic pathway loci

Douglas W. Smith, N. Schork, D. O'Connor, 2007, Journal of hypertension.

Catecholamine Release–Inhibitory Peptide Catestatin (Chromogranin A352–372): Naturally Occurring Amino Acid Variant Gly364Ser Causes Profound Changes in Human Autonomic Activity and Alters Risk for Hypertension

Eleazar Eskin, Nicholas J Schork, Rany M Salem, 2007, Circulation.

Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure.

N. Schork, D. O'Connor, R. Salem, 2008, Kidney international.

Genetic variation within a metabolic motif in the chromogranin a promoter: pleiotropic influence on cardiometabolic risk traits in twins.

D. O'Connor, N. Martin, J. Whitfield, 2012, American journal of hypertension.

Peptide YY (PYY) gene polymorphisms in the 3'-untranslated and proximal promoter regions regulate cellular gene expression and PYY secretion and metabolic syndrome traits in vivo.

C. Nievergelt, D. O'Connor, S. Mahata, 2009, The Journal of clinical endocrinology and metabolism.

Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology.

Douglas W. Smith, N. Schork, D. O'Connor, 2004, American journal of human genetics.

Catecholamine Storage Vesicles: Role of Core Protein Genetic Polymorphisms in Hypertension

D. O'Connor, S. Mahata, M. Mahata, 2010, Current hypertension reports.

Heritable Influence of DBH on Adrenergic and Renal Function: Twin and Disease Studies

C. Nievergelt, D. O'Connor, M. Mahata, 2013, PloS one.

Heredity of Endothelin Secretion: Human Twin Studies Reveal the Influence of Polymorphism at the Chromogranin A Locus, a Novel Determinant of Endothelial Function

Douglas W. Smith, N. Schork, D. O'Connor, 2007, Circulation.

Conserved regulatory motifs at phenylethanolamine N-methyltransferase (PNMT) are disrupted by common functional genetic variation: an integrated computational/experimental approach

D. O'Connor, S. Subramaniam, J. Rodriguez-Flores, 2010, Mammalian Genome.

The Catecholamine Release-Inhibitory “Catestatin” Fragment of Chromogranin A: Naturally Occurring Human Variants with Different Potencies for Multiple Chromaffin Cell Nicotinic Cholinergic Responses

D. O'Connor, S. Mahata, M. Mahata, 2004, Molecular Pharmacology.

Heredity and cardiometabolic risk: naturally occurring polymorphisms in the human neuropeptide Y2 receptor promoter disrupt multiple transcriptional response motifs

Kuixing Zhang, D. O'Connor, G. Schmid-Schoenbein, 2013, Journal of hypertension.

Chromogranin A polymorphisms are associated with hypertensive renal disease.

Douglas W. Smith, N. Schork, D. O'Connor, 2008, Journal of the American Society of Nephrology : JASN.