Artak Tovmasyan

发表

The complex mechanistic aspects of redox-active compounds, commonly regarded as SOD mimics

I. Batinic-Haberle, I. Spasojević, Artak Tovmasyan, 2013 .

Metalloporphyrins as Therapeutic Catalytic Oxidoreductants in Central Nervous System Disorders

R. Pearlstein, H. Sheng, D. Warner, 2013 .

Roles of Phytoestrogen in the Pathophysiology of Intracranial Aneurysm

M. Lawton, J. Baranoski, S. Eguchi, 2021, Stroke.

Superoxide dismutase mimics and other redox‐active therapeutics

I. Batinic-Haberle, Artak Tovmasyan, 2016 .

Post-illumination cellular effects of photodynamic treatment

I. Batinic-Haberle, Artak Tovmasyan, J. Craik, 2017, PloS one.

Simple biological systems for assessing the activity of superoxide dismutase mimics.

Artak Tovmasyan, J. S. Rebouças, Ludmil Benov, 2014, Antioxidants & redox signaling.

Anticancer therapeutic potential of Mn porphyrin/ascorbate system.

Dean P. Jones, M. Dewhirst, T. Venkatraman, 2015, Free radical biology & medicine.

A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP5+, Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line

D. S. St. Clair, W. S. St. Clair, I. Batinic-Haberle, 2022, Oxidative medicine and cellular longevity.

H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways

I. Batinic-Haberle, H. Sheng, I. Spasojević, 2021, Oxidative medicine and cellular longevity.

Mn Porphyrin-Based Redox-Active Drugs: Differential Effects as Cancer Therapeutics and Protectors of Normal Tissue Against Oxidative Injury.

I. Batinic-Haberle, I. Spasojević, Artak Tovmasyan, 2018, Antioxidants & redox signaling.

Mn Porphyrin-Based Redox-Active Therapeutics

I. Batinic-Haberle, I. Spasojević, Artak Tovmasyan, 2016 .

Radioprotection of the Brain White Matter by Mn(III) N-Butoxyethylpyridylporphyrin–Based Superoxide Dismutase Mimic MnTnBuOE-2-PyP5+

M. Dewhirst, R. Rodriguiz, W. Wetsel, 2014, Molecular Cancer Therapeutics.

Design, Mechanism of Action, Bioavailability and Therapeutic Effects of Mn Porphyrin-Based Redox Modulators

I. Batinic-Haberle, H. Sheng, D. Warner, 2012, Medical Principles and Practice.

Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate

M. Dewhirst, K. Leong, K. Aird, 2011, Free radical research.

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.

M. Dewhirst, K. Leong, I. Batinic-Haberle, 2011, Free radical biology & medicine.

Sublethal Photodynamic Treatment Does Not Lead to Development of Resistance

I. Batinic-Haberle, Artak Tovmasyan, Ludmil Benov, 2018, Front. Microbiol..

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP5+, Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme

I. Batinic-Haberle, P. Lam, K. Hui, 2016, Stem Cell Reviews and Reports.

Mn porphyrin in combination with ascorbate acts as a pro-oxidant and mediates caspase-independent cancer cell death.

I. Batinic-Haberle, G. Devi, Artak Tovmasyan, 2014, Free radical biology & medicine.

Targeting Mitochondria by Zn(II)N-Alkylpyridylporphyrins: The Impact of Compound Sub-Mitochondrial Partition on Cell Respiration and Overall Photodynamic Efficacy

I. Batinic-Haberle, P. Cobine, Artak Tovmasyan, 2014, PloS one.

Manganese-based superoxide dismutase mimics modify both acute and long-term outcome severity in a Drosophila melanogaster model of classic galactosemia.

Dean P. Jones, J. Fridovich-Keil, I. Batinic-Haberle, 2014, Antioxidants & redox signaling.

Fe Porphyrin-Based SOD Mimic and Redox-Active Compound, (OH)FeTnHex-2-PyP4+, in a Rodent Ischemic Stroke (MCAO) Model: Efficacy and Pharmacokinetics as Compared to Its Mn Analogue, (H2O)MnTnHex-2-PyP5+

I. Batinic-Haberle, H. Sheng, D. Warner, 2020, Antioxidants.

Opinion on Schmidt et al.

I. Batinic-Haberle, I. Spasojević, Artak Tovmasyan, 2016, Antioxidants & redox signaling.

Important cellular targets for antimicrobial photodynamic therapy

I. Batinic-Haberle, Artak Tovmasyan, J. Craik, 2016, Applied Microbiology and Biotechnology.

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.

I. Batinic-Haberle, H. Sheng, D. Warner, 2012, Free radical biology & medicine.

Amphiphilic cationic Zn-porphyrins with high photodynamic antimicrobial activity.

I. Batinic-Haberle, Artak Tovmasyan, J. Craik, 2015, Future microbiology.

Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.

D. Butterfield, C. V. Vander Kooi, D. S. St. Clair, 2016, Free radical biology & medicine.

Antibacterial Activity of Synthetic Cationic Iron Porphyrins

I. Batinic-Haberle, Artak Tovmasyan, Ludmil Benov, 2020, Antioxidants.

Radiation-Mediated Tumor Growth Inhibition Is Significantly Enhanced with Redox-Active Compounds That Cycle with Ascorbate.

Ting-Ting Huang, I. Batinic-Haberle, I. Spasojević, 2018, Antioxidants & redox signaling.

Ascorbate-dependent and ascorbate-independent Mn porphyrin cytotoxicity: anticancer activity of Mn porphyrin-based SOD mimics through ascorbate-dependent and -independent routes

I. Batinic-Haberle, Artak Tovmasyan, Ludmil Benov, 2021, Redox report : communications in free radical research.

Late administration of Mn porphyrin-based SOD mimic enhances diabetic complications☆

M. Oriowo, I. Batinic-Haberle, Artak Tovmasyan, 2013, Redox biology.

Neurobehavioral radiation mitigation to standard brain cancer therapy regimens by Mn(III) n‐butoxyethylpyridylporphyrin‐based redox modifier

M. Dewhirst, R. Rodriguiz, W. Wetsel, 2016, Environmental and molecular mutagenesis.

Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology.

I. Batinic-Haberle, H. Sheng, D. Warner, 2013, Inorganic chemistry.

Quisinostat is a brain-penetrant radiosensitizer in glioblastoma

N. Sanai, Artak Tovmasyan, E. L. Melendez, 2022, bioRxiv.

Important cellular targets for antimicrobial photodynamic therapy

I. Batinic-Haberle, Artak Tovmasyan, J. Craik, 2016, Applied Microbiology and Biotechnology.

SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.

K. Leong, I. Batinic-Haberle, I. Spasojević, 2014, Antioxidants & redox signaling.

Challenges encountered during development of Mn porphyrin-based, potent redox-active drug and superoxide dismutase mimic, MnTnBuOE-2-PyP5+, and its alkoxyalkyl analogues.

I. Batinic-Haberle, I. Spasojević, Artak Tovmasyan, 2017, Journal of inorganic biochemistry.

Post-Irradiation Treatment with a Superoxide Dismutase Mimic, MnTnHex-2-PyP5+, Mitigates Radiation Injury in the Lungs of Non-Human Primates after Whole-Thorax Exposure to Ionizing Radiation

K. Owzar, I. Batinic-Haberle, A. Weaver, 2018, Antioxidants.

Effect of Molecular Characteristics on Cellular Uptake, Subcellular Localization, and Phototoxicity of Zn(II) N-Alkylpyridylporphyrins*

I. Batinic-Haberle, Artak Tovmasyan, L. Benov, 2013, The Journal of Biological Chemistry.

Manganese superoxide dismutase, MnSOD and its mimics.

D. S. St. Clair, I. Batinic-Haberle, I. Spasojević, 2012, Biochimica et biophysica acta.

Manganese porphyrin redox state in endothelial cells: Resonance Raman studies and implications for antioxidant protection towards peroxynitrite

I. Batinic-Haberle, R. Radi, Artak Tovmasyan, 2018, Free radical biology & medicine.

A comprehensive evaluation of catalase-like activity of different classes of redox-active therapeutics.

I. Batinic-Haberle, R. Radi, I. Ivanović‐Burmazović, 2015, Free radical biology & medicine.

Cationic amphiphilic Zn-porphyrin with high antifungal photodynamic potency

I. Batinic-Haberle, Artak Tovmasyan, J. Craik, 2017, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy.

I. Batinic-Haberle, Artak Tovmasyan, Ludmil Benov, 2017, Photodiagnosis and photodynamic therapy.

Rational Design of Superoxide Dismutase (SOD) Mimics: The Evaluation of the Therapeutic Potential of New Cationic Mn Porphyrins with Linear and Cyclic Substituents

I. Batinic-Haberle, R. Radi, I. Spasojević, 2014, Inorganic chemistry.

Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.

I. Batinic-Haberle, M. Trucco, Artak Tovmasyan, 2013, Antioxidants & redox signaling.

Superoxide dismutase mimic, MnTE-2-PyP5+ ameliorates acute and chronic proctitis following focal proton irradiation of the rat rectum☆

J. Crapo, I. Batinic-Haberle, R. Pearlstein, 2013, Redox biology.

An educational overview of the chemistry, biochemistry and therapeutic aspects of Mn porphyrins – From superoxide dismutation to H2O2-driven pathways

I. Batinic-Haberle, I. Spasojević, Artak Tovmasyan, 2015, Redox biology.

Differential localization and potency of manganese porphyrin superoxide dismutase-mimicking compounds in Saccharomyces cerevisiae

J. Valentine, I. Batinic-Haberle, I. Spasojević, 2014, Redox biology.

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.

I. Batinic-Haberle, H. Sheng, D. Warner, 2013, Free radical biology & medicine.

Methoxy-derivatization of alkyl chains increases the in vivo efficacy of cationic Mn porphyrins. Synthesis, characterization, SOD-like activity, and SOD-deficient E. coli study of meta Mn(III) N-methoxyalkylpyridylporphyrins.

I. Batinic-Haberle, H. Sheng, D. Warner, 2011, Dalton transactions.

Simultaneous determination of LY3214996, abemaciclib, and M2 and M20 metabolites in human plasma, cerebrospinal fluid, and brain tumor by LC-MS/MS

N. Sanai, Artak Tovmasyan, T. Margaryan, 2022, Journal of pharmaceutical analysis.

Redox-Active Mn Porphyrin-based Potent SOD Mimic, MnTnBuOE-2-PyP5+, Enhances Carbenoxolone-Mediated TRAIL-Induced Apoptosis in Glioblastoma Multiforme

I. Batinic-Haberle, P. Lam, K. Hui, 2016, Stem Cell Reviews and Reports.

CNS bioavailability and radiation protection of normal hippocampal neurogenesis by a lipophilic Mn porphyrin-based superoxide dismutase mimic, MnTnBuOE-2-PyP5+

Ting-Ting Huang, I. Batinic-Haberle, I. Spasojević, 2017, Redox biology.

Novel Manganese-Porphyrin Superoxide Dismutase-Mimetic Widens the Therapeutic Margin in a Preclinical Head and Neck Cancer Model.

M. Dewhirst, G. Palmer, D. Brizel, 2015, International journal of radiation oncology, biology, physics.

Mn Porphyrin-Based SOD Mimic and Vitamin C Enhance Radiation-Induced Tumor Growth Inhibition

Dean P. Jones, M. Dewhirst, Y. Go, 2015 .

Pharmacokinetics, Brain Hippocampus and Cortex, and Mitochondrial Accumulation of a New Generation of Lipophilic Redox-Active Therapeutic, Mn(III) Meso Tetrakis(N-n-butoxyethylpyridinium-2-yl)porphyrin, MnTnBuOE-2-PyP5+, in Comparison with its Ethyl and N-hexyl Analogs, MnTE-2-PyP5+ and MnTnHex-2-Py

Ting-Ting Huang, I. Batinic-Haberle, H. Sheng, 2013 .

Erratum to: Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

M. Dewhirst, D. S. St. Clair, I. Batinic-Haberle, 2010, Amino Acids.

Novel amphiphilic cationic porphyrin and its Ag(II) complex as potential anticancer agents.

Boris Harutyunyan, I. Spasojević, Artak Tovmasyan, 2014, Journal of inorganic biochemistry.

Porphyrin‐Based SOD Mimic MnTnBuOE‐2‐PyP5+ Inhibits Mechanisms of Aortic Valve Remodeling in Human and Murine Models of Aortic Valve Sclerosis

R. Levy, S. Hazen, M. Sacks, 2018, Journal of the American Heart Association.

Folic Acid Improves Parkin-Null Drosophila Phenotypes and Transiently Reduces Vulnerable Dopaminergic Neuron Mitochondrial Hydrogen Peroxide Levels and Glutathione Redox Equilibrium

Artak Tovmasyan, Lori M. Buhlman, Amber N. Juba, 2022, Antioxidants.

Mitochondrial ROS cause motor deficits induced by synaptic inactivity: Implications for synapse pruning

I. Batinic-Haberle, M. Murphy, I. Megson, 2018, Redox biology.

CTNI-48. A PHASE 0 ‘TRIGGER’ TRIAL OF CDK4/6 PLUS ERK1/2 INHIBITORS IN RECURRENT GLIOBLASTOMA

N. Sanai, A. Tien, Artak Tovmasyan, 2021, Neuro-Oncology.

Preclinical Testing of a Novel Niclosamide Stearate Prodrug Therapeutic (NSPT) Shows Efficacy Against Osteosarcoma

B. Brigman, W. Eward, D. Needham, 2020, Molecular Cancer Therapeutics.

Synthesis and in vitro anticancer activity of water-soluble cationic pyridylporphyrins and their metallocomplexes

Artak Tovmasyan, R. Aroutiounian, A. Shahkhatuni, 2008 .

Automated Writing Evaluation: The Accuracy of Grammarly’s Feedback on Form

Artak Tovmasyan, Marina Dodigovic, 2021, International Journal of TESOL Studies.

In Vitro Testing of Cyto- and Genotoxicity of New Porphyrin Water-Soluble Metal Derivatives

Artak Tovmasyan, R. Aroutiounian, S. Haroutiunian, 2007, International journal of toxicology.

Mn porphyrins as novel molecular magnetic resonance imaging contrast agents.

T. Amrhein, T. Venkatraman, C. Lascola, 2012, Journal of endourology.

Accumulation of Porphyrin-based SOD Mimics in Mitochondria is Proportional to Their Lipophilicity: S. cerevisiae Study of ortho Mn(III) N-alkylpyridylporphyrins

J. Valentine, I. Batinic-Haberle, I. Spasojević, 2010 .

Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP5+

K. Owzar, I. Batinic-Haberle, Ž. Vujašković, 2014, Redox biology.

Redox Proteomics of 4T1 Breast Cancer Cell After Treatment with MnTE-2-PyP5+/Ascorbate System

Dean P. Jones, I. Batinic-Haberle, Y. Go, 2016 .

Mn porphyrin-based SOD mimic, MnTnHex-2-PyP5+, and non-SOD mimic, MnTBAP3−, suppressed rat spinal cord ischemia/reperfusion injury via NF-κB pathways

I. Batinic-Haberle, Artak Tovmasyan, J. S. Rebouças, 2014, Free radical research.

Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.

I. Batinic-Haberle, H. Sheng, D. Warner, 2013, Free radical biology & medicine.

Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities

M. Dewhirst, D. S. St. Clair, I. Batinic-Haberle, 2010, Amino Acids.

Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells.

I. Batinic-Haberle, M. Trucco, Artak Tovmasyan, 2013, Antioxidants & redox signaling.

SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways.

K. Leong, I. Batinic-Haberle, I. Spasojević, 2014, Antioxidants & redox signaling.

Metalloporphyrins as therapeutic catalytic oxidoreductants in central nervous system disorders.

R. Pearlstein, H. Sheng, Artak Tovmasyan, 2014, Antioxidants & redox signaling.

A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity.

I. Batinic-Haberle, H. Sheng, D. Warner, 2012, Free radical biology & medicine.

Diverse functions of cationic Mn(III) N-substituted pyridylporphyrins, recognized as SOD mimics.

M. Dewhirst, K. Leong, I. Batinic-Haberle, 2011, Free radical biology & medicine.

Cationic Mn Porphyrins Change Their Action from anti- to pro-oxidative in the Presence of Cellular Reductants: Relevance to understanding the beneficial therapeutic effects of SOD mimics in vivo

Artak Tovmasyan, I. Kos, Ludmil Benov, 2010 .

Photodynamic inactivation of Gram (-) and Gram (+) microorganisms by cationic porphyrins and metalloporphyrins

Anna G. Gyulkhandanyan, Aram G. Gyulkhandanyan, Grigor V. Gyulkhandanyan, 2009, World Congress of the International Photodynamic Association.