P. Váchal

发表

A direct functionalization of tertiary alkyl bromides with O-, N-, and C-nucleophiles

P. Váchal, Joan M. Fletcher, W. Hagmann, 2007 .

Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents.

Peter S. Kutchukian, P. Kutchukian, Zhengwei Peng, 2016, Angewandte Chemie.

Selective functionalization of complex heterocycles via an automated strong base screening platform

Rebecca T. Ruck, Y. Liu, M. Reibarkh, 2017 .

High-throughput purification platform in support of drug discovery.

P. Váchal, J. Tata, L. Xia, 2012, ACS combinatorial science.

Cholesteryl ester transfer protein (CETP) inhibitors based on cyclic urea, bicyclic urea and bicyclic sulfamide cores.

D. Johns, P. Váchal, Q. Deng, 2020, Bioorganic & medicinal chemistry letters.

Profiling and Application of Photoredox C(sp3)-C(sp2) Cross-Coupling in Medicinal Chemistry.

P. Váchal, M. Wismer, S. Colletti, 2018, ACS medicinal chemistry letters.

1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia.

J. Demartino, E. Sherer, P. Váchal, 2012, Journal of medicinal chemistry.

Fluorescence Properties and Dipole Moments of Novel Fused Thienobenzofurans. Solvent and Structural Effects

C. Párkányi, J. Aaron, J. Svoboda, 2011, Journal of Fluorescence.

Synthesis of HDAC Inhibitor Libraries via Microscale Workflow.

R. Myers, P. Váchal, M. Maletic, 2021, ACS medicinal chemistry letters.

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

Kevin Bateman, Christopher J. Welch, Simon Berritt, 2015, Science.

Structure-based analysis and optimization of a highly enantioselective catalyst for the strecker reaction.

P. Váchal, E. Jacobsen, P. Vachal, 2002, Journal of the American Chemical Society.

Enantioselective catalytic addition of HCN to ketoimines. Catalytic synthesis of quaternary amino acids.

P. Váchal, E. Jacobsen, Eric N. Jacobsen, 2000, Organic letters.

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules.

Tim Cernak, Sriram Tyagarajan, P. Váchal, 2016, Chemical Society reviews.

Late-stage functionalization of biologically active heterocycles through photoredox catalysis.

Shane W. Krska, P. Váchal, S. Krska, 2014, Angewandte Chemie.

SYNTHESIS AND ANALGESIC ACTIVITY OF SOME 1-BENZOFURANS, 1-BENZOTHIOPHENES AND INDOLES

P. Váchal, I. Krejci, S. Rádl, 2000 .

Thieno[3,2- b ]benzofuran - Synthesis and Reactions

J. Svoboda, P. Váchal, P. Pihera, 1997 .

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules.

Shane W. Krska, P. Váchal, T. Cernak, 2016, Chemical Society reviews.

A new approach to the synthesis of benzofuro[3,2-b]quinolines, benzothieno[3,2-b]quinolines and indolo[3,2-b]quinolines†

P. Váchal, S. Rádl, Petr Konvička, 2000 .

Development of indazole mineralocorticoid receptor antagonists and investigation into their selective late-stage functionalization.

K. Houk, J. Madwed, R. DeVita, 2019, Bioorganic & medicinal chemistry letters.

New heterocyclic core structure for chiral liquid crystals

I. Stibor, J. Svoboda, P. Váchal, 1999 .

Thieno[3,2-b]benzofuran — Synthesis and Reactions.

J. Svoboda, P. Váchal, P. Pihera, 1998 .

Practical Synthesis of a Soluble Schiff Base Catalyst for the Asymmetric Strecker Reaction

P. Váchal, Julius Su, E. Jacobsen, 2001 .

General facile synthesis of 2,5-diarylheteropentalenes

P. Váchal, L. Toth, Petr Vachal, 2004 .

Chemoselective Peptide Modification via Photocatalytic Tryptophan β-Position Conjugation.

Li-Kang Zhang, Alexei V Buevich, P. Váchal, 2018, Journal of the American Chemical Society.

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.

Joseph James Duffy, D. Johns, Rupesh P. Amin, 2021, Journal of medicinal chemistry.

Accelerating the discovery of DGAT1 inhibitors through the application of parallel medicinal chemistry (PMC).

Shirly Pinto, R. Nargund, P. Váchal, 2019, Bioorganic & medicinal chemistry letters.

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc04751j

Bing Li, Peter S. Kutchukian, Ian W. Davies, 2016, Chemical science.

Discovery of Novel Indoline Cholesterol Ester Transfer Protein Inhibitors (CETP) through a Structure-Guided Approach.

D. Johns, A. Crespo, P. Váchal, 2016, ACS medicinal chemistry letters.

Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.

G. Chrebet, P. Váchal, J. Hale, 2006, Bioorganic & Medicinal Chemistry Letters.

Highly Selective and Potent Agonists of Sphingosine‐1‐phosphate 1 (S1P1) Receptor.

P. Váchal, 2006 .

Synthesis and study of alendronate derivatives as potential prodrugs of alendronate sodium for the treatment of low bone density and osteoporosis.

M. Maccoss, P. Váchal, F. Kesisoglou, 2006, Journal of medicinal chemistry.

Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.

M. Cleary, D. Johns, T. Roddy, 2014, European journal of pharmacology.

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.

Andreas Verras, Yang Yu, Edward C Sherer, 2017, Journal of medicinal chemistry.

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity.

Donald F Thompson, L. Shearman, A. Frassetto, 2009, Journal of medicinal chemistry.

A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions

Ian W. Davies, Michael K. Wismer, I. Davies, 2017, ACS central science.

Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor

Jeffrey T. Kuethe, D. Johns, T. Tucker, 2023, Circulation.