W. Higuchi

W. Higuchi, K. Papangkorn, John W. Higuchi, 2018, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Rapid method of obtaining the clear aqueous filtrate of an oil-water emulsion.

G. Zografi, W. Higuchi, A. Goldberg, 1967, Journal of pharmaceutical sciences.

Kinetics of aggregation in suspensions. Effects of added electrolytes on the aggregation rates of latex particles in aqueous ionic surfactant solutions.

W. Higuchi, D. Flanagan, T. O. Rhee, 1965, Journal of pharmaceutical sciences.

Mechanistic study of chemical skin permeation enhancers with different polar and lipophilic functional groups.

N. He, S. K. Li, W. Higuchi, 2004, Journal of pharmaceutical sciences.

Transport of β-Estradiol in Freshly Excised Human Skin in Vitro: Diffusion and Metabolism in Each Skin Layer

A. Ghanem, W. Higuchi, W. Good, 1994, Pharmaceutical Research.

An Application of Transdermal Antiviral Delivery Systems to the Establishment of a Novel Animal Model Approach in the Efficacy Evaluation for Dermatological Formulations

A. Ghanem, W. Higuchi, M. Su, 1994 .

The Dermal Barrier to Local and Systemic Drug Delivery

G. Flynn, J. Fox, K. Knutson, 1985 .

Some hydrodynamic boundary layer influences on mass transfer coefficients

G. Flynn, E. Williams, G. Amidon, 1984 .

Skin as an active metabolizing barrier I: Theoretical analysis of topical bioavailability.

H. Ando, W. Higuchi, N. Ho, 1977, Journal of pharmaceutical sciences.

Iontophoretic transport across a synthetic membrane and human epidermal membrane: a study of the effects of permeant charge.

K. Peck, S. K. Li, A. Ghanem, 1997, Journal of pharmaceutical sciences.

Physicochemical aspects of transdermal permeation

K. Knutson, W. Higuchi, W. J. Lambert, 1987 .

Efficacy of the injectable calcium phosphate ceramics suspensions containing magnesium, zinc and fluoride on the bone mineral deficiency in ovariectomized rats.

A. Ito, M. Otsuka, Y. Tokudome, 2008, Journal of pharmaceutical sciences.

Effect of controlled zinc release on bone mineral density from injectable Zn-containing beta-tricalcium phosphate suspension in zinc-deficient diseased rats.

N. Ichinose, A. Ito, M. Otsuka, 2004, Journal of biomedical materials research. Part A.

Calcium-level responsive controlled drug delivery from implant dosage forms to treat osteoporosis in an animal model.

M. Otsuka, W. Higuchi, Y. Matsuda, 2000, Advanced drug delivery reviews.

Effect of Plasma‐calcium‐level‐responsive Oestradiol Release from Apatitic Bone Cement on Bone Mineral Density in Ovariectomized Rats

J. Fox, W. Higuchi, Y. Matsuda, 1999, The Journal of pharmacy and pharmacology.

Oestradiol Release from Self‐setting Apatitic Bone Cement Responsive to Plasma‐calcium Level in Ovariectomized Rats, and its Physicochemical Mechanism

J. Fox, M. Otsuka, W. Higuchi, 1997, The Journal of pharmacy and pharmacology.

Cholesterol crystallite nucleation in supersaturated model biles from a thermodynamic standpoint.

W. Higuchi, Chen-Lun Liu, 2002, Biochimica et biophysica acta.

Dissolution kinetics of cholesterol in simulated bile II: influence of simulated bile composition.

W. Higuchi, A. Hofmann, K. Kwan, 1978, Journal of pharmaceutical sciences.

Mechanisms of dissolution of human cholesterol gallstones.

W. Higuchi, S. Prakongpan, F. Young, 1973, Journal of pharmaceutical sciences.

A rapid method for the measurement of cholesterol thermodynamic activity in bile salt-lecithin-cholesterol solutions.

W. Higuchi, C. Liu, P. H. Lee, 1993, Journal of pharmaceutical sciences.

Mechanism for the Retardation of the Acid Dissolution Rate of Hydroxyapatite by Strontium

W. Higuchi, F. Young, M. Dedhiya, 1973, Journal of dental research.

Delivery of liposome membrane-associated sterols through silastic membranes.

N. Weiner, J. Kreuter, W. Higuchi, 1981, Biochimica et biophysica acta.

Calcium and 1-hydroxyethylidene-1, 1-bisphosphonic acid : polynuclear complex formation in the physiological range of pH

J. Fox, W. Higuchi, M. Lamson, 1984 .

Theoretical analysis of diffusional movement through heterogeneous barriers

W. Higuchi, T. Higuchi, 1960 .

Effects of long-term hydration leading to the development of polar channels in hairless mouse stratum corneum.

K. Knutson, W. Higuchi, W. J. Lambert, 1989, Journal of pharmaceutical sciences.

Diffusional model for transport rate studies across membranes.

W. Higuchi, R. Stehle, 1967, Journal of pharmaceutical sciences.

Analysis of human buccal absorption of drugs by physical model approach.

W. Higuchi, N. Ho, K. Vora, 1972, Journal of pharmaceutical sciences.

Noninvasive Ocular Drug Delivery System of Dexamethasone Sodium Phosphate in the Treatment of Experimental Uveitis Rabbit.

W. Higuchi, K. Papangkorn, John W. Higuchi, 2017, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Enhancement of Argon Laser Effect on Dissolution and Loss of Human Enamel

J. Fox, G. Powell, W. Higuchi, 1993 .

Effect of Fluoride Pretreatment on the Solubility of Synthetic Carbonated Apatite

W. Higuchi, A. Baig, A. Barry, 2003, Calcified Tissue International.

Effect of carbonate content and crystallinity on the metastable equilibrium solubility behavior of carbonated apatites

J. Fox, M. Otsuka, W. Higuchi, 1996 .

Novel Animal Model for Evaluating Topical Efficacy of Antiviral Agents: Flux Versus Efficacy Correlations in the Acyclovir Treatment of Cutaneous Herpes Simplex Virus Type 1 (HSV-1) Infections in Hairless Mice

W. Higuchi, M. Su, E. Kern, 1992, Pharmaceutical Research.

Physical model approach in the study of the transport of alkyl amines across a silicone rubber membrane in a two-chamber diffusion cell.

J. Fox, W. Higuchi, D. Patel, 1984, Journal of Pharmacy and Science.

Model transport studies utilizing lecithin spherules. I. Critical evaluations of several physical models in the determination of the permeability coefficient for glucose.

T. Yotsuyanagi, W. Higuchi, Z. U. Chowhan, 1972, Biochimica et biophysica acta.

Predicted absorption rates with simultaneous bulk fluid flow in the intestinal tract.

G. Amidon, W. Higuchi, N. Ho, 1981, Journal of theoretical biology.

Self-setting hydroxyapatite cement: a novel skeletal drug-delivery system for antibiotics.

J. Fox, M. Otsuka, W. Higuchi, 1992, Journal of pharmaceutical sciences.

A novel skeletal drug delivery system for anti-bacterial drugs using self-setting hydroxyapatite cement.

J. Fox, M. Otsuka, W. Higuchi, 1990, Chemical & pharmaceutical bulletin.

Influence of Dodecylamine Hydrochloride Adsorption on the Dissolution Kinetics of Hydroxyapatite

J. Fox, P. Pithayanukul, W. Higuchi, 1984 .

Dissolution rates of high energy polyvinylpyrrolidone (PVP)-sulfathiazole coprecipitates.

W. Higuchi, A. Simonelli, S. Mehta, 1969, Journal of pharmaceutical sciences.

Inhibition of sulfathiazole crystal growth by polyvinylpyrrolidone.

W. Higuchi, A. Simonelli, S. Mehta, 1970, Journal of pharmaceutical sciences.

Two-phase method for the investigation of interphase transport. I. Theoretical aspects.

M. A. Farvar, W. Higuchi, S. Howard, 1969, Journal of pharmaceutical sciences.

Cholesterol solubility in organic solvents.

W I Higuchi, G. Flynn, W. Higuchi, 1979, Journal of pharmaceutical sciences.

In vitro model for transport of solutes in three-phase system. II. Experimental considerations.

W I Higuchi, W. Higuchi, R G Stehle, 1972, Journal of pharmaceutical sciences.

Diffusional Models Useful in Biopharmaceutics: Drug Release Rate Processes

W. Higuchi, 1967 .

Determination of binding affinity for chenodeoxycholate in equilibrium with sulfobutylether-β-cyclodextrin.

W. Higuchi, Chen-Lun Liu, Shu-Yu Jhou, 2012, Journal of pharmaceutical sciences.

Mechanistic studies of the effect of hydroxypropyl-beta-cyclodextrin on in vitro transdermal permeation of corticosterone through hairless mouse skin.

S. K. Li, A. Ghanem, W. Higuchi, 2003, International journal of pharmaceutics.

Rate of crystal growth of sulfathiazole and methylprednisolone.

W. Higuchi, A. Simonelli, S. Mehta, 1970, Journal of pharmaceutical sciences.

CHOLESTEROL PARTICLE GROWTH AND DISSOLUTION RATES IN AQUEOUS MEDIA.

W. Higuchi, H. Y. Saad, 1965, Journal of pharmaceutical sciences.

RATE OF SOLUTE TRANSPORT OUT OF EMULSION DROPLETS IN MICRON SIZE RANGE.

W. Higuchi, 1964, Journal of pharmaceutical sciences.

Experimental method for studying growth rates of particles in aqueous media.

W. Higuchi, P. Lau, 1962, Journal of pharmaceutical sciences.

Dissolution rate behavior of solid cholesterol preparations in bile acid solutions.

W. Higuchi, K. Feld, 1981, Journal of pharmaceutical sciences.

EPR Properties of Synthetic Apatites, Deorganified Dentine, and Enamel

W. Higuchi, E. Haskell, G. Kenner, 1998, Calcified Tissue International.

Dissolution rates of finely divided drug powders. I. Effect of a distribution of particle sizes in a diffusion-controlled process.

W. Higuchi, W I HIGUCHI, E N HIESTAND, 1963, Journal of pharmaceutical sciences.

Effect of particle size on zinc release from zinc containing tricalcium phosphate (ZnTCP) in Zn-deficient osteoporosis rats.

N. Ichinose, A. Ito, M. Otsuka, 2003, Bio-medical materials and engineering.

Structure and Calculation of the Binding Energy of Gaseous Alkali Halide Dimers

C. T. O'konski, W. Higuchi, 1955 .

Effect of geometrical structure on drug release rate of a three-dimensionally perforated porous apatite/collagen composite cement.

A. Ito, M. Otsuka, W. Higuchi, 2010, Journal of pharmaceutical sciences.

Effect of geometrical cement size on in vitro and in vivo indomethacin release from self-setting apatite cement.

J. Fox, M. Otsuka, W. Higuchi, 1998, Journal of controlled release : official journal of the Controlled Release Society.

A novel skeletal drug delivery system using self-setting calcium phosphate cement VIII: the relationship between in vitro and in vivo drug release from indomethacin-containing cement

J. Fox, M. Otsuka, W. Higuchi, 1997 .

Dissolution rates of high energy sulfathiazole--povidone coprecipitates II: characterization of form of drug controlling its dissolution rate via solubility studies.

W I Higuchi, W. Higuchi, A P Simonelli, 1976, Journal of pharmaceutical sciences.

Relationships Among Carbonated Apatite Solubility, Crystallite Size, and Microstrain Parameters

J. Fox, R. Young, M. Otsuka, 1999, Calcified Tissue International.

Quantitative Relationship between Carbonated Apatite Metastable Equilibrium Solubility and Dissolution Kinetics

J. Fox, G. Powell, M. Otsuka, 1994 .

Metastable Equilibrium Solubility Behavior of Carbonated Apatites

J. Fox, G. Powell, M. Otsuka, 1994 .

Growth kinetics of fluorapatite deposition on synthetic hydroxyapatite seed crystals

J. Fox, W. Higuchi, S. C. Dave, 1989 .

The influence of EHDP on the dissolution rate behavior of heat-treated and non-heat-treated hydroxyapatites

J. Fox, M. Otsuka, W. Higuchi, 1989 .

The influence of dodecylamine hydrochloride adsorption on the dissolution rate behavior of heat-treated and non-heat-treated hydroxyapatite

J. Fox, M. Otsuka, W. Higuchi, 1987 .

The influence of dodecylamine hydrochloride on the dissolution kinetics of heat-treated hydroxyapatite samples

J. Fox, W. Higuchi, N. Muhammad, 1986 .

Unifying criteria for dissolution kinetics of various hydroxyapatite preparations

J. Fox, W. Higuchi, P. W. Cho, 1986 .

The influence of ion activity product on remineralization behavior of carbonate-apatite pellets, hydroxyapatite pellets and hydroxyapatite powder

J. Fox, W. Higuchi, N. Muhammad, 1984 .

Hydroxyapatite dissolution rates in fluoride/dodecylamine solutions

J. Fox, P. Pithayanukul, W. Higuchi, 1984 .

Dissolution rate of apatite powders in acidic fluoride solutions and the relationship to hydroxyapatite disk and bovine enamel behavior

J. Fox, W. Higuchi, A. Ludwig, 1983 .

Kinetics and Mechanism of Hydroxyapatite Crystal Dissolution in Weak Acid Buffers Using the Rotating Disk Method

J. Fox, W. Higuchi, Maw-Sheng Wu, 1976, Journal of dental research.

Metastable Equilibrium Solubility Distribution and Dissolution Kinetics of Carbonate Apatite Powders

J. Fox, M. Otsuka, W. Higuchi, 1995 .

Quantitative Determination of Lattice Fluoride Effects on the Solubility and Crystallinity of Carbonated Apatites with Incorporated Fluoride

M. Otsuka, W. Higuchi, K. Moribe, 2012, Caries Research.

Synchronized Crystal Dissolution Behavior for Tooth Enamel and Synthetic (NBS) Hydroxyapatite

W. Higuchi, J. Hefferren, M. Fawzi, 1977, Journal of dental research.

Mechanisms of Enamel Dissolution in Acid Buffers

W. Higuchi, J. Hefferren, J. A. Gray, 1965, Journal of dental research.

Intraoral uptake of fluoride by presoftened enamel following systemic administration and fluoride mouthrinsing.

C. Kowalski, M. Zimmermann, W. Higuchi, 1985, Caries research.

Effect of Acid Type on Kinetics and Mechanism of Dental Enamel Demineralization

J. Fox, W. Higuchi, M. Patel, 1987, Journal of dental research.

The mechanism of action of solution fluoride upon the demineralization rate of human enamel.

W. Higuchi, J. Hefferren, N. A. Mir, 1969, Archives of oral biology.

A new two-site model for hydroxyapatite dissolution in acidic media☆

J. Fox, W. Higuchi, M. Fawzi, 1978 .

Combined effects of laser irradiation and chemical inhibitors on the dissolution of dental enamel.

J L Fox, W I Higuchi, J. Fox, 1992, Caries research.

Mechanism of hydroxyapatite dissolution. Synergistic effects of solution fluoride, strontium, and phosphate

W. Higuchi, F. Young, M. Dedhiya, 1974 .

A Thermometric Method for Thermodynamics Studies and Molecular Weight Determinations in Solutions

W. Higuchi, T. Higuchi, E. Rippie, 1959 .

Iontophoretic drug delivery: effects of physicochemical factors on the skin uptake of nonpeptide drugs.

W. Higuchi, A. Malick, C. R. Behl, 1989, Journal of pharmaceutical sciences.

Effect of Sodium Bicarbonate Amount on In Vitro Indomethacin Release from Self-Setting Carbonated-Apatite Cement

J. Fox, M. Otsuka, W. Higuchi, 1997, Pharmaceutical Research.

A novel skeletal drug delivery system using self-setting calcium phosphate cement. 9: Effects of the mixing solution volume on anticancer drug release from homogeneous drug-loaded cement.

J. Fox, M. Otsuka, W. Higuchi, 1995, Journal of pharmaceutical sciences.

A novel skeletal drug delivery system using self-setting calcium phosphate cement. 7. Effect of biological factors on indomethacin release from the cement loaded on bovine bone.

J. Fox, M. Otsuka, W. Higuchi, 1994, Journal of pharmaceutical sciences.

A novel skeletal drug-delivery system using self-setting calcium phosphate cement. 4. Effects of the mixing solution volume on the drug-release rate of heterogeneous aspirin-loaded cement.

J. Fox, M. Otsuka, W. Higuchi, 1994, Journal of pharmaceutical sciences.

The kinetics and mechanisms of reactions of human tooth enamel in buffered solutions of high fluoride concentrations.

S. Valvani, W. Higuchi, J. Hefferren, 1974, Archives of oral biology.

Estimation of cholesterol solubilization by a mixed micelle binding model in aqueous tauroursodeoxycholate:lecithin:cholesterol solutions.

H. Chiang, W. Higuchi, Chen-Lun Liu, 2008, Journal of pharmaceutical sciences.

Initial Dissolution Rate Studies on Dental Enamel after CO2 Laser Irradiation

J L Fox, G L Powell, W I Higuchi, 1992, Journal of dental research.

Mechanism of cholesterol monohydrate dissolution in taurocholate—lecithin media—correlation between equilibrium dialysis results and dissolution rates

W. Higuchi, A. Hofmann, A. Wanichsiriroj, 1984 .

Age and anatomical site influences on alkanol permeation of skin of the male hairless mouse

G. Flynn, W. Higuchi, N. Ho, 1984 .

Controlled (trans) dermal delivery of an antiviral agent (acyclovir). I: An in vivo animal model for efficacy evaluation in cutaneous HSV-1 infections

Seung-Ho Choi, W. Higuchi, M. Su, 1990 .

The influence of azone propylene glycol and polyethylene glycol on in vitro skin penetration of trifluorothymidine

W. Higuchi, S. Spruance, D. Freeman, 1986 .

Quantitative Examination of the Simple Micelle–Mixed Micelle Coexistence for the Taurocholate–Lecithin System by GP-HPLC

W. Higuchi, H. Naganuma, Chen-Lun Liu, 1997 .

Cholesterol monohydrate dissolution rates and solubilities in aqueous taurocholate, taurochenodeoxycholate, and tauroursodeoxycholate solutions: A comparative study

N. Mazer, W. Higuchi, Paul H. Lee, 1990 .

Silicone polymer uptake method for determination of cholesterol thermodynamic activity in model bile systems.

W. Higuchi, P. H. Lee, K. Takayama, 1988, Journal of pharmaceutical sciences.

Simple micelle—mixed micelle coexistence equilibria for the taurocholate—, taurochenodeoxycholate—, and tauroursodeoxycholate—lecithin systems

M. Arakawa, W. Higuchi, Paul H. Lee, 1987 .

Examination of the Sephadex G10 beads uptake method for determination of bile salt monomer concentration in taurocholate-lecithin solutions.

W. Higuchi, P. H. Lee, S. Noro, 1985, Journal of pharmaceutical sciences.

Mechanism of cholesterol gallstone dissolution. Analysis of the kinetics of cholesterol monohydrate dissolution in taurocholate/lecithin solutions by the Mazer, Benedek, and Carey model

E. Gulari, W. Higuchi, M. Alkan, 1981 .

Dissolution kinetics of cholesterol in simulated bile I: Influence of bile acid type and concentration, bile acid-lecithin ration, and added electrolyte.

W. Higuchi, A. Hofmann, A. Molokhia, 1977, Journal of pharmaceutical sciences.

Dissolution rate studies of cholesterol monohydrate in bile acid-lecithin solutions using the rotatingdisk method.

W. Higuchi, A. Molokhia, S. Prakongpan, 1976, Journal of pharmaceutical sciences.

Factors to be considered in the evaluation of bioavailability and bioequivalence of topical formulations.

G. Flynn, V. Shah, A. Ghanem, 1992, Skin pharmacology : the official journal of the Skin Pharmacology Society.

Quantitative Structure–Enhancement Relationship and the Microenvironment of the Enhancer Site of Action

S. K. Li, W. Higuchi, 2015 .

Assessing the influence of ethanol on simultaneous diffusion and metabolism of ß-estradiol in hairless mouse skin for the ‘asymmetric’ situation in vitro

A. Ghanem, W. Higuchi, W. Good, 1992 .

Polymorphism and drug availability. II. Dissolution rate behavior of the polymorphic forms of sulfathiazole and methylprednisolone.

W. Higuchi, S. Mehta, P. D. Bernardo, 1967, Journal of pharmaceutical sciences.

Passive and oxymetazoline-enhanced delivery with a lens device: pharmacokinetics and efficacy studies with rabbits.

S. K. Li, W. Higuchi, Anthony L Tuitupou, 2008, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Theoretical model studies of drug absorption and transport in the gastrointestinal tract.i.

W. Higuchi, N. Ho, A. Suzuki, 1970, Journal of pharmaceutical sciences.

Examination of penetration routes and distribution of ionic permeants during and after transscleral iontophoresis with magnetic resonance imaging.

E. Jeong, S. K. Li, W. Higuchi, 2007, International journal of pharmaceutics.

Physical model evaluation of topical prodrug delivery-simultaneous transport and bioconversion of vidarabine-5'-valerate II: Parameter determinations.

J. Fox, W. Higuchi, N. Ho, 1979, Journal of pharmaceutical sciences.

Physical model evaluation of topical prodrug delivery-simultaneous transport and bioconversion of vidarabine-5'-valerate I: Physical model development.

J L Fox, W I Higuchi, J. Fox, 1979, Journal of pharmaceutical sciences.

General physical model for simultaneous diffusion and metabolism in biological membranes. The computational approach for the steady-state case

Jeffrey L. Fox, William I. Higuchi, J. Fox, 1979 .

Influence of crystallite microstrain on surface complexes governing the metastable equilibrium solubility behavior of carbonated apatites.

M. Otsuka, W. Higuchi, K. Moribe, 2008, Journal of colloid and interface science.

Relationships Involving Metastable Equilibrium Solubility, Surface Complexes, and Crystallite Disorder with Carbonated Apatites

W. Higuchi, A. Baig, N. Zhang, 2001, Calcified Tissue International.

Physical model approach to the design of laser irradiation regimens to improve resistance to dental caries

Jeffrey L. Fox, Jer Hsu, William I. Higuchi, 1996, Photonics West.

Kinetic Factors in the Tooth-Plaque-Saliva Model Systems

W. Higuchi, 1974, Journal of dental research.

Physical Model for Plaque Action in the Tooth-Plaque-Saliva System

W. Higuchi, F. Young, T. Koulourides, 1970, Journal of dental research.

A novel skeletal drug-delivery system using self-setting calcium phosphate cement. 3. Physicochemical properties and drug-release rate of bovine insulin and bovine albumin.

J. Fox, M. Otsuka, W. Higuchi, 1994, Journal of pharmaceutical sciences.

Effect of particle size of metastable calcium phosphates on mechanical strength of a novel self-setting bioactive calcium phosphate cement.

J. Fox, M. Otsuka, W. Higuchi, 1995, Journal of biomedical materials research.

A novel skeletal drug delivery system using a self-setting calcium phosphate cement. 5. Drug release behavior from a heterogeneous drug-loaded cement containing an anticancer drug.

J. Fox, M. Otsuka, W. Higuchi, 1994, Journal of pharmaceutical sciences.

Fluorescent probe studies of the interactions of 1-alkyl-2-pyrrolidones with stratum corneum lipid liposomes.

W. Jiskoot, J. Herron, S. K. Li, 1996, Journal of pharmaceutical sciences.

A mechanistic study of the effects of the 1-alkyl-2-pyrrolidones on bilayer permeability of stratum corneum lipid liposomes: a comparison with hairless mouse skin studies.

D. Crommelin, S. K. Li, A. Ghanem, 1995, Journal of pharmaceutical sciences.

Effect of geometrical structure on the biodegradation of a three-dimensionally perforated porous apatite/collagen composite bone cell scaffold.

H. Ohshima, A. Ito, M. Otsuka, 2010, Biological & pharmaceutical bulletin.

A novel skeletal drug delivery system using self-setting calcium phosphate cement. 2. Physicochemical properties and drug release rate of the cement-containing indomethacin.

J. Fox, M. Otsuka, W. Higuchi, 1994, Journal of pharmaceutical sciences.

Drug Release from a Three-Dimensionally Perforated Porous Apatite/Collagen Composite Cement

A. Ito, M. Otsuka, W. Higuchi, 2012 .

Effect of nanostructure on biodegradation behaviors of self-setting apatite/collagen composite cements containing vitamin K2 in rats.

M. Otsuka, W. Higuchi, K. Otsuka, 2006, Journal of biomedical materials research. Part B, Applied biomaterials.

Effect of Micropore Structure on Drug Release Form Self-Setting Calcium Phosphate Cement Containing Anti-Cancer Agent

J. Fox, M. Otsuka, W. Higuchi, 1996 .

Mechanisms of interphase transport. I. Theoretical considerations of diffusion and interfacial barriers in transport of solubilized systems.

G. Zografi, W. Higuchi, N. Ho, 1967, Journal of pharmaceutical sciences.

Effect of laser irradiation on the dissolution kinetics of hydroxyapatite preparations.

J. Fox, G. Powell, M. Otsuka, 1990, Journal of pharmaceutical sciences.

Analysis of data on drug release from emulsions. II. Pyridine release from water-in-oil emulsions as a function of pH.

W. Higuchi, T. Koizumi, 1968, Journal of pharmaceutical sciences.

Analysis of data on drug release from emulsions. 3. Boundary effect on pyridine release from water-in-oil emulsions as a function of pH.

W. Higuchi, T. Koizumi, 1968, Journal of pharmaceutical sciences.

Correlation of microenvironmental drug concentration with inhibition of growth of microorganisms on surfaces

W. Higuchi, E. Cesar, T. Sonobe, 1983, Antimicrobial Agents and Chemotherapy.

Macro- and molecular physical-chemical considerations in understanding drug transport in the stratum corneum

Russell O. Potts, William I. Higuchi, R. Potts, 1985 .

Mechanistic studies of branched-chain alkanols as skin permeation enhancers.

N. He, S. K. Li, W. Higuchi, 2004, Journal of pharmaceutical sciences.

Influences of alkyl group chain length and polar head group on chemical skin permeation enhancement.

S. K. Li, W. Higuchi, K. Warner, 2001, Journal of pharmaceutical sciences.

Influence of the permeation enhancers 1-alkyl-2-pyrrolidones on permeant partitioning into the stratum corneum.

S. K. Li, W. Higuchi, S. Shimabayashi, 1998, Journal of pharmaceutical sciences.

Mechanistic studies of the 1-alkyl-2-pyrrolidones as skin permeation enhancers.

W I Higuchi, K. Peck, S. K. Li, 1995, Journal of pharmaceutical sciences.

Electrostatic interaction of oil droplets with adsorbed surface-active ions in dilute electrolyte solutions.

W. Higuchi, N. Ho, A. Suzuki, 1970, Journal of pharmaceutical sciences.

Effect of geometrical structure on the in vivo quality change of a three-dimensionally perforated porous bone cell scaffold made of apatite/collagen composite.

A. Ito, M. Otsuka, W. Higuchi, 2013, Journal of biomedical materials research. Part B, Applied biomaterials.

Systems approach to vaginal delivery of drugs II: In situ vaginal absorption of unbranched aliphatic alcohols.

G. Flynn, T. Yotsuyanagi, W. Higuchi, 1976, Journal of pharmaceutical sciences.

Heterogeneity Effects on Permeability–Partition Coefficient Relationships in Human Stratum Corneum

William I. Higuchi, Bradley D. Anderson, B. D. Anderson, 1988, Pharmaceutical Research.

Topical vaginal drug delivery I: effect of the estrous cycle on vaginal membrane permeability and diffusivity of vidarabine in mice.

J. Fox, W. Higuchi, C. C. Hsu, 1983, Journal of pharmaceutical sciences.

Systems approach to vaginal delivery of drugs III: Simulation studies interfacing steroid release from silicone matrix and vaginal absorption in rabbits.

G. Flynn, W. Higuchi, N. Ho, 1976, Journal of pharmaceutical sciences.

Hydration and percutaneous absorption: I. Influence of hydration on alkanol permeation through hairless mouse skin.

G. Flynn, W. Higuchi, N. Ho, 1980, The Journal of investigative dermatology.

Vaginal drug absorption in the rhesus monkey: Bioavailability method and assessment of estrogens

G. Flynn, W. Higuchi, M. Langworthy, 1979 .

Systems approach to vaginal delivery of drugs I: development of in situ vaginal drug absorption procedure.

G. Flynn, T. Yotsuyanagi, W. Higuchi, 1975, Journal of pharmaceutical sciences.

Topical vaginal drug delivery in the guinea pig. I. Effect of estrous cycle on the vaginal membrane permeability of vidarabine

J. Fox, W. Higuchi, N. Ho, 1985 .

Permeability of thermally damaged skin III: Influence of scalding temperature on mass transfer of water and n-alkanols across hairless mouse skin

G. Flynn, W. Higuchi, K. A. Walters, 1981 .

Systems approach to vaginal delivery of drugs V: in situ vaginal absorption of 1-alkanoic acids.

G. Flynn, W. Higuchi, N. Ho, 1977, Journal of pharmaceutical sciences.

Systems approach to vaginal delivery of drugs IV: methodology for determination of membrane surface pH.

G. Flynn, W. Higuchi, N. Ho, 1977, Journal of pharmaceutical sciences.

Estimation of Skin Target Site Acyclovir Concentrations Following Controlled (Trans)dermal Drug Delivery in Topical and Systemic Treatment of Cutaneous HSV-1 Infections in Hairless Mice

W. Higuchi, Wei-qi Song, M. Su, 1994, Pharmaceutical Research.

An application of the C∗ concept in predicting the topical efficacy of finite dose acyclovir in the treatment of cutaneous HSV-1 infections in hairless mice

A. Ghanem, W. Higuchi, M. Su, 1993 .

Synthesis and evaluation of a series of 2'-O-acyl derivatives of 9-beta-D-arabinofuranosyladenine as antiherpes agents.

G. Arnett, W. Higuchi, S. D. Kumar, 1984, Journal of medicinal chemistry.

Control of drug concentration-time profiles in vivo by zero-order transdermal delivery systems

T. Okano, S. W. Kim, F. Komada, 1987 .

Influence of 1-dodecylazacycloheptan-2-one (Azone) on the topical therapy of cutaneous herpes simplex virus type 1 infection in hairless mice with 2',3'-di-O-acetyl-9-beta-D-arabinofuranosyladenine and 5'-O-valeryl-9-beta-D-arabinofuranosyladenine.

G. Flynn, J. Fox, K. Sugibayashi, 1985, Journal of pharmaceutical sciences.

Topical Delivery of Antiviral Agents: In Vivo / In Vitro Correlations

G. Flynn, W. Higuchi, N. Ho, 1984 .

Evaluation of prodrugs of 9-beta-D-arabinofuranosyladenine for therapeutic efficacy in the topical treatment of genital herpesvirus infections in guinea pigs

G. Arnett, W. Higuchi, S. D. Kumar, 1983, Antimicrobial Agents and Chemotherapy.

Quantitative mechanistic studies in simultaneous fluid flow and intestinal absorption using steroids as model solutes

W. Higuchi, N. Ho, I. Komiya, 1980 .

SYNTHESIS AND EVALUATION OF A SERIES OF 2′-O-ACYL DERIVATIVES OF 9-β-D-ARABINOFURANOSYLADENINE AS ANTIHERPES AGENTS

G. Arnett, W. Higuchi, S. D. Kumar, 1984 .

Theoretical model studies of intestinal drug absorption. IV. Bile acid transport at premicellar concentrations across diffusion layer-membrane barrier.

W. Higuchi, N. Ho, 1974, Journal of pharmaceutical sciences.

Design of 9-beta-D-arabinofuranosyladenine (ara-A) transdermal delivery system for animal studies: regulation of drug concentration in vivo.

T. Okano, F. Komada, W. Higuchi, 1991, Journal of pharmaceutical sciences.

Preformulation of an Ara-A transdermal delivery system: Membrane fabrication and characterization

S. W. Kim, W. Higuchi, O. Teruo, 1987 .

Correlation of in vivo topical efficacies with in vitro predictions using acyclovir formulations in the treatment of cutaneous HSV-1 infections in hairless mice: an evaluation of the predictive value of the C* concept.

A. Ghanem, W. Higuchi, E. Kern, 1996, Antiviral research.

Assessment of correlation between skin target site free drug concentration and the in vivo topical antiviral efficacy in hairless mice for (E)-5-(2-bromovinyl)-2'-deoxyuridine and acyclovir formulations.

E. De Clercq, A. Ghanem, W. Higuchi, 1998, Journal of pharmaceutical sciences.

Relationship of skin target site free drug concentration (C*) to the in vivo efficacy: an extensive evaluation of the predictive value of the C* concept using acyclovir as a model drug.

A. Ghanem, W. Higuchi, E. Kern, 1997, Journal of pharmaceutical sciences.

STUDIES IN SIMULTANEOUS FLUID FLOW AND INTJZSTINAL ABSORPTION USING STEROIDS AS MODEL SOLUTES

W. Higuchi, Park, A. Kamani, 2002 .

Physical model evaluation of topical prodrug delivery--simultaneous transport and bioconversion of vidarabine-5'-valerate IV: Distribution of esterase and deaminase enzymes in hairless mouse skin.

J. Fox, W. Higuchi, N. Ho, 1980, Journal of pharmaceutical sciences.

Lattice model simulation of adsorption of linear, multisegmented molecules onto CaF2 out of organic solvents II. Adsorption ofn-alkyl amines out ofn-hexane,n-dodecane, cyclohexane, adn benzene, and alkyl diamines out of benzene

W. Higuchi, J. Bladon, 1981 .

Lattice model simulation of adsorption of linear, multisegmented molecules onto CaF2 out of organic solvents. I. Adsorption ofn-alkyl alcohols out ofn-hexane andn-dodecane

W. Higuchi, J. Bladon, 1981 .

Theoretical calculations of solvent effects on the adsorption of linear molecules using the multilayer lattice model

W. Higuchi, J. Bladon, A. Molokhia, 1975 .

Oil-water distribution of p-alkylpyridines.

W. Higuchi, K. Yeh, 1976, Journal of pharmaceutical sciences.

Systems approach to study of solute transport across membranes using suspension cultures of mammalian cells. II. Experimental procedures and uptake studies with cholesterol.

W. Higuchi, N. Ho, C. Shipman, 1972, Journal of pharmaceutical sciences.

Systems approach to the study of drug transport across membranes using suspension cultures of mammalian cells. I. Theoretical diffusion models.

W. Higuchi, N. Ho, C. Shipman, 1972, Journal of theoretical biology.

Quantitation of simultaneous diffusion and metabolism of β-estradiol in hairless mouse skin: Enzyme distribution and intrinsic diffusion/metabolism parameters

A. Ghanem, W. Higuchi, W. Good, 1990 .

Mechanisms for interface-controlled transport of cholesterol in micellar sodium cholate-lecithin and micellar sodium cholate-lecithin-sodium oleate systems

T. Yotsuyanagi, W. Higuchi, O. Gatmaitan, 1977 .

Comparison of theoretical equations for potential energy of electrostatic repulsion of colloidal particles at constant surface charge.

W. Higuchi, N. Ho, H. Toguchi, 1973, Journal of pharmaceutical sciences.

Quantitative Evaluation of Ethanol Effects on Diffusion and Metabolism of β-Estradiol in Hairless Mouse Skin

W. Higuchi, Wei-qi Song, W. Good, 1991, Pharmaceutical Research.

Structure-activity relationship for chemical skin permeation enhancers: probing the chemical microenvironment of the site of action.

T. Suhonen, N. He, S. K. Li, 2003, Journal of pharmaceutical sciences.

Physical model evaluation of topical prodrug delivery--simultaneous transport and bioconversion of vidarabine-5'-valerate V: Mechanistic analysis of influence of nonhomogeneous enzyme distributions in hairless mouse skin.

J. Fox, W. Higuchi, N. Ho, 1980, Journal of pharmaceutical sciences.

Direct membrane method for the study of interface-controlled transport of cholesterol in aqueous media.

J. Fox, W. Higuchi, M. G. Karth, 1985, Journal of pharmaceutical sciences.

Mechanism of cholesterol gallstone dissolution. II. Correlation between the effect of the alkyl amines as cholesterol gallstone dissolution rate accelerators and the degree of binding of the alkyl amines to the bile acid micelles

W. Higuchi, D. Patel, 1980 .

Dissolution rates of cholesterol monohydrate crystals and human cholesterol gallstones in bile acid-lecithin solutions: enhancing effect of added alkyl quaternary ammonium salts.

W. Higuchi, S. Prakongpan, F. Young, 1973, Journal of pharmaceutical sciences.

Interfacially controlled transport of micelle-solubilized sterols across an oil-water interface in two ionic surfactant systems.

W. Higuchi, V. Surpuriya, 1972, Journal of pharmaceutical sciences.

Interfacial barriers to the transport of sterols and other organic compounds at the aqueous polysorbate 80-hexadecane interface.

A. Bikhazi, W. Higuchi, 1971, Biochimica et biophysica acta.

Interfacial barriers in interphase transport. II. Influence of additives upon the transport of diethylphthalate across the hexadecane-gelatin-water interface.

A. Ghanem, W. Higuchi, A. Simonelli, 1970, Journal of pharmaceutical sciences.

Release of medroxyprogesterone acetate from a silicone polymer.

W I Higuchi, W. Higuchi, T J Roseman, 1970, Journal of pharmaceutical sciences.

Interfacial barriers in interphase transport: retardation of the transport of diethylphthalate across the hexadecane-water interface by an adsorbed gelatin film.

A. Ghanem, W. Higuchi, A. Simonelli, 1969, Journal of pharmaceutical sciences.

Ion-exchange membrane assisted transdermal iontophoretic delivery of salicylate and acyclovir.

S. K. Li, W. Higuchi, S. Ibrahim, 2009, International journal of pharmaceutics.

Investigation of factors influencing release of solid drug dispersed in inert matrices.

W I Higuchi, W. Higuchi, S J Desai, 1966, Journal of pharmaceutical sciences.

Release rates of solid drug mixtures dispersed in inert matrixes. 3. Binary mixture of acid drugs released into alkaline media.

W. Higuchi, A. Simonelli, F. Sjuib, 1972, Journal of pharmaceutical sciences.

Drug membrane transport enhancement using high energy drug polyvinylpyrrolidone (PVP) co-precipitates

M. A. Farvar, O. Corrigan, W. Higuchi, 1980 .

Analysis of theoretical behavior of a proposed zero-order drug delivery system.

R A Lipper, W I Higuchi, R. A. Lipper, 1977, Journal of pharmaceutical sciences.

Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: Physical properties and clinical application

G. Flynn, N. LaRusso, R. Maccarty, 1980 .

Dissolution rates of polyphase mixtures.

W I Higuchi, W. Higuchi, S J Desai, 1965, Journal of pharmaceutical sciences.

Solubilization in nonpolar solvents. Influence of the chain length of solvent on the solubilization of water by dioctyl sodium sulfosuccinate.

W. Higuchi, J. Misra, 1962, Journal of pharmaceutical sciences.

Predictions of the particle size distribution changes in emulsions and suspensions by digital computation

W. Higuchi, N. Ho, A. Suzuki, 1969 .

Penetration enhancing effect of Azone on the transport of 5-fluorouracil across the hairless rat skin

W. Higuchi, Sugibayashi Kenji, Morimoto Yasunori, 1986 .

RHEOMETRIC STUDY OF PARTICLE-PARTICLE INTERACTIONS IN SUSPENSIONS.

W. Higuchi, R. Stehle, 1965, Journal of pharmaceutical sciences.

Dissolution rates of finely divided drug powders. II. Micronized methyl-prednisolone.

W. Higuchi, W I HIGUCHI, E L ROWE, 1963, Journal of pharmaceutical sciences.

Two-step interfacial barrier mechanism for the transport of micelle-solubilized solute across an oil-water interface.

W. Higuchi, V. Surpuriya, 1972, Biochimica et Biophysica Acta.

Quantitative analysis of the interfacial barrier to membrane transport of cholesterol solubilized in a charged micellar system.

W. Higuchi, N. Ho, M. G. Karth, 1985, Journal of pharmaceutical sciences.

Dissolution of model gallstones in bile acid solutions I: implications for T-tube infusion treatment of retained common duct stones with the cholate system.

W. Higuchi, A. Hofmann, A. M. Molokjia, 1975, Journal of pharmaceutical sciences.

Enhancing effect of calcium ions on transport of cholesterol from aqueous sodium taurocholate-lecithin micellar phase to oil phase.

W. Higuchi, V. Surpuriya, 1974, Journal of pharmaceutical sciences.

Participation of micelle at crystal-solution interface in rate-determining step for cholesterol gallstone dissolution in unsaturated bile media.

W. Higuchi, S. Prakongpan, V. Surpuriya, 1973, Journal of pharmaceutical sciences.

Interfacial barrier limited interphase transport of cholesterol in the aqueous polysorbate 80-hexadecane system.

A. Bikhazi, W. Higuchi, 1970, Journal of pharmaceutical sciences.

The development of a rat/human skin flap served by a defined and accessible vasculature on a congenitally athymic (nude) rat.

G. Krueger, W. Higuchi, L. Pershing, 1985, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Effect of the absorption enhancer, Azone, on the transport of 5‐fluorouracil across hairless rat skin

K. Sugibayashi, Y. Morimoto, W. Higuchi, 1985, The Journal of pharmacy and pharmacology.

Iontophoresis of polypeptides: effect of ethanol pretreatment of human skin.

W. Higuchi, M. Su, C. R. Behl, 1990, Journal of pharmaceutical sciences.

Transdermal iontophoretic drug delivery: mechanistic analysis and application to polypeptide delivery.

A. Ghanem, W. Higuchi, C. R. Behl, 1989, Journal of pharmaceutical sciences.

Quantitative, mechanistic and physiologically realistic approach to the biopharmaceutical design of oral drug delivery systems

H. Merkle, W. Higuchi, N. Ho, 1983 .

Mesophase formation during in vitro cholesterol gallstone dissolution: a specific effect of ursodeoxycholic acid.

O. Corrigan, W. Higuchi, A. Hofmann, 1981, Journal of pharmaceutical sciences.

Dissolution rates of model gallstones in human and animal biles and importance of interfacial resistance.

W. Higuchi, A. Hofmann, R. Danzinger, 1977, Journal of pharmaceutical sciences.

Mechanistic studies of flux variability of neutral and ionic permeants during constant current dc iontophoresis with human epidermal membrane.

Honggang Zhu, S. K. Li, W. Higuchi, 2004, International journal of pharmaceutics.

Investigation of properties of human epidermal membrane under constant conductance alternating current iontophoresis.

Honggang Zhu, K. Peck, S. K. Li, 2003, Journal of controlled release : official journal of the Controlled Release Society.

Quantitative description of the effect of molecular size upon electroosmotic flux enhancement during iontophoresis for a synthetic membrane and human epidermal membrane.

W I Higuchi, V Srinivasan, K. Peck, 1996, Journal of pharmaceutical sciences.

Macromolecule transport in and effective pore size of ethanol pretreated human epidermal membrane

William I. Higuchi, V. Srinivasan, A. Ghanem, 1994 .

Skin alteration and convective solvent flow effects during iontophoresis: I. Neutral solute transport across human skin

W. Higuchi, V. Srinivasan, S. M. Sims, 1991 .

Studies on the Effects of Applied Voltage and Duration on Human Epidermal Membrane Alteration/Recovery and the Resultant Effects upon Iontophoresis

A. Ghanem, W. Higuchi, H. Inada, 1994, Pharmaceutical Research.

Transscleral Iontophoresis for Noninvasive Ocular Drug Delivery of Macromolecules.

S. K. Li, W. Higuchi, B. Ambati, 2020, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.

Cholesterol monohydrate dissolution rate studies in aqueous micellar sodium chenodeoxycholate solutions.

W. Higuchi, N. Ho, S. Gupta, 1985, Journal of pharmaceutical sciences.

Cholesterol monohydrate dissolution rate studies in aqueous micellar solutions of alpha-(nonylphenyl)-omega-hydroxydeca(oxyethylene), n-alkylamines, and fatty acids.

W. Higuchi, N. Ho, S. Gupta, 1985, Journal of Pharmacy and Science.

Cholesterol Monohydrate Dissolution Rate Studies in Aqueous Micellar Solutions of α-(Nonylphenyl)-ω-Hydroxydeca(Oxyethylene), n-Alkylamines, and Fatty Acids

W. Higuchi, N. Ho, S. Gupta, 1985 .

Theoretical treatment of cholesterol monohydrate dissolution in Renex-690/ionic surfactant systems based on a physical model approach☆

W. Higuchi, N. Ho, S. Gupta, 1984 .

Cholesterol monohydrate dissolution rate studies in aqueous micellar solutions of polyoxyethylene nonylphenol ether and ionic surfactants

W. Higuchi, N. Ho, S. Gupta, 1984 .

Mechanism of cholesterol gallstone dissolution. III. Electrophoretic studies showing the correlation between the bile micellarcharge and the effect of alkyl amines as cholesterol gallstone dissolution rate accelerators

W. Higuchi, J. Oncley, D. Patel, 1980 .

Microelectrophoresis and adsorption studies of cholesterol particles in bile salt and alkyl surfactant systems.

W. Higuchi, D. Mufson, 1970, Journal of pharmaceutical sciences.

Interfacial barriers in interphase transport. 3. Transport of cholesterol and other organic solutes into hexadecane-gelatin-water matrices.

A. Ghanem, W. Higuchi, A. Simonelli, 1970, Journal of pharmaceutical sciences.

The Retardation of Enamel Dissolution Rates by Adsorbed Long-Chain Ammonium Chlorides

W. Higuchi, J. Hefferren, T. J. Roseman, 1969, Journal of dental research.

Cholesterol particle growth and dissolution rates II. Retardation effects of cholate.

W. Higuchi, H. Y. Saad, 1965, Journal of pharmaceutical sciences.

Kinetics and Mechanisms of Cholesterol Gallstone Dissolution

W. Higuchi, 1984, Hepatology.

Cholesterol gallstone dissolution rate accelerators I: Exploratory investigations.

W. Higuchi, A. Hofmann, A. Molokhia, 1977, Journal of pharmaceutical sciences.

Influence of benzalkonium chloride on the dissolution rate behavior of several solid-phase preparations of cholesterol in bile acid solutions.

W. Higuchi, K. Feld, C. Su, 1982, Journal of pharmaceutical sciences.

Mesophase formation during cholesterol dissolution in ursodeoxycholate-lecithin solutions: new mechanism for gallstone dissolution in humans.

O. Corrigan, W. Higuchi, A. Hofmann, 1980, Journal of pharmaceutical sciences.

Principles and criteria in the development and optimization of topical therapeutic products.

G. Flynn, V. Shah, W. Higuchi, 1992, Pharmaceutical research.

Principles and criteria in the development and optimization of topical therapeutic products.

G. Flynn, V. Shah, W. Higuchi, 1992, Journal of pharmaceutical sciences.

Kinetics of flocculation and-or coalescence of dilute oil-in-water emulsions.

W. Higuchi, N. Ho, D. Bernstein, 1971, Journal of pharmaceutical sciences.

Permeation of hairless mouse skin II: membrane sectioning techniques and influence on alkanol permeabilities.

G. Flynn, W. Higuchi, H. Dürrheim, 1981, Journal of pharmaceutical sciences.

Comparison of three lasers on demineralization of human enamel

Jeffrey L. Fox, William I. Higuchi, G. Lynn Powell, 1993, Photonics West - Lasers and Applications in Science and Engineering.

Dose-Dependent Enhancement Effects of Azone on Skin Permeability

K. Knutson, W. Higuchi, W. J. Lambert, 1989, Pharmaceutical Research.

Mechanisms of interphase transport. II. Theoretical considerations and experimental evaluation of interfacially controlled transport in solubilized systems.

W. Higuchi, A. Goldberg, 1969, Journal of pharmaceutical sciences.

A Monomer-Micelle Model for the Formation of Simple Taurocholate Micelles

H. Chiang, W. Higuchi, Chen-Lun Liu, 2010 .

Quasielastic Light Scattering and Cholesterol Thermodynamic Activity Studies of the Micelle-to-Vesicle Transition in Conjugated Ursodeoxycholate-Lecithin-Cholesterol Solutions

N. Mazer, W. Higuchi, U. Jain, 1994 .

EFFECTS OF SHORT RANGE SURFACE-SEGMENT FORCES ON THE CONFIGURATION OF AN ADSORBED FLEXIBLE CHAIN POLYMER

W. Higuchi, 1961 .

A test of the becker-doering theory of nucleation kinetics☆☆☆

C. T. O'konski, W. Higuchi, 1960 .

The Kinetics of Nucleation in Turbulent Jets

C. T. O'konski, W. Higuchi, 1956 .

Quantitative interpretation of in vivo buccal absorption of n-alkanoic acids by the physical model approach.

W. Higuchi, N. Ho, 1971, Journal of pharmaceutical sciences.

Kinetics of rapid aggregation in suspensions. Comparison of experiments with the Smoluchowski theory.

W. Higuchi, A. P. Lemberger, G. Stelter, 1963, Journal of pharmaceutical sciences.

Permeability of Thermally Damaged Skin: I. Immediate Influences of 60°C Scalding on Hairless Mouse Skin

G. Flynn, W. Higuchi, N. Ho, 1980 .

Variability in dissolution rates of cholesterol pellets in bile acid solutions.

W. Higuchi, K. Feld, 1981, Journal of pharmaceutical sciences.

Polymorphism and drug availability. Solubility relationships in the methylprednisolone system.

W. Higuchi, T. Higuchi, J. W. Shell, 1963, Journal of pharmaceutical sciences.

SOLUBILITY AND DISSOLUTION RATES IN REACTIVE MEDIA.

J. Wagner, W. Higuchi, W I HIGUCHI, 1964, Journal of pharmaceutical sciences.

A New Relationship for the Dielectric Properties of Two Phase Mixtures

W. Higuchi, 1958 .

The Structure of Lipids by Spectroscopic and X-Ray Techniques.

W. Higuchi, 1966 .

Metastable Equilibrium Solubility Behavior of Carbonated Apatite in the Presence of Solution Strontium

W. Higuchi, A. Baig, D. Heslop, 2003, Calcified Tissue International.

In vivo percutaneous penetration / absorption Sponsored by the American Association of Pharmaceutical Scientists

R. Guy, H. Maibach, G. Flynn, 2002 .

In vitro estimates of topical bioavailability.

H. Ando, W. Higuchi, N. Ho, 1977, Journal of pharmaceutical sciences.

Physical model approach to understanding finite dose transport and uptake of hydrocortisone in hairless guinea-pig skin

William I. Higuchi, A. Ghanem, W. Higuchi, 1992 .

Fluoride remineralization of demineralized bovine tooth enamel and hydroxyapatite pellets.

J. Fox, W. Higuchi, M. Yonese, 1981, Journal of pharmaceutical sciences.

Electron Probe Micro-analysis for Subsurface Demineralization and Remineralization of Dental Enamel

W. Higuchi, J. S. Chu, W. Nash, 1989, Journal of dental research.

Quantitative microradiographic study of simultaneous demineralization/remineralization of dental enamel in weak acid buffers.

J. Fox, W. Higuchi, D. H. Bergstrom, 1984, Journal of pharmaceutical sciences.

Solution activity product (KFAP) and simultaneous demineralization-remineralization in bovine tooth enamel and hydroxyapatite pellets.

J. Fox, W. Higuchi, J. Hefferren, 1983, Journal of pharmaceutical sciences.

Novel topical fluoride-delivery system for remineralization of dental enamel: optimization studies

J. Fox, W. Higuchi, Y. Kanaya, 1983 .

A possible second site for hydroxyapatite dissolution in acidic media

J. Fox, W. Higuchi, J. Hefferren, 1978 .

Unusual Dissolution Behavior of Tooth Enamel and Synthetic HAP Crystals Under High Partial Saturation Conditions

W. Higuchi, M. Fawzi, J.J. Hefferren, 1977, Journal of dentistry research.

Quantitative microradiography for studying dental enamel demineralization and remineralization.

J. Fox, W. Higuchi, D. H. Bergstrom, 1984, Journal of pharmaceutical sciences.

Novel topical fluoride delivery system II: remineralization of human teeth.

J. Fox, W. Higuchi, M. Yonese, 1981, Journal of pharmaceutical sciences.

Novel topical fluoride delivery system I: remineralization of ground bovine teeth.

J. Fox, W. Higuchi, M. Yonese, 1981, Journal of pharmaceutical sciences.

In vivo Remineralization Using a Sustained Topical Fluoride Delivery System

J. Fox, W. Higuchi, L. J. Abrahams, 1980, Journal of dental research.

Physical model for lesion formation in the presence of low levels of solution fluoride.

J. Fox, W. Higuchi, D. H. Bergstrom, 1995, Journal of pharmaceutical sciences.

Calculation of intercrystalline solution composition during in vitro subsurface lesion formation in dental minerals.

J. Fox, M. Otsuka, W. Higuchi, 1996, Journal of pharmaceutical sciences.

A new acid abrasion procedure for studying F profiles in demineralized/remineralized bovine tooth enamel.

J. Fox, W. Higuchi, J. Hefferren, 1983, Caries research.

Dissolution rate behavior of hydroxyapatite-fluorapatite mixtures.

J. Fox, D. Crommelin, W. Higuchi, 1983, Caries research.

DISSOLUTION KINETICS OF A WEAK ACID, 1,1-HEXAMETHYLENE P-TOLYLSULFONYLSEMICARBAZIDE, AND ITS SODIUM SALT.

W. Higuchi, W I HIGUCHI, W E HAMLIN, 1965, Journal of pharmaceutical sciences.

Hydration and percutaneous absorption III: Influences of stripping and scalding on hydration alteration of the permeability of hairless mouse skin to water and n-alkanols.

G. Flynn, W. Higuchi, N. Ho, 1982, Journal of pharmaceutical sciences.

Particle size effect of metastable calcium phosphates on crushing strength of self-setting bioactive calcium phosphate cement.

J. Fox, M. Otsuka, W. Higuchi, 1993, Chemical & pharmaceutical bulletin.

A comparative study of the metastable equilibrium solubility behavior of high-crystallinity and low-crystallinity carbonated apatites using pH and solution strontium as independent variables.

W I Higuchi, M. Otsuka, W. Higuchi, 2005, Journal of colloid and interface science.

Design of oral drug delivery systems – Past, present and future

H. Merkle, W. Higuchi, N. Ho, 1983 .

Model studies of epidermal permeability.

Y. H. Kim, W I Higuchi, A. Ghanem, 1992, Seminars in dermatology.

Argon laser effect on demineralization of human enamel

Jeffrey L. Fox, William I. Higuchi, G. L. Powell, 1992, Photonics West - Lasers and Applications in Science and Engineering.

Drug release from wax matrices. II. Application of a mixture theory to the suflanilamide--wax system.

W I Higuchi, J B Schwartz, W. Higuchi, 1968, Journal of pharmaceutical sciences.

Examination of iontophoretic transport of ionic drugs across skin: baseline studies with the four-electrode system

J. Fox, S. Pons, W. Higuchi, 1989 .

Effect of Age on Rat Bone Solubility and Crystallinity

S. Miller, W. Higuchi, A. Baig, 2002, Calcified Tissue International.

Baseline studies with the four-electrode system: the effect of skin permeability increase and water transport on the flux of a model uncharged solute during iontophoresis

W. Higuchi, M. Su, V. Srinivasan, 1989 .

Lag time data for characterizing the pore pathway of intact and chemically pretreated human epidermal membrane

William I. Higuchi, K. Peck, S. K. Li, 1998 .

Release rates of solid drug mixtures dispersed in inert matrixes. IV. Binary mixture of amphoteric drugs released into reactive media.

W. Higuchi, A. Simonelli, F. Sjuib, 1972, Journal of pharmaceutical sciences.

Model selection for complex systems involving polynuclear species

J. Fox, W. Higuchi, M. Lamson, 1985 .

Plasma Calcium Level‐responsive Oestradiol Release From Self‐setting Apatitic Bone Cement in Ovariectomized Rats

J. Fox, M. Otsuka, W. Higuchi, 1996 .

The influence of iso-propanol, n-propanol and n-butanol on stratum corneum lipid phase behavior

K. Knutson, W. Higuchi, S. Krill, 1993 .

Baseline studies on iontophoretic transport in hairless mouse skin: the effect of applied voltage drop and ph on the iontophoresis of a model weak electrolyte

W. Higuchi, S. M. Sims, 1990 .

Silicone elastomer uptake method for determination of free 1-alkyl-2-pyrrolidone concentration in micelle and hydroxypropyl-beta-cyclodextrin systems used in skin transport studies.

S. K. Li, W. Higuchi, D. Shaker, 2008, Journal of pharmaceutical sciences.

Systems approach to the study of drug transport across membranes using suspension culture of mammalian cells. V. Simultaneous poassive transport and biosynthesis.

H. Ando, W. Higuchi, N. Ho, 1976, Journal of theoretical biology.

Theoretical model studies of drug absorption and transport in the gastrointestinal tract. II.

W. Higuchi, N. Ho, A. Suzuki, 1970, Journal of pharmaceutical sciences.

Transmission electron microscopic confirmation of the morphological predictions of the two-site model for hydroxyapatite dissolution☆

J. Fox, W. Higuchi, A. Katdare, 1978 .

Chemometric evaluation of physicochemical properties of carbonated-apatitic preparations by Fourier transform infrared spectroscopy.

M. Otsuka, W. Higuchi, A. Baig, 2012, Journal of biomedical materials research. Part A.

Heat-treatment-induced Reduction in the Apparent Solubility of Human Dental Enamel

G. Powell, M. Otsuka, W. Higuchi, 1994, Journal of dental research.

Interaction of electric field and electro-osmotic effects in determining iontophoretic enhancement of anions and cations

W. Higuchi, V. Srinivasan, S. M. Sims, 1991 .

Dissolution rate-solubility behavior of 3-(1-methyl-2-pyrrolidinyl)-indole as a function of hydrogen-ion concentration.

W. Higuchi, W. E. Hamlin, 1966, Journal of pharmaceutical sciences.

A model for iontophoresis incroporating the effect of convective solvent flow

W. Higuchi, V. Srinivasan, 1990 .

Monooctanoin, a dissolution agent for retained cholesterol bile duct stones: physical properties and clinical application.

G. Flynn, N. LaRusso, R. Maccarty, 1980, Gastroenterology.

In vitro release of 9-β-d-arabinofuranosyladenine from thermo-responsive copoly(acryloyl-l-proline methyl ester/styrene) gels

W. Higuchi, Masaru Yoshida, H. Omichi, 1994 .

Permeation of skin and eschar by antiseptics I: baseline studies with phenol.

G. Flynn, W. Higuchi, N. Ho, 1983, Journal of Pharmacy and Science.

Kinetics and mechanism of the reaction between hydroxyapatite and fluoride in aqueous acidic media.

W. Higuchi, Z. Liang, 1973, The Journal of physical chemistry.

Permeation of skin and eschar by antiseptics II: influence of controlled burns on the permeation of phenol.

G. Flynn, W. Higuchi, N. Ho, 1983, Journal of pharmaceutical sciences.

Model transport studies utilizing lecithin spherules IV: transport of D-glucose in spherules prepared from lecithin, dicetyl phosphate, and cholesterol.

W. Higuchi, Z. U. Chowhan, 1974, Journal of pharmaceutical sciences.

Principles and Criteria in the Development and Optimization of Topical Therapeutic Products

G. Flynn, V. Shah, W. Higuchi, 1992, Pharmaceutical Research.

Effects of Ethanol on the Transport of β-Estradiol in Hairless Mouse Skin: Comparison of Experimental Data with a New Theoretical Model

J. Fox, A. Ghanem, W. Higuchi, 1987 .

Model transport studies utilizing lecithin spherules. II. Transport of 3-O-methyl- 14 C-D-glucose in D-glucose solution.

T. Yotsuyanagi, W. Higuchi, Z. U. Chowhan, 1973, Journal of Pharmacy and Science.

Model transport studies utilizing lecithin spherules. 3. Transport of taurocholic acid-(cholic- 3 H(G)) in buffered D-glucose solutions.

W. Higuchi, Z. U. Chowhan, 1973, Journal of pharmaceutical sciences.

A two phase series model for the transport of steroids across the fully hydrated stratum corneum

W I Higuchi, T. Yotsuyanagi, W. Higuchi, 1972, The Journal of pharmacy and pharmacology.

Human epidermal membrane constant conductance iontophoresis: alternating current to obtain reproducible enhanced permeation and reduced lag times of a nonionic polar permeant.

Honggang Zhu, K. Peck, A. Ghanem, 2002, International journal of pharmaceutics.

Analysis of diffusion through concentric right circular cylinders and concentric spheres.

G. Flynn, W. Higuchi, N. Ho, 1976, Journal of pharmaceutical sciences.