J. Xiang

发表

Mechanistic aspects of the CH alkynylation reaction of acetylenic triflones. Determination of phenyl versus cyclohexyl migratory aptitude for a vinylidine carbene

P. Fuchs, J. Xiang, 1996 .

Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.

K. Svenson, J. Bard, T. Mansour, 2009, Journal of medicinal chemistry.

Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties.

J. D. Clark, J. McKew, J. Xiang, 2009, Bioorganic & medicinal chemistry.

Living cationic polymerization of styrene in the presence of tetrabutylammonium salts

K. Matyjaszewski, J. Xiang, Chih-Hwa Lin, 1993 .

Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016.

T. Mansour, J. Xiang, E. Saiah, 2011, The Journal of organic chemistry.

Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.

K. Svenson, J. Bard, T. Mansour, 2013, ACS medicinal chemistry letters.

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.

J. Skotnicki, E. Feyfant, J. Xiang, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.

T. Rush, J. Xiang, S. Tam, 2006, Bioorganic & medicinal chemistry letters.

Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1.

Jing Chen, J. Xiang, D. Erbe, 2003, Bioorganic & medicinal chemistry.

Chemospecific alkynylation of organic iodides

P. Fuchs, J. Xiang, 1998 .

Use of allylic triflones for allylation of C-H bonds

P. Fuchs, J. Xiang, D. Curran, 1998 .

Alkenylation of C−H Bonds via Reaction with Vinyl and Dienyl Triflones. Stereospecific Synthesis of Trisubstituted Vinyl Triflones via Organocopper Addition to Acetylenic Triflones1

Philip L. Fuchs, P. Fuchs, J. Xiang, 1996 .

Stereospecific Alkenylation of C−H Bonds via Reaction with β-Heteroatom-Functionalized Trisubstituted Vinyl Triflones1

P. Fuchs, J. Xiang, Wanlong Jiang, 1997 .

Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.

T. Rush, J. Skotnicki, J. Levin, 2005, Bioorganic & medicinal chemistry.

Synthesis and SAR of highly selective MMP-13 inhibitors.

T. Rush, J. Skotnicki, J. Levin, 2005, Bioorganic & medicinal chemistry letters.

β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action

J. McKew, T. Mansour, J. Xiang, 2007 .

Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I

J. Xiang, M. Tam, J. Tobin, 2005 .

Salt and solvent effects in “living” carbocationic polymerization

K. Matyjaszewski, J. Xiang, Chih-Hwa Lin, 1994 .

Stereo- and Regiospecific Syntheses of α- and β-Substituted Vinyl and Dienyl Triflones via the Stille Reaction1

P. Fuchs, J. Xiang, and A. Mahadevan, 1996 .

Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.

J. McKew, T. Mansour, J. Xiang, 2008, Journal of medicinal chemistry.

beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action.

J. McKew, T. Mansour, J. Xiang, 2007, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

J. Xiang, M. Tam, J. Tobin, 2005, Bioorganic & Medicinal Chemistry Letters.

Comparative pharmacokinetics and metabolism studies in lean and diet- induced obese mice: an animal efficacy model for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.

J. Xiang, E. Saiah, Zhao‐Kui Wan, 2011, Drug Metabolism Letters.

Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.

J. Xiang, L. Xing, S. Tam, 2011, Bioorganic & medicinal chemistry letters.