I. Tabas

发表

Macrophage death and defective inflammation resolution in atherosclerosis

I. Tabas, 2010, Nature Reviews Immunology.

Role of cholesterol and lipid organization in disease

F. Maxfield, I. Tabas, 2005, Nature.

Macrophages in the Pathogenesis of Atherosclerosis

K. Moore, I. Tabas, K. Moore, 2011, Cell.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

John L Cleveland, Masaaki Komatsu, Katsuhiko Kitamoto, 2008, Autophagy.

Atherosclerosis--an inflammatory disease.

K. Williams, I. Tabas, I Tabas, 1999, The New England journal of medicine.

Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.

Ira Tabas, Y. Marcel, I. Tabas, 2011, Cell metabolism.

The response-to-retention hypothesis of early atherogenesis.

K. Williams, I. Tabas, I. Tabas, 1995, Arteriosclerosis, thrombosis, and vascular biology.

A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

O. Farokhzad, U. V. von Andrian, Lorena Riol-Blanco, 2014, Nano letters (Print).

FoxOs integrate pleiotropic actions of insulin in vascular endothelium to protect mice from atherosclerosis.

R. DePinho, D. Accili, K. Tsuchiya, 2012, Cell metabolism.

Insulin resistance, hyperglycemia, and atherosclerosis.

K. Bornfeldt, I. Tabas, 2011, Cell metabolism.

Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet

Brian C. Pridgen, A. Tall, J. Breslow, 2009, Circulation research.

Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity

A. Ferrante, I. Tabas, L. Ozcan, 2015, PloS one.

[37] Lipoprotein-liposome interactions

A. Tall, K. Williams, I. Tabas, 1986 .

p53 and atherosclerosis.

I. Tabas, 2001, Circulation research.

Ira Tabas , Kevin Jon Williams and Jan Borén and Therapeutic Implications Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis : Update

J. Borén, K. Williams, I. Tabas, 2007 .

Recognition of vesicular lipoproteins by the apolipoprotein B,E receptor of cultured fibroblasts.

A. Tall, C. Blum, K. Williams, 1986, Journal of lipid research.

The role of non‐resolving inflammation in atherosclerosis

I. Tabas, Amanda C. Doran, C. Kasikara, 2018, The Journal of clinical investigation.

How an artery heals.

E. Fisher, K. Williams, I. Tabas, 2015, Circulation research.

Induction of ER Stress in Macrophages of Tuberculosis Granulomas

G. Kaplan, L. Bekker, C. Nathan, 2010, PloS one.

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

O. Farokhzad, M. Islam, Junqing Wang, 2020, Science Translational Medicine.

The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice

G. Barish, P. Tobias, L. Curtiss, 2013, Innate immunity.

Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis

I. Tabas, M. Kockx, Dajun Zhang, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Role of endoplasmic reticulum stress in metabolic disease and other disorders.

I. Tabas, L. Ozcan, 2012, Annual review of medicine.

Mechanisms of Fibrosis Development in Nonalcoholic Steatohepatitis

R. Schwabe, I. Tabas, U. Pajvani, 2020 .

IEW Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

I. Tabas, 2011 .

IRE1beta inhibits chylomicron production by selectively degrading MTP mRNA.

D. Ron, M. Hussain, R. Jungreis, 2008, Cell metabolism.

Impaired MEK Signaling and SERCA Expression Promote ER Stress and Apoptosis in Insulin-Resistant Macrophages and Are Reversed by Exenatide Treatment

A. Tall, I. Tabas, Gang Li, 2012, Diabetes.

Association of Plasma Sphingomyelin Levels and Incident Coronary Heart Disease Events in an Adult Population: Multi-Ethnic Study of Atherosclerosis

G. Burke, S. Shea, J. Yeboah, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Nonoxidative modifications of lipoproteins in atherogenesis.

I. Tabas, Ira Tabas, 1999, Annual review of nutrition.

Phospholipid metabolism in cholesterol-loaded macrophages

I. Tabas, 1997, Current opinion in lipidology.

Dachshund Depletion Disrupts Mammary Gland Development and Diverts the Composition of the Mammary Gland Progenitor Pool

B. Spike, R. Pestell, Zhiping Li, 2018, Stem cell reports.

Macrophage Inflammation, Erythrophagocytosis, and Accelerated Atherosclerosis in Jak2V617F Mice

A. Tall, R. Levine, O. Soehnlein, 2018, Circulation research.

Interference with ER stress and restoration of efferocytosis in the treatment of advanced atherosclerosis

I. Tabas, E. Thorp, L. Ozcan, 2012 .

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1.

R. Pestell, Wei Wang, R. Ramakrishnan, 2019, Blood.

Mechanisms of ER stress-induced apoptosis in atherosclerosis.

I. Tabas, Christopher M. Scull, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

E. Chen, M. Blüher, M. Czech, 2018, Nature.

ACAT Inhibition Reduces the Progression of Preexisting, Advanced Atherosclerotic Mouse Lesions Without Plaque or Systemic Toxicity

Christine M. Miller, E. Fisher, J. Rong, 2013, Arteriosclerosis, thrombosis, and vascular biology.

In search of an endpoint.

P. Kovanen, I. Tabas, 2000, Current opinion in lipidology.

Deficiency of AXL in Bone Marrow-Derived Cells Does Not Affect Advanced Atherosclerotic Lesion Progression

I. Tabas, G. Matsushima, J. Proto, 2016, Scientific Reports.

Macrophages Govern the Progression and Termination of Inflammation in Atherosclerosis and Metabolic Diseases

G. Fredman, I. Tabas, 2014 .

Macrophage autophagy plays a protective role in advanced atherosclerosis.

Jennifer Martinez, I. Tabas, J. Robbins, 2012, Cell metabolism.

Mechanisms and consequences of efferocytosis in advanced atherosclerosis

I. Tabas, E. Thorp, 2009, Journal of leukocyte biology.

Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress.

I. Tabas, 2009, Antioxidants & redox signaling.

Signal Transducer and Activator of Transcription-1 Is Critical for Apoptosis in Macrophages Subjected to Endoplasmic Reticulum Stress In Vitro and in Advanced Atherosclerotic Lesions In Vivo

R. Virmani, F. Kolodgie, I. Tabas, 2008, Circulation.

Signal transduction pathways in free cholesterol-loaded macrophages: cell biological insight into the progression of atherosclerosis

I. Tabas, 2004 .

A reporter for tracking the UPR in vivo reveals patterns of temporal and cellular stress during atherosclerotic progression

M. Miura, T. Iwawaki, I. Tabas, 2011, Journal of Lipid Research.

Pivotal role of calcium/calmodulin-dependent protein kinase II in ER stress-induced apoptosis

I. Tabas, L. Ozcan, 2010, Cell cycle.

Forkhead Transcription Factors (FoxOs) Promote Apoptosis of Insulin-Resistant Macrophages During Cholesterol-Induced Endoplasmic Reticulum Stress

Alexander S. Banks, R. DePinho, D. Accili, 2008, Diabetes.

Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways.

Mark E. Anderson, E. Olson, R. Bassel-Duby, 2009, The Journal of clinical investigation.

The UPR in atherosclerosis

I. Tabas, I. Tabas, Alex-Xianghua Zhou, 2013, Seminars in Immunopathology.

Zn2+-stimulated Sphingomyelinase Is Secreted by Many Cell Types and Is a Product of the Acid Sphingomyelinase Gene*

K. Williams, E. Schuchman, I. Tabas, 1996, The Journal of Biological Chemistry.

Emerging roles of mitochondria ROS in atherosclerotic lesions: causation or association?

I. Tabas, Ying Wang, Ying C Wang, 2014, Journal of atherosclerosis and thrombosis.

Lack of Association Between Adiponectin Levels and Atherosclerosis in Mice

D. Teupser, S. Factor, P. Scherer, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Maladaptive regeneration — the reawakening of developmental pathways in NASH and fibrosis

R. Schwabe, I. Tabas, U. Pajvani, 2020, Nature Reviews Gastroenterology & Hepatology.

Hepatocyte TAZ / WWTR 1 P romotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis Graphical

R. Schwabe, R. Chung, J. Caviglia, 2022 .

Free Cholesterol Accumulation in Macrophage Membranes Activates Toll-Like Receptors and p38 Mitogen-Activated Protein Kinase and Induces Cathepsin K

Michael C. Ostrowski, P. Libby, A. Tall, 2009, Circulation research.

ABCA1 and ABCG1 Protect Against Oxidative Stress–Induced Macrophage Apoptosis During Efferocytosis

A. Tall, J. Witztum, C. Welch, 2010, Circulation research.

Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.

Scott B. Crown, J. Cleveland, O. Ilkayeva, 2020, Cell metabolism.

ABCA1-mediated Cholesterol Efflux Is Defective in Free Cholesterol-loaded Macrophages

I. Tabas, Bo Feng, 2002, The Journal of Biological Chemistry.

MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity

R. Birge, R. Ramakrishnan, I. Tabas, 2018, Science Signaling.

FoxOs promote apoptosis of insulin resistant macrophages during cholesterol-induced ER stress

Alexander S. Banks, D. Accili, A. Tall, 2008 .

A New Activator of Hepatocyte CaMKII in Fasting and Type 2 Diabetes

I. Tabas, L. Ozcan, 2018, Diabetes.

MerTK receptor cleavage promotes plaque necrosis and defective resolution in atherosclerosis

M. Daemen, G. Fredman, I. Tabas, 2017, The Journal of clinical investigation.

MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation

G. Fredman, Chyuan-Sheng Lin, I. Tabas, 2016, Proceedings of the National Academy of Sciences.

The influence of particle size and multiple apoprotein E-receptor interactions on the endocytic targeting of beta-VLDL in mouse peritoneal macrophages

F. Maxfield, J. Myers, T. Innerarity, 1991, The Journal of cell biology.

Endocytosed beta-VLDL and LDL are delivered to different intracellular vesicles in mouse peritoneal macrophages

F. Maxfield, I. Tabas, X. X. Xu, 1990, The Journal of cell biology.

Mechanisms and Consequences of Cholesterol Loading in Macrophages

I. Tabas, 1998 .

Boosting Inflammation Resolution in Atherosclerosis

G. Fredman, I. Tabas, 2017 .

Resolvin D1 limits 5-lipoxygenase nuclear localization and leukotriene B4 synthesis by inhibiting a calcium-activated kinase pathway

J. Backs, G. Fredman, I. Tabas, 2014, Proceedings of the National Academy of Sciences.

Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity

S. Cremers, M. Gaestel, B. Hubbard, 2015, Diabetes.

CD11c+ Dendritic Cells Maintain Antigen Processing, Presentation Capabilities, and CD4+ T-Cell Priming Efficacy Under Hypercholesterolemic Conditions Associated With Atherosclerosis

P. Libby, A. Lichtman, I. Tabas, 2008, Circulation research.

Efferocytosis in health and disease

I. Tabas, Arif Yurdagul, Amanda C. Doran, 2019, Nature Reviews Immunology.

In search of a starting point.

P. Kovanen, I. Tabas, 2001, Current opinion in lipidology.

MerTK Cleavage on Resident Cardiac Macrophages Compromises Repair After Myocardial Ischemia Reperfusion Injury

Daniel C. Lee, I. Tabas, W. Muller, 2017, Circulation research.

Hypercholesterolemia induces T cell expansion in humanized immune mice

V. D’Agati, Hui Wang, M. Sykes, 2018, The Journal of clinical investigation.

Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.

E. Olson, J. Backs, I. Tabas, 2013, Cell metabolism.

A Therapeutic Silencing RNA Targeting Hepatocyte TAZ Prevents and Reverses Fibrosis in Nonalcoholic Steatohepatitis in Mice

R. Schwabe, A. Kannt, K. Jahn-Hofmann, 2019, Hepatology communications.

Differential effects of pioglitazone on advanced atherosclerotic lesions.

I. Tabas, E. Thorp, 2009, The American journal of pathology.

Ira Tabas The Importance of Lesion Stage and Phagocytic Efficiency Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis

I. Tabas, 2005 .

Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein.

I. Tabas, D. Cohen, J. M. Báez, 2005, The Biochemical journal.

Homozygosity for an Allele Encoding Deacetylated FoxO1 Protects Macrophages From Cholesterol-Induced Inflammation Without Increasing Apoptosis

Alexander S. Banks, D. Accili, K. Tsuchiya, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Plasma sphingomyelin and subclinical atherosclerosis: findings from the multi-ethnic study of atherosclerosis.

J. Nelson, A. Tall, S. Shea, 2006, American journal of epidemiology.

Secretory sphingomyelinase.

I. Tabas, 1999, Chemistry and physics of lipids.

Sphingolipids and atherosclerosis: a mechanistic connection? A therapeutic opportunity?

I. Tabas, 2004, Circulation.

Efferocytosis induces macrophage proliferation to help resolve tissue injury.

Na Kong, I. Tabas, Arif Yurdagul, 2021, Cell metabolism.

Chapter 22 Lipids and atherosclerosis

I. Tabas, 2002 .

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis.

R. Schwabe, Xiaoming Yang, K. Guan, 2020, Cell metabolism.

Allosteric MAPKAPK2 inhibitors improve plaque stability in advanced atherosclerosis

B. Hubbard, I. Tabas, Arif Yurdagul, 2021, bioRxiv.

Mitochondrial Oxidative Stress Promotes Atherosclerosis and Neutrophil Extracellular Traps in Aged Mice

A. Tall, I. Tabas, Wei Wang, 2017, Arteriosclerosis, thrombosis, and vascular biology.

Macrophage Mitochondrial Oxidative Stress Promotes Atherosclerosis and Nuclear Factor-&kgr;B–Mediated Inflammation in Macrophages

P. Rabinovitch, I. Tabas, Ying Wang, 2014, Circulation research.

Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution

G. Gusarova, I. Tabas, Arif Yurdagul, 2018, Immunity.

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

I. Tabas, Gang Li, L. Ozcan, 2010, The Journal of cell biology.

ATVB in Focus Cell Death in Cardiovascular Disease

M. Bennett, I. Tabas, Christopher M. Scull, 2011 .

An Apolipoprotein(a) Peptide Delays Chylomicron Remnant Clearance and Increases Plasma Remnant Lipoproteins and Atherosclerosis In Vivo

M. Koschinsky, C. Devlin, I. Tabas, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Mechanisms of Fibrosis Development in NASH.

R. Schwabe, I. Tabas, U. Pajvani, 2020, Gastroenterology.

The reactivity of desmosterol and other shellfish- and xanthomatosis-associated sterols in the macrophage sterol esterification reaction.

I. Tabas, S. Feinmark, N. Beatini, 1989, The Journal of clinical investigation.

Abrogating Foam Cell Formation in Hyperlipidemic Mice Loss of SRA and CD 36 Activity Reduces Atherosclerotic Lesion Complexity

K. Moore, J. Alvarez‐Leite, I. Tabas, 2008 .

C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions.

J. Borén, R. Kaufman, Chyuan-Sheng Lin, 2015, Circulation research.

Targeting soluble DPP-4 for insulin resistance: Origin matters.

I. Tabas, L. Ozcan, D. Ghorpade, 2020, The Journal of clinical endocrinology and metabolism.

Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity

M. Bessler, Keiko Nakamura, I. Tabas, 2020, The Journal of clinical investigation.

Genetic alterations of IL-1 receptor antagonist in mice affect plasma cholesterol level and foam cell lesion size

C. Devlin, I. Tabas, E. Hirsch, 2002, Proceedings of the National Academy of Sciences of the United States of America.

p 53 and Atherosclerosis

I. Tabas, 2001 .

Apoptosis and efferocytosis in mouse models of atherosclerosis.

I. Tabas, 2007, Current drug targets.

Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

R. Schwabe, J. Zucman‐Rossi, M. Karin, 2022, Nature.

PPARγ Deacetylation Confers the Antiatherogenic Effect and Improves Endothelial Function in Diabetes Treatment

D. Accili, A. Tall, L. Qiang, 2020, Diabetes.

Increased CD36 protein as a response to defective insulin signaling in macrophages.

D. Accili, A. Tall, H. Okamoto, 2004, The Journal of clinical investigation.

Suppression of Macrophage Eicosanoid Synthesis by Atherogenic Lipoproteins Is Profoundly Affected by Cholesterol-Fatty Acyl Esterification and the Niemann-Pick C Pathway of Lipid Trafficking*

C. Leslie, I. Tabas, A. R. Leventhal, 2004, Journal of Biological Chemistry.

Identification and characterization of an acyl-CoA:triterpene acyltransferase activity in rabbit and human tissues.

J. Clader, I. Tabas, L. L. Chen, 1991, Journal of lipid research.

Accelerating the pace of atherosclerosis research.

D. Rader, A. Daugherty, I. Tabas, 2015, Arteriosclerosis, thrombosis, and vascular biology.

Results Suppression of Myeloid Cell mitoOS Protects Against Atherosclerosis and Reduces Myeloid Cell Accumulation in Aged Mice

A. Tall, I. Tabas, Ying Wang, 2017 .

Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs.

G. Hansson, I. Tabas, E. Thorp, 2013, The Journal of clinical investigation.

Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis.

R. Schwabe, R. Birge, R. Chung, 2019, Cell metabolism.

Cardiology: Bad matters made worse

I. Tabas, 2012, Nature.

The J774 Macrophage Model of Native LDL-Induced Foam Cell Formation

A. Tall, I. Tabas, G. Boykow, 1987 .

TAZ-induced Cybb contributes to liver tumor formation in non-alcoholic steatohepatitis.

R. Schwabe, E. Verna, I. Tabas, 2021, Journal of hepatology.

Inflammation and its Resolution as Determinants of Acute Coronary Syndromes

Ira Tabas, Peter Libby, P. Libby, 2014, Circulation research.

The stimulation of the cholesterol esterification pathway by atherogenic lipoproteins in macrophages

I. Tabas, 1995, Current opinion in lipidology.

CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis

I. Tabas, Arif Yurdagul, Hanrui Zhang, 2022, Science Translational Medicine.

An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo.

J. Herz, D. Farber, I. Tabas, 2014, The Journal of clinical investigation.

Early Embryonic Lethality in Mice with Targeted Deletion of the CTP:Phosphocholine Cytidylyltransferase α Gene (Pcyt1a)

S. Magdaleno, S. Jackowski, I. Tabas, 2005, Molecular and Cellular Biology.

A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis

John G Doench, J. Doench, Katherine R. Croce, 2022, Nature communications.

HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis

K. Tracey, B. Diamond, I. Tabas, 2019, Proceedings of the National Academy of Sciences.

Intracellular and Intercellular Aspects of Macrophage Immunometabolism in Atherosclerosis.

K. Bornfeldt, I. Tabas, 2020, Circulation research.

Consequences of cellular cholesterol accumulation: basic concepts and physiological implications.

Ira Tabas, I. Tabas, 2002, The Journal of clinical investigation.

ODC (Ornithine Decarboxylase)-Dependent Putrescine Synthesis Maintains MerTK (MER Tyrosine-Protein Kinase) Expression to Drive Resolution.

Wei Tao, Jinjun Shi, Na Kong, 2021, Arteriosclerosis, thrombosis, and vascular biology.

Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis

R. Schwabe, KyeongJin Kim, M. Graham, 2018, Science Translational Medicine.

Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

Ira Tabas, Petri T. Kovanen, Magnus Bäck, 2019, Nature Reviews Cardiology.

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

D. Ron, I. Tabas, 2011, Nature Cell Biology.

Free cholesterol-induced cytotoxicity a possible contributing factor to macrophage foam cell necrosis in advanced atherosclerotic lesions.

I. Tabas, 1997, Trends in cardiovascular medicine.

Boosting Inflammation Resolution in Atherosclerosis: The Next Frontier for Therapy.

G. Fredman, I. Tabas, 2017, The American journal of pathology.

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

David M. Jones, E. Connolly, G. Fredman, 2016, Nature Communications.

Targeted nanoparticles containing the proresolving peptide Ac2-26 protect against advanced atherosclerosis in hypercholesterolemic mice

O. Farokhzad, M. Perretti, G. Fredman, 2015, Science Translational Medicine.

Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles

Robert Langer, Suresh Gadde, Ira Tabas, 2013, Proceedings of the National Academy of Sciences.

Macrophage Phenotype and Function in Different Stages of Atherosclerosis.

K. Bornfeldt, I. Tabas, 2016, Circulation research.

Cholesterol in health and disease.

I. Tabas, 2002, The Journal of clinical investigation.

Rabbit and human liver contain a novel pentacyclic triterpene ester with acyl-CoA: cholesterol acyltransferase inhibitory activity.

J. Clader, A. McPhail, I. Tabas, 1990, The Journal of biological chemistry.

Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice

K. Moore, M. Freeman, J. Alvarez‐Leite, 2009, Arteriosclerosis, thrombosis, and vascular biology.

Anti-Inflammatory Therapy in Chronic Disease: Challenges and Opportunities

Ira Tabas, Christopher K. Glass, C. Glass, 2013, Science.

Monocyte-Macrophages and T Cells in Atherosclerosis.

A. Lichtman, I. Tabas, 2017, Immunity.

Recent insights into the cellular biology of atherosclerosis

Ira Tabas, G. Garcı́a-Cardeña, G. Owens, 2015, The Journal of cell biology.

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

KyeongJin Kim, L. Qiang, Junjie Yu, 2021, Science Translational Medicine.

Loss of Subcellular Lipid Transport Due to ARV1 Deficiency Disrupts Organelle Homeostasis and Activates the Unfolded Protein Response*

H. Bussemaker, Eunjee Lee, A. Tinkelenberg, 2011, The Journal of Biological Chemistry.

Apoptosis and plaque destabilization in atherosclerosis: the role of macrophage apoptosis induced by cholesterol

I. Tabas, I Tabas, 2004, Cell Death and Differentiation.

Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling.

Ira Tabas, I. Tabas, E. Thorp, 2015, Circulation research.

Macrophage Trafficking, Inflammatory Resolution, and Genomics in Atherosclerosis: JACC Macrophage in CVD Series (Part 2).

K. Moore, J. Björkegren, E. Fisher, 2018, Journal of the American College of Cardiology.

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis.

R. Schwabe, R. Chung, J. Caviglia, 2016, Cell metabolism.

Inflammation and plaque vulnerability

P. Libby, G. Hansson, I. Tabas, 2015, Journal of internal medicine.

Macrophage Apoptosis in Advanced Atherosclerosis

I. Tabas, Gang Li, Jenelle M. Timmins, 2009, Annals of the New York Academy of Sciences.

Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP.

D. Ron, I. Tabas, E. Thorp, 2009, Cell metabolism.

Consequences and Therapeutic Implications of Macrophage Apoptosis in Atherosclerosis: The Importance of Lesion Stage and Phagocytic Efficiency

I. Tabas, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Cholesterol and phospholipid metabolism in macrophages.

I. Tabas, I. Tabas, I Tabas, 2000, Biochimica et biophysica acta.

microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis

Rachel C. Bandler, K. Moore, K. Rayner, 2017, Arteriosclerosis, thrombosis, and vascular biology.

Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis

G. Fredman, I. Tabas, Arif Yurdagul, 2018, Front. Cardiovasc. Med..

Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.

J. Yates, D. Accili, A. Fukamizu, 2012, Cell metabolism.

Cholesterol-induced Apoptotic Macrophages Elicit an Inflammatory Response in Phagocytes, Which Is Partially Attenuated by the Mer Receptor*

A. Tall, Marie-Christine Gerbod-Giannone, Yankun Li, 2006, Journal of Biological Chemistry.

Atherogenic lipids and lipoproteins trigger CD36-TLR2-dependent apoptosis in macrophages undergoing endoplasmic reticulum stress.

K. Moore, M. Koschinsky, D. Golenbock, 2010, Cell metabolism.

Dendritic cells in atherosclerosis

I. Tabas, Manikandan Subramanian, 2013, Seminars in Immunopathology.

Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)*

C. Blobel, T. Vaisar, I. Tabas, 2011, The Journal of Biological Chemistry.

TNFα induces ABCA1 through NF-κB in macrophages and in phagocytes ingesting apoptotic cells

A. Tall, Marie-Christine Gerbod-Giannone, Yankun Li, 2006 .

Calcium signalling and ER stress in insulin resistance and atherosclerosis

I. Tabas, I Tabas, L. Ozcan, 2016, Journal of internal medicine.

Mertk Receptor Mutation Reduces Efferocytosis Efficiency and Promotes Apoptotic Cell Accumulation and Plaque Necrosis in Atherosclerotic Lesions of Apoe−/− Mice

D. Schrijvers, I. Tabas, E. Thorp, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.

L. Wilsbacher, I. Tabas, E. Thorp, 2021, The Journal of clinical investigation.

Efferocytosis in health and disease

I. Tabas, Arif Yurdagul, Amanda C. Doran, 2019, Nature Reviews Immunology.

TAM receptors in cardiovascular disease

P. Maffia, G. Lemke, I. Tabas, 2019, Cardiovascular research.

Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages

F. Maxfield, T. A. Ryan, I. Tabas, 2017, Cell.

Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis

Yihai Cao, Wei Tao, Jinjun Shi, 2021, Nature Reviews Cardiology.

The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis

I. Tabas, E. Thorp, Manikandan Subramanian, 2011, European journal of immunology.

Atherosclerosis and Inflammation

K. Williams, I. Tabas, 2002, Science.

The response-to-retention hypothesis of atherogenesis reinforced.

K. Williams, I. Tabas, K. Williams, 1998, Current opinion in lipidology.

Opportunity? Sphingolipids and Atherosclerosis : A Mechanistic Connection? A Therapeutic

Ira Tabas, I. Tabas, 2012 .

The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis

M. Kitakaze, I. Tabas, 2010 .

Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis.

Suresh Gadde, Ira Tabas, O. Farokhzad, 2016, ACS nano.

Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages

Douglas T. Golenbock, Ira Tabas, K. Moore, 2006, Proceedings of the National Academy of Sciences.

Ira Tabas , Kevin Jon Williams and Jan Borén and Therapeutic Implications Subendothelial Lipoprotein Retention as the Initiating Process in Atherosclerosis : Update

J. Borén, K. Williams, I. Tabas, 2007 .

Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions.

D. Accili, A. Tall, C. Welch, 2006, Cell metabolism.

TITLE: Molecular Mechanisms and Treatment Strategies for Obesity-Associated Coronary Artery Disease, an Imminent Military Epidemic

Principal Investigator, I. Tabas, 2006 .

Role of cholesterol and lipid organization in

I. Tabas, R. Maxfield, 2005 .

Acyl coenzyme A:cholesterol acyl transferase in macrophages utilizes a cellular pool of cholesterol oxidase-accessible cholesterol as substrate.

W. Rosoff, I. Tabas, G. Boykow, 1988, The Journal of biological chemistry.

The actin cytoskeleton is important for the stimulation of cholesterol esterification by atherogenic lipoproteins in macrophages.

F. Maxfield, J. Myers, X. Zha, 1994, The Journal of biological chemistry.

Common Therapeutic Targets in Cardiometabolic Disease

G. Fredman, I. Tabas, L. Ozcan, 2014, Science Translational Medicine.

The Impact of Macrophage Insulin Resistance on Advanced Atherosclerotic Plaque Progression

D. Accili, A. Tall, I. Tabas, 2010, Circulation research.

The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis Ira Tabas

M. Kitakaze, I. Tabas, 2010 .

Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice.

A. Tall, Yibin Wang, Takafumi Senokuchi, 2009, The Journal of clinical investigation.

The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis.

D. Accili, A. Tall, F. Forcheron, 2007, Novartis Foundation symposium.

The inflammatory cytokine response of cholesterol‐enriched macrophages is dampened by stimulated pinocytosis

Yankun Li, I. Tabas, 2007, Journal of leukocyte biology.

A Two-Carbon Switch to Sterol-Induced Autophagic Death

I. Tabas, 2007, Autophagy.

Pulling down the plug on atherosclerosis: Finding the culprit in your heart

I. Tabas, 2011, Nature Medicine.

The neutrophil-lymphocyte ratio and incident atherosclerotic events: analyses from five contemporary randomized trials.

P. Libby, P. Ridker, R. Glynn, 2021, European heart journal.

Letter by Williams and Tabas regarding article "atherosclerosis 2005: recent discoveries and novel hypotheses".

Ira Tabas, K. Williams, I. Tabas, 2006, Circulation.

Lipoprotein retention--and clues for atheroma regression.

K. Williams, I. Tabas, K. Williams, 2005, Arteriosclerosis, thrombosis, and vascular biology.

2016 Russell Ross Memorial Lecture in Vascular Biology: Molecular–Cellular Mechanisms in the Progression of Atherosclerosis

I. Tabas, 2017, Arteriosclerosis, thrombosis, and vascular biology.

Eradicating the Burden of Atherosclerotic Cardiovascular Disease by Lowering Apolipoprotein B Lipoproteins Earlier in Life

Jennifer G. Robinson, Neha J. Pagidipati, M. Pencina, 2018, Journal of the American Heart Association.

Pioglitazone Increases Macrophage Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Nondiabetic Low-Density Lipoprotein Receptor-Null Mice

F. Gonzalez, I. Tabas, Y. Shah, 2007, Circulation.

Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis.

M. Reilly, D. Saleheen, G. Fredman, 2021, The Journal of clinical investigation.

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

R. Zechner, G. Haemmerle, D. Kratky, 2010, The Journal of Biological Chemistry.

CAMKII&ggr; suppresses an efferocytosis pathway in macrophages and promotes atherosclerotic plaque necrosis

A. Tall, G. Fredman, I. Tabas, 2017, The Journal of clinical investigation.

LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux

A. Tall, J. Gustafsson, I. Tabas, 2018, Cell reports.

Interleukin-3/Granulocyte Macrophage Colony–Stimulating Factor Receptor Promotes Stem Cell Expansion, Monocytosis, and Atheroma Macrophage Burden in Mice With Hematopoietic ApoE Deficiency

A. Tall, A. Murphy, J. Witztum, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.

S. Milstein, D. Rader, A. Tall, 2012, The Journal of clinical investigation.

The UPR in atherosclerosis

I. Tabas, Alex-Xianghua Zhou, 2013, Seminars in Immunopathology.

Making things stick in the fight against atherosclerosis.

I. Tabas, 2013, Circulation research.

Efferocytosis-Induced Lactate Enables the Proliferation of Pro-Resolving Macrophages to Mediate Tissue Repair

I. Tabas, M. Schilperoort, D. Ngai, 2023, bioRxiv.

Circulating indian hedgehog is a marker of the hepatocyte-TAZ pathway in experimental NASH and is elevated in humans with NASH.

L. N. Valenti, E. Parks, R. Rector, 2023, JHEP reports : innovation in hepatology.

Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance.

M. Bessler, R. Pestell, I. Tabas, 2016, Cell reports.

Hepatocyte DACH 1 Is Incr eased in Obesity via Nuclear Exclusion of HDAC 4 and Promotes Hepatic Insulin Resistance Graphical

M. Bessler, R. Pestell, I. Tabas, 2016 .

Heart disease: Death-defying plaque cells

Ira Tabas, I. Tabas, 2016, Nature.

Blockade of IL-6 signaling alleviates atherosclerosis in Tet2-deficient clonal hematopoiesis

P. Libby, A. Tall, R. Levine, 2023, Nature Cardiovascular Research.

A new RIDDle in DC-mediated cross-presentation

I. Tabas, Manikandan Subramanian, 2014, Nature Immunology.

NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis

I. Tabas, Gang Li, L. Ozcan, 2010, The Journal of cell biology.

Molecular Mechanisms and Treatment Strategies for Obesity-Associated Coronary Artery Disease, an Imminent Military Epidemic

I. Tabas, 2006 .

Mechanisms of ER stress-induced apoptosis in atherosclerosis.

I. Tabas, Christopher M. Scull, Martin R. Bennett, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase.

Y. Marcel, I. Tabas, M. Ouimet, 2011, Cell metabolism.