D. Edwards

M. Lim, D. Edwards, K. Leco, 1996, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Intradermal air pouch leukocytosis as an in vivo test for nanoparticles

S. Michaeli, G. Opdenakker, I. Loinaz, 2013, International journal of nanomedicine.

Spontaneous immortalization of mouse embryo cells: strain differences and changes in gene expression with particular reference to retroviral gag-pol genes.

D. Denhardt, D. Edwards, C. Parfett, 1991, Experimental cell research.

Differential screening of a cDNA library with cDNA probes amplified in a heterologous host: isolation of murine GRP78 (BiP) and other serum-regulated low-abundance mRNAs.

D. Denhardt, D. Edwards, C. Parfett, 1989, Gene.

A study of mitochondrial and nuclear transcription with cloned cDNA probes. Changes in the relative abundance of mitochondrial transcripts after stimulation of quiescent mouse fibroblasts.

D. Denhardt, D. Edwards, David T. Denhardt, 1985, Experimental cell research.

Differential expression of the ccn3 (nov) proto-oncogene in human prostate cell lines and tissues

R. Ball, D. Edwards, K. Sethia, 2001, Molecular pathology : MP.

Tissue inhibitor of metalloproteinases (TIMP, aka EPA): structure, control of expression and biological functions.

D. Denhardt, D. Edwards, U. Malyankar, 1993, Pharmacology & therapeutics.

Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis.

M. Duddy, A. Bar-Or, V. Yong, 2003, Brain : a journal of neurology.

Autoimmune Encephalomyelitis Specific Cell Types in Experimental Key Metalloproteinases Are Expressed by

D. Edwards, T. Owens, H. Toft-hansen, 2004 .

THE MATRIX METALLOPROTEINASES AND THEIR INHIBITORS

D. Edwards, J. Gavrilović, J. Cross, 2005 .

Hepatocyte growth factor/scatter factor enhances the invasion of mesothelioma cell lines and the expression of matrix metalloproteinases

M. Jaurand, D. Edwards, I. Clark, 2000, British Journal of Cancer.

Cellular mechanisms for focal proteolysis and the regulation of the microenvironment

D. Edwards, V. Knäuper, S. Atkinson, 2000 .

Comparative analysis of the expression patterns of metalloproteinases and their inhibitors in breast neoplasia, sporadic colorectal neoplasia, pulmonary carcinomas and malignant non-Hodgkin's lymphomas in humans.

A. Kossakowska, Dale Edwards, D. Edwards, 1996, British Journal of Cancer.

Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species.

M. Hollenberg, D. Edwards, G. Murphy, 2001, The Biochemical journal.

ADAMTS-1 and syndecan-4 intersect in the regulation of cell migration and angiogenesis

D. Edwards, S. Akbareian, S. Robinson, 2019, Journal of Cell Science.

Metalloproteinase‐dependent and ‐independent processes contribute to inhibition of breast cancer cell migration, angiogenesis and liver metastasis by a disintegrin and metalloproteinase with thrombospondin motifs‐15

Lindsay S. Cooley, A. Krüger, D. Edwards, 2015, International journal of cancer.

Development of a novel tumor-targeted vascular disrupting agent activated by MT-MMPs

M. Bibby, J. Atkinson, L. Patterson, 2010 .

Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis

J. Schneider, C. Ruhrberg, D. Edwards, 2015, Disease Models & Mechanisms.

Extracellular matrix and matrix metalloproteinases in sciatic nerve

D. Edwards, J. Gavrilović, C. A. Krekoski, 2003, Journal of neuroscience research.

G-helix of Maspin Mediates Effects on Cell Migration and Adhesion*

V. Ellis, D. Edwards, R. Bass, 2010, The Journal of Biological Chemistry.

Sequence motifs of tissue inhibitor of metalloproteinases 2 (TIMP-2) determining progelatinase A (proMMP-2) binding and activation by membrane-type metalloproteinase 1 (MT1-MMP).

D. Edwards, P. Soloway, G. Murphy, 2003, The Biochemical journal.

Tissue inhibitor of metalloproteinases-1 (TIMP-1) RNA is expressed at elevated levels in malignant non-Hodgkin's lymphomas.

A. Kossakowska, D. Edwards, S. Urbanski, 1991, Blood.

Proteolytic activity of human non-Hodgkin's lymphomas.

A. Kossakowska, M. Lim, D. Edwards, 1998, The American journal of pathology.

The activity of a designer tissue inhibitor of metalloproteinases (TIMP)-1 against native membrane type 1 matrix metalloproteinase (MT1-MMP) in a cell-based environment.

D. Edwards, G. Murphy, S. Atkinson, 2010, Cancer letters.

The cancer degradome : proteases and cancer biology

D. Edwards, 2008 .

New insights into the plasticity of the endothelial phenotype.

Lindsay S. Cooley, D. Edwards, 2011, Biochemical Society transactions.

Regulation of tissue inhibitor of metalloproteinases‐1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures

P. Heinrich, E. Roeb, K. Decker, 1993, Hepatology.

Expression and modulation of matrix metalloproteinase-2 and tissue inhibitors of metalloproteinases in human embryonic CNS stem cells.

D. Edwards, P. Forsyth, G. Murphy, 1999, Neuroreport.

Leukemic blasts program bone marrow adipocytes to generate a protumoral microenvironment.

J. Watkins, D. Edwards, T. Oellerich, 2017, Blood.

MMP2 activity is critical for TGFβ2-induced matrix contraction--implications for fibrosis.

D. Edwards, I. M. Wormstone, J. Reddan, 2012, Investigative ophthalmology & visual science.

Increase in gelatinase-specificity of matrix metalloproteinase inhibitors correlates with antimetastatic efficacy in a T-cell lymphoma model.

A. Krüger, R. Khokha, H. Krell, 2002, Cancer research.

Determinants of Human B Cell Migration Across Brain Endothelial Cells1

M. Duddy, A. Bar-Or, J. Antel, 2003, The Journal of Immunology.

Lens MMP 2 Activity is Critical for TGF b 2-Induced Matrix Contraction — Implications for Fibrosis

D. Edwards, I. M. Wormstone, J. Reddan, 2012 .

ARY inase expression in early mou itory factor and epidermal

G. Schultz, X. Zhang, Gro, 1995 .

Transcriptional regulation of two serum-induced RNAs in mouse fibroblasts: equivalence of one species to B2 repetitive elements

D. Denhardt, D. Edwards, C. Parfett, 1985, Molecular and cellular biology.

HIF1α drives chemokine factor pro-tumoral signaling pathways in acute myeloid leukemia

D. Edwards, K. Bowles, Yu Sun, 2018, Oncogene.

Quantitative reverse transcription-polymerase chain reaction (RT-PCR): a comparison of primer-dropping, competitive, and real-time RT-PCRs.

D. Edwards, S. Wall, 2002, Analytical biochemistry.

Differential expression of matrix metalloproteinases during impaired wound healing of the diabetes mouse.

K. Harding, D. Edwards, S. Wall, 2002, The Journal of investigative dermatology.

A pBR322-derived vector for cloning blunt-ended cDNA: its use to detect molecular clones of low-abundance mRNAs.

D. Denhardt, D. Edwards, C. Parfett, 1985, DNA.

Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro.

D. Davies, D. Zicha, D. Edwards, 2007, International journal of oncology.

Expression of MMPs andTIMPs in Mammalian Cells

K. Yeow, D. Edwards, B. Phillips, 2001 .

NOTES & TIPS

D. Edwards, S. Wall, 2022 .

Tissue inhibitor of metalloproteinases‐2 (TIMP‐2) in rat liver cells is increased by lipopolysaccharide and prostaglandin E2

P. Heinrich, E. Roeb, S. Matern, 1995, FEBS letters.

The Human Tissue Inhibitor of Metalloproteinases (TIMP)-1 Gene Contains Repressive Elements within the Promoter and Intron 1*

D. Edwards, I. Clark, D. Young, 2000, The Journal of Biological Chemistry.

Expression of genes for non-collagenous proteins during embryonic bone formation.

B. Hogan, J. Heath, S. Nomura, 1989, Connective tissue research.

Expression of MMPs and TIMPs in mammalian cells.

K. Yeow, D. Edwards, B. Phillips, 2001, Methods in molecular biology.

Expression of multiple heparin-binding growth factor species by murine embryonal carcinoma and embryonic stem cells.

J. Heath, D. Edwards, G. Paterno, 1989, Development.

Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

J. Heath, P. Angel, D. Edwards, 1987, The EMBO journal.

Increase of Anti-Metastatic Efficacy by Selectivity- But Not Affinity-Optimization of Synthetic Serine Protease Inhibitors

A. Krüger, T. Steinmetzer, J. Quigley, 2003, Biological chemistry.

Dysregulated Expression of Adamalysin-Thrombospondin Genes in Human Breast Carcinoma

R. Ball, D. Edwards, A. Girling, 2004, Clinical Cancer Research.

Elevated membrane-type matrix metalloproteinases in gliomas revealed by profiling proteases and inhibitors in human cancer cells.

V. Yong, D. Edwards, C. Pennington, 2003, Molecular cancer research : MCR.

Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization

B. Hogan, J. Heath, S. Nomura, 1988, The Journal of cell biology.

Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates

D. Russell, D. Edwards, M. Cook, 2011, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Metalloproteinase inhibitors: biological actions and therapeutic opportunities

Gillian Murphy, Andrew H. Baker, D. Edwards, 2002, Journal of Cell Science.

Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations.

J. Nichols, A. Smith, S. Tóth, 1990, Genes & development.

Epithelial carcinogenesis: dynamic interplay between neoplastic cells and their microenvironment.

L. Coussens, D. Edwards, L. V. van Kempen, 2002, Differentiation; research in biological diversity.

Hormonal regulation of matrix metalloproteinase inhibitors in rat granulosa cells and ovaries.

M. Kindy, D. Edwards, T. Curry, 1991, Endocrinology.

Growth factors and cytokines upregulate gelatinase expression in bone marrow CD34(+) cells and their transmigration through reconstituted basement membrane.

J. Rozmus, D. Edwards, J. Nabholtz, 1999, Blood.

NADPH oxidase-2 derived superoxide drives mitochondrial transfer from bone marrow stromal cells to leukemic blasts.

D. Edwards, K. Bowles, S. Rushworth, 2017, Blood.

Treatment of Malignant Gliomas by Therapies Against Matrix Metalloproteinases

C. Matouk, D. Edwards, P. Forsyth, 2020 .

Gelatinase-A (MMP-2), gelatinase-B (MMP-9) and membrane type matrix metalloproteinase-1 (MT1-MMP) are involved in different aspects of the pathophysiology of malignant gliomas

R. Johnston, D. Edwards, P. Forsyth, 1999, British Journal of Cancer.

Identification of a serum-inducible messenger RNA (5B10) as the mouse homologue of calcyclin: tissue distribution and expression in metastatic, ras-transformed NIH 3T3 cells.

L. Murphy, P. Waterhouse, A. Craig, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

The ADAM metalloproteinases

D. Edwards, C. Pennington, M. Handsley, 2008, Molecular Aspects of Medicine.

Genome-Wide Responses of Female Fruit Flies Subjected to Divergent Mating Regimes

Dave T. Gerrard, T. Chapman, D. Edwards, 2013, PloS one.

MicroRNAs and the hallmarks of cancer

T. Dalmay, D. Edwards, T Dalmay, 2006, Oncogene.

Expression Profiles and Clinical Correlations of Degradome Components in the Tumor Microenvironment of Head and Neck Squamous Cell Carcinoma

Y. Okada, R. Ala-aho, V. Kähäri, 2010, Clinical Cancer Research.

Altered Microenvironment Promotes Progression of Preinvasive Breast Cancer: Myoepithelial Expression of αvβ6 Integrin in DCIS Identifies High-risk Patients and Predicts Recurrence

J. Cuzick, I. Šestak, G. Thomas, 2013, Clinical Cancer Research.

The β3‐integrin endothelial adhesome regulates microtubule‐dependent cell migration

J. Schneider, M. Parsons, D. Edwards, 2018, EMBO reports.

The Comparative Role of Activator Protein 1 and Smad Factors in the Regulation of Timp-1 and MMP-1 Gene Expression by Transforming Growth Factor-β1*

D. Edwards, I. Clark, A. Rowan, 2003, The Journal of Biological Chemistry.

Metalloproteinases are enriched in microglia compared with leukocytes and they regulate cytokine levels in activated microglia

A. Bar-Or, V. Yong, D. Edwards, 2007, Glia.

Prostate Cancer DESNT : A Poor Prognosis Category of Human Prostate Cancer

R. Eeles, D. Neal, C. Cooper, 2017 .

Quantitative Real-Time PCR Analysis of Degradome Gene Expression

D. Edwards, C. Pennington, S. Pilgrim, 2008 .

Acute Depletion of Endothelial &bgr;3-Integrin Transiently Inhibits Tumor Growth and Angiogenesis in Mice

J. Schneider, M. Fruttiger, D. Edwards, 2014, Circulation research.

Metalloproteinases and their inhibitors in tumor angiogenesis

D. Edwards, M. Handsley, Dylan R. Edwards, 2005, International journal of cancer.

MINI REVIEW Metalloproteinases and their inhibitors in tumor angiogenesis

D. Edwards, M. Handsley, 2005 .

Expression analysis of the entire MMP and TIMP gene families during mouse tissue development

G. Schultz, D. Edwards, C. Pennington, 2004, FEBS Letters.

TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy.

D. Edwards, P. Soloway, A. Eddy, 2001, Journal of the American Society of Nephrology : JASN.

Matrix Metalloproteinase-9/Gelatinase B Is Required for Process Outgrowth by Oligodendrocytes

Z. Werb, V. Yong, D. Edwards, 1999, The Journal of Neuroscience.

Non-Hodgkin's Lymphomas and Tissue Inhibitor of Metalloproteinase (TIMP-1) Expression in Malignant Interleukin-6 Regulation of Matrix Metalloproteinase (MMP-2 and MMP-9)

T. Grogan, A. Kossakowska, D. Edwards, 2013 .

Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas

Anna Janowska-Wieczorek, Thomas M. Grogan, T. Grogan, 1999 .

Endocrinology and paracrinology: Roles of growth factors during peri-implantation development

G. Schultz, M. Arcellana‐Panlilio, D. Edwards, 1995 .

Roles of growth factors during peri-implantation development.

G. Schultz, M. Arcellana‐Panlilio, X. Zhang, 1995, Human reproduction.

Identification of degradome components associated with prostate cancer progression by expression analysis of human prostatic tissues

R. Ball, N. Maitland, V. Ellis, 2005, British Journal of Cancer.

Expression of matrix metalloproteinases (MMP‐2 and ‐9) and tissue inhibitors of metalloproteinases (TIMP‐1 and ‐2) in acute myelogenous leukaemia blasts: comparison with normal bone marrow cells

A. Kossakowska, A. Matsuzaki, D. Edwards, 1999, British journal of haematology.

Interleukin-6 regulation of matrix metalloproteinase (MMP-2 and MMP-9) and tissue inhibitor of metalloproteinase (TIMP-1) expression in malignant non-Hodgkin's lymphomas.

T. Grogan, A. Kossakowska, D. Edwards, 1999, Blood.

Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.

P. Waterhouse, M. Nilsen-Hamilton, D. Denhardt, 1986, Cancer research.

Laser‐capture microdissection in prostate cancer research: establishment and validation of a powerful tool for the assessment of tumour–stroma interactions

R. Ball, D. Edwards, K. Sethia, 2008, BJU international.

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

D. Edwards, J. Decock, J. Jones, 2017, Breast Cancer Research.

Cell signalling and the control of gene transcription.

D. Edwards, Dylan R. Edwards, Dylan R. Edwards, 1994, Trends in pharmacological sciences.

Tumor Fibroblast-Associated Metalloproteases

A. Noël, D. Edwards, A. Masset, 2011 .

Matrix metalloproteinase-8 functions as a metastasis suppressor through modulation of tumor cell adhesion and invasion.

X. Puente, C. López-Otín, A. Gutiérrez-Fernández, 2008, Cancer research.

An Adverse Role for Matrix Metalloproteinase 12 after Spinal Cord Injury in Mice

V. Wee Yong, V. Yong, S. Rivest, 2003, The Journal of Neuroscience.

Novel Degradome Markers in Breast Cancer

P. Span, F. Sweep, D. Edwards, 2008 .

Protein synthesis inhibitors differentially superinduce c‐fos and c‐jun by three distinct mechanisms: lack of evidence for labile repressors.

D. Edwards, L. Mahadevan, 1992, The EMBO journal.

The regulation of matrix metalloproteinases and their inhibitors.

D. Edwards, I. Clark, T. Swingler, 2008, The international journal of biochemistry & cell biology.

Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs).

D. Edwards, G. Murphy, V. Knäuper, 2002, Journal of cell science.

Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro

Lindsay S. Cooley, E. Thompson, D. Edwards, 2010, Journal of Cell Science.

Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis.

A. Kossakowska, D. Edwards, Samuel S. Lee, 1998, The American journal of pathology.

Src stimulates fibroblast growth factor receptor-2 shedding by an ADAM15 splice variant linked to breast cancer.

C. Blobel, C. Overall, D. Edwards, 2009, Cancer research.

Phosphorylation-dependent Interactions between ADAM15 Cytoplasmic Domain and Src Family Protein-tyrosine Kinases*

M. Houslay, S. Robbins, D. Edwards, 2002, The Journal of Biological Chemistry.

Proteinase expression in early mouse embryos is regulated by leukaemia inhibitory factor and epidermal growth factor.

G. Schultz, M. Arcellana‐Panlilio, X. Zhang, 1995, Development.

Identification of an initiator-like element essential for the expression of the tissue inhibitor of metalloproteinases-4 (Timp-4) gene.

G. Schultz, D. Edwards, I. Clark, 2002, The Biochemical journal.

Tenascin-C stimulates glioma cell invasion through matrix metalloproteinase-12.

V. Yong, D. Edwards, V Wee Yong, 2006, Cancer research.

Proteases in cancer drug delivery.

P. Loadman, G. Opdenakker, D. Edwards, 2016, Advanced drug delivery reviews.

Activation of p38 and JNK MAPK pathways abrogates requirement for new protein synthesis for phorbol ester mediated induction of select MMP and TIMP genes.

D. Edwards, I. Clark, D. Young, 2008, Matrix biology : journal of the International Society for Matrix Biology.

TGF-β-Elicited Induction of Tissue Inhibitor of Metalloproteinases (TIMP)-3 Expression in Fibroblasts Involves Complex Interplay between Smad3, p38α, and ERK1/2

S. Leivonen, V. Kähäri, D. Edwards, 2013, PloS one.

CHAPTER 16 - Regulation of transcription by transforming growth factor-β

J. Heath, D. Edwards, 1991 .

Specialized plasmid vectors for cloning cDNA.

P. Waterhouse, D. Denhardt, D. Edwards, 1988, Biotechnology.

Transcriptional activity of the human tissue inhibitor of metalloproteinases 1 (TIMP-1) gene in fibroblasts involves elements in the promoter, exon 1 and intron 1.

T. Bech-Hansen, M. Bahr, D. Edwards, 1997, The Biochemical journal.

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.

D. Edwards, I. Clark, A. Rowan, 2010, Matrix biology : journal of the International Society for Matrix Biology.

The roles of ADAMTS metalloproteinases in tumorigenesis and metastasis.

Richard J. R. Kelwick, D. Edwards, R. Kelwick, 2011, Frontiers in bioscience.

ADAMTS8 and ADAMTS15 expression predicts survival in human breast carcinoma

P. Span, F. Sweep, V. Tjan-Heijnen, 2006, International journal of cancer.

Metalloproteinases in biology and pathology of the nervous system

V. Wee Yong, Christopher Power, Peter Forsyth, 2001, Nature Reviews Neuroscience.

TISSUE INHIBITOR OF METALLOPROTEINASE-3 IS UP-REGULATED BY TRANSFORMING GROWTH FACTOR-β1 IN VITRO AND EXPRESSED IN FIBROBLASTIC FOCI IN VIVO IN IDIOPATHIC PULMONARY FIBROSIS

M. Selman, A. Pardo, M. Checa, 2006, Experimental lung research.

Metalloproteinase Expression in PMA-stimulated THP-1 Cells

M. Sampson, D. Hughes, D. Edwards, 2003, Journal of Biological Chemistry.

ADAMs and protein disulfide isomerase: the key to regulated cell-surface protein ectodomain shedding?

D. Edwards, R. Bass, 2010, The Biochemical journal.

Oncostatin M Stimulates c-Fos to Bind a Transcriptionally Responsive AP-1 Element within the Tissue Inhibitor of Metalloproteinase-1 Promoter*

D. Edwards, C. Richards, F. Botelho, 1998, The Journal of Biological Chemistry.

Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

R. Khokha, D. Edwards, K. Leco, 1994, The Journal of biological chemistry.

High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma

G. Sutherland, R. Johnston, D. Edwards, 2004, Journal of Neuro-Oncology.

Membrane-type 4 matrix metalloproteinase promotes breast cancer growth and metastases.

Carine Munaut, Jean-Michel Foidart, Gillian Murphy, 2006, Cancer research.

Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro

Lindsay S. Cooley, E. Thompson, D. Edwards, 2010, Development.

Differential mRNA expression of renal cortical tissue inhibitor of metalloproteinase-1, -2, and -3 in experimental hydronephrosis.

H. van Goor, D. Edwards, J. Diamond, 1995, Journal of the American Society of Nephrology : JASN.

Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse.

R. Khokha, V. Han, D. Edwards, 1996, Biology of reproduction.

Tissue inhibitor of metalloproteinases-1 promotes liver metastasis by induction of hepatocyte growth factor signaling.

A. Krüger, K. Brew, L. Coussens, 2007, Cancer research.

Distinct Functionality of Tumor Cell–Derived Gelatinases during Formation of Liver Metastases

A. Krüger, K. Brand, D. Edwards, 2008, Molecular Cancer Research.

Combination of Tumor Necrosis Factor-α Ablation and Matrix Metalloproteinase Inhibition Prevents Heart Failure After Pressure Overload in Tissue Inhibitor of Metalloproteinase-3 Knock-Out Mice

R. Khokha, O. Sanchez, G. Oudit, 2005, Circulation research.

Systemic Ablation of MMP-9 Triggers Invasive Growth and Metastasis of Pancreatic Cancer via Deregulation of IL6 Expression in the Bone Marrow

Achim Krüger, A. Krüger, G. Opdenakker, 2016, Molecular Cancer Research.

MMP-9 ablation-induced invasive growth of pancreatic cancer Systemic ablation of MMP-9 triggers invasive growth and metastasis of pancreatic cancer via deregulation of IL-6 expression in the bone marrow

Sonja, A. Krüger, P. Knolle, 2016 .

mRNA profiling of the cancer degradome in oesophago–gastric adenocarcinoma

S. Paterson-Brown, K. Gray, R. Skipworth, 2012, British Journal of Cancer.

Matrix metalloproteinases: protective roles in cancer

D. Edwards, J. Decock, Sally Thirkettle, 2011, Journal of cellular and molecular medicine.

The Tissue Inhibitors of Metalloproteinases (TIMPs): Biology and Regulation

D. Edwards, 2000 .

Avoiding spam in the proteolytic internet: future strategies for anti-metastatic MMP inhibition.

A. Krüger, R. Kates, D. Edwards, 2010, Biochimica et biophysica acta.

Expression Pattern of Metalloproteinases and Their Inhibitors Changes with the Progression of Human Sporadic Colorectal Neoplasia

A. Kossakowska, D. Edwards, E. Shaffer, 1993, Diagnostic molecular pathology : the American journal of surgical pathology, part B.

PI3Kδ and PI3Kγ isoforms have distinct functions in regulating pro-tumoural signalling in the multiple myeloma microenvironment

D. Edwards, K. Bowles, S. Rushworth, 2017, Blood Cancer Journal.

Identification of novel peptide motifs in the serpin maspin that affect vascular smooth muscle cell function.

L. Brown, D. Edwards, R. Bass, 2017, Biochimica et biophysica acta. Molecular cell research.

Signaling Metastasis by Induction of Hepatocyte Growth Factor Tissue Inhibitor of Metalloproteinases-1 Promotes Liver

A. Krüger, K. Brew, L. Coussens, 2007 .

Matrix metalloproteinases mediate the dismantling of mesenchymal structures in the tadpole tail during thyroid hormone‐induced tail resorption

Jae‐Chang Jung, D. Edwards, K. Leco, 2002, Developmental dynamics : an official publication of the American Association of Anatomists.

Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix.

K. Yeow, D. Edwards, G. Murphy, 2002, Matrix biology : journal of the International Society for Matrix Biology.

The β3-integrin endothelial adhesome regulates microtubule dependent cell migration

D. Edwards, M. Bass, M. Mogensen, 2017, bioRxiv.

Angiogenesis in Mice 3-Integrin Transiently Inhibits Tumor Growth and β Acute Depletion of Endothelial

J. Schneider, M. Fruttiger, D. Edwards, 2014 .

Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines

R. Skipworth, K. Fearon, G. Stewart, 2008, British Journal of Cancer.

Conformation-Specific Inhibitory Anti-MMP-7 Monoclonal Antibody Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Chemotherapeutic Cell Kill

Jean P. Gaffney, M. Eisenstein, A. Krüger, 2021, Cancers.

ADAMTS9, a member of the ADAMTS family, in Xenopus development

G. Wheeler, D. Edwards, Inès Desanlis, 2018, Gene expression patterns : GEP.

Comprehensive profiling and localisation of the matrix metalloproteinases in urothelial carcinoma

I. Mills, D. Neal, H. Leung, 2006, British Journal of Cancer.

ADAM15 mediates upregulation of Claudin-1 expression in breast cancer cells

D. Edwards, Z. Poghosyan, V. Knäuper, 2019, Scientific Reports.

Distinct Functions of Natural ADAM-15 Cytoplasmic Domain Variants in Human Mammary Carcinoma

Paul N. Span, A. Krüger, P. Span, 2008, Molecular Cancer Research.

Improved design of riboprobes from pBluescript and related vectors for in situ hybridization.

D. Edwards, M. Bolander, H. Witkiewicz, 1993, BioTechniques.

Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function

D. Edwards, J. Marshall, J. Decock, 2017, Breast Cancer Research.

Matrix Metalloproteinase 8 (Collagenase 2) Induces the Expression of Interleukins 6 and 8 in Breast Cancer Cells

D. Edwards, C. Pennington, H. Arnold, 2013, The Journal of Biological Chemistry.

ERK5 signalling in prostate cancer promotes an invasive phenotype

I. Ahmad, H. Leung, E. Keller, 2011, British Journal of Cancer.

Diverse and potent activities of HGF/SF in skin wound repair

E. Gherardi, D. Edwards, T. Fan, 2004, The Journal of pathology.

Relationship between the clinical aggressiveness of large cell immunoblastic lymphomas and expression of 92 kDa gelatinase (type IV collagenase) and tissue inhibitor of metalloproteinases-1 (TIMP-1) RNAs.

A. Kossakowska, D. Edwards, S. Huchcroft, 1992, Oncology research.

Analysis of hypoxia-associated gene expression in prostate cancer: lysyl oxidase and glucose transporter-1 expression correlate with Gleason score.

J. Ross, F. Habib, K. Gray, 2008, Oncology reports.

Tissue inhibitor of metalloproteinase-3 is up-regulated by transforming growth factor-beta1 in vitro and expressed in fibroblastic foci in vivo in idiopathic pulmonary fibrosis.

M. Selman, A. Pardo, M. Checa, 2006, Experimental lung research.

Key Metalloproteinases Are Expressed by Specific Cell Types in Experimental Autoimmune Encephalomyelitis1

D. Edwards, T. Owens, H. Toft-hansen, 2004, The Journal of Immunology.

Expression of timp-1, timp-2, 72-kda and 92-kda type-iv collagenase transcripts in human astrocytoma cell-lines - correlation with astrocytoma cell invasiveness.

P. Dirks, L. Becker, D. Edwards, 1995, International journal of oncology.

Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA.

B. Hogan, J. Heath, S. Nomura, 1989, Development.

Growth and Differentiation Factors of Embryonic Stem Cells

Austin G Smith, J. Heath, D. Edwards, 1989 .

Brk/PTK6 and Involucrin Expression May Predict Breast Cancer Cell Responses to Vitamin D3

S. Eccles, S. Hare, A. Harvey, 2023, International Journal of Molecular Sciences.

An adverse role for matrix metalloproteinase (MMP)-12 following spinal cord injury in mice.

V. Yong, S. Rivest, D. Edwards, 2003 .

The Tissue Inhibitors of Metalloproteinases (TIMPs)

D. Edwards, 2001 .

Targeted photodynamic therapy of breast cancer cells using antibody-phthalocyanine-gold nanoparticle conjugates

D. A. Russell, D. Russell, D. Edwards, 2011, Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.

Insights into the Mechanism of Quantum Dot-Sensitized Singlet Oxygen Production for Photodynamic Therapy

D. A. Russell, T. Nann, D. Russell, 2012 .

Expression profiling of metalloproteinases and their inhibitors in cartilage.

A. Parker, L. Shepstone, S. Donell, 2004, Arthritis and rheumatism.

Tissue inhibitor of metalloproteinases‐3 is the major metalloproteinase inhibitor in the decidualizing murine uterus

G. Schultz, D. Edwards, K. Leco, 1996, Molecular reproduction and development.

Broad Antitumor and Antiangiogenic Activities of AG3340, a Potent and Selective MMP Inhibitor Undergoing Advanced Oncology Clinical Trials

Charles D. McDermott, H. Zou, S. Bender, 1999, Annals of the New York Academy of Sciences.

Regulation of tissue inhibitor of metalloproteinases‐1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures

P. Heinrich, E. Roeb, K. Decker, 1993, Hepatology.

Reprogramming of TIMP‐1 and TIMP‐3 expression profiles in brain microvascular endothelial cells and astrocytes in response to proinflammatory cytokines

T. Kordula, J. Bereta, D. Edwards, 1999, FEBS letters.