A. Amalfitano

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Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells.

E. P. Black, Z. Hartman, A. Amalfitano, 2007, Virology.

Campylobacter jejuni-Induced Activation of Dendritic Cells Involves Cooperative Signaling through Toll-Like Receptor 4 (TLR4)-MyD88 and TLR4-TRIF Axes

A. Amalfitano, V. Rathinam, D. Appledorn, 2009, Infection and Immunity.

Novel Adenovirus Vectors ‘Capsid-Displaying’ a Human Complement Inhibitor

M. Frank, Z. Hartman, A. Amalfitano, 2010, Journal of Innate Immunity.

Molecular Therapy: The Journal of the American Society of Gene Therapy | Gene Function and Disease

A. Amalfitano, E. Albright, 2003 .

Recent advances in gene therapy for lysosomal storage disorders

A. Amalfitano, D. Rastall, 2015, The application of clinical genetics.

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

E. Saridakis, D. Georgiadis, A. Amalfitano, 2013, Proceedings of the National Academy of Sciences.

Gene therapy for lysosomal storage diseases: progress, challenges and future prospects.

A. Amalfitano, S. Seregin, 2011, Current pharmaceutical design.

beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2.

N. Parameswaran, A. Amalfitano, D. Appledorn, 2010, Virus research.

Optimization of vaccine responses with an E1, E2b, E3 deleted Ad5 vector circumvents pre-existing anti-vector immunity

D. Niedzwiecki, H. Lyerly, M. Morse, 2009, Cancer Gene Therapy.

Dystrophin expression in muscle following gene transfer with a fully deleted ("gutted") adenovirus is markedly improved by trans-acting adenoviral gene products.

J. Nalbantoglu, A. Kamen, S. Fletcher, 2001, Human gene therapy.

CRACC-targeting Fc-fusion protein induces activation of NK cells and DCs and improves T cell immune responses to antigenic targets.

N. Kaminski, A. Amalfitano, S. Seregin, 2016, Vaccine.

ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis

A. Amalfitano, Laura Mccabe, D. Rastall, 2018, Scientific Reports.

ERAP1 is a critical regulator of inflammasome-mediated proinflammatory and ER stress responses

A. Amalfitano, S. Godbehere, Y. Aldhamen, 2022, BMC immunology.

Current and Future Treatments for Lysosomal Storage Disorders

A. Amalfitano, D. Rastall, 2017, Current Treatment Options in Neurology.

Long-term, high-level hepatic secretion of acid α-glucosidase for Pompe disease achieved in non-human primates using helper-dependent adenovirus

A. Amalfitano, D. Palmer, P. Ng, 2016, Gene Therapy.

Persistence of an [E1-, polymerase-] adenovirus vector despite transduction of a neoantigen into immune-competent mice.

A. Amalfitano, H. Hu, D. Serra, 1999, Human gene therapy.

Cutting Edge: Coding Single Nucleotide Polymorphisms of Endoplasmic Reticulum Aminopeptidase 1 Can Affect Antigenic Peptide Generation In Vitro by Influencing Basic Enzymatic Properties of the Enzyme

P. Voulgari, A. Drosos, M. Tsujimoto, 2011, The Journal of Immunology.

Basic Enzymatic Properties of the Enzyme Peptide Generation In Vitro by Influencing Aminopeptidase 1 Can Affect Antigenic Polymorphisms of Endoplasmic Reticulum Cutting Edge: Coding Single Nucleotide

P. Voulgari, A. Drosos, M. Tsujimoto, 2011 .

An Adenoviral Vaccine Encoding Full-Length Inactivated Human Her2 Exhibits Potent Immunogenicty and Enhanced Therapeutic Efficacy without Oncogenicity

W. Barry, Dong-Wan Kim, N. Spector, 2010, Clinical Cancer Research.

Applications of adenoviral vector-mediated gene transfer in cardiovascular research.

A. Amalfitano, D. Serra, Fang Xu, 2006, Methods in molecular medicine.

ELOVL4-Mediated Production of Very Long-Chain Ceramides Stabilizes Tight Junctions and Prevents Diabetes-Induced Retinal Vascular Permeability

W. Hauswirth, S. Boye, D. Antonetti, 2018, Diabetes.

ERAP1 functions override the intrinsic selection of specific antigens as immunodominant peptides, thereby altering the potency of antigen-specific cytolytic and effector memory T-cell responses.

A. Amalfitano, S. Seregin, S. Godbehere, 2014, International immunology.

Synergism from combined immunologic and pharmacologic inhibition of HER2 in vivo

W. Barry, N. Spector, X. Ren, 2010, International journal of cancer.

Myeloid‐specific GPCR kinase‐2 negatively regulates NF‐κB1p105‐ERK pathway and limits endotoxemic shock in mice

G. Dorn, N. Parameswaran, A. Amalfitano, 2011, Journal of cellular physiology.

Packaging of an AAV vector encoding human acid alpha-glucosidase for gene therapy in glycogen storage disease type II with a modified hybrid adenovirus-AAV vector.

D. Koeberl, A. Amalfitano, Baodong Sun, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II.

D. Koeberl, A. Amalfitano, Baodong Sun, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II.

D. Koeberl, A. Amalfitano, T. Clay, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Delivery of human apolipoprotein (apo) E to liver by an (E1 - , E3 - , polymerase - , pTP - ) adenovirus vector containing a liver-specific promoter inhibits atherogenesis in immunocompetent apoE-deficient mice

J. S. Owen, I. Graham, G. Dickson, 2006 .

Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms.

P. Hagen, A. Amalfitano, Lisheng Zhang, 2005, Cardiovascular research.

Adenovirus-based vaccination against Clostridium difficile toxin A allows for rapid humoral immunity and complete protection from toxin A lethal challenge in mice.

A. Amalfitano, S. Seregin, S. Godbehere, 2012, Vaccine.

The mdx‐amplification‐resistant mutation system assay, a simple and rapid polymerase chain reaction‐based detection of the mdx allele

J. Chamberlain, A. Amalfitano, 1996, Muscle & nerve.

Different roles for two enhancer domains in the organ- and age-specific pattern of polyomavirus replication in the mouse.

A. Amalfitano, M. Fluck, L. Martin, 1992, Molecular and cellular biology.

Regulation of Epithelial Differentiation in Rat Intestine by Intraluminal Delivery of an Adenoviral Vector or Silencing RNA Coding for Schlafen 3

Kelian Sun, M. Basson, A. Amalfitano, 2013, PloS one.

Production and Characterization of Improved Adenovirus Vectors with the E1, E2b, and E3 Genes Deleted

J. Chamberlain, A. Amalfitano, M. Hauser, 1998, Journal of Virology.

Vaccine Platforms Combining Circumsporozoite Protein and Potent Immune Modulators, rEA or EAT-2, Paradoxically Result in Opposing Immune Responses

A. Amalfitano, D. Appledorn, S. Seregin, 2011, PloS one.

SLAMF7 Signaling Reprograms T Cells Towards Exhaustion in the Tumor Microenvironment

A. Amalfitano, S. Godbehere, Y. Aldhamen, 2020, SSRN Electronic Journal.

Persistence of high sustained antibodies to enzyme replacement therapy despite extensive immunomodulatory therapy in an infant with Pompe disease: need for agents to target antibody-secreting plasma cells.

J. Charrow, A. Rosenberg, A. Amalfitano, 2012, Molecular genetics and metabolism.

CHINESE HAMSTER OVARY CELL-DERIVED RECOMBINANT HUMAN ACID α -GLUCOSIDASE IN INFANTILE-ONSET POMPE DISEASE

G. Herman, T. Voit, A. Amalfitano, 2009 .

SLAMF7 modulates B cells and adaptive immunity to regulate susceptibility to CNS autoimmunity

A. Amalfitano, S. Godbehere, Y. Aldhamen, 2022, Journal of Neuroinflammation.

Progress and problems when considering gene therapy for GSD-II.

A. Kiang, A. Amalfitano, 2007, Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology.

Improved Production of Gutted Adenovirus in Cells Expressing Adenovirus Preterminal Protein and DNA Polymerase

J. Chamberlain, D. Hartigan-O’Connor, A. Amalfitano, 1999, Journal of Virology.

Nephrotic Syndrome Complicating α-Glucosidase Replacement Therapy for Pompe Disease

J. Phillips, Yuan-Tsong Chen, A. Fogo, 2004, Pediatrics.

P19-47. Novel adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag, Pol, Nef despite the presence of Ad5 immunity

A. Amalfitano, F. Jones, E. Gabitzsch, 2009, Retrovirology.

Improved adenovirus packaging cell lines to support the growth of replication-defective gene-delivery vectors.

J. Chamberlain, A. Amalfitano, C. Begy, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Wild-type adenoviruses from groups A–F evoke unique innate immune responses, of which HAd3 and SAd23 are partially complement dependent

H. Jiang, A. Kiang, M. Frank, 2008, Gene Therapy.

SLAM Family Receptor Signaling in Viral Infections: HIV and Beyond

A. Amalfitano, Y. Aldhamen, Patrick O’Connell, 2019, Vaccines.

Recombinant human acid α-glucosidase enzyme therapy for infantile glycogen storage disease type II: Results of a phase I/II clinical trial

J. Charrow, J. Phillips, Yuan-Tsong Chen, 2001, Genetics in Medicine.

Systemic correction of the muscle disorder glycogen storage disease type II after hepatic targeting of a modified adenovirus vector encoding human acid-alpha-glucosidase.

N. Raben, A. Amalfitano, P. Plotz, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice.

A. Kiang, Z. Hartman, A. Amalfitano, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Glycogen storage in multiple muscles of old GSD‐II mice can be rapidly cleared after a single intravenous injection with a modified adenoviral vector expressing hGAA

Yuan-Tsong Chen, A. Amalfitano, E. Ding, 2005, The journal of gene medicine.

Improved efficacy of gene therapy approaches for Pompe disease using a new, immune-deficient GSD-II mouse model

A. Amalfitano, J. Dai, E. Ding, 2004, Gene Therapy.

Long-term correction of glycogen storage disease type II with a hybrid Ad-AAV vector.

D. Koeberl, A. Amalfitano, A. Bird, 2003, Molecular therapy : the journal of the American Society of Gene Therapy.

Efficacy of gene therapy for a prototypical lysosomal storage disease (GSD-II) is critically dependent on vector dose, transgene promoter, and the tissues targeted for vector transduction.

Yuan-Tsong Chen, A. Amalfitano, B. Hodges, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Long-term efficacy after [E1-, polymerase-] adenovirus-mediated transfer of human acid-alpha-glucosidase gene into glycogen storage disease type II knockout mice.

A. Amalfitano, Y. T. Chen, A. McVie-Wylie, 2001, Human gene therapy.

Towards a molecular therapy for glycogen storage disease type II (Pompe disease).

A. Amalfitano, Y. T. Chen, A. Amalfitano, 2000, Molecular medicine today.

Response to Reuser

A. Amalfitano, P. Kishnani, Yt Chen, 2012, Genetics in Medicine.

Utility of Adenovirus-Based Vectors for Multiple Cancer Vaccine Approaches

Z. Hartman, A. Amalfitano, 2004 .

Replication-attenuated Human Adenoviral Type 4 vectors elicit capsid dependent enhanced innate immune responses that are partially dependent upon interactions with the complement system.

Z. Hartman, A. Amalfitano, D. Appledorn, 2008, Virology.

Utilization of adenovirus vectors for multiple gene transfer applications.

A. Amalfitano, 2004, Methods.

Immunogenicity when utilizing adenovirus serotype 4 and 5 vaccines expressing circumsporozoite protein in naïve and Adenovirus (Ad5) immune mice

A. Amalfitano, S. Seregin, Nathaniel J. Schuldt, 2012, Malaria Journal.

Acute regression of advanced and retardation of early aortic atheroma in immunocompetent apolipoprotein-E (apoE) deficient mice by administration of a second generation [E1(-), E3(-), polymerase(-)] adenovirus vector expressing human apoE.

J. S. Owen, I. Graham, G. Dickson, 2002, Human molecular genetics.

Multiple innate inflammatory responses induced after systemic adenovirus vector delivery depend on a functional complement system.

A. Kiang, M. Frank, Z. Hartman, 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

Decreased Vector Gene Expression from E2b Gene-Deleted Adenovirus Serotype 5 Vaccines Intensifies Proinflammatory Immune Responses

A. Amalfitano, S. Godbehere, Y. Aldhamen, 2017, Clinical and Vaccine Immunology.

Overcoming pre-existing adenovirus immunity by genetic engineering of adenovirus-based vectors

A. Amalfitano, S. Seregin, 2009, Expert opinion on biological therapy.

A preliminary and comparative evaluation of a novel Ad5 [E1-, E2b-] recombinant-based vaccine used to induce cell mediated immune responses.

A. Amalfitano, R. Gayle, E. Gabitzsch, 2009, Immunology letters.

Production and Characterization of Improved Adenovirus Vectors with the E 1 , E 2 b , and E 3 Genes Deleted

J. Chamberlain, A. Amalfitano, M. Hauser, 1998 .

Adenovirus Vectors with the 100K Gene Deleted and Their Potential for Multiple Gene Therapy Applications

A. Amalfitano, B. Hodges, E. Ding, 2001, Journal of Virology.

Δ9-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7–Stimulated Human Coculture

N. Kaminski, A. Amalfitano, R. Crawford, 2019, The Journal of Pharmacology and Experimental Therapeutics.

D 9 -Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7 – Stimulated Human Coculture s

N. Kaminski, A. Amalfitano, R. Crawford, 2019 .

Induction of Wilms' Tumor Protein (WT1)–Specific Antitumor Immunity Using a Truncated WT1-Expressing Adenovirus Vaccine

D. Niedzwiecki, H. Lyerly, M. Morse, 2009, Clinical Cancer Research.

Isolation and characterization of packaging cell lines that coexpress the adenovirus E1, DNA polymerase, and preterminal proteins: implications for gene therapy

A. Amalfitano, JS Chamberlain, 1997, Gene Therapy.

β -Arrestins modulate Adenovirus vector induced innate immune responses: differential regulation by β -arrestin-1 and β -arrestin-2

N. Parameswaran, A. Amalfitano, D. Appledorn, 2010 .

Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients

Frank R. Jones, Elizabeth S. Gabitzsch, Joseph P. Balint, 2013, Cancer Immunology, Immunotherapy.

Liver toxicities typically induced by first-generation adenoviral vectors can be reduced by use of E1, E2b-deleted adenoviral vectors.

A. Amalfitano, B. Hodges, E. Ding, 2003, Human gene therapy.

Separating fact from fiction: assessing the potential of modified adenovirus vectors for use in human gene therapy.

R. Parks, A. Amalfitano, 2002, Current gene therapy.

Multiply deleted [E1, polymerase‐, and pTP‐] adenovirus vector persists despite deletion of the preterminal protein

J. Chamberlain, A. Amalfitano, B. Hodges, 2000, The journal of gene medicine.

SLAMF7 Is a Critical Negative Regulator of IFN-α–Mediated CXCL10 Production in Chronic HIV Infection

N. Kaminski, A. Amalfitano, S. Godbehere, 2018, The Journal of Immunology.

Use of DAF-displaying adenovirus vectors reduces induction of transgene- and vector-specific adaptive immune responses in mice.

A. Amalfitano, D. Appledorn, S. Seregin, 2011, Human gene therapy.

Complex interactions with several arms of the complement system dictate innate and humoral immunity to adenoviral vectors

A. Kiang, A. Amalfitano, D. Appledorn, 2008, Gene Therapy.

Glucose tetrasaccharide as a biomarker for monitoring the therapeutic response to enzyme replacement therapy for Pompe disease.

Yuan-Tsong Chen, D. Millington, A. Amalfitano, 2005, Molecular genetics and metabolism.

Strain-specific rate of shutdown of CMV enhancer activity in murine liver confirmed by use of persistent [E1(-), E2b(-)] adenoviral vectors.

A. Amalfitano, B. Hodges, E. Ding, 2004, Virology.

Transient pretreatment with glucocorticoid ablates innate toxicity of systemically delivered adenoviral vectors without reducing efficacy.

A. Amalfitano, D. Appledorn, S. Seregin, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells

Heidi L. Rehm, J. R. Holt, David P. Corey, 2004, Nature.

Next-generation adenoviral vectors: new and improved

A. Amalfitano, 1999, Gene Therapy.

Organ- and age-specific replication of polyomavirus in mice

M. Oldstone, A. Amalfitano, J. Wirth, 1992, Journal of virology.

Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome

F. Speleman, C. Petit, R. Coimbra, 2003, Nature Genetics.

Autoimmune Disease-Associated Variants of Extracellular Endoplasmic Reticulum Aminopeptidase 1 Induce Altered Innate Immune Responses by Human Immune Cells

D. Georgiadis, A. Amalfitano, E. Stratikos, 2015, Journal of Innate Immunity.

Immune Recognition of Gene Transfer Vectors: Focus on Adenovirus as a Paradigm

A. Amalfitano, S. Seregin, Y. Aldhamen, 2011, Front. Immun..

Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3‐ and CLN2‐deficient neurons

D. Koeberl, A. Amalfitano, R. Boustany, 2002, Annals of neurology.

The CLN3 gene is a novel molecular target for cancer drug discovery.

A. Amalfitano, R. Boustany, A. Proia, 2002, Cancer research.

The CLN 3 Gene is a Novel Molecular Target for Cancer Drug Discovery 1

A. Amalfitano, R. Boustany, A. Proia, 2002 .

Adenovirus Infection Triggers a Rapid, MyD88-Regulated Transcriptome Response Critical to Acute-Phase and Adaptive Immune Responses In Vivo

A. Kiang, Z. Hartman, A. Amalfitano, 2006, Journal of Virology.

The role of ERAP1 in autoinflammation and autoimmunity.

A. Amalfitano, Yuliya Pepelyayeva, 2019, Human immunology.

In Vivo Neuronal Targeting of Genes

A. Amalfitano, 1998 .

Improved adenoviral vectors for gene therapy of Duchenne muscular dystrophy

J. Chamberlain, A. Amalfitano, S. Hauschka, 1997, Neuromuscular Disorders.

Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications.

Z. Hartman, A. Amalfitano, D. Appledorn, 2008, Virus research.

Improving Adenovirus Based Gene Transfer: Strategies to Accomplish Immune Evasion

A. Amalfitano, S. Seregin, 2010, Viruses.

Malaria vaccines: focus on adenovirus based vectors.

A. Amalfitano, Nathaniel J. Schuldt, N. Schuldt, 2012, Vaccine.

Methods to Mitigate Immune Responses to Adenoviral Vectors

A. Amalfitano, Y. Aldhamen, Y. A. Aldhamen, 2016 .

Sublingual Administration of an Adenovirus Serotype 5 (Ad5)-Based Vaccine Confirms Toll-Like Receptor Agonist Activity in the Oral Cavity and Elicits Improved Mucosal and Systemic Cell-Mediated Responses against HIV Antigens despite Preexisting Ad5 Immunity

A. Amalfitano, D. Appledorn, S. Seregin, 2010, Clinical and Vaccine Immunology.

Toll-like receptors impact on safety and efficacy of gene transfer vectors.

S. Hensley, A. Amalfitano, Andrea Amalfitano, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens

A. Amalfitano, Irini Evnouchidou, I. York, 2013, Autoimmunity.

ERAP1 deficient mice have reduced Type 1 regulatory T cells and develop skeletal and intestinal features of Ankylosing Spondylitis

A. Amalfitano, Laura Mccabe, D. Rastall, 2018, Scientific Reports.

Endoplasmic Reticulum Aminopeptidase-1 Functions Regulate Key Aspects of the Innate Immune Response

A. Amalfitano, S. Seregin, Sungjin Kim, 2013, PloS one.

Manipulation of EAT-2 expression promotes induction of multiple beneficial regulatory and effector functions of the human innate immune system as a novel immunomodulatory strategy.

A. Amalfitano, S. Seregin, S. Godbehere, 2014, International immunology.

Expression of the SLAM Family of Receptors Adapter EAT-2 as a Novel Strategy for Enhancing Beneficial Immune Responses to Vaccine Antigens

A. Amalfitano, D. Appledorn, S. Seregin, 2011, The Journal of Immunology.

Vaccine Antigens Enhancing Beneficial Immune Responses to Adapter EAT-2 as a Novel Strategy for Expression of the SLAM Family of Receptors Godbehere and

A. Amalfitano, D. Appledorn, Sarah, 2010 .

Imiquimod and interferon-alpha augment monocyte-mediated astrocyte secretion of MCP-1, IL-6 and IP-10 in a human co-culture system

N. Kaminski, A. Amalfitano, R. Crawford, 2019, Journal of Neuroimmunology.

A New Adenovirus Based Vaccine Vector Expressing an Eimeria tenella Derived TLR Agonist Improves Cellular Immune Responses to an Antigenic Target

Darin F. Quach, A. Amalfitano, J. Mccormick, 2010, PloS one.

Adenovirus vectors for renal-targeted gene delivery.

A. Amalfitano, D. Appledorn, S. Seregin, 2008, Contributions to nephrology.

Improved cytotoxic T-lymphocyte immune responses to a tumor antigen by vaccines co-expressing the SLAM-associated adaptor EAT-2

A. Amalfitano, B. Schutte, D. Appledorn, 2013, Cancer Gene Therapy.

Mice expressing human ERAP1 variants associated with ankylosing spondylitis have altered T-cell repertoires and NK cell functions, as well as increased in utero and perinatal mortality

D. Peters, A. Amalfitano, D. Rastall, 2017, International immunology.

Mdx mice inducibly expressing dystrophin provide insights into the potential of gene therapy for duchenne muscular dystrophy.

J. Chamberlain, A. Amalfitano, B. Hodges, 2000, Human molecular genetics.

THE mdx-AMPLIFICATION-RESISTANT MUTATION SYSTEM ASSAY , A SIMPLE AND RAPID POLYMERASE CHAIN mdx ALLELE REACTlON-BASED DETECTION OF THE

J. Chamberlain, A. Amalfitano, 2022 .

Dubowitz syndrome: a defect in the cholesterol biosynthetic pathway?

R. Kelley, A. Amalfitano, Y. T. Chen, 1999, American journal of medical genetics.

Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo.

M. Frank, Z. Hartman, A. Amalfitano, 2010, Blood.

CR1/2 is an important suppressor of Adenovirus induced innate immune responses and is required for induction of neutralizing antibodies

A. Amalfitano, D. Appledorn, S. Seregin, 2009, Gene Therapy.

TRIF, and TRIF-Interacting TLRs Differentially Modulate Several Adenovirus Vector-Induced Immune Responses

N. Parameswaran, A. Amalfitano, D. Appledorn, 2009, Journal of Innate Immunity.

Adenovirus Vector-Induced Innate Inflammatory Mediators, MAPK Signaling, As Well As Adaptive Immune Responses Are Dependent upon Both TLR2 and TLR9 In Vivo1

N. Parameswaran, N. Van Rooijen, A. Amalfitano, 2008, The Journal of Immunology.

Vivo Dependent upon Both TLR 2 and TLR 9 In As Well As Adaptive Immune Responses Are Inflammatory Mediators , MAPK Signaling , Adenovirus Vector-Induced Innate and

N. Parameswaran, N. Rooijen, A. Amalfitano, 2008 .

Stimulation of Innate Immunity by In Vivo Cyclic di-GMP Synthesis Using Adenovirus

C. Waters, A. Amalfitano, Benjamin J. Koestler, 2014, Clinical and Vaccine Immunology.

G‐protein coupled receptor kinase 5 mediates lipopolysaccharide‐induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice

N. Parameswaran, N. Packiriswamy, A. Amalfitano, 2011, Journal of cellular physiology.

In Vivo Synthesis of Cyclic-di-GMP Using a Recombinant Adenovirus Preferentially Improves Adaptive Immune Responses against Extracellular Antigens

C. Waters, A. Amalfitano, Benjamin J. Koestler, 2016, The Journal of Immunology.

This information is current as against Extracellular Antigens Improves Adaptive Immune Responses Recombinant Adenovirus Preferentially In Vivo Synthesis of Cyclic-di-GMP Using a

Cristiane, C. Waters, A. Amalfitano, 2016 .

A Common Single Nucleotide Polymorphism in Endoplasmic Reticulum Aminopeptidase 2 Induces a Specificity Switch That Leads to Altered Antigen Processing

G. Panayotou, E. Saridakis, D. Georgiadis, 2012, The Journal of Immunology.

Regulation of lipopolysaccharide‐induced inflammatory response and endotoxemia by β‐arrestins

N. Parameswaran, D. Sharma, A. Amalfitano, 2010, Journal of cellular physiology.

Strengthened tumor antigen immune recognition by inclusion of a recombinant Eimeria antigen in therapeutic cancer vaccination

A. Amalfitano, D. Appledorn, S. Godbehere, 2015, Cancer Immunology, Immunotherapy.

Chinese hamster ovary cell-derived recombinant human acid alpha-glucosidase in infantile-onset Pompe disease.

G. Herman, R. C. Rogers, T. Voit, 2006, The Journal of pediatrics.

Compound heterozygosity for loss‐of‐function FARSB variants in a patient with classic features of recessive aminoacyl‐tRNA synthetase‐related disease

S. Oprescu, A. Antonellis, A. Amalfitano, 2018, Human mutation.

Abstract 2994: Engineered STING-targeting immunotherapy delays B16 melanoma tumor growth and significantly improves animal survival as compared to an immune-checkpoint inhibitor

C. Waters, A. Amalfitano, S. Godbehere, 2017 .

HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-&ggr;-inducible protein 10 levels compared with nonusing HIV patients

N. Kaminski, A. Amalfitano, R. Crawford, 2017, AIDS.

Recombinant adenovirus vectors activate the alternative complement pathway, leading to the binding of human complement protein C3 independent of anti-ad antibodies.

M. Frank, A. Amalfitano, Haixiang Jiang, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

TRIF Is a Critical Negative Regulator of TLR Agonist Mediated Activation of Dendritic Cells In Vivo

A. Amalfitano, D. Appledorn, S. Seregin, 2011, PloS one.

Bone inflammation and altered gene expression with type I diabetes early onset

A. Amalfitano, D. Appledorn, R. C. Schwartz, 2009, Journal of cellular physiology.

Multiple muscles in the AMD quail can be “cross‐corrected” of pathologic glycogen accumulation after intravenous injection of an [E1‐, polymerase‐] adenovirus vector encoding human acid‐α‐glucosidase

A. Amalfitano, T. Kikuchi, M. Mizutani, 2003, The journal of gene medicine.

Vaccines Expressing the Innate Immune Modulator EAT-2 Elicit Potent Effector Memory T Lymphocyte Responses despite Pre-Existing Vaccine Immunity

A. Amalfitano, S. Seregin, S. Godbehere, 2012, The Journal of Immunology.

Nephrotic syndrome complicating alpha-glucosidase replacement therapy for Pompe disease.

J. Phillips, Yuan-Tsong Chen, A. Fogo, 2004, Pediatrics.

Δ9-Tetrahydrocannabinol suppresses monocyte-mediated astrocyte production of MCP-1 and IL-6 in a TLR7-stimulated human co-culture.

N. Kaminski, A. Amalfitano, R. Crawford, 2019, The Journal of pharmacology and experimental therapeutics.

APOE ε3 Gene Transfer Attenuates Brain Damage after Experimental Stroke

B. McColl, G. Dickson, K. Horsburgh, 2007 .

Pre-Existing Vaccine Immunity Memory T Lymphocyte Responses despite Modulator EAT-2 Elicit Potent Effector Vaccines Expressing the Innate Immune Godbehere and

Schuldt, A. Amalfitano, S. Seregin, 2012 .

Low probability of double integration in transformation of nonpermissive cells by polyomavirus

A. Amalfitano, S. Y. Oh, K. Friderici, 1990, Journal of virology.

Different roles for two enhancer domains in the organ- and age-specific pattern of polyomavirus replication in the mouse

A. Amalfitano, M. Fluck, L. Martin, 1992 .

Activation of human natural killer cells by the novel innate immune modulator recombinant Eimeria antigen.

A. Amalfitano, S. Seregin, S. Godbehere, 2013, Human immunology.

A modified adenovirus can transfect cochlear hair cells in vivo without compromising cochlear function

A. Amalfitano, A. Luebke, B. Hodges, 2001, Gene Therapy.

The Application of Clinical Genetics Dovepress Recent Advances in Gene Therapy for Lysosomal Storage Disorders

A. Amalfitano, David Pw Rastall, David Pw Rastall, 2022 .

Adenoviral delivery of an immunomodulatory protein to the tumor microenvironment controls tumor growth

A. Amalfitano, S. Godbehere, Y. Aldhamen, 2021, Molecular Therapy Oncolytics.

A Common Single Nucleotide Polymorphism in ER

G. Panayotou, E. Saridakis, D. Georgiadis, 2012 .

Altered Antigen Processing Induces a Specificity Switch That Leads to in Endoplasmic Reticulum Aminopeptidase 2 A Common Single Nucleotide Polymorphism

Martina, Efstratios, G. Panayotou, 2012 .

Enzymatic Properties of the Enzyme Peptide Generation In Vitro by Influencing Aminopeptidase 1 Can Affect Antigenic Polymorphisms of Endoplasmic Reticulum Cutting Edge : Coding Single Nucleotide Amalfitano