S. Burel

发表

Preclinical evaluation of the toxicological effects of a novel constrained ethyl modified antisense compound targeting signal transducer and activator of transcription 3 in mice and cynomolgus monkeys.

B. Monia, Shin-Young Park, S. Henry, 2013, Nucleic acid therapeutics.

Early-Stage Identification and Avoidance of Antisense Oligonucleotides Causing Species-Specific Inflammatory Responses in Human Volunteers Peripheral Blood Mononuclear Cells

S. Henry, B. Baker, T. Machemer, 2021, bioRxiv.

Non-CpG-Containing Antisense 2′-Methoxyethyl Oligonucleotides Activate a Proinflammatory Response Independent of Toll-Like Receptor 9 or Myeloid Differentiation Factor 88

S. Henry, S. Burel, J. Senn, 2005, Journal of Pharmacology and Experimental Therapeutics.

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

M. Benson, Shuling Guo, B. Monia, 2020, ESC heart failure.

Underlying Immune Disorder May Predispose Some Transthyretin Amyloidosis Subjects to Inotersen-Mediated Thrombocytopenia.

B. Monia, S. Henry, T. Machemer, 2020, Nucleic acid therapeutics.

Unique O-Methoxyethyl Ribose-DNA Chimeric Oligonucleotide Induces an Atypical Melanoma Differentiation-Associated Gene 5-Dependent Induction of Type I Interferon Response

S. Freier, S. Henry, T. Machemer, 2012, Journal of Pharmacology and Experimental Therapeutics.

Comparison of the Class Effects of Antisense Oligonucleotides in CByB6F1-Tg(HRAS)2Jic and CD-1 Mice

S. Henry, J. Matson, S. Burel, 2018, Toxicologic pathology.

Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes.

S. Booten, S. Murray, M. Graham, 2016, Journal of medicinal chemistry.

Investigation into the Mechanism(s) That Leads to Platelet Decreases in Cynomolgus Monkeys During Administration of ISIS 104838, a 2’-MOE-Modified Antisense Oligonucleotide

J. Nolan, S. Henry, S. Burel, 2018, Toxicological sciences : an official journal of the Society of Toxicology.

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

S. Crooke, S. Burel, T. Vickers, 2021, Nucleic acids research.

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

Christopher E. Hart, H. Bui, S. Crooke, 2016, Molecular therapy : the journal of the American Society of Gene Therapy.

Safety, Pharmacokinetic, and Pharmacodynamic Evaluation of a 2′-(2-Methoxyethyl)-D-ribose Antisense Oligonucleotide–Triantenarry N-Acetyl-galactosamine Conjugate that Targets the Human Transmembrane Protease Serine 6

Shuling Guo, S. Henry, S. Burel, 2021, The Journal of Pharmacology and Experimental Therapeutics.

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

Christopher E. Hart, S. Freier, M. Sabripour, 2015, Nucleic acids research.

Inflammatory Non-CpG Antisense Oligonucleotides Are Signaling Thought TLR9 in Human Burkitt Lymphoma B Bjab Cells.

S. Damle, S. Henry, T. Machemer, 2022, Nucleic acid therapeutics.

Mechanism Driven Early Stage Identification and Avoidance of Antisense Oligonucleotides Causing TRL9 Mediated Inflammatory Responses in Bjab cells

S. Damle, S. Henry, T. Machemer, 2021, bioRxiv.

Assessment of the Effects of 2'-Methoxyethyl Antisense Oligonucleotides on Platelet Count in Cynomolgus Nonhuman Primates.

S. Bhanot, S. Henry, S. Burel, 2017, Nucleic acid therapeutics.

AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations

I. Weissman, H. Iwasaki, T. Miyamoto, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Deletion of an AML1-ETO C-terminal NcoR/SMRT-interacting region strongly induces leukemia development.

Ming Yan, K. Akashi, H. Iwasaki, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Hybrid Mouse Diversity Panel Identifies Genetic Architecture Associated with the Acute Antisense Oligonucleotide-Mediated Inflammatory Response to a 2'-O-Methoxyethyl Antisense Oligonucleotide.

Richard G. Lee, Calvin Pan, R. Crooke, 2019, Nucleic acid therapeutics.

The Distinct and Cooperative Roles of Toll-Like Receptor 9 and Receptor for Advanced Glycation End Products in Modulating In Vivo Inflammatory Responses to Select CpG and Non-CpG Oligonucleotides.

Shuling Guo, S. Henry, C. Bennett, 2017, Nucleic acid therapeutics.

Dichotomy of AML1-ETO Functions: Growth Arrest versus Block of Differentiation

D. Tenen, Dong-er Zhang, T. Pabst, 2001, Molecular and Cellular Biology.