Takashi Kobayashi

发表

Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.

Y. Maehara, H. Ogata, A. Yoshimura, 2006, Gastroenterology.

Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin

N. Minato, M. Matsumoto, H. Scott, 2007, Nature Immunology.

Reduced Tyk2 gene expression in β-cells due to natural mutation determines susceptibility to virus-induced diabetes

K. Akashi, M. Hara, Hisakata Yamada, 2015, Nature Communications.

A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2006, Biochemical and biophysical research communications.

Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation

Y. Okada, A. Yoshimura, H. Yoshida, 2009, Cancer science.

Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes.

A. Yoshimura, G. Takaesu, H. Mori, 2007, Biochemical and biophysical research communications.

Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved.

H. Ogata, A. Yoshimura, G. Takaesu, 2006, Gastroenterology.

TRAF6 Is Essential for Maintenance of Regulatory T Cells That Suppress Th2 Type Autoimmunity

R. Morita, A. Yoshimura, M. Walsh, 2013, PloS one.

Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia

S. Takeda, Takashi Iezaki, H. Ochi, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Suppressor of Cytokine Signaling-1 Gene Responses by Dendritic Cells Lacking the Induction of Hyper Th1 Cell-Type Immune

H. Aburatani, M. Kubo, A. Yoshimura, 2010 .

Induction of Hyper Th1 Cell-Type Immune Responses by Dendritic Cells Lacking the Suppressor of Cytokine Signaling-1 Gene1

H. Aburatani, M. Kubo, A. Yoshimura, 2005, The Journal of Immunology.

TRAF 6 Is a Critical Factor for Dendritic Cell Maturation and Development on high surface expression of CD 11 c and differential expression of the conventional T cell markers CD 4 and CD

C. Hunter, J. Caamaño, L. Turka, 2003 .

Positive and negative roles of IL-6, STAT3, and SOCS3 in inflammatory arthritis.

A. Yoshimura, Takashi Kobayashi, I. Kinjyo, 2007, Advances in experimental medicine and biology.

Dengue transmission model by means of viremic adult immuno-competent mouse

E. Konishi, Yutaka Suzuki, I. Kurane, 2014, Parasites & Vectors.

Supramolecular Targeting of B16F10 Melanoma Cells With Nanoparticles Consisting of a DEAE-Dextran-MMA Copolymer-Paclitaxel Complex In vivo and In vitro

M. Mizuno, J. Yoshida, Y. Eshita, 2012 .

Development of a portable reverse transcription loop‐mediated isothermal amplification system to detect the E1 region of Chikungunya virus in a cost‐effective manner

K. Murakami, Takashi Kobayashi, Naganori Kamiyama, 2020, Genes to cells : devoted to molecular & cellular mechanisms.

Ribavirin inhibits Zika virus (ZIKV) replication in vitro and suppresses viremia in ZIKV-infected STAT1-deficient mice

E. Matsubara, S. Tajima, Y. Eshita, 2017, Antiviral Research.

Autoimmune sialadenitis is associated with the upregulation of chemokine/chemokine receptor pairs in T cell-specific TRAF6-deficient mice.

Y. Eshita, Takashi Kobayashi, T. Ozaki, 2018, Biochemical and biophysical research communications.

Comprehensive lipidomics of lupus‐prone mice using LC–MS/MS identifies the reduction of palmitoylethanolamide that suppresses TLR9‐mediated inflammation

T. Masaki, Takashi Kobayashi, Naganori Kamiyama, 2022, Genes to cells : devoted to molecular & cellular mechanisms.

Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels.

A. Yoshimura, D. Yoshiga, G. Takaesu, 2007, Molecular endocrinology.

Impaired initiation of contact hypersensitivity by FTY720.

K. Kabashima, Takashi Kobayashi, Y. Tokura, 2008, The Journal of investigative dermatology.

Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2009, Immunity.

Inflammatory Disease during Hemopoiesis Induces Th2-Polarized TNF Receptor-Associated Factor 6 Deficiency

L. Turka, M. Walsh, Yongwon Choi, 2003 .

Oral administration of antibiotics results in fecal occult bleeding due to metabolic disorders and defective proliferation of the gut epithelial cell in mice

K. Murakami, Takashi Kobayashi, T. Ozaki, 2018, Genes to cells : devoted to molecular & cellular mechanisms.

TRAF6 is a T cell–intrinsic negative regulator required for the maintenance of immune homeostasis

L. Turka, Taesoo Kim, Yongwon Choi, 2006, Nature Medicine.

Osteoclast differentiation independent of the TRANCE–RANK–TRAF6 axis

Y. Kadono, W. Yeh, H. Nakano, 2005, The Journal of experimental medicine.

An RNA-binding protein αCP-1 is involved in the STAT3-mediated suppression of NF-κB transcriptional activity

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2007 .

Suppressor of Cytokine Signaling-1 Gene Responses by Dendritic Cells Lacking the Induction of Hyper Th1 Cell-Type Immune

H. Aburatani, M. Kubo, A. Yoshimura, 2010 .

Suppressors of Cytokine Signaling-1 and -3 Regulate Osteoclastogenesis in the Presence of Inflammatory Cytokines1

A. Yoshimura, Y. Iwamoto, K. Taniguchi, 2005, The Journal of Immunology.

Osteoclastogenesis in the Presence Suppressors of Cytokine Signaling-1 and-3

A. Yoshimura, Y. Iwamoto, K. Taniguchi, 2005 .

TRAF6 Is Required for Generation of the B-1a B Cell Compartment as well as T Cell-Dependent and -Independent Humoral Immune Responses

Y. Kadono, S. Akira, T. Kaisho, 2009, PloS one.

Epithelial TRAF6 drives IL-17-mediated psoriatic inflammation.

K. Ishii, T. Nomura, M. Hayden, 2018, JCI insight.

Suppressor of cytokine signaling 1 protects mice against concanavalin A–induced hepatitis by inhibiting apoptosis

A. Yoshimura, H. Yoshida, G. Takaesu, 2008, Hepatology.

A Major Lipid Raft Protein Raftlin Modulates T Cell Receptor Signaling and Enhances Th17-Mediated Autoimmune Responses1

A. Yoshimura, S. Fukuyama, G. Takaesu, 2009, The Journal of Immunology.

CLP1 acts as the main RNA kinase in mice.

J. Penninger, Kazumasa Hada, Takashi Kobayashi, 2020, Biochemical and biophysical research communications.

Tumor necrosis factor receptor-associated factor 6 is required to inhibit foreign body giant cell formation and activate osteoclasts under inflammatory and infectious conditions

K. Miyamoto, T. Miyamoto, Masaya Nakamura, 2018, Journal of Bone and Mineral Metabolism.

Downregulation of ZNF395 Drives Progression of Pancreatic Ductal Adenocarcinoma through Enhancement of Growth Potential

K. Murakami, K. Yada, M. Inomata, 2021, Pathobiology.

Role of simvastatin in tumor lymphangiogenesis and lymph node metastasis

Y. Eshita, Takashi Kobayashi, Naganori Kamiyama, 2018, Clinical & Experimental Metastasis.

SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis.

L. Hennighausen, A. Yoshimura, J. Manis, 2007, Immunity.

Mal-function of TLRs by SOCS

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2006, Nature Immunology.

Keeping DCs awake by putting SOCS1 to sleep.

A. Yoshimura, Takashi Kobayashi, 2005, Trends in immunology.

An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2007, International immunology.

IL-1β and TNFα-initiated IL-6-STAT3 pathway is critical in mediating inflammatory cytokines and RANKL expression in inflammatory arthritis.

A. Yoshimura, Y. Toyama, H. Yoshida, 2011, International immunology.

Histamine regulates T-cell and antibody responses by differential expression of H1 and H2 receptors

Marek Jutel, C. Akdis, M. Jutel, 2001, Nature.

TGF‐β1 suppresses IFN‐γ‐induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2006 .

TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2006, Genes to cells : devoted to molecular & cellular mechanisms.

Supermolecular drug challenge to overcome drug resistance in cancer cells.

M. Mizuno, J. Yoshida, Y. Eshita, 2018, Drug discovery today.

Medicinal facilities to B16F10 melanoma cells for distant metastasis control with a supramolecular complex by DEAE-dextran-MMA copolymer/paclitaxel

M. Mizuno, J. Yoshida, Y. Eshita, 2015, Drug Delivery and Translational Research.

Anticancer efficacy of a supramolecular complex of a 2-diethylaminoethyl–dextran–MMA graft copolymer and paclitaxel used as an artificial enzyme

M. Mizuno, J. Yoshida, Y. Eshita, 2014, Beilstein journal of nanotechnology.

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor–β1

Satoru Fukuyama, Hiromasa Inoue, A. Yoshimura, 2006, The Journal of experimental medicine.

Loss of Suppressor of Cytokine Signaling 1 in Helper T Cells Leads to Defective Th17 Differentiation by Enhancing Antagonistic Effects of IFN-γ on STAT3 and Smads1

A. Yoshimura, H. Yoshida, Y. Nakanishi, 2008, The Journal of Immunology.

Selective Expansion of Foxp3-Positive Regulatory T Cells and Immunosuppression by Suppressors of Cytokine Signaling 3-Deficient Dendritic Cells1

Katsuaki Sato, T. Wyss-Coray, A. Yoshimura, 2007, The Journal of Immunology.

The Roles of IL-17, IL-21, and IL-23 in the Helicobacter pylori Infection and Gastrointestinal Inflammation: A Review

Y. Yamaoka, A. Abdurachman, Takashi Kobayashi, 2021, Toxins.

STAT6 Inhibits TGF-β1-mediated Foxp3 Induction through Direct Binding to the Foxp3 Promoter, Which Is Reverted by Retinoic Acid Receptor*

A. Yoshimura, S. Kato, G. Takaesu, 2008, Journal of Biological Chemistry.

Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*♦

A. Yoshimura, H. Yoshida, G. Takaesu, 2008, Journal of Biological Chemistry.

Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-κB signaling

T. Iwanaga, Toshiro Sato, T. Akiyama, 2018, The Journal of experimental medicine.

Regulation of human autoimmune regulator (AIRE) gene translation by miR-220b.

K. Akashi, N. Shimizu, A. Yoshimura, 2013, Gene.

SMAD1 signaling is critical for initial commitment of germ cell lineage from mouse epiblast

Y. Matsui, K. Hayashi, Takashi Kobayashi, 2002, Mechanisms of Development.

Distinct molecular mechanism for initiating TRAF6 signalling

Hao Wu, Yongwon Choi, Sujay K. Singh, 2002, Nature.

Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells.

A. Yoshimura, H. Yoshida, G. Takaesu, 2008, International immunology.

HTLV-1 Tax-mediated TAK1 activation involves TAB2 adapter protein.

A. Yoshimura, H. Yoshida, G. Takaesu, 2008, Biochemical and biophysical research communications.

DUSP4 is involved in the enhanced proliferation and survival of DUSP4-overexpressing cancer cells.

Takashi Kobayashi, N. Hijiya, T. Uchida, 2020, Biochemical and biophysical research communications.

STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

L. Hennighausen, C. Hunter, D. Beiting, 2016, mBio.

FLN29 Deficiency Reveals Its Negative Regulatory Role in the Toll-like Receptor (TLR) and Retinoic Acid-inducible Gene I (RIG-I)-like Helicase Signaling Pathway*

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2008, Journal of Biological Chemistry.

FLN29, a Novel Interferon- and LPS-inducible Gene Acting as a Negative Regulator of Toll-like Receptor Signaling*

H. Aburatani, A. Yoshimura, Y. Yamanashi, 2005, Journal of Biological Chemistry.

An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway.

A. Yoshimura, H. Sakurai, G. Takaesu, 2009, Biochemical and biophysical research communications.

Regulation of the Subcellular Localization of Tumor Necrosis Factor Receptor–associated Factor (TRAF)2 by TRAF1 Reveals Mechanisms of TRAF2 Signaling

Yongwon Choi, M. Walsh, Yongwon Choi, 2002, The Journal of experimental medicine.

STAT 3 and Smads γ Effects of IFN-Differentiation by Enhancing Antagonistic Helper T Cells Leads to Defective Th 17 Loss of Suppressor of Cytokine Signaling 1 in

A. Yoshimura, H. Yoshida, Y. Nakanishi, 2008 .

The Lethal(2)-Essential-for-Life [L(2)EFL] Gene Family Modulates Dengue Virus Infection in Aedes aegypti

A. James, S. Kawashima, C. Sugimoto, 2020, International journal of molecular sciences.

The role of TRAF6 in signal transduction and the immune response.

M. Walsh, Yongwon Choi, Takashi Kobayashi, 2004, Microbes and infection.

TRAF6 and MEKK1 Play a Pivotal Role in the RIG-I-like Helicase Antiviral Pathway*

S. Akira, A. Yoshimura, T. Kawai, 2008, Journal of Biological Chemistry.

Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis.

A. Yoshimura, Takeru Yoshimura, K. Sonoda, 2009, Rheumatology.

TNF Receptor-Associated Factor 6 Deficiency during Hemopoiesis Induces Th2-Polarized Inflammatory Disease 1

L. Turka, M. Walsh, Yongwon Choi, 2003, The Journal of Immunology.

Dysbiosis of the Gut Microbiota on the Inflammatory Background due to Lack of Suppressor of Cytokine Signalling-1 in Mice

Y. Yamaoka, K. Murakami, M. Kodama, 2019, Inflammatory Intestinal Diseases.

Secondary Unconjugated Bile Acids Induce Hepatic Stellate Cell Activation

Y. Iwashita, M. Ohta, M. Inomata, 2018, International journal of molecular sciences.

TGFβ-activated kinase 1 (TAK1)-binding proteins (TAB) 2 and 3 negatively regulate autophagy.

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2012, Journal of biochemistry.

Corrigendum to “A novel zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling” [Biochem. Biophys. Res. Commun. 344 (2006) 1023–1030]

A. Yoshimura, G. Takaesu, Takashi Kobayashi, 2007 .

Ess2 bridges transcriptional regulators and spliceosomal complexes via distinct interacting domains.

M. Makishima, Takashi Kobayashi, Sayuri Takahashi, 2018, Biochemical and biophysical research communications.

Bone phenotype in melanocortin 2 receptor-deficient mice

S. Takeda, Takashi Kobayashi, M. Matsumoto, 2020, Bone reports.

Protease inhibitory activity of secretory leukocyte protease inhibitor ameliorates murine experimental colitis by protecting the intestinal epithelial barrier

K. Takeda, K. Murakami, Takashi Kobayashi, 2021, Genes to cells : devoted to molecular & cellular mechanisms.

TRAF6 is a critical factor for dendritic cell maturation and development.

C. Hunter, J. Caamaño, L. Turka, 2003, Immunity.

This information is current as 3-Deficient Dendritic Cells by Suppressors of Cytokine Signaling Regulatory T Cells and Immunosuppression Selective Expansion of Foxp 3-Positive

Katsuaki Sato, T. Wyss-Coray, A. Yoshimura, 2007 .

IFNγ-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice

Seiya Kato, A. Yoshimura, S. Kato, 2006, The Journal of experimental medicine.

Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia

A. Yoshimura, T. Taketomi, R. Kato, 2005, Nature Neuroscience.

Loss of SOCS3 Gene Expression Converts STAT3 Function from Anti-apoptotic to Pro-apoptotic*

A. Yoshimura, S. Fukuyama, G. Takaesu, 2006, Journal of Biological Chemistry.

TRAF6-Dependent Mitogen-Activated Protein Kinase Activation Differentially Regulates the Production of Interleukin-12 by Macrophages in Response to Toxoplasma gondii

C. Hunter, Yongwon Choi, Takashi Kobayashi, 2004, Infection and Immunity.

Aberrant IL-4 production by SOCS3-over-expressing T cells during infection with Leishmania major exacerbates disease manifestations.

A. Yoshimura, Takashi Kobayashi, H. Yoshida, 2011, International immunology.

Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells.

Shizuo Komune, S. Komune, A. Yoshimura, 2007, International immunology.

Abnormal functional and morphological regulation of the gastric mucosa in histamine H2 receptor-deficient mice.

Takashi Kobayashi, Y. Ishihara, S. Okabe, 2000, The Journal of clinical investigation.

Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of pancreatic ductal adenocarcinoma

Y. Iwashita, M. Ohta, M. Inomata, 2020, Surgery Today.

Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.

D. Marguet, D. Drucker, U. Ribel, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis

H. Kouji, Takashi Kobayashi, Y. Hatano, 2019, Annals of dermatology.

Cutting Edge: Requirement for TRAF6 in the Induction of T Cell Anergy1

L. Turka, Taesoo Kim, Yongwon Choi, 2008, The Journal of Immunology.

Induction of T Cell Anergy Cutting Edge: Requirement for TRAF6 in the

R. Hannah, L. Turka, Taesoo Kim, 2022 .

Susceptibility of Aedes flavopictus miyarai and Aedes galloisi mosquito species in Japan to dengue type 2 virus

N. Komalamisra, Y. Eshita, K. Hayashida, 2016 .