T. Yeh

发表

DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity.

C. Chen, Y. Chao, Jen‐Shin Song, 2021, Life sciences.

Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.

Yi-Hui Peng, A. Yueh, J. Hsu, 2015, Journal of medicinal chemistry.

Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy.

Yi-Hui Peng, Y. Chao, Su-Ying Wu, 2016, Journal of medicinal chemistry.

Targeting Tumor Associated Phosphatidylserine with New Zinc Dipicolylamine-Based Drug Conjugates.

C. Chen, Yu-Wei Liu, B. Gray, 2017, Bioconjugate chemistry.

Antimitotic and vascular disrupting agents: 2-hydroxy-3,4,5-trimethoxybenzophenones.

T. Yeh, J. Liou, Jang-Yang Chang, 2014, European journal of medicinal chemistry.

Synthesis and Structure–Activity Relationships of 1‐Benzyl‐4,5,6‐trimethoxyindoles as a Novel Class of Potent Antimitotic Agents

H. Hsieh, T. Yeh, J. Liou, 2009, ChemMedChem.

Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.

H. Hsieh, J. Hsu, M. Coumar, 2020, Bioorganic chemistry.

Paclitaxel gelatin nanoparticles for intravesical bladder cancer therapy.

V. Bergdall, J. Au, Jie Wang, 2011, The Journal of urology.

N-Indolylglycosides bearing modifications at the glucose C6-position as sodium-dependent glucose co-transporter 2 inhibitors.

C. Chen, Y. Chao, Szu-Huei Wu, 2016, Bioorganic & medicinal chemistry.

Synthesis, activity, and pharmacokinetic properties of a series of conformationally-restricted thiourea analogs as novel hepatitis C virus inhibitors.

A. Yueh, Y. Chao, T. Yeh, 2010, Bioorganic & medicinal chemistry.

High-performance liquid chromatography-electrospray mass spectrometry for the simultaneous determination of multiple active components in Sheng-Mai San, a prescription of traditional Chinese medicine.

T. Yeh, H. Yao, Yi-Wei Chang, 2008, Phytochemical analysis : PCA.

Formulating Paclitaxel in Nanoparticles Alters Its Disposition

J. Au, Ze Lu, M. Wientjes, 2005, Pharmaceutical Research.

Rejuvenating hepatic tumor microenvironment immunity with a phosphatidylserine-targeting small molecule drug conjugate.

T. Yeh, L. Tsou, Kuan-Liang Liu, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

A novel, potent, and orally bioavailable thiazole HCV NS5A inhibitor for the treatment of hepatitis C virus.

C. Chen, A. Yueh, Y. Chao, 2019, European journal of medicinal chemistry.

A Potent, Selective, and Orally Bioavailable HCV NS5A Inhibitor for Treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazol-2-yl)pyrrolidine-2-carboxamide.

A. Yueh, Y. Chao, Jen‐Shin Song, 2017, Journal of medicinal chemistry.

BPR0C261 is a novel orally active antitumor agent with antimitotic and anti‐angiogenic activities

Chi-Hung Lin, C. Chen, Y. Chao, 2011, Cancer science.

Potent and orally active purine-based fetal hemoglobin inducers for treating β-thalassemia and sickle cell disease.

C. Chen, Y. Chou, Chun-Hung Lin, 2020, European journal of medicinal chemistry.

Repurposing old drugs as antiviral agents for coronaviruses

C. Chen, Szu-Huei Wu, Shiow-Ju Lee, 2020, Biomedical Journal.

Effect of shengmai san on insulin resistance, tumor necrosis factor-alpha and oxidative stress in rats fed on a high-fat diet

M. Chiang, C. Lii, T. Yeh, 2020 .

Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System

C. Chen, Chien Ho, Yen-Ju Chen, 2020, Scientific Reports.

Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors.

C. Chen, Y. Chao, Szu-Huei Wu, 2019, Bioorganic chemistry.

Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2.

C. Chen, Y. Chao, Szu-Huei Wu, 2018, European journal of medicinal chemistry.

Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-dioxygenase inhibitors.

Yi-Hui Peng, Su-Ying Wu, Jen‐Shin Song, 2020, Journal of medicinal chemistry.

Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice

C. Yeh, T. Yeh, T. Tsai, 2022, Journal of Biomedical Science.

Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91.

C. Chen, Y. Chao, Chin-Tarng Lin, 2010, Pharmacological research.

5-Aroylindoles Act as Selective Histone Deacetylase 6 Inhibitors Ameliorating Alzheimer's Disease Phenotypes.

Chia-Ron Yang, T. Yeh, J. Liou, 2018, Journal of medicinal chemistry.

Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.

C. Chen, Xin Chen, Y. Chao, 2009, Bioorganic & medicinal chemistry.

A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment

Jen‐Shin Song, Yunching Chen, Yi-Yu Ke, 2021, Proceedings of the National Academy of Sciences.

Enhanced oral bioavailability of paclitaxel by D-alpha-tocopheryl polyethylene glycol 400 succinate in mice.

C. Chen, Y. Chao, T. Yeh, 2008, International journal of pharmaceutics.

Bromomethylthioindole Inspired Carbazole Hybrids as Promising Class of Anti-MRSA Agents.

Jen‐Shin Song, Jinq-chyi Lee, Yu-Wei Liu, 2016, ACS medicinal chemistry letters.

Resistance Studies of a Dithiazol Analogue, DBPR110, as a Potential Hepatitis C Virus NS5A Inhibitor in Replicon Systems

A. Yueh, Y. Chao, Su-Ying Wu, 2012, Antimicrobial Agents and Chemotherapy.

BPR1K653, a Novel Aurora Kinase Inhibitor, Exhibits Potent Anti-Proliferative Activity in MDR1 (P-gp170)-Mediated Multidrug-Resistant Cancer Cells

H. Hsieh, T. Lien, J. Hsu, 2011, PloS one.

Rapid and sensitive determination of fentanyl in dog plasma by on-line solid-phase extraction integrated with a hydrophilic column coupled to tandem mass spectrometry.

Y. Chao, T. Yeh, H. Yao, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Protective Effect of CXCR4 Antagonist DBPR807 against Ischemia-Reperfusion Injury in a Rat and Porcine Model of Myocardial Infarction: Potential Adjunctive Therapy for Percutaneous Coronary Intervention

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2022, International journal of molecular sciences.

Identification of phenanthroindolizines and phenanthroquinolizidines as novel potent anti-coronaviral agents for porcine enteropathogenic coronavirus transmissible gastroenteritis virus and human severe acute respiratory syndrome coronavirus

Y. Chao, J. Jan, Shiow-Ju Lee, 2010, Antiviral Research.

1‐Arylsulfonyl‐5‐(N‐hydroxyacrylamide)indolines Histone Deacetylase Inhibitors Are Potent Cytokine Release Suppressors

Chia-Ron Yang, C. Teng, T. Yeh, 2013, Chembiochem : a European journal of chemical biology.

2-Aroylquinoline-5,8-diones as potent anticancer agents displaying tubulin and heat shock protein 90 (HSP90) inhibition.

T. Yeh, J. Liou, Jang-Yang Chang, 2016, Organic & biomolecular chemistry.

Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes.

C. Chen, Y. Chao, Chieh-Jui Hsieh, 2011, Journal of medicinal chemistry.

BPR1M97, a dual mu opioid receptor/nociceptin-orphanin FQ peptide receptor agonist, produces potent antinociceptive effects with safer properties than morphine

H. Loh, C. Shih, Wan-Ting Chang, 2020, Neuropharmacology.

Activation of delta-opioid receptor contributes to the antinociceptive effect of oxycodone in mice.

H. Loh, P. Law, T. Yeh, 2016, Pharmacological research.

1-(2,4-Dibromophenyl)-3,6,6-trimethyl-1,5,6,7-tetrahydro-4H-indazol-4-one: A Novel Opioid Receptor Agonist with Less Accompanying Gastrointestinal Dysfunction than Morphine

C. Chen, H. Loh, P. Law, 2017, Anesthesiology.

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.

Y. Chao, Su-Ying Wu, Jen‐Shin Song, 2018, Bioorganic chemistry.

BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy

C. Chen, Y. Chao, T. Yeh, 2019, Translational oncology.

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.

C. Chen, C. Teng, S. Pan, 2012, Journal of medicinal chemistry.

Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor.

Xin Chen, Y. Chao, Chih-Hsiang Huang, 2009, Biochemical pharmacology.

2,6-Difluorobenzamide derivatives as store-operated calcium channel (SOC) inhibitors.

Wei-Chiao Chang, T. Yeh, J. Liou, 2022, European journal of medicinal chemistry.

Targeting the Phosphatidylserine-Immune Checkpoint with a Small-Molecule Maytansinoid Conjugate

C. Chen, T. Yeh, T. Hsu, 2022, Journal of medicinal chemistry.

(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

C. Chen, Xin Chen, Y. Chao, 2010, Bioorganic & medicinal chemistry letters.

Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.

C. Chen, Xin Chen, Y. Chao, 2009, Bioorganic & medicinal chemistry letters.

Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations.

C. Chen, Y. Chao, J. Hsu, 2015, European journal of medicinal chemistry.

Biotransformation of 6-Methoxy-3-(3′,4′,5′-trimethoxy-benzoyl)-1H-indole (BPR0L075), a Novel Antimicrotubule Agent, by Mouse, Rat, Dog, and Human Liver Microsomes

H. Hsieh, C. Chen, Y. Chao, 2007, Drug Metabolism and Disposition.

Shengmai San reduces hepatic lipids and lipid peroxidation in rats fed on a high-cholesterol diet.

C. Chen, M. Chiang, T. Yeh, 2008, Journal of ethnopharmacology.

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

H. Hsieh, C. Liao, Su-Ying Wu, 2011, Journal of medicinal chemistry.

The inhibitory effect of polyunsaturated fatty acids on human CYP enzymes.

C. Chen, T. Yeh, J. T. Hsu, 2006, Life sciences.

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

H. Hsieh, C. Chen, Su-Ying Wu, 2009, Journal of medicinal chemistry.

Synthesis and biological evaluation of tylophorine-derived dibenzoquinolines as orally active agents: exploration of the role of tylophorine e ring on biological activity.

Y. Chao, Shiow-Ju Lee, T. Yeh, 2012, Journal of medicinal chemistry.

Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced o

Y. Chao, Jen‐Shin Song, T. Yeh, 2013, Journal of medicinal chemistry.

Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2011, Bioorganic & medicinal chemistry.

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

Sing-Yi Wang, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2010, Journal of medicinal chemistry.

3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2012, Bioorganic & medicinal chemistry letters.

Structure–Activity Relationship Studies of 3‐Aroylindoles as Potent Antimitotic Agents

Yi-Wei Chang, Hsing-Pang Hsieh, Uan-Kang Tan, 2006, ChemMedChem.

Quantitative determination of salidroside in rat plasma by on-line solid-phase extraction integrated with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.

T. Yeh, H. Yao, Yi-Wei Chang, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Benzo[b]thiophene-2-carboxamides as novel opioid receptor agonists with potent analgesic effect and reduced constipation.

C. Chen, H. Loh, C. Shih, 2022, European journal of medicinal chemistry.

Effects of Bu-Zhong-Yi-Qi-Tang on hepatic drug-metabolizing enzymes and plasma tolbutamide concentration in rats.

Y. Kuo, S. Kitamura, C. Lii, 2012, Journal of ethnopharmacology.

Paclitaxel-Loaded Gelatin Nanoparticles for Intravesical Bladder Cancer Therapy

Ze Lu, Max Tsai, M. Wientjes, 2004, Clinical Cancer Research.

Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.

Yi-Hui Peng, Su-Ying Wu, Jen‐Shin Song, 2021, European journal of medicinal chemistry.

Pharmacokinetics of Anti-SARS-CoV Agent Niclosamide and Its Analogs in Rats

H. Hsieh, C. Chen, T. Yeh, 2006 .

Artificial intelligence approach fighting COVID-19 with repurposing drugs

Huey-Kang Sytwu, Wen-Hsing Lin, Szu-Huei Wu, 2020, Biomedical Journal.

Discovery of BPR1R024, an Orally Active and Selective CSF1R Inhibitor that Exhibits Antitumor and Immunomodulatory Activity in a Murine Colon Tumor Model.

H. Hsieh, C. Chen, C. Shih, 2021, Journal of medicinal chemistry.

Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of BPR0L075, a novel antimicrotuble agent, in rat plasma: application to a pharmacokinetic study.

H. Hsieh, C. Chen, Y. Chao, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins

C. Chen, Jen‐Shin Song, C. Shih, 2021, Journal of medicinal chemistry.

Computational and ultrastructural toxicology of a nanoparticle, Quantum Dot 705, in mice.

Ming-Hsien Tsai, Raymond S H Yang, Louis W. Chang, 2008, Environmental science & technology.

Discovery of a Furanopyrimidine-Based Epidermal Growth Factor Receptor Inhibitor (DBPR112) as a Clinical Candidate for the Treatment of Non-Small Cell Lung Cancer.

Yi-Hui Peng, H. Hsieh, C. Chen, 2019, Journal of medicinal chemistry.

Noncytotoxic suramin as a chemosensitizer in patients with advanced non-small-cell lung cancer: a phase II study.

M. Grever, M. Wientjes, T. Bekaii-Saab, 2008, Annals of oncology : official journal of the European Society for Medical Oncology.

Phase I study of low-dose suramin as a chemosensitizer in patients with advanced non-small cell lung cancer.

M. Grever, G. Otterson, M. Villalona-Calero, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

Yung Chang Hsu, C. Chen, J. Hsu, 2016, Oncotarget.

Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.

H. Hsieh, C. Chen, Y. Chao, 2010, Anticancer research.

P2-230: A Phase I Study of Nontoxic Suramin As A Chemosensitizer In Pretreated/Refractory Non-Small Cell Lung Cancer (NSCLC) Patients

T. Olencki, M. Wientjes, G. Otterson, 2007 .

Modulation of chemotherapy resistance with low dose suramin in refractory non-small cell lung cancer (NSCLC) patients: A phase I study of sequential non-cross resistant chemotherapy

T. Olencki, G. Otterson, A. Grainger, 2005 .

Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.

Xin Chen, Y. Chao, Jen‐Shin Song, 2010, Journal of medicinal chemistry.

Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy

C. Chen, Jen‐Shin Song, Jinq-chyi Lee, 2022, Journal of medicinal chemistry.

Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study.

Louis W. Chang, P. Lin, T. Yeh, 2009, Toxicological sciences : an official journal of the Society of Toxicology.

Synthesis and Evaluation of Small Molecule Drug Conjugates Harnessing Thioester-Linked Maytansinoids

C. Chen, T. Yeh, T. Hsu, 2022, Pharmaceutics.

Effects of Carrier on Disposition and Antitumor Activity of Intraperitoneal Paclitaxel

Ze Lu, Jessie L.-S. Au, M. Guillaume Wientjes, 2007, Pharmaceutical Research.

Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer

H. Hsieh, M. Coumar, T. Yeh, 2017, Scientific Reports.

BPR0C305, an orally active microtubule-disrupting anticancer agent

Chi-Hung Lin, C. Chen, Y. Chao, 2013, Anti-cancer drugs.

Development of Furanopyrimidine-Based Orally Active Third-Generation EGFR Inhibitors for the Treatment of Non-Small Cell Lung Cancer

H. Hsieh, C. Chen, T. Lien, 2023, Journal of medicinal chemistry.

Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors.

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2012, European journal of medicinal chemistry.

Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors.

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2017, Journal of medicinal chemistry.

Evaluation of the Antitumor Effects of BPR1J-340, a Potent and Selective FLT3 Inhibitor, Alone or in Combination with an HDAC Inhibitor, Vorinostat, in AML Cancer

C. Chen, Y. Chao, T. Yeh, 2014, PloS one.

Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment

Ming-Hsien Tsai, Louis W. Chang, Pinpin Lin, 2007, Environmental health perspectives.

Discovery of 1‐(2,4‐Dichlorophenyl)‐4‐ethyl‐5‐(5‐(2‐(4‐(trifluoromethyl)phenyl)ethynyl)thiophen‐2‐yl)‐N‐(piperidin‐1‐yl)‐1H‐pyrazole‐3‐carboxamide as a Potential Peripheral Cannabinoid‐1 Receptor Inverse Agonist

Y. Chao, Jen‐Shin Song, T. Yeh, 2010, ChemMedChem.

Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells.

S. Pan, T. Yeh, J. Liou, 2014, Journal of medicinal chemistry.

Kinetics and tissue distribution of neutron-activated zinc oxide nanoparticles and zinc nitrate in mice: effects of size and particulate nature

Ming-Hsien Tsai, Fong-In Chou, Pinpin Lin, 2012, Nanotechnology.

The inhibitory effect of tannic acid on cytochrome P450 enzymes and NADPH-CYP reductase in rat and human liver microsomes.

T. Yeh, S. Lan, H. Yao, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effect of taurine supplementation on cytochrome P450 2E1 and oxidative stress in the liver and kidneys of rats with streptozotocin-induced diabetes.

C. Chen, P. Lin, M. Chiang, 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Synthesis and evaluation of novel 7H-pyrrolo-[2,3-d]pyrimidine derivatives as potential anticancer agents.

T. Yeh, J. Liou, Yi-Min Liu, 2019, Future medicinal chemistry.

Impacts of Intralipid on Nanodrug Abraxane Therapy and on the Innate Immune System

C. Chen, Chien Ho, Yen-Ju Chen, 2020, Scientific Reports.

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors (GISTs) and Acute Myeloid Leukemia (AML).

Yi-Hui Peng, C. Chen, Su-Ying Wu, 2019, Journal of medicinal chemistry.

Comparative tissue distributions of cadmium chloride and cadmium-based quantum dot 705 in mice: Safety implications and applications

Louis W. Chang, P. Lin, Chung-Shi Yang, 2011, Nanotoxicology.

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.

Yi-Hui Peng, C. Chen, Su-Ying Wu, 2019 .

Nontoxic Suramin as a Chemosensitizer in Patients: Dosing Nomogram Development

M. Grever, G. Otterson, M. Villalona-Calero, 2006, Pharmaceutical Research.

P-229 Phase II evaluation of low dose suramin as a modulator of paclitaxel/carboplatin (P/C) in non-small cell lung cancer (NSCLC) patients

M. Grever, G. Otterson, M. Villalona-Calero, 2003 .

1-Arylsulfonyl-5-(N-hydroxyacrylamide)tetrahydroquinolines as potent histone deacetylase inhibitors suppressing the growth of prostate cancer cells.

S. Pan, T. Yeh, J. Liou, 2015, European journal of medicinal chemistry.

In vitro and in vivo studies of a potent capsid-binding inhibitor of enterovirus 71.

C. Chiu, J. Horng, S. Shih, 2016, The Journal of antimicrobial chemotherapy.

Resistance Analysis and Characterization of a Thiazole Analogue, BP008, as a Potent Hepatitis C Virus NS5A Inhibitor

A. Yueh, Y. Chao, T. Yeh, 2011, Antimicrobial Agents and Chemotherapy.

Overcoming vincristine resistance in cancer: Computational design and discovery of piperine‐inspired P‐glycoprotein inhibitors

H. Hsieh, M. Coumar, T. Yeh, 2020, Chemical biology & drug design.

CYP1A2 genetic polymorphisms are associated with early antidepressant escitalopram metabolism and adverse reactions.

C. Hsiao, Yu-Li Liu, T. Yeh, 2013, Pharmacogenomics.

Linker Optimization and Therapeutic Evaluation of Phosphatidylserine-Targeting Zinc Dipicolylamine-based Drug Conjugates.

C. Chen, Yu-Wei Liu, B. Gray, 2019, Journal of medicinal chemistry.

Protective effects of 10,11-dihydro-5H-dibenzo[b,f]azepine hydroxamates on vascular cognitive impairment.

L. Chan, T. Yeh, J. Liou, 2019, European journal of medicinal chemistry.

Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease.

Jen‐Shin Song, Chi-Hui Tsai, Yi-Yu Ke, 2023, European journal of medicinal chemistry.

Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice

C. Yeh, T. Yeh, T. Tsai, 2022, Journal of biomedical science.

Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants.

Yi-Hui Peng, C. Chen, Su-Ying Wu, 2019, Journal of medicinal chemistry.

Discovery, structure-activity relationship studies, and anti-nociceptive effects of N-(1,2,3,4-tetrahydro-1-isoquinolinylmethyl)benzamides as novel opioid receptor agonists.

H. Loh, P. Law, C. Shih, 2017, European journal of medicinal chemistry.

Click Chemistry and Multicomponent Reaction for Linker Diversification of Zinc Dipicolylamine-Based Drug Conjugates

C. Chen, T. Yeh, Tai-Yu Chiu, 2022, Frontiers in Chemistry.

Delta‐opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice

H. Loh, P. Law, T. Yeh, 2019, European journal of pharmacology.

3D‐QSAR‐Assisted Drug Design: Identification of a Potent Quinazoline‐Based Aurora Kinase Inhibitor

Yung Chang Hsu, H. Hsieh, Y. Chao, 2013, ChemMedChem.

Pharmacokinetic Interaction Between Intravenous 2′,3′-Dideoxyinosine and Pentamidine in Rats

J. Au, M. Wientjes, T. Yeh, 1996, Pharmaceutical Research.

Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2013, Bioorganic & medicinal chemistry.

Novel Nrf2/ARE activator, trans-Coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38α/MAPKAPK-2 and PK-N3 signaling pathway.

Wei-min Liu, C. Shih, T. Yeh, 2015, Chemical research in toxicology.

Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer

H. Hsieh, M. Coumar, T. Yeh, 2017, Scientific Reports.

Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice.

Y. Chao, Jen‐Shin Song, T. Yeh, 2009, Journal of Medicinal Chemistry.

Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities.

Y. Chao, T. Yeh, Kak‐Shan Shia, 2010, Pharmacological research.

BPRDP056, a novel small molecule drug conjugate specifically targeting phosphatidylserine for cancer therapy

C. Chen, T. Yeh, Min-Hsien Wang, 2020, Translational oncology.

Involvement of oxidative stress and activation of aryl hydrocarbon receptor in elevation of CYP1A1 expression and activity in lung cells and tissues by arsenic: an in vitro and in vivo study.

Louis W. Chang, P. Lin, T. Yeh, 2009, Toxicological sciences : an official journal of the Society of Toxicology.