W. Jiaang

发表

DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity.

C. Chen, Y. Chao, Jen‐Shin Song, 2021, Life sciences.

A Novel Dengue Virus Inhibitor, BP13944, Discovered by High-Throughput Screening with Dengue Virus Replicon Cells Selects for Resistance in the Viral NS2B/NS3 Protease

A. Yueh, Szu-Huei Wu, Shiow-Ju Lee, 2013, Antimicrobial Agents and Chemotherapy.

A three-dimensional pharmacophore model for dipeptidyl peptidase IV inhibitors.

I. Lu, N. Mahindroo, Xin Chen, 2008, European journal of medicinal chemistry.

Potent and orally active purine-based fetal hemoglobin inducers for treating β-thalassemia and sickle cell disease.

C. Chen, Y. Chou, Chun-Hung Lin, 2020, European journal of medicinal chemistry.

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors.

H. Hsieh, C. Chen, Xin Chen, 2006, Bioorganic & medicinal chemistry letters.

Facile solid-phase synthesis of an antifreeze glycoprotein.

Shui-Tein Chen, M. Chang, W. Jiaang, 2001, Chemistry.

(1,3-Diphenyl-1H-pyrazol-4-yl)-methylamine Analogues as Inhibitors of Dipeptidyl Peptidases

C. Chen, Xin Chen, Y. Chao, 2009 .

Novel trans-2-aryl-cyclopropylamine analogues as potent and selective dipeptidyl peptidase IV inhibitors.

C. Chen, Xin Chen, Y. Chao, 2009, Bioorganic & medicinal chemistry.

Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors.

I. Lu, Xin Chen, Su-Ying Wu, 2005, Bioorganic & medicinal chemistry letters.

Resistance Studies of a Dithiazol Analogue, DBPR110, as a Potential Hepatitis C Virus NS5A Inhibitor in Replicon Systems

A. Yueh, Y. Chao, Su-Ying Wu, 2012, Antimicrobial Agents and Chemotherapy.

BPR1J-097, a novel FLT3 kinase inhibitor, exerts potent inhibitory activity against AML

Y. Chao, W. Jiaang, C-W Chen, 2011, British Journal of Cancer.

Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor.

Xin Chen, Y. Chao, Chih-Hsiang Huang, 2009, Biochemical pharmacology.

(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

C. Chen, Xin Chen, Y. Chao, 2010, Bioorganic & medicinal chemistry letters.

Rational design and synthesis of potent and long-lasting glutamic acid-based dipeptidyl peptidase IV inhibitors.

C. Chen, Xin Chen, Y. Chao, 2009, Bioorganic & medicinal chemistry letters.

Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations.

C. Chen, Y. Chao, J. Hsu, 2015, European journal of medicinal chemistry.

Synthesis of 3,3-Dimethylglutamic Acid Derivatives as DPP-IV Inhibitors and Evaluation of Their Chemical Stability

Y. Chao, T. Hsu, W. Jiaang, 2011 .

Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8.

Xin Chen, Shiow-Ju Lee, T. Hsu, 2005, Bioorganic & medicinal chemistry letters.

Discovery and evaluation of 3-phenyl-1H-5-pyrazolylamine-based derivatives as potent, selective and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2011, Bioorganic & medicinal chemistry.

Identification of Novel Anti-Liver Cancer Small Molecules with Better Therapeutic Index Than Sorafenib via Zebrafish Drug Screening Platform

C. Yuh, G. Lai, T. Hsu, 2019, Cancers.

3-Phenyl-1H-5-pyrazolylamine-based derivatives as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2012, Bioorganic & medicinal chemistry letters.

Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.

H. Hsieh, C. Chen, Y. Chao, 2013, Journal of medicinal chemistry.

The Scope and Limitations of Intramolecular Radical Cyclizations of Acylsilanes with Alkyl, Aryl, and Vinyl Radicals

K. Tang, Chih-hao Huang, W. Jiaang, 1997 .

Group transfer from silicon to carbon via tandem radical cyclizations of acylsilanes

K. Tang, W. Jiaang, Y. Tsai, 1996 .

Radical cyclizations of bromo acylsilanes and intramolecular trapping of the rearranged α-silyloxy radicals

K. Tang, W. Jiaang, Y. Tsai, 1993 .

A concise synthesis of the O-glycosylated amino acid building block; using phenyl selenoglycoside as a glycosyl donor

Shui-Tein Chen, W. Jiaang, Meng‐Yang Chang, 2000 .

THE STUDY OF THE KINETICS OF INTRAMOLECULAR RADICAL CYCLIZATIONS OF ACYLSILANES VIA THE INTRAMOLECULAR COMPETITION METHOD

K. Tang, W. Jiaang, L. Chang, 1999 .

Reductions, Reductive Alkylations, and Intramolecular Cyclizations of Acyl Silanes with Samarium Diiodide or Tributyltin Hydride.

Jim-Min Fang, W. Jiaang, T. Chuang, 1996, The Journal of organic chemistry.

Acylsilanes as Geminal Radical Acceptor/Radical Donor Equivalents in Tandem Cyclization/Addition Reactions

W. Jiaang, D. Curran, Michael R. Palovich, 1993 .

Benzothiazolium compounds: novel classes of inhibitors that suppress the nitric oxide production in RAW264.7 cells stimulated by LPS/IFNgamma.

N. Mahindroo, Shiow-Ju Lee, T. Hsu, 2005, Bioorganic & medicinal chemistry letters.

Facile Solid Phase Synthesis of YEE(ah-GalNAc)3, a Ligand with Known High Affinity for the Asialoglycoprotein Receptor

Shui-Tein Chen, W. Jiaang, P. Tseng, 2000 .

BPR1J373, an Oral Multiple Tyrosine Kinase Inhibitor, Targets c-KIT for the Treatment of c-KIT–Driven Myeloid Leukemia

C. Chen, J. Hsu, Li‐Tzong Chen, 2016, Molecular Cancer Therapeutics.

BPR1J373, a novel multitargeted kinase inhibitor, effectively suppresses the growth of gastrointestinal stromal tumor

J. Fletcher, C. Chen, Chun‐Chieh Wu, 2018, Cancer science.

Xanthine Derivatives Reveal an Allosteric Binding Site in Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2)

Yi-Hui Peng, Su-Ying Wu, T. Hsu, 2021, Journal of medicinal chemistry.

Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.

Xin Chen, Y. Chao, Jen‐Shin Song, 2010, Journal of medicinal chemistry.

Pyrazolylamine Derivatives Reveal the Conformational Switching between Type I and Type II Binding Modes of Anaplastic Lymphoma Kinase (ALK).

P. Lyu, Yi-Hui Peng, Su-Ying Wu, 2016, Journal of medicinal chemistry.

Evaluation of the Antitumor Effects of BPR1J-340, a Potent and Selective FLT3 Inhibitor, Alone or in Combination with an HDAC Inhibitor, Vorinostat, in AML Cancer

C. Chen, Y. Chao, T. Yeh, 2014, PloS one.

The dimeric transmembrane domain of prolyl dipeptidase DPP‐IV contributes to its quaternary structure and enzymatic activities

Xin Chen, M. Hwang, W. Jiaang, 2010, Protein science : a publication of the Protein Society.

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors (GISTs) and Acute Myeloid Leukemia (AML).

Yi-Hui Peng, C. Chen, Su-Ying Wu, 2019, Journal of medicinal chemistry.

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.

Yi-Hui Peng, C. Chen, Su-Ying Wu, 2019 .

Current advances and therapeutic potential of agents targeting dipeptidyl peptidases-IV, -II, 8/9 and fibroblast activation protein.

Shu-Jen Chen, W. Jiaang, 2011, Current topics in medicinal chemistry.

A Synthesis of Cytonin (Taiwanin A), an Antitumor Lignan

Shui-Tein Chen, W. Jiaang, A. Tseng, 2000 .

Resistance Analysis and Characterization of a Thiazole Analogue, BP008, as a Potent Hepatitis C Virus NS5A Inhibitor

A. Yueh, Y. Chao, T. Yeh, 2011, Antimicrobial Agents and Chemotherapy.

Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants.

Yi-Hui Peng, C. Chen, Su-Ying Wu, 2019, Journal of medicinal chemistry.

3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes.

H. Hsieh, C. Chen, Xin Chen, 2007, Bioorganic & medicinal chemistry letters.

Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2013, Bioorganic & medicinal chemistry.

2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

I. Lu, H. Hsieh, C. Chen, 2006, Journal of medicinal chemistry.