S. Iwasaki

发表

Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of the Glucagon-Like Peptide-1 Receptor Agonist Exenatide to Characterize Its Antiobesity Effects in Diet-Induced Obese Mice

Tomohiro Andou, S. Iwasaki, Teruki Hamada, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Comparison of predictability for human pharmacokinetics parameters among monkeys, rats, and chimeric mice with humanised liver

S. Iwasaki, Ikumi Chisaki, N. Amano, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.

Y. Nakano, Masanori Watanabe, S. Iwasaki, 2017, Bioorganic & medicinal chemistry.

Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug–drug interactions using physiologically based pharmacokinetic modelling approach

Andy Z. X. Zhu, S. Iwasaki, Noriyasu Sano, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Quantitative prediction of the extent of drug–drug interaction using a physiologically based pharmacokinetic model that includes inhibition of drug metabolism determined in cryopreserved hepatocytes

S. Iwasaki, N. Amano, H. Hirabayashi, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse

S. Iwasaki, Ikumi Chisaki, N. Amano, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B.

S. Iwasaki, T. Nomura, Kazuhide Nakamura, 2017, Cancer research.

Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.

H. Oki, S. Iwasaki, S. Morimoto, 2022, European journal of medicinal chemistry.

Selective Acetyl-CoA Carboxylase 1 Inhibitor Improves Hepatic Steatosis and Hepatic Fibrosis in a Preclinical Nonalcoholic Steatohepatitis Model

D. Erion, Masanori Watanabe, S. Iwasaki, 2021, The Journal of Pharmacology and Experimental Therapeutics.

The J domain of Tpr2 regulates its interaction with the proapoptotic and cell-cycle checkpoint protein, Rad9.

S. Xiang, S. Iwasaki, X. Sun, 2001, Biochemical and biophysical research communications.

Discovery of novel somatostatin receptor subtype 5 (SSTR5) antagonists: Pharmacological studies and design to improve pharmacokinetic profiles and human Ether-a-go-go-related gene (hERG) inhibition.

Y. Shimizu, Y. Nakano, Masanori Watanabe, 2017, Bioorganic & medicinal chemistry.

Unbound liver concentration is the true inhibitor concentration that determines cytochrome P450-mediated drug–drug interactions in rat liver

S. Iwasaki, N. Amano, H. Hirabayashi, 2017, Xenobiotica; the fate of foreign compounds in biological systems.

A Translational Physiologically Based Pharmacokinetics/Pharmacodynamics Framework of Target-Mediated Disposition, Target Inhibition and Drug–Drug Interactions of Bortezomib

Andy Z. X. Zhu, K. Venkatakrishnan, C. Xia, 2020, The AAPS Journal.

Brain microvascular endothelial cells derived from human induced pluripotent stem cells as in vitro model for assessing blood-brain barrier transferrin receptor-mediated transcytosis

M. Matsusaki, K. Kawabata, Tomoko Yamaguchi, 2022, Materials today. Bio.

TAK-676: A Novel Stimulator of Interferon Genes (STING) Agonist Promoting Durable IFN-dependent Antitumor Immunity in Preclinical Studies

T. Traore, V. Kolev, M. Okaniwa, 2022, Cancer research communications.

A novel membrane fusion-mediated plant immunity against bacterial pathogens.

M. Nishimura, K. Tamura, I. Hara-Nishimura, 2009, Genes & development.

T-448, a specific inhibitor of LSD1 enzyme activity, improves learning function without causing thrombocytopenia in mice

H. Oki, R. Hara, S. Iwasaki, 2018, Neuropsychopharmacology.

Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys

S. Iwasaki, Teruki Hamada, Noriyasu Sano, 2019, Pharmaceutical Research.

Biodistribution and delivery of oligonucleotide therapeutics to the central nervous system: Advances, challenges, and future perspectives

S. Iwasaki, Syunsuke Yamamoto, A. Goto, 2022, Biopharmaceutics & drug disposition.

Discovery of a novel series of GPR119 agonists: Design, synthesis, and biological evaluation of N-(Piperidin-4-yl)-N-(trifluoromethyl)pyrimidin-4-amine derivatives.

Kenjiro Sato, S. Iwasaki, Koji Watanabe, 2021, Bioorganic & medicinal chemistry.

Advanced translational PBPK model for transferrin receptor-mediated drug delivery to the brain.

H. Kusuhara, S. Iwasaki, T. Yoneyama, 2023, Journal of controlled release : official journal of the Controlled Release Society.

Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver

S. Iwasaki, Ikumi Chisaki, N. Amano, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

An Automated Multicycle Immunoaffinity Enrichment Approach Developed for Sensitive Mouse IgG1 Antibody Drug Analysis in Mouse Plasma Using LC/MS/MS.

S. Iwasaki, M. Qian, Dong Wei, 2021, Analytical chemistry.

Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys

S. Iwasaki, Teruki Hamada, Noriyasu Sano, 2019, Pharmaceutical Research.

Discovery of a novel series of indolinylpyrimidine-based GPR119 agonists: Elimination of ether-a-go-go-related gene liability using a hydrogen bond acceptor-focused approach.

Kenjiro Sato, S. Iwasaki, M. Kamaura, 2021, Bioorganic & medicinal chemistry.

Sinusoidal Organic Anion-Transporting Polypeptide 1B1/1B3 and Bile Canalicular Multidrug Resistance-Associated Protein 2 Play an Essential Role in the Hepatobiliary Disposition of a Synthetic Cyclic Dinucleotide (STING Agonist)

C. Xia, S. Iwasaki, Bei-Ching Chuang, 2022, The AAPS Journal.