R. Bortell

D. Harlan, M. Atkinson, David M. Blodgett, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Coordinate occupancy of AP-1 sites in the vitamin D-responsive and CCAAT box elements by Fos-Jun in the osteocalcin gene: model for phenotype suppression of transcription.

K. Wright, A. V. van Wijnen, V. Shalhoub, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Multiple levels of steroid hormone‐dependent control of osteocalcin during osteoblast differentiation: Glucocorticoid regulation of basal and vitamin D stimulated gene expression

G. Stein, J. Lian, A. V. van Wijnen, 1998, Journal of cellular biochemistry.

TGFβ1 Prevents the down‐regulation of type I procollagen, fibronectin, and TGFβ1 gene expression associated with 3T3‐L1 pre‐adipocyte differentiation

G. Stein, J. Stein, R. Bortell, 1994 .

Contributions of distal and proximal promoter elements to glucocorticoid regulation of osteocalcin gene transcription.

G. Stein, J. Lian, A. V. van Wijnen, 1995, Molecular endocrinology.

Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD–scid IL-2rgnull RIP-DTR mice engrafted with human islets

D. Harlan, P. Herrera, D. Greiner, 2015, Diabetes, metabolic syndrome and obesity : targets and therapy.

Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein-DNA interactions at basal and enhancer promoter elements.

G. Stein, J. Lian, J. Stein, 1993, Proceedings of the National Academy of Sciences of the United States of America.

GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis

M. Atkinson, Qinghua Wang, Zhong-Ping Feng, 2014, Diabetes.

Characterization of high density lipoprotein-bound and soluble RT6 released following administration of anti-RT6.1 monoclonal antibody.

H. Brewer, J. Moss, D. Greiner, 1998, Journal of immunology.

Human Immune System Development and Rejection of Human Islet Allografts in Spontaneously Diabetic NOD-Rag1null IL2rγnull Ins2Akita Mice

A. Powers, D. Greiner, P. Diiorio, 2010, Diabetes.

Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats

J. Leszyk, S. Tam, D. Hinerfeld, 2010, Experimental biology and medicine.

A new isolation method for rat intraepithelial lymphocytes

Amrik J Singh, D. Greiner, R. Bortell, 1999, Journal of Immunological Methods.

The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse

J. Moss, D. Greiner, R. Bortell, 2004, Molecular and Cellular Biochemistry.

Levels of Art2+ Cells but not Soluble Art2 Protein Correlate with Expression of Autoimmune Diabetes in the BB Rat

D. Waite, J. Moss, D. Greiner, 2001, Autoimmunity.

The RT6 (Art2) family of ADP-ribosyltransferases in rat and mouse.

J. Moss, D. Greiner, R. Bortell, 1999 .

Genetic ablation of lymphocytes and cytokine signaling in nonobese diabetic mice prevents diet‐induced obesity and insulin resistance

R. Friedline, Jason K. Kim, D. Greiner, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Histone H4 proximal promoter mediates a complex transcriptional response during differentiation of 3T3L1 adipocytes

G. Stein, J. Stein, R. Bortell, 1995, Journal of cellular physiology.

Differential regulation of H4 histone gene expression in 3T3‐L1 pre‐adipocytes during arrest of proliferation following contact inhibition or differentiation and its modulation by TGFβ1

G. Stein, A. V. van Wijnen, J. Stein, 1992 .

Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome.

F. Urano, L. Zhu, R. Kaufman, 2012, Cell metabolism.

Failure of alpha-galactosylceramide to prevent diabetes in virus-inducible models of type 1 diabetes in the rat.

D. Greiner, P. Diiorio, L. Shultz, 2009, In vivo.

Ian4 is required for mitochondrial integrity and T cell survival

S. Corvera, D. Greiner, R. Bortell, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The Rat T-Cell Surface Protein RT6 Is Associated With src Family Tyrosine Kinases and Generates an Activation Signal

M. Czech, J. Klarlund, D. Greiner, 1996, Diabetes.

The BB/Wor rat and the balance hypothesis of autoimmunity.

D. Greiner, R. Bortell, M. Rigby, 1996, Diabetes/metabolism reviews.

Developmental expression and hormonal regulation of the rat matrix GLA protein (MGP) gene in chondrogenesis and osteogenesis

G. Stein, J. Lian, R. Bortell, 1991, Journal of cellular biochemistry.

Regulatory Role of Arginine 204 in the Catalytic Activity of Rat Alloantigens ART2a and ART2b*

J. Moss, R. Bortell, Linda A. Stevens, 2003, Journal of Biological Chemistry.

Characterization of Mouse Rt6.1 NAD:Arginine ADP-ribosyltransferase*

D. Greiner, Joel Moss, R. Bortell, 1997, The Journal of Biological Chemistry.

The T cell marker RT6 in a rat model of autoimmune diabetes.

J. Moss, D. Greiner, R. Bortell, 1997, Advances in experimental medicine and biology.

Mouse RT6 locus 1 and rat RT6.2 are NAD+. Arginine ADP-ribosyltransferases with auto-ADP-ribosylation activity.

J. Moss, D. Greiner, R. Bortell, 1997, Advances in experimental medicine and biology.

Rat RT6.2 and mouse Rt6 locus 1 are NAD+: arginine ADP ribosyltransferases with auto-ADP ribosylation activity.

J. Moss, D. Greiner, R. Bortell, 1996, Journal of immunology.

Substrate specificity of soluble and membrane‐associated ADP‐ribosyltransferase ART2.1

J. Moss, A. Morrison, A. Chung, 2006, Journal of cellular biochemistry.

The BB/Wor rat and the balance hypothesis of autoimmunity.

D. Greiner, R. Bortell, M. Rigby, 1996, Diabetes/metabolism reviews.

AATF mediates anti-apoptotic effect of the unfolded protein response through transcriptional regulation of AKT1

M. Permutt, F. Urano, L. Zhu, 2009, Cell Death and Differentiation.

VITAMIN D REGULATION OF THE BONE SPECIFIC OSTEOCALCIN GENE IS FUNCTIONALLY RELATED TO OSTEOBLAST GROWTH AND DIFFERENTIATION

G. Stein, J. Lian, J. Bidwell, 1991 .

Inhibition of induced endochondral bone development in caffeine‐treated rats

G. Stein, J. Lian, R. Bortell, 1993, Journal of cellular biochemistry.

Proximal promoter binding protein contributes to developmental, tissue‐restricted expression of the rat osteocalcin gene

G. Stein, J. Lian, J. Stein, 1995, Journal of cellular biochemistry.

Disruption of the cytoskeleton with cytochalasin D induces c-fos gene expression.

G. Stein, G. Zambetti, J. Stein, 1991, Experimental cell research.

Variations in vitamin D receptor transcription factor complexes associated with the osteocalcin gene vitamin D responsive element in osteoblasts and osteosarcoma cells

G. Stein, J. Lian, A. V. van Wijnen, 1994, Journal of cellular biochemistry.

Nitrofurantoin inhibition of mouse liver mitochondrial respiration involving NAD-linked substrates.

R. Bortell, A. Neims, L. O. Lim, 1986, Toxicology and applied pharmacology.

Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1.

Kathryn L. Lipson, F. Urano, R. Bortell, 2006, Cell metabolism.

Synthetic polyamine analogues as antineoplastics.

J. Vinson, R. Bergeron, R. Bortell, 1988, Journal of medicinal chemistry.

Constitutive transcription of the osteocalcin gene in osteosarcoma cells is reflected by altered protein-DNA interactions at promoter regulatory elements.

G. Stein, J. Lian, J. Stein, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Vitamin D-responsive protein-DNA interactions at multiple promoter regulatory elements that contribute to the level of rat osteocalcin gene expression.

P. Gavazzo, G. Stein, J. Lian, 1992, Proceedings of the National Academy of Sciences of the United States of America.

10 – Molecular Mechanisms That Mediate a Functional Relationship between Proliferation and Differentiation

G. Stein, J. Lian, R. Bortell, 1992 .

Identification and characterization of two proximal elements in the rat osteocalcin gene promoter that may confer species‐specific regulation

G. Stein, J. Lian, J. Stein, 1993, Journal of cellular biochemistry.

Identification of multiple glucocorticoid receptor binding sites in the rat osteocalcin gene promoter.

G. Stein, J. Lian, E. Alnemri, 1993, Biochemistry.

Concerted control of multiple histone promoter factors during cell density inhibition of proliferation in osteosarcoma cells: reciprocal regulation of cell cycle-controlled and bone-related genes.

G. Stein, J. Lian, A. V. van Wijnen, 1993, Cancer research.

Transcriptional element H4‐site II of cell cycle regulated human H4 histone genes is a multipartite protein/DNA interaction site for factors HiNF‐D, HiNF‐M, and HiNF‐P: Involvement of phosphorylation

G. Stein, J. Lian, A. V. van Wijnen, 1991, Journal of cellular biochemistry.

11,12-Epoxyeicosatrienoic acid stimulates endogenous mono-ADP-ribosylation in bovine coronary arterial smooth muscle.

W. Campbell, R. Bortell, C. L. Chen, 1999, Circulation research.

in Bovine Coronary Arterial Smooth Muscle 11 , 12-Epoxyeicosatrienoic Acid Stimulates Endogenous Mono-ADP-Ribosylation

W. Campbell, Pin-Lan Li, R. Bortell, 1999 .

Cytoplasmic Polyadenylation Element Binding Protein Deficiency Stimulates PTEN and Stat3 mRNA Translation and Induces Hepatic Insulin Resistance

F. Urano, R. Friedline, J. Richter, 2012, PLoS genetics.

A novel transgenic mouse model of lysosomal storage disorder.

S. Shaffer, Alan Cheng, D. Greiner, 2016, American journal of physiology. Gastrointestinal and liver physiology.

Loss of RT6 message and most circulating T cells after thymectomy of diabetes prone BB rats.

D. Waite, F. Koch-Nolte, R. Bortell, 1994, Autoimmunity.

A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats

M. Brodsky, Jennifer P. Wang, R. Bortell, 2016, Diabetes.

Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia*

Marina T. DiStefano, M. Czech, Jason K. Kim, 2016, The Journal of Biological Chemistry.

Human &bgr;-cell regeneration: progress, hurdles, and controversy

Agata Jurczyk, R. Bortell, L. Alonso, 2014, Current opinion in endocrinology, diabetes, and obesity.

A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours

D. Greiner, Gang Han, Liang Zhao, 2016, Nature Communications.

Role of cilia in normal pancreas function and in diseased states.

P. Diiorio, Agata Jurczyk, R. Bortell, 2014, Birth defects research. Part C, Embryo today : reviews.

Humanized Mice in Translational Immunology

D. Greiner, L. Shultz, R. Bortell, 2016 .

End Sequence Analysis ToolKit ( ESAT ) expands the extractable from single cell RNA-seq experiments

Maxim N. Artyomov, Allon M. Klein, D. Harlan, 2016 .

Viral Infection of Engrafted Human Islets Leads to Diabetes

B. Barton, D. Greiner, R. Finberg, 2014, Diabetes.

Closing the Circle between the Bedside and the Bench

D. Greiner, R. Bortell, A. Rossini, 2008, Annals of the New York Academy of Sciences.

The role of innate immune pathways in type 1 diabetes pathogenesis

R. Bortell, Steven C. Pino, Annie J. Kruger, 2010, Current opinion in endocrinology, diabetes, and obesity.

Transcriptionally active nuclei isolated from intact bone reflect modified levels of gene expression in skeletal development and pathology

G. Stein, J. Lian, J. Stein, 1994, Journal of cellular biochemistry.

Aflatoxin incidence in feeds, toxicology and possible residue hazards in foods.

R. Bortell, O. Osuna, G. T. Edds, 1980, Proceedings, annual meeting of the United States Animal Health Association.

Acute experimentally induced aflatoxicosis in the weanling pony.

R. Bortell, Simpson Cf, G. T. Edds, 1983, American journal of veterinary research.

Hyperglycemia-Induced Proliferation of Adult Human Beta Cells Engrafted Into Spontaneously Diabetic Immunodeficient NOD-Rag1null IL2r&ggr;null Ins2Akita Mice

M. Atkinson, A. Powers, D. Greiner, 2011, Pancreas.

Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes

F. Urano, P. Diiorio, Agata Jurczyk, 2013, Diabetologia.

Phenotype suppression: A postulated molecular mechanism for mediating the relationship of proliferation and differentiation by Fos/Jun interactions at AP‐1 sites in steroid responsive promoter elements of tissue‐specific genes

G. Stein, J. Lian, R. Bortell, 1991, Journal of cellular biochemistry.

Cell Structure and Gene Expression: Contributions of the Extracellular Matrix to Regulation of Osteoblast Growth and Differentiation

G. Stein, J. Lian, S. Pockwinse, 1991 .

Recovery of viable endocrine‐specific cells and transcriptomes from human pancreatic islet‐engrafted mice

D. Harlan, M. Garber, S. Redick, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Isolation and characterization of a cDNA from a human histone H2B gene which is reciprocally expressed in relation to replication-dependent H2B histone genes during HL60 cell differentiation.

G. Stein, J. Lian, J. Stein, 1991, Biochemistry.

TGF beta 1 prevents the down-regulation of type I procollagen, fibronectin, and TGF beta 1 gene expression associated with 3T3-L1 pre-adipocyte differentiation.

G. Stein, J. Stein, R. Bortell, 1994, Journal of cellular biochemistry.

Expression in BALB/c and C57BL/6 mice of Rt6-1 and Rt6-2 ADP-ribosyltransferases that differ in enzymatic activity: C57BL/6 Rt6-1 is a natural transferase knockout.

J. Moss, D. Greiner, R. Bortell, 1997, Journal of immunology.

GABA Promotes Human β-Cell Proliferation and Modulates Glucose Homeostasis

M. Atkinson, Qinghua Wang, Zhong-Ping Feng, 2014, Diabetes.

Hyperglycemia-Induced Proliferation of Adult Human Beta Cells Engrafted Into Spontaneously Diabetic Immunodeficient NOD-Rag1null IL2r&ggr;null Ins2Akita Mice

M. Atkinson, A. Powers, D. Greiner, 2011, Pancreas.

Possible type 1 diabetes risk prediction: Using ultrasound imaging to assess pancreas inflammation in the inducible autoimmune diabetes BBDR model

D. Harlan, D. Greiner, N. Walsh, 2017, PloS one.

lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient

Agata Jurczyk, Linda Leehy, R. Bortell, 2015 .

AATF mediates anti-apoptotic effect of the unfolded protein response through transcriptional regulation of AKT1

M. Permutt, F. Urano, L. Zhu, 2009, Cell Death and Differentiation.