J. Shryock

发表

Sulfonylureas uncouple glucose-dependence for GPR40-mediated enhancement of insulin secretion from INS-1E cells

Ming Yang, J. W. Chisholm, S. Soelaiman, 2010, Molecular and Cellular Endocrinology.

A Novel, Potent, and Selective Inhibitor of Cardiac Late Sodium Current Suppresses Experimental Arrhythmias

Lin Wu, Lina Yao, W. Crumb, 2012, The Journal of Pharmacology and Experimental Therapeutics.

Reduction of Repolarization Reserve Unmasks the Proarrhythmic Role of Endogenous Late Na Ϩ Current in the Heart Female Rabbit Isolated Heart Model

C. January, J. Shryock, S. Rajamani, 2022 .

Antagonism by Ranolazine of the Pro-Arrhythmic Effects of Increasing Late INa in Guinea Pig Ventricular Myocytes

J. Shryock, L. Belardinelli, Lin Wu, 2004, Journal of cardiovascular pharmacology.

Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells.

J. Shryock, L. Belardinelli, M. Ozeck, 1998, Molecular pharmacology.

Differential A1 adenosine receptor reserve for two actions of adenosine on guinea pig atrial myocytes.

D. Dennis, J. Shryock, L. Belardinelli, 1997, Molecular pharmacology.

Larger late sodium current density as well as greater sensitivities to ATX II and ranolazine in rabbit left atrial than left ventricular myocytes.

J. Shryock, Ying Wu, Pei-hua Zhang, 2014, American journal of physiology. Heart and circulatory physiology.

Ranolazine Attenuates Hypoxia- and Hydrogen Peroxide-induced Increases in Sodium Channel Late Openings in Ventricular Myocytes

J. Shryock, L. Belardinelli, Pei-hua Zhang, 2014, Journal of cardiovascular pharmacology.

Use of preclinical assays to predict risk of drug-induced torsades de pointes.

J. Shryock, L. Belardinelli, Yejia Song, 2005, Heart rhythm.

Antilipolytic Activity of a Novel Partial A1 Adenosine Receptor Agonist Devoid of Cardiovascular Effects: Comparison with Nicotinic Acid

J. Shryock, L. Belardinelli, A. Dhalla, 2007, Journal of Pharmacology and Experimental Therapeutics.

Regadenoson, a selective A2A adenosine receptor agonist, causes dose-dependent increases in coronary blood flow velocity in humans

R. Kerensky, J. Shryock, L. Belardinelli, 2007, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

An apoptosis signal‐regulating kinase 1 inhibitor reduces cardiomyocyte apoptosis and infarct size in a rat ischemia‐reperfusion model

R. Kloner, W. Dai, J. Shryock, 2012, Journal of cardiovascular pharmacology.

Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A₁ adenosine receptor.

María Kimatrai Salvador, K. Varani, O. Cruz-López, 2012, Bioorganic & medicinal chemistry.

Synthesis of 2-amino-3-heteroaroylthiophenes and evaluation of their activity as potential allosteric enhancers at the human A1 receptor.

J. Shryock, P. Borea, P. Baraldi, 2004, European journal of medicinal chemistry.

A mechanistic approach to assess the proarrhythmic risk of QT-prolonging drugs in preclinical pharmacologic studies.

J. Shryock, L. Belardinelli, Yejia Song, 2004, Journal of electrocardiology.

The A2A adenosine receptor mediates coronary vasodilation.

E. Ongini, A. Monopoli, G. Lozza, 1998, The Journal of pharmacology and experimental therapeutics.

A partial agonist of the A1-adenosine receptor selectively slows AV conduction in guinea pig hearts

J. Shryock, L. Belardinelli, Lin Wu, 2001 .

Tonic activity of the rat adipocyte A1‐adenosine receptor

J. Shryock, L. Belardinelli, H. Liang, 2002, British journal of pharmacology.

Myocardial Adenosine Receptors

J. Shryock, L. Belardinelli, C. Kollias-Baker, 1995 .

Agonist-independent effect of an allosteric enhancer of the A1 adenosine receptor in CHO cells stably expressing the recombinant human A1 receptor.

J. Harrison, M. Jacobson, J. Shryock, 1997, The Journal of pharmacology and experimental therapeutics.

A partial agonist of the A(1)-adenosine receptor selectively slows AV conduction in guinea pig hearts.

J. Shryock, L. Belardinelli, L. Wu, 2001, American journal of physiology. Heart and circulatory physiology.

LQTS mutation N1325S in cardiac sodium channel gene SCN5A causes cardiomyocyte apoptosis, cardiac fibrosis and contractile dysfunction in mice.

Z. Popović, J. Shryock, L. Belardinelli, 2011, International journal of cardiology.

Ranolazine as an Adjunct to Cardioplegia: A Potential New Therapeutic Application

R. Kloner, B. Simkhovich, Hyosook Hwang, 2009, Journal of cardiovascular pharmacology and therapeutics.

Cardiac electrophysiological actions of adenosine

J. Shryock, L. Belardinelli, Yejia Song, 1998 .

Selective A2-adenosine receptor agonists do not alter action potential duration, twitch shortening, or cAMP accumulation in guinea pig, rat, or rabbit isolated ventricular myocytes.

J. Shryock, L. Belardinelli, S. Baker, 1993, Circulation research.

Ambrisentan and Tadalafil Synergistically Relax Endothelin-Induced Contraction of Rat Pulmonary Arteries

J. Shryock, L. Belardinelli, L. Yao, 2011, Hypertension.

Inhibition of the late sodium current slows t-tubule disruption during the progression of hypertensive heart disease in the rat.

Sanjiv J. Shah, J. Ng, D. Gupta, 2013, American journal of physiology. Heart and circulatory physiology.

Antiadrenergic and Hemodynamic Effects of Ranolazine in Conscious Dogs

M. Ochoa, T. Hintze, J. Shryock, 2011, Journal of cardiovascular pharmacology.

Contribution of frequency-augmented inward Ca2+ current to myocardial contractility.

A. Curtis, J. Shryock, H. Knot, 2009, Canadian journal of physiology and pharmacology.

Abnormal left ventricular relaxation in patients with long QT syndrome.

J. Shryock, L. Belardinelli, A. Dhalla, 2009, European heart journal.

vascular development in neonatal rats with hyperoxic lung injury Ambrisentan reduces pulmonary arterial hypertension but does not stimulate alveolar and

M. Guazzi, F. Walther, P. Steendijk, 2015 .

Inhibition of Phosphodiesterase Type III Before Aortic Cross-Clamping Preserves Intramyocardial Cyclic Adenosine Monophosphate During Cardiopulmonary Bypass

J. Shryock, T. Martin, E. Lobato, 2001, Anesthesia and analgesia.

Extraction of adenine nucleotides from cultured endothelial cells.

R. Berne, J. Shryock, R. Rubio, 1986, Analytical biochemistry.

Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion.

R. Kloner, J. Shryock, L. Belardinelli, 2009, American Journal of Physiology. Heart and Circulatory Physiology.

Ranolazine as a Cardioplegia Additive Improves Recovery of Diastolic Function in Isolated Rat Hearts

R. Kloner, B. Simkhovich, Hyosook Hwang, 2009, Circulation.

The Late Na+ Current (INa) Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late INa and Cause Ventricular Diastolic Dysfunction

J. Shryock, L. Belardinelli, Yejia Song, 2009, Journal of Pharmacology and Experimental Therapeutics.

The late I Na Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late I Na and Cause Ventricular Diastolic Dysfunction

J. Shryock, L. Belardinelli, Yejia Song, 2009 .

The mechanism of ranolazine action to reduce ischemia-induced diastolic dysfunction

J. Shryock, L. Belardinelli, H. Fraser, 2006 .

Does Adenosine Function as a Retaliatory Metabolite in the Heart

J. Shryock, L. Belardinelli, 1992 .

Role of A2A‐adenosine receptor activation for ATP‐mediated coronary vasodilation in guinea‐pig isolated heart

J. Shryock, L. Belardinelli, C. Seubert, 2000, British journal of pharmacology.

Antiarrhythmic Effects of Ranolazine in a Guinea Pig in Vitro Model of Long-QT Syndrome

C. Antzelevitch, J. Shryock, L. Belardinelli, 2004, Journal of Pharmacology and Experimental Therapeutics.

Modulation of Cardiomyocyte Membrane Currents by A 1 Adenosine Receptors

J. Shryock, L. Belardinelli, Yejia Song, 1995 .

Inhibitor Ranolazine Attenuates Effects of Palmitoyl-L-Carnitine to Increase Late INa and Cause Ventricular Diastolic Dysfunction

J. Shryock, L. Belardinelli, Yejia Song, 2009 .

Sinus node dysfunction in ATX-II-induced in-vitro murine model of long QT3 syndrome and rescue effect of ranolazine.

W. Lammers, Xin Wang, J. Shryock, 2008, Progress in biophysics and molecular biology.

Synthesis and biological effects of novel 2-amino-3-naphthoylthiophenes as allosteric enhancers of the A1 adenosine receptor.

J. Shryock, S. Merighi, P. Borea, 2003, Journal of medicinal chemistry.

The A 2 A Adenosine Receptor Mediates Coronary Vasodilation 1

E. Ongini, A. Monopoli, G. Lozza, 1998 .

Effects of dipyridamole on coronary collateralization and myocardial perfusion in patients with ischaemic cardiomyopathy.

J. Shryock, L. Belardinelli, R. Belardinelli, 2001, European heart journal.

A2A-adenosine receptor reserve for coronary vasodilation.

G. Spalluto, B. Cacciari, E. Ongini, 1998, Circulation.

Regadenoson, a Novel Pharmacologic Stress Agent for Use in Myocardial Perfusion Imaging, Does Not Have a Direct Effect on the QT Interval in Conscious Dogs

M. Ochoa, T. Hintze, J. Shryock, 2008, Journal of cardiovascular pharmacology.

The cardiac effects of a novel A1-adenosine receptor agonist in guinea pig isolated heart.

J. Martens, D. Dennis, J. Shryock, 1994, The Journal of pharmacology and experimental therapeutics.

A new method of sampling blood for measurement of plasma adenosine.

J. Hill, J. Shryock, L. Belardinelli, 1990, The American journal of physiology.

Partial A(1) adenosine receptor agonists from a molecular perspective and their potential use as chronic ventricular rate control agents during atrial fibrillation (AF).

J. Shryock, L. Belardinelli, Lin Wu, 2004, Current topics in medicinal chemistry.

Synthesis and biological effects of a new series of 2-amino-3-benzoylthiophenes as allosteric enhancers of A1-adenosine receptor.

I. Lampronti, A. Zaid, J. Shryock, 2000, Bioorganic & medicinal chemistry letters.

A Novel Partial Agonist of the A1 -Adenosine Receptor and Evidence of Receptor Homogeneity in Adipocytes

J. Shryock, L. Belardinelli, Lin Wu, 2006, Journal of Pharmacology and Experimental Therapeutics.

Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP, a cocaine use–dependent inhibitor of dopamine synthesis

M. Olive, J. Shryock, N. Chu, 2010, Nature Medicine.

Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.

Jin Yang, C. Chang, S. Viatchenko‐Karpinski, 2014, Journal of molecular and cellular cardiology.

Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology.

J. Shryock, L. Belardinelli, 1997, The American journal of cardiology.

Effects of adenosine and adenine nucleotides on the atrioventricular node of isolated guinea pig hearts.

G. A. West, R. Berne, J. Dimarco, 1984, Circulation.

Adenosine Receptor by Adenine Nucleotides

Sheng-Nan Wu, E. Ragazzi, J. Shryock, 2005 .

Electrophysiological and receptor binding studies to assess activation of the cardiac adenosine receptor by adenine nucleotides.

E. Ragazzi, J. Shryock, L. Belardinelli, 1991, Circulation research.

Ionic basis of the electrophysiological actions of adenosine on cardiomyocytes

J. Shryock, L. Belardinelli, Yejia Song, 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Release of adenosine from pig aortic endothelial cells during hypoxia and metabolic inhibition.

R. Berne, J. Shryock, R. Rubio, 1988, The American journal of physiology.

Cellular basis for the negative dromotropic effect of adenosine on rabbit single atrioventricular nodal cells.

J. Shryock, L. Belardinelli, D Wang, 1996, Circulation research.

Adenosine receptor activation induces vascular endothelial growth factor in human retinal endothelial cells.

R. Tarnuzzer, I. Biaggioni, M. Grant, 1999, Circulation research.

A slowly inactivating sodium current contributes to spontaneous diastolic depolarization of atrial myocytes.

J. Shryock, L. Belardinelli, Yejia Song, 2009, American journal of physiology. Heart and circulatory physiology.

Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine

J. Shryock, L. Belardinelli, H. Fraser, 2006, Heart.

Block of Na+ currents and suppression of action potentials in embryonic rat dorsal root ganglion neurons by ranolazine

J. Shryock, S. Rajamani, L. Belardinelli, 2012, Neuropharmacology.

The arrhythmogenic consequences of increasing late INa in the cardiomyocyte.

C. Antzelevitch, J. Shryock, S. Rajamani, 2013, Cardiovascular research.

A novel irreversible antagonist of the A1-adenosine receptor.

J. Shryock, L. Belardinelli, P. Scammells, 1996, Molecular pharmacology.

Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.

J. Shryock, L. Belardinelli, Lin Wu, 2012, American journal of physiology. Cell physiology.

Selective Attenuation of Isoproterenol-Stimulated Arrhythmic Activity by a Partial Agonist of Adenosine A1 Receptor

J. Shryock, L. Belardinelli, Lin Wu, 2002, Circulation.

Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine.

Lin Wu, Charles Antzelevitch, C. Antzelevitch, 2008, Heart rhythm.

Blocking Late Sodium Current Reduces Hydrogen Peroxide-Induced Arrhythmogenic Activity and Contractile Dysfunction

L. Maier, S. Wagner, J. Shryock, 2006, Journal of Pharmacology and Experimental Therapeutics.

induced arrhythmogenic activity and contractile dysfunction

L. Maier, S. Wagner, J. Shryock, 2006 .

Role of Late Sodium Channel Current in Arrhythmogenesis

J. Shryock, 2011 .

Rapid Kinetic Interactions of Ranolazine With HERG K+ Current

J. Shryock, S. Rajamani, L. Belardinelli, 2008, Journal of cardiovascular pharmacology.

Late sodium current inhibition as a new cardioprotective approach.

R. Kloner, J. Shryock, L. Belardinelli, 2008, Journal of molecular and cellular cardiology.

Inhibition of late sodium current to reduce electrical and mechanical dysfunction of ischaemic myocardium

J. Shryock, L. Belardinelli, 2008, British journal of pharmacology.

Ranolazine, a Novel Anti‐Anginal Agent, Does Not Alter Isosorbide Dinitrate‐ or Sildenafil‐Induced Changes in Blood Pressure in Conscious Dogs

M. Ochoa, T. Hintze, J. Shryock, 2006, European journal of pharmacology.

An Increase in Late Sodium Current Potentiates the Proarrhythmic Activities of Low-Risk QT-Prolonging Drugs in Female Rabbit Hearts

J. Shryock, L. Belardinelli, Lin Wu, 2006, Journal of Pharmacology and Experimental Therapeutics.

Pathological Roles of the Cardiac Sodium Channel Late Current (Late INa)

J. Shryock, S. Rajamani, L. Belardinelli, 2013 .

Reducing the Late Sodium Current Improves Cardiac Function during Sodium Pump Inhibition by Ouabain

J. Balschi, J. Ingwall, J. Shryock, 2011, Journal of Pharmacology and Experimental Therapeutics.

The Role of Cellular Sodium and Calcium Loading in Cardiac Energetics and Arrhythmogenesis: Contribution of the Late Sodium Current

J. Shryock, S. Rajamani, L. Belardinelli, 2008 .

The role of late I Na in development of cardiac arrhythmias.

C. Antzelevitch, J. Shryock, S. Rajamani, 2014, Handbook of experimental pharmacology.

Nav1.5-dependent persistent Na+ influx activates CaMKII in rat ventricular myocytes and N1325S mice.

S. Viatchenko‐Karpinski, J. Shryock, S. Rajamani, 2011, American journal of physiology. Cell physiology.

Late Sodium Current Contributes to the Reverse Rate-Dependent Effect of IKr Inhibition on Ventricular Repolarization

Lin Wu, Donald M. Bers, Peihua Zhang, 2011, Circulation.

Pathophysiology and pharmacology of the cardiac "late sodium current.".

Antonio Zaza, J. Shryock, L. Belardinelli, 2008, Pharmacology & therapeutics.

Augmentation of late sodium current unmasks the proarrhythmic effects of amiodarone.

J. Ruskin, C. Antzelevitch, J. Shryock, 2008, Cardiovascular research.

Cardiac late Na⁺ current: proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress.

W. Giles, H. Karagueuzian, J. Shryock, 2015, Heart rhythm.

Pharmacology and therapeutic applications of A1 adenosine receptor ligands.

J. Shryock, L. Belardinelli, A. Dhalla, 2003, Current topics in medicinal chemistry.

Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists

S. Soelaiman, J. Shryock, L. Belardinelli, 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.

Potentiating Effect of Acetylcholine on Stimulation by Isoproterenol of L‐Type Ca2+ Current and Arrhythmogenic Triggered Activity in Guinea Pig Ventricular Myocytes

J. Shryock, L. Belardinelli, Yejia Song, 1998, Journal of cardiovascular electrophysiology.

Selective action of metoprolol to attenuate regadenoson-induced tachycardia in conscious dogs

Suhua Zhang, M. Ochoa, T. Hintze, 2012, Journal of Nuclear Cardiology.

Caffeine Attenuates the Duration of Coronary Vasodilation and Changes in Hemodynamics Induced by Regadenoson (CVT-3146), a Novel Adenosine A2A Receptor Agonist

M. Ochoa, T. Hintze, J. Shryock, 2007, Journal of cardiovascular pharmacology.

Binding of the novel nonxanthine A2A adenosine receptor antagonist [3H]SCH58261 to coronary artery membranes.

E. Ongini, A. Monopoli, S. Dionisotti, 1996, Circulation research.

Selective attenuation by adenosine of arrhythmogenic action of isoproterenol on ventricular myocytes.

J. Shryock, L. Belardinelli, H. Knot, 2001, American journal of physiology. Heart and circulatory physiology.

Block of Tetrodotoxin-sensitive, Nav1.7, and Tetrodotoxin-resistant, Nav1.8, Na+ channels by Ranolazine

J. Shryock, S. Rajamani, L. Belardinelli, 2008, Channels.

Properties of solubilized and reconstituted A1 adenosine receptors from bovine brain.

K. Palczewski, E. Ragazzi, J. Shryock, 1991, Pharmacological research.

Downregulation and desensitization of A1-adenosine receptors in embryonic chicken heart.

J. Linden, J. Shryock, L. Belardinelli, 1989, The American journal of physiology.

Use-dependent block of cardiac late Na(+) current by ranolazine.

J. Makielski, J. Shryock, S. Rajamani, 2009, Heart rhythm.

Ranolazine Antagonizes the Effects of Increased Late Sodium Current on Intracellular Calcium Cycling in Rat Isolated Intact Heart

J. Shryock, L. Belardinelli, J. Kelly, 2009, Journal of Pharmacology and Experimental Therapeutics.

Evaluation of N-0861, (+-)-N6-endonorbornan-2-yl-9-methyladenine, as an A1 subtype-selective adenosine receptor antagonist in the guinea pig isolated heart.

J. Shryock, L. Belardinelli, H. C. Travagli, 1992, The Journal of pharmacology and experimental therapeutics.

Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.

K. Varani, O. Cruz-López, J. Shryock, 2008, Journal of medicinal chemistry.

Protein kinase C and Ca2+–calmodulin‐dependent protein kinase II mediate the enlarged reverse INCX induced by ouabain‐increased late sodium current in rabbit ventricular myocytes

J. Shryock, L. Belardinelli, Ying Wu, 2015, Experimental physiology.

An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes.

J. Shryock, L. Belardinelli, Luiz Belardinelli, 2008, American journal of physiology. Heart and circulatory physiology.

Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart.

C. January, J. Shryock, S. Rajamani, 2009, American journal of physiology. Heart and circulatory physiology.

Use-dependent block of cardiac late Na(+) current by ranolazine.

J. Makielski, J. Shryock, S. Rajamani, 2009, Heart rhythm.

1,3-Dipropyl-8-[2-(5,6-epoxy)norbornyl]xanthine, a potent, specific and selective A1 adenosine receptor antagonist in the guinea pig heart and brain and in DDT1MF-2 cells.

D. Dennis, J. Shryock, L. Belardinelli, 1995, The Journal of pharmacology and experimental therapeutics.

Sea nettle (Chrysaora quinquecirrha) nematocyst venom: mechanism of action on muscle.

C. Bianchi, J. Shryock, 1983, Toxicon : official journal of the International Society on Toxinology.