N. Barucci

发表

Dual-acting peptide with prolonged glucagon-like peptide-1 receptor agonist and glucagon receptor antagonist activity for the treatment of type 2 diabetes.

Astrid A. Ortiz, C. Pan, J. Buxton, 2007, The Journal of endocrinology.

Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors.

V. Paralkar, D. Goldberg, W. Zavadoski, 2016, Bioorganic & medicinal chemistry letters.

Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise.

G. Shulman, M. Mueckler, J. Ren, 2000, American journal of physiology. Endocrinology and metabolism.

The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.

Michael D. Hamilton, J. Pfefferkorn, N. Barucci, 2012, Bioorganic & medicinal chemistry letters.

Designing glucokinase activators with reduced hypoglycemia risk: discovery of N,N-dimethyl-5-(2-methyl-6-((5-methylpyrazin-2-yl)-carbamoyl)benzofuran-4-yloxy)pyrimidine-2-carboxamide as a clinical candidate for the treatment of type 2 diabetes mellitus

M. Ammirati, J. Treadway, S. Liras, 2011 .

Differential effects of safflower oil versus fish oil feeding on insulin-stimulated glycogen synthesis, glycolysis, and pyruvate dehydrogenase flux in skeletal muscle: a 13C nuclear magnetic resonance study.

G. Shulman, G. Cline, N. Barucci, 1999, Diabetes.

Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors.

V. Paralkar, D. Goldberg, W. Zavadoski, 2016, Bioorganic & Medicinal Chemistry Letters.

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.

G. Shulman, M. White, E. Kraegen, 1999, Diabetes.

Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors.

V. Paralkar, D. Goldberg, W. Zavadoski, 2017, Bioorganic & medicinal chemistry letters.

Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss.

J. Livingston, S. Gardell, T. Claus, 2007, Endocrinology.

A human APOC3 missense variant and monoclonal antibody accelerate apoC-III clearance and lower triglyceride-rich lipoprotein levels

Ildikó V. Tóth, D. Rader, S. Kathiresan, 2017, Nature Medicine.

The Hepatoselective Glucokinase Activator PF-04991532 Ameliorates Hyperglycemia without Causing Hepatic Steatosis in Diabetic Rats

J. Trimmer, T. Rolph, Jiangli Yan, 2014, PloS one.

Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.

Jing Chen, David B Duignan, Robert Aiello, 2012, Journal of medicinal chemistry.

Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle.

G. Shulman, N. Barucci, B. Jucker, 1999, American journal of physiology. Endocrinology and metabolism.

PDE-10A inhibitors as insulin secretagogues.

Lei Zhu, J. Livingston, T. Claus, 2007, Bioorganic & medicinal chemistry letters.

disposal in rat skeletal muscle Metabolic control analysis of insulin-stimulated glucose

G. Shulman, N. Barucci, B. Jucker, 2016 .

Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle.

G. Shulman, N. Barucci, B. Jucker, 1999, The American journal of physiology.

Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV stability and enhance in vivo glucose disposal.

K. Lumb, J. Buxton, T. Claus, 2006, Journal of medicinal chemistry.

A stapled lipopeptide platform for preventing and treating highly pathogenic viruses of pandemic potential

Marina Godes, L. Walensky, W. Zavadoski, 2024, Nature communications.