X. Li

发表

Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise.

X. Li, J. Zhuo, 2007, Clinical science.

AT2 receptor‐mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR

X. Li, R. Widdop, Xiao C Li, 2004, British journal of pharmacology.

The vasoprotective axes of the renin‐angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases

X. Li, J. Zhuo, Jianfeng Zhang, 2017, Pharmacological research.

Luminal ANG II is internalized as a complex with AT1R/AT2R heterodimers to target endoplasmic reticulum in LLC-PK1 cells.

H. Drummond, X. Li, J. Zhuo, 2017, American journal of physiology. Renal physiology.

Increased expression and co-localization of ACE, angiotensin II AT(1) receptors and inducible nitric oxide synthase in atherosclerotic human coronary arteries.

G. Dusting, M. Ohishi, X. Li, 2010, International journal of physiology, pathophysiology and pharmacology.

Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice.

X. Li, J. Zhuo, T. Liao, 2008, Clinical science.

Proximal Tubule-Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) in the Kidney Attenuates Ang II (Angiotensin II)-Induced Hypertension in Mice.

X. Li, J. Zhuo, Xinchun Zhou, 2019, Hypertension.

Augmentation of angiotensinogen expression in the proximal tubule by intracellular angiotensin II via AT1a/MAPK/NF-кB signaling pathways.

H. Kobori, L. Navar, X. Li, 2016, American journal of physiology. Renal physiology.

In vivo regulation of AT 1 a receptor-mediated intracellular uptake of [ 125 I ] Val 5-ANG II in the kidneys and adrenals of AT 1 a receptor-deficient mice

X. Li, J. Zhuo, 2008 .

In vivo regulation of AT1a receptor-mediated intracellular uptake of [125I]Val5-ANG II in the kidneys and adrenals of AT1a receptor-deficient mice.

X. Li, J. Zhuo, 2008, American journal of physiology. Renal physiology.

Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice.

L. Navar, X. Li, J. Zhuo, 2007, American journal of physiology. Renal physiology.

Selective knockdown of AT1 receptors by RNA interference inhibits Val5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells.

X. Li, J. Zhuo, 2007, American journal of physiology. Cell physiology.

Genetic deletion of AT 1 a receptors attenuates intracellular accumulation of ANG II in the kidney of AT 1 a receptor-deficient mice

L. Navar, X. Li, J. Zhuo, 2007 .

Selective knockdown of AT 1 receptors by RNA interference inhibits Val 5-ANG II endocytosis and NHE-3 expression in immortalized rabbit proximal tubule cells

X. Li, J. Zhuo, 2007 .

angiotensin II in the kidneys and adrenals of AT1a receptor-deficient mice

X. Li, J. Zhuo, 2007 .

Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting

F. Geurts, A. Nishiyama, D. Batlle, 2022, Pharmacological Reviews.

Role of caveolin 1 in AT1a receptor-mediated uptake of angiotensin II in the proximal tubule of the kidney.

X. Li, J. Zhuo, Victor Gu, 2014, American journal of physiology. Renal physiology.

Current Insights and New Perspectives on the Roles of Hyperglucagonemia in Non-Insulin–Dependent Type 2 Diabetes

X. Li, J. Zhuo, 2013, Current Hypertension Reports.

Cross-talk between angiotensin II and glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangial cells.

O. Carretero, X. Li, J. Zhuo, 2006, Biochemical pharmacology.

Glucagon Receptor–Mediated Extracellular Signal–Regulated Kinase 1/2 Phosphorylation in Rat Mesangial Cells: Role of Protein Kinase A and Phospholipase C

O. Carretero, X. Li, J. Zhuo, 2006, Hypertension.

AT1 receptor-mediated uptake of angiotensin II and NHE-3 expression in proximal tubule cells through a microtubule-dependent endocytic pathway.

X. Li, J. Zhuo, U. Hopfer, 2009, American journal of physiology. Renal physiology.

Intracellular ANG II directly induces in vitro transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors.

X. Li, J. Zhuo, 2008, American journal of physiology. Cell physiology.

AT1 receptor-activated signaling mediates angiotensin IV-induced renal cortical vasoconstriction in rats.

M. Ohishi, X. Li, J. Zhuo, 2006, American journal of physiology. Renal physiology.

Phosphoproteomic analysis of AT1 receptor-mediated signaling responses in proximal tubules of angiotensin II-induced hypertensive rats.

X. Li, J. Zhuo, 2011, Kidney international.

Pharmacodynamic Contribution to the Vasodilator Effect of Chronic AT1 Receptor Blockade in SHR

X. Li, J. Paull, R. Widdop, 2001, Hypertension.

AT1a receptor signaling is required for basal and water deprivation-induced urine concentration in AT1a receptor-deficient mice.

X. Li, J. Zhuo, Y. Shao, 2012, American journal of physiology. Renal physiology.

receptor-deficient mice 1a deprivation-induced urine concentration in AT receptor signaling is required for basal and water

X. Li, J. Zhuo, Y. Shao, 2012 .

AT 1 a receptor signaling is required for basal and water deprivation-induced urine concentration in AT 1 a receptor-deficient mice

X. Li, J. Zhuo, Y. Shao, 2012 .

Intrarenal transfer of an intracellular fluorescent fusion of angiotensin II selectively in proximal tubules increases blood pressure in rats and mice.

J. Cook, X. Li, J. Zhuo, 2011, American journal of physiology. Renal physiology.

AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla.

X. Li, J. Zhuo, Y. Shao, 2009, Kidney international.

Characterization and localization of Ac-SDKP receptor binding sites using 125I-labeled Hpp-Aca-SDKP in rat cardiac fibroblasts.

O. Carretero, X. Li, J. Zhuo, 2007, American journal of physiology. Heart and circulatory physiology.

Mechanisms of AT1a receptor-mediated uptake of angiotensin II by proximal tubule cells: a novel role of the multiligand endocytic receptor megalin.

X. Li, J. Zhuo, 2014, American journal of physiology. Renal physiology.

Intratubular, Intracellular, and Mitochondrial Angiotensin II/AT1 (AT1a) Receptor/NHE3 Signaling Plays a Critical Role in Angiotensin II-Induced Hypertension and Kidney Injury

X. Li, J. Zhuo, A. Leite, 2021, Frontiers in Physiology.

Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension in NHE3-deficient mice with transgenic rescue of NHE3 in small intestines

G. Shull, X. Li, J. Zhuo, 2015, Physiological reports.

Role of the Na+/H+ exchanger 3 in angiotensin II-induced hypertension.

G. Shull, X. Li, J. Zhuo, 2015, Physiological genomics.

Genetic and genomic evidence for an important role of the Na+/H+ exchanger 3 in blood pressure regulation and angiotensin II-induced hypertension.

X. Li, J. Zhuo, Jianfeng Zhang, 2019, Physiological genomics.

Proximal Tubule-Specific Deletion of Angiotensin II Type 1a Receptors in the Kidney Attenuates Circulating and Intratubular Angiotensin II–Induced Hypertension in PT-Agtr1a−/− Mice

X. Li, J. Zhuo, Xinchun Zhou, 2021, Hypertension.

Proximal Tubule–Specific Deletion of the NHE3 (Na+/H+ Exchanger 3) Promotes the Pressure-Natriuresis Response and Lowers Blood Pressure in Mice

X. Li, J. Zhuo, M. Tauc, 2018, Hypertension.

Effects of AT1 Receptor‐Mediated Endocytosis of Extracellular Ang II on Activation of Nuclear Factor‐κB in Proximal Tubule Cells

O. Carretero, X. Li, J. Zhuo, 2006, Annals of the New York Academy of Sciences.

AT1 receptor‐mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatase

L. Navar, O. Carretero, X. Li, 2006, American journal of physiology. Renal physiology.

New insights and perspectives on intrarenal renin-angiotensin system: Focus on intracrine/intracellular angiotensin II

X. Li, J. Zhuo, 2011, Peptides.

The Renin-Angiotensin System and the Kidney: New Insights and Perspectives

X. Li, J. Zhuo, 2015 .

The Intratubular and Intracrine Renin-Angiotensin System in the Proximal Tubules of the Kidney and Its Roles in Angiotensin II-Induced Hypertension

X. Li, J. Zhuo, Jianfeng Zhang, 2019, Selected Chapters from the Renin-Angiotensin System.

The Na+/H+ Exchanger 3 in the Intestines and the Proximal Tubule of the Kidney: Localization, Physiological Function, and Key Roles in Angiotensin II-Induced Hypertension

X. Li, J. Zhuo, A. Leite, 2022, Frontiers in Physiology.

New Frontiers in the Intrarenal Renin-Angiotensin System: A Critical Review of Classical and New Paradigms

X. Li, J. Zhuo, F. Ferrão, 2013, Front. Endocrinol..

Nuclear factor-κB as a hormonal intracellular signaling molecule: focus on angiotensin II-induced cardiovascular and renal injury

X. Li, J. Zhuo, 2008, Current opinion in nephrology and hypertension.

Evidence for a Physiological Mitochondrial Angiotensin II System in the Kidney Proximal Tubules

X. Li, J. Zhuo, Xinchun Zhou, 2020, Hypertension.

Intratubular and intracellular renin-angiotensin system in the kidney: a unifying perspective in blood pressure control.

X. Li, J. Zhuo, Jiangfeng Zhang, 2018, Clinical science.

Proximal tubule-dominant transfer of AT(1a) receptors induces blood pressure responses to intracellular angiotensin II in AT(1a) receptor-deficient mice.

X. Li, J. Zhuo, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney.

X. Li, J. Zhuo, Victor Gu, 2012, American journal of physiology. Regulatory, integrative and comparative physiology.

Intracellular ANG II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells.

L. Navar, O. Carretero, J. Garvin, 2006, American journal of physiology. Renal physiology.

Recent Updates on the Proximal Tubule Renin-Angiotensin System in Angiotensin II-Dependent Hypertension

X. Li, J. Zhuo, 2016, Current Hypertension Reports.

De Novo DNA (de)Methylation in the Kidney.

X. Li, J. Zhuo, 2018, Hypertension.

New Insights into the Critical Importance of Intratubular Na+/H+ Exchanger 3 and Its Potential Therapeutic Implications in Hypertension

X. Li, J. Zhuo, M. Soleimani, 2021, Current Hypertension Reports.

Review: Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells

X. Li, J. Zhuo, 2007, Journal of the renin-angiotensin-aldosterone system : JRAAS.

Genetic Deletion of AT1a Receptor or Na+/H+ Exchanger 3 Selectively in the Proximal Tubules of the Kidney Attenuates Two-Kidney, One-Clip Goldblatt Hypertension in Mice

X. Li, J. Zhuo, Ryosuke Sato, 2022, International journal of molecular sciences.

Angiotensin III/AT2 Receptor/NHE3 Signaling Pathway in the Proximal Tubules of the Kidney: A Novel Natriuretic and Antihypertensive Mechanism in Hypertension

X. Li, J. Zhuo, 2019, Journal of the American Heart Association.

Angiotensin II and AT1a Receptors in the Proximal Tubules of the Kidney: New Roles in Blood Pressure Control and Hypertension

X. Li, J. Zhuo, A. Leite, 2022, International journal of molecular sciences.