L. Baggio

发表

D. Drucker, L. Baggio, 2007, Gastroenterology.

Glucagon-Like Peptide-1 Receptor Activation Modulates Pancreatitis-Associated Gene Expression But Does Not Modify the Susceptibility to Experimental Pancreatitis in Mice

D. Drucker, L. Baggio, J. Koehler, 2009, Diabetes.

Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans

R. Holman, S. Stevens, D. Drucker, 2020, Nature Communications.

Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition.

D. Drucker, Jacqueline L. Beaudry, J. Tanti, 2019, Cell metabolism.

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat–Fed Diabetic Mice

D. Drucker, L. Baggio, Jonathan E. Campbell, 2015, Diabetes.

Islet Amyloid Polypeptide/GLP‐1/Exendin

D. Drucker, L. Baggio, 2003 .

Reduction of DPP-4 Activity on Bone Quality in Mice Differential Effects of PPAR-{ gamma } Activation versus Chemical or Genetic

D. Drucker, M. Grynpas, T. Willett, 2011 .

Differential effects of PPAR-{gamma} activation versus chemical or genetic reduction of DPP-4 activity on bone quality in mice.

D. Drucker, M. Grynpas, T. Willett, 2011, Endocrinology.

Development and characterization of a glucagon-like peptide 1-albumin conjugate: the ability to activate the glucagon-like peptide 1 receptor in vivo.

D. Drucker, L. Baggio, J. Castaigne, 2003, Diabetes.

Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.

B. Yusta, D. Drucker, Holly Bates, 2017, Cell metabolism.

Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.

B. Yusta, D. Drucker, J. Ayala, 2017, Cell metabolism.

Cardiac function in mice lacking the glucagon-like peptide-1 receptor.

D. Drucker, I. Mungrue, L. Baggio, 2003, Endocrinology.

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice

R. Seeley, D. Drucker, S. Heximer, 2017, Molecular metabolism.

GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice.

C. Streutker, B. Yusta, D. Drucker, 2013, Endocrinology.

Hematopoietic cell– versus enterocyte-derived dipeptidyl peptidase-4 differentially regulates triglyceride excursion in mice

D. Drucker, Jacqueline L. Beaudry, L. Baggio, 2020, JCI insight.

Glucagon-like peptide-1 receptor co-agonists for treating metabolic disease

D. Drucker, L. Baggio, 2020, Molecular metabolism.

Cellular specificity of proexendin-4 processing in mammalian cells in vitro and in vivo.

D. Drucker, F. Adatia, P. Brubaker, 2002, Endocrinology.

New Developments in the Biology of the Glucagon‐Like Peptides GLP‐1 and GLP‐2

B. Yusta, D. Drucker, Yuanfang Liu, 2000, Annals of the New York Academy of Sciences.

Energy Homeostasis and Gastrointestinal Endocrine Differentiation Do Not Require the Anorectic Hormone Peptide YY

D. Drucker, Susan E. Schonhoff, A. Leiter, 2005, Molecular and Cellular Biology.

Ghrelin Is a Novel Regulator of GLP-1 Secretion

D. Drucker, P. Brubaker, L. Baggio, 2014, Diabetes.

The incretin receptors for GLP-1 and GIP are essential for the sustained metabolic actions of vildagliptin in mice

D. Drucker, L. Baggio, G. Flock, 2007 .

Incretin Receptors for Glucagon-Like Peptide 1 and Glucose-Dependent Insulinotropic Polypeptide Are Essential for the Sustained Metabolic Actions of Vildagliptin in Mice

D. Drucker, L. Baggio, G. Flock, 2007, Diabetes.

Sustained Expression of Exendin-4 Does Not Perturb Glucose Homeostasis, β-Cell Mass, or Food Intake in Metallothionein-Preproexendin Transgenic Mice*

D. Drucker, F. Adatia, P. Brubaker, 2000, The Journal of Biological Chemistry.

Inactivation of the cardiomyocyte glucagon-like peptide-1 receptor (GLP-1R) unmasks cardiomyocyte-independent GLP-1R-mediated cardioprotectionab

R. Seeley, D. Drucker, Minsuk Kim, 2014, Molecular metabolism.

Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction

D. Drucker, O. Ilkayeva, C. Newgard, 2014, Molecular metabolism.

The gut hormone receptor GIPR links energy availability to the control of hematopoiesis

D. Drucker, L. Baggio, J. Koehler, 2020, Molecular metabolism.

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

M. Gassmann, P. Halban, D. Drucker, 2011, Nature Medicine.

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice.

D. Drucker, T. Kieffer, L. Baggio, 2000, Endocrinology.

Glucagon Family of Peptides and their Receptors

D. Drucker, L. Baggio, 2004 .

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation.

R. Seeley, B. Yusta, D. Drucker, 2022, Cell metabolism.

Genetic disruption of the Gipr in Apoe−/− mice promotes atherosclerosis

D. Drucker, L. Baggio, Brent A. McLean, 2022, Molecular metabolism.

Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice.

D. Drucker, A. Powers, D. Sandoval, 2019, Cell metabolism.

Glucagon-Like Peptide-1 Receptor Agonists Increase Pancreatic Mass by Induction of Protein Synthesis

Brett G Larsen, D. Drucker, J. Jelsing, 2014, Diabetes.

Gipr Is Essential for Adrenocortical Steroidogenesis; However, Corticosterone Deficiency Does Not Mediate the Favorable Metabolic Phenotype of Gipr−/− Mice

D. Drucker, Holly Bates, Y. Seino, 2011, Diabetes.

GLP-1 receptor activation modulates pancreatitis-associated gene expression but does not modify the susceptibility to experimental pancreatitis in mice

D. Drucker, L. Baggio, J. Koehler, 2009 .

Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action.

R. Seeley, D. Drucker, L. Baggio, 2019, Cell reports.

TCF 1 links GIPR signaling to the control of beta cell function and survival

C. Streutker, P. MacDonald, J. Wrana, 2015 .

Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditure.

D. Drucker, L. Baggio, Daniel J Drucker, 2004, Gastroenterology.

The Glucagon Receptor Is Required for the Adaptive Metabolic Response to Fasting

D. Drucker, M. J. Charron, L. Baggio, 2022 .

GLP-1R Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice

R. Henkelman, D. Drucker, A. Riazi, 2009, Diabetes.

Double incretin receptor knockout (DIRKO) mice reveal an essential role for the enteroinsular axis in transducing the glucoregulatory actions of DPP-IV inhibitors.

J. Holst, Tanya Hansotia, D. Drucker, 2004, Diabetes.

GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress.

B. Yusta, D. Drucker, Hongyun Li, 2006, Cell metabolism.

Biology of Incretins: Glp-1 and Gip This Review Focuses on the Mechanisms Regulating the Synthesis, Secretion, Biological Actions, and Therapeutic Relevance of the Incretin Peptides Glu- Cose-dependent Insulinotropic Polypeptide (gip) and Glucagon-like Peptide-1 (glp-1). the Pub- Lished Literature W

D. Drucker, L. Baggio, 2022 .

TCF7 is not essential for glucose homeostasis in mice

D. Drucker, Jacqueline L. Beaudry, Brandon L. Panaro, 2021, Molecular metabolism.

Hypoglycemia, defective islet glucagon secretion, but normal islet mass in mice with a disruption of the gastrin gene.

Yazhou Li, D. Drucker, D. Finegood, 2003, Gastroenterology.

GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

M. Surette, B. Yusta, D. Drucker, 2015, Diabetes.

GLP-1 receptor (GLP-1R) agonists modulate enteric immune responses through the intestinal intraepithelial lymphocyte (IEL) GLP-1R

M. Surette, B. Yusta, D. Drucker, 2015 .

A recombinant human glucagon-like peptide (GLP)-1-albumin protein (albugon) mimics peptidergic activation of GLP-1 receptor-dependent pathways coupled with satiety, gastrointestinal motility, and glucose homeostasis.

D. Drucker, L. Baggio, T. Brown, 2004, Diabetes.

Glucagon-like peptide-2 receptor modulates islet adaptation to metabolic stress in the ob/ob mouse.

D. Drucker, L. Baggio, C. Longuet, 2010, Gastroenterology.

GLP-1 Receptor Expression Within the Human Heart

C. Streutker, B. Yusta, D. Drucker, 2018, Endocrinology.

Agonist Liraglutide Activates Cytoprotective Pathways and Improves Outcomes After Experimental Myocardial Infarction in Mice

R. Henkelman, D. Drucker, A. Riazi, 2009 .

The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances beta-cell function but does not inhibit gastric emptying in mice.

D. Drucker, J. Lovshin, L. Baggio, 2008, Endocrinology.

An albumin-exendin-4 conjugate engages central and peripheral circuits regulating murine energy and glucose homeostasis.

D. Drucker, L. Baggio, Qingling Huang, 2008, Gastroenterology.

Exendin-4 modulates diabetes onset in nonobese diabetic mice.

D. Drucker, L. Baggio, P. Poussier, 2008, Endocrinology.

Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26.

D. Marguet, D. Drucker, U. Ribel, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Treatment of type 2 diabetes with the designer cytokine IC7Fc

P. Meikle, M. Febbraio, D. Drucker, 2019, Nature.

TCF1 links GIPR signaling to the control of beta cell function and survival

C. Streutker, P. MacDonald, J. Wrana, 2015, Nature Medicine.

Loss of Glp2r signaling activates hepatic stellate cells and exacerbates diet-induced steatohepatitis in mice.

B. Yusta, D. Drucker, Shai Fuchs, 2020, JCI insight.

Liver Fibroblast Growth Factor 21 (FGF21) is Required for the Full Anorectic Effect of the Glucagon-Like Peptide-1 Receptor Agonist Liraglutide in Male Mice fed High Carbohydrate Diets

R. Seeley, D. Drucker, Matthew J. Potthoff, 2023, bioRxiv.

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice

D. Drucker, J. Jelsing, N. Vrang, 2017, Molecular metabolism.

GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress

B. Yusta, D. Drucker, Hongyun Li, 2006 .

Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons.

C. Saper, D. Drucker, J. Elmquist, 2002, The Journal of clinical investigation.

Glucagon-like peptide-1 receptors in the brain: controlling food intake and body weight.

D. Drucker, L. Baggio, 2014, The Journal of clinical investigation.

Fibroblast growth factor-21 is required for weight loss induced by the glucagon-like peptide-1 receptor agonist liraglutide in male mice fed high carbohydrate diets

R. Seeley, D. Drucker, Matthew J. Potthoff, 2023, Molecular metabolism.

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice

D. Drucker, Jacqueline L. Beaudry, L. Baggio, 2019, Molecular metabolism.

The GIPR is Predominantly Localized to Non-Adipocyte Cell Types Within White Adipose Tissue.

D. Drucker, F. Reimann, F. Gribble, 2022, Diabetes.

Glucagon-like peptide-1 and glucagon-like peptide-2

D. Drucker, L. Baggio, 2004 .

Harnessing the Therapeutic Potential of Glucagon-Like Peptide-1

D. Drucker, L. Baggio, 2002, Treatments in endocrinology.

, Subir the Anorectic Hormone Peptide YY Endocrine Differentiation Do Not Require Energy Homeostasis and Gastrointestinal

D. Drucker, Susan E. Schonhoff, A. Leiter, 2005 .

Physiological roles of the GIP receptor in murine brown adipose tissue

D. Drucker, Holly Bates, L. Baggio, 2019, Molecular metabolism.

Lymphocytic Infiltration and Immune Activation in Metallothionein Promoter–Exendin-4 (MT-Exendin) Transgenic Mice

D. Drucker, J. Wither, L. Baggio, 2006, Diabetes.

Glucagon receptor signaling is essential for control of murine hepatocyte survival.

C. Streutker, B. Yusta, D. Drucker, 2008, Gastroenterology.

IN PRESS lucagon Receptor Signaling Is Essential for Control of Murine epatocyte Survival

C. Streutker, B. Yusta, D. Drucker, 2022 .

GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.

B. Yusta, D. Drucker, P. Brubaker, 2015, Cell metabolism.

Chronic exposure to GLP-1R agonists promotes homologous GLP-1 receptor desensitization in vitro but does not attenuate GLP-1R-dependent glucose homeostasis in vivo.

D. Drucker, L. Baggio, Jung‐Guk Kim, 2004, Diabetes.

Therapeutic approaches to preserve islet mass in type 2 diabetes.

D. Drucker, L. Baggio, 2006, Annual review of medicine.

The glucagon receptor is required for the adaptive metabolic response to fasting.

L. Baggio, E. M. Sinclair, M. Maziarz, 2008, Cell metabolism.

Glucagon-like peptide-1 and glucagon-like peptide-2

D. Drucker, L. Baggio, 2004 .

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, regulates fasting glycemia and nonenteral glucose clearance in mice.

D. Drucker, T. Kieffer, L. Baggio, 2000, Endocrinology.

Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.

B. Yusta, L. Baggio, Bojana Gladanac, 2017, Cell metabolism.