G. Whitlock

发表

Design of monoamine reuptake inhibitors: SSRIs, SNRIs and NRIs

M. Andrews, A. Brown, P. Fish, 2008 .

Structure-activity relationships of N-substituted piperazine amine reuptake inhibitors.

P. Fish, G. Whitlock, A. Stobie, 2006, Bioorganic & medicinal chemistry letters.

N-[(3S)-Pyrrolidin-3-yl]benzamides as novel dual serotonin and noradrenaline reuptake inhibitors: impact of small structural modifications on P-gp recognition and CNS penetration.

P. Fish, T. Ryckmans, S. Phillips, 2009, Bioorganic & medicinal chemistry letters.

1-(2-Phenoxyphenyl)methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity.

Julian Blagg, P. Fish, J. Blagg, 2008, Bioorganic & medicinal chemistry letters.

Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity.

Alan Stobie, P. Fish, G. Whitlock, 2008, Bioorganic & medicinal chemistry letters.

Identification of Type‐II Inhibitors Using Kinase Structures

R. Kurumbail, Yogesh Sabnis, Chris Phillips, 2012, Chemical biology & drug design.

N-Benzyl-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amines as selective dual serotonin/noradrenaline reuptake inhibitors.

P. Fish, G. Whitlock, A. Stobie, 2007, Bioorganic & medicinal chemistry letters.

A novel series of highly selective inhibitors of MMP-3.

G. Whitlock, K. Dack, Mark L. Lewis, 2007, Bioorganic & medicinal chemistry letters.

Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells.

Jennifer A. Ward, X. Jacq, E. Tate, 2016, ACS chemical biology.

Asymmetric Synthesis of Cyclic Ethers by Rearrangement of Oxonium Ylides Generated from Chiral Copper Carbenoids

G. Whitlock, J. S. Clark, C. Burns, 1998 .

Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.

M. Andrews, A. Brown, P. Fish, 2011, Bioorganic & medicinal chemistry letters.

N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors.

P. Fish, G. Whitlock, A. Stobie, 2008, Bioorganic & medicinal chemistry letters.

Derivatives of (3S)-N-(biphenyl-2-ylmethyl)pyrrolidin-3-amine as selective noradrenaline reuptake inhibitors: Reducing P-gp mediated efflux by modulation of H-bond acceptor capacity.

P. Fish, T. Ryckmans, N. Barta, 2008, Bioorganic & medicinal chemistry letters.

Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity.

A. Brown, L. Maes, G. Whitlock, 2015, Journal of medicinal chemistry.

Enantioselective Synthesis ofent-Stellettamide A: Asymmetric Dipolar Cycloadditions with Me3SiCHN2

E. Carreira, G. Whitlock, 2000 .

Catalytic asymmetric hydroboration with heterotopic P-N ligands: Trends in enantioselectivity with increased steric demand

G. Whitlock, John M. Brown, J. Valk, 1995 .

N-(1,2-diphenylethyl)piperazines: a new class of dual serotonin/noradrenaline reuptake inhibitor.

A. Brown, P. Fish, G. Whitlock, 2006, Bioorganic & medicinal chemistry letters.

Enantioselective Synthesis of ent-Stellettamide A via a Novel Dipolar Cycloaddition Reaction of (Trimethylsilyl)diazomethane.

E. Carreira, G. Whitlock, 1997, The Journal of organic chemistry.

A short synthesis of (±)-decarestrictine L

G. Whitlock, J. S. Clark, J. Clark, 1994 .

4-Piperidines and 3-pyrrolidines as dual serotonin and noradrenaline reuptake inhibitors: design, synthesis and structure-activity relationships.

M. Andrews, P. Fish, G. Whitlock, 2009, Bioorganic & medicinal chemistry letters.

Discovery of a novel azepine series of potent and selective 5-HT2C agonists as potential treatments for urinary incontinence.

P. Brennan, G. McMurray, G. Whitlock, 2009, Bioorganic & medicinal chemistry letters.

6,7-Dihydro-5H-pyrrolo[1,2-a] imidazoles as potent and selective alpha1A adrenoceptor partial agonists.

P. Fish, G. Whitlock, Lee R. Roberts, 2009, Bioorganic & medicinal chemistry letters.

Stereoselective synthesis of tetrahydropyran-3-ones by rearrangement of oxonium ylides generated from metal carbenoids.

G. Whitlock, J. S. Clark, Shende Jiang, 2003, Chemical communications.

A concise enantioselective synthesis of the fungal metabolite (+)-decarestrictine L

Thomas C. Fessard, G. Whitlock, J. S. Clark, 2006 .

Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity.

C. Musonda, M. Witty, G. Whitlock, 2009, Bioorganic & medicinal chemistry letters.

Enantioselective Synthesis of ent-Stellettamide A via a Novel Dipolar Cycloaddition Reaction of (Trimethylsilyl)diazomethane.

E. Carreira, G. Whitlock, 1997, The Journal of organic chemistry.

Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space

Alexander Alex, David S. Millan, A. Alex, 2011 .

Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.

Yogesh Sabnis, J. Chrencik, G. Whitlock, 2017, Journal of medicinal chemistry.

Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform.

Elizabeth Farrant, G. Whitlock, M. Ramjee, 2013, Journal of medicinal chemistry.

Understanding CYP2D6 interactions.

M. D. de Groot, G. Whitlock, Florian Wakenhut, 2009, Drug discovery today.

Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.

Robert P. DePianta, V. Shanmugasundaram, A. Brown, 2014, Journal of medicinal chemistry.

Novel 2-imidazoles as potent, selective and CNS penetrant alpha1A adrenoceptor partial agonists.

G. McMurray, G. Whitlock, A. Stobie, 2008, Bioorganic & medicinal chemistry letters.

DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis

I. Gilbert, V. Yardley, B. Nare, 2021, Journal of medicinal chemistry.

Novel 2-imidazoles as potent and selective alpha1A adrenoceptor partial agonists.

G. McMurray, G. Whitlock, A. Stobie, 2008, Bioorganic & medicinal chemistry letters.

Small-molecule anti-inflammatory drug compositions for the treatment of asthma: a patent review (2013 – 2014)

G. Whitlock, K. Gibson, P. Glossop, 2015, Expert opinion on therapeutic patents.

Pharmacological Properties of 2-((R-5-Chloro-4-methoxymethylindan-1-yl)-1H-imidazole (PF-3774076), a Novel and Selective α1A-Adrenergic Partial Agonist, in in Vitro and in Vivo Models of Urethral Function

G. McMurray, G. Whitlock, A. Stobie, 2009, Journal of Pharmacology and Experimental Therapeutics.

Potent and selective alpha1A adrenoceptor partial agonists--novel imidazole frameworks.

P. Brennan, G. Whitlock, A. Stobie, 2009, Bioorganic & medicinal chemistry letters.

Potent and Selective α1A Adrenoceptor Partial Agonists — Novel Imidazole Frameworks.

P. Brennan, G. Whitlock, A. Stobie, 2009 .

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.

Malcolm C. Mackenny, P. Fish, T. Ryckmans, 2008, Bioorganic & medicinal chemistry letters.

Chloroquine-astemizole hybrids with potent in vitro and in vivo antiplasmodial activity.

C. Musonda, M. Witty, G. Whitlock, 2009, Bioorganic & medicinal chemistry letters.

Discovery of Novel Azepine Series of Potent and Selective 5‐HT2C Agonists as Potential Treatments for Urinary Incontinence.

P. Brennan, G. McMurray, G. Whitlock, 2010 .

Potent and selective nonpeptidic inhibitors of procollagen C-proteinase.

Julian Blagg, P. Fish, R. Butt, 2007, Journal of medicinal chemistry.

Second generation N-(1,2-diphenylethyl)piperazines as dual serotonin and noradrenaline reuptake inhibitors: improving metabolic stability and reducing ion channel activity.

P. Fish, S. Phillips, G. Whitlock, 2010, Bioorganic & medicinal chemistry letters.

Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity.

L. Maes, G. Whitlock, J. M. Gardner, 2015, Journal of medicinal chemistry.

Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition.

Malcolm C. Mackenny, P. Fish, T. Ryckmans, 2008, Bioorganic & medicinal chemistry letters.