B. Clark

发表

N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake.

J. Harris, J. Gilmore, C. Wolfe, 2006, Bioorganic & medicinal chemistry letters.

Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.

D. McKinzie, S. Iyengar, B. Clark, 2013, Bioorganic & medicinal chemistry letters.

Syntheses of 7-Carboxyindolylglycines Utilising Glycine Cation Equivalents

B. Clark, J. R. Harris, 1997 .

5.24 – Doubly Bonded Metalloid Functions, R1C(X)SiR22 R1C(X)BR2, R1C(X)GeR22

B. Clark, 1995 .

Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.

D. Jane, B. Clark, S. Conway, 2001, Bioorganic & medicinal chemistry letters.

New multi-bridged cryptands: Polyazamacrocyclic schiff bases formed in a tetrapode capping reaction

B. Clark, G. Timms, J. Olkowski, 1995 .

Synthesis of the anti-trypanosomal agent (±)-hydroxyanthecotulide by Cr(ii)-catalysed allylation and Meyer-Schuster rearrangement.

E. Talbot, B. Clark, D. M. Hodgson, 2012, Chemical communications.

Catalytic asymmetric synthesis of (+)-anthecotulide using enyne and Meyer-Schuster rearrangements.

E. Talbot, B. Clark, D. M. Hodgson, 2011, Organic letters.

Stereoselective synthesis of β-(hydroxymethylaryl/alkyl)-α-methylene-γ-butyrolactones.

E. Talbot, B. Clark, D. M. Hodgson, 2011, Organic letters.

The extraordinary reactions of phenyldimethylsilyllithium with N,N-disubstituted amides.

I. Fleming, B. Clark, Usha Ghosh, 2004, Organic & biomolecular chemistry.

Enantiomerically pure nucleophiles in diastereoselective palladium catalysed allylic substitution reactions.

B. Clark, Jonathan M. J. Williams, Mark E. Humphries, 2003, Chirality.

Regio- and enantio-selective enolisations of cyclic ketones using chiral lithium amide bases

B. Clark, N. Simpkins, K. Bambridge, 1995 .

Formation of α-dialkylamino alkyllithium intermediates in the reaction of N,N-dialkylamides with PhMe2SiLi followed by a second lithium reagent, and their alkylation, fragmentation, cyclisation and rearrangement by proton transfer

I. Fleming, B. Clark, S. Mack, 1998 .

A novel regiodivergent resolution reaction mediated by a homochiral lithium amide base

B. Clark, N. Simpkins, K. Bambridge, 1992 .

α-Amino esters as nucleophiles in diastereoselective palladium catalysed allylic substitution reactions

B. Clark, Jonathan M. J. Williams, Mark E. Humphries, 1998 .

(+)-2-Methyl-4-carboxyphenylglycine (LY367385) selectively antagonises metabotropic glutamate mGluR1 receptors

B. Clark, A. Kingston, J. R. Harris, 1997 .

Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective

D. McKinzie, D. Clawson, S. Atwell, 2015, Journal of medicinal chemistry.

Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain struct

D. McKinzie, D. Clawson, S. Atwell, 2015, Journal of medicinal chemistry.

The synthesis and rearrangement of epoxypyrones

B. Clark, J. Baldwin, S. Morgan, 1981 .

Electrophysiological characterisation of the human N-type Ca2+ channel III: pH-dependent inhibition by a synthetic macrocyclic polyamine

A. Randall, D. Bleakman, B. Clark, 1999, Neuropharmacology.

The Role of Type 1 Metabotropic Glutamate Receptors in the Generation of Dorsal Root Reflexes Induced by Acute Arthritis or the Spinal Infusion of 4-Aminopyridine in the Anesthetized Rat.

K. Westlund, E. Sher, Li Zhang, 2000, The journal of pain : official journal of the American Pain Society.

Evaluation of the activity of a novel metabotropic glutamate receptor antagonist (±)-2-amino-2-(3-cis and trans-carboxycyclobutyl-3-(9-thioxanthyl)propionic acid) in the in vitro neonatal spinal cord and in an in vivo pain model

E. Sher, D. Schoepp, B. Clark, 1999, Neuroscience.

N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake.

J. Harris, J. Gilmore, C. Wolfe, 2006, Bioorganic & medicinal chemistry letters.

Discovery and structure-activity relationships of novel selective norepinephrine and dual serotonin/norepinephrine reuptake inhibitors.

J. Findlay, P. Gallagher, J. Boot, 2005, Bioorganic & medicinal chemistry letters.

Inhibition of group I metabotropic glutamate receptor responses in vivo in rats by a new generation of carboxyphenylglycine-like amino acid antagonists

D. Schoepp, B. Clark, J. Tizzano, 2002, Neuroscience Letters.

(+)-2-Methyl-4-carboxyphenylglycine (LY367385) Selectively Antagonises Metabotropic Glutamate mGluR1 Receptors.

B. Clark, A. Kingston, J. R. Harris, 1998 .