I. Mcintosh

发表

Absorption, metabolism and excretion of [14C]omarigliptin, a once-weekly DPP-4 inhibitor, in humans

S. Xu, D. Tatosian, I. Mcintosh, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolism and Disposition in Humans of Raltegravir (MK-0518), an Anti-AIDS Drug Targeting the Human Immunodeficiency Virus 1 Integrase Enzyme

I. Mcintosh, J. Wagner, K. Lasseter, 2007, Drug Metabolism and Disposition.

The preclinical efficacy, selectivity and pharmacologic profile of MK-5932, an insulin-sparing selective glucocorticoid receptor modulator.

C. Chiu, John H. Shin, C. D. Thompson, 2014, European journal of pharmacology.

DMD056580 818..827

K. Koeplinger, I. Mcintosh, Li Sun, 2014 .

Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway

K. Koeplinger, I. Mcintosh, K. Kassahun, 2011, Drug Metabolism and Disposition.

Zafirlukast Metabolism by Cytochrome P450 3A4 Produces an Electrophilic α,β-Unsaturated Iminium Species That Results in the Selective Mechanism-Based Inactivation of the Enzyme

T. Baillie, I. Mcintosh, G. Doss, 2005 .

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

T. Baillie, Wei Tang, D. Dean, 2001, Chemical research in toxicology.

Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor.

A. D. Rodrigues, I. Mcintosh, C. Rodeheffer, 2001, Drug metabolism and disposition: the biological fate of chemicals.

Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies.

Sean Yu, Kevin P Bateman, T. Baillie, 2008, Rapid communications in mass spectrometry : RCM.

Simultaneous determination of urinary free cortisol and 6beta-hydroxycortisol by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry and its application for estimating hepatic CYP3A induction.

A. D. Rodrigues, C. Tang, I. Mcintosh, 2000, Journal of chromatography. B, Biomedical sciences and applications.

Zafirlukast metabolism by cytochrome P450 3A4 produces an electrophilic alpha,beta-unsaturated iminium species that results in the selective mechanism-based inactivation of the enzyme.

T. Baillie, I. Mcintosh, G. Doss, 2005, Chemical research in toxicology.

Disposition and Metabolism of the Cathepsin K Inhibitor Odanacatib in Humans

K. Koeplinger, I. Mcintosh, S. Stoch, 2014, Drug Metabolism and Disposition.

An Investigation of Instability in Dried Blood Spot Samples for Pharmacokinetic Sampling in Phase 3 Trials of Verubecestat

K. Bateman, S. Ren, I. Mcintosh, 2022, The AAPS Journal.