Sanjeev Kumar

发表

Absorption, metabolism and excretion of [14C]omarigliptin, a once-weekly DPP-4 inhibitor, in humans

S. Xu, D. Tatosian, I. Mcintosh, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Sanjeev Kumar, 2004, Bioorganic & medicinal chemistry letters.

Extrapolation of Diclofenac Clearance from in Vitro Microsomal Metabolism Data: Role of Acyl Glucuronidation and Sequential Oxidative Metabolism of the Acyl Glucuronide

T. Baillie, K. Samuel, Sanjeev Kumar, 2002, Journal of Pharmacology and Experimental Therapeutics.

Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans

D. Dean, Sanjeev Kumar, A. Bergman, 2010, Drug Metabolism and Disposition.

Pharmacokinetics, Metabolism, and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Rats and Rhesus Monkeys

D. Dean, Sanjeev Kumar, M. Braun, 2010, Drug Metabolism and Disposition.

Glutathione S-Transferase Catalyzed Desulfonylation of a Sulfonylfuropyridine

Sanjeev Kumar, G. Doss, T. F. Walsh, 2010, Drug Metabolism and Disposition.

Selective Small-Molecule Agonists of G Protein–Coupled Receptor 40 Promote Glucose-Dependent Insulin Secretion and Reduce Blood Glucose in Mice

Yun-ping Zhou, J. Berger, N. Thornberry, 2008, Diabetes.

Lymphatic Absorption, Metabolism, and Excretion of a Therapeutic Peptide in Dogs and Rats

Sanjeev Kumar, M. Braun, C. Adreani, 2013, Drug Metabolism And Disposition.

Separation and quantification of two diastereomers of a Drug Candidate in rat plasma by ultra-high pressure liquid chromatography/mass spectrometry.

Sanjeev Kumar, R. Edom, S. Vincent, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Pharmacokinetics and Interactions of a Novel CCR5 Receptor Antagonist with Ritonavir in Rats and Monkeys: Role of CYP3A and P-glycoprotein

T. Baillie, Jiunn H. Lin, Sanjeev Kumar, 2002 .

N-acetylation of the glutamate residue of intact glutathione conjugates in rats: a novel pathway for the metabolic processing of thiol adducts of xenobiotics.

Sanjeev Kumar, G. Doss, R. Stearns, 2004, Drug metabolism and disposition: the biological fate of chemicals.

Metabolism and excretion of [14C]taranabant, a cannabinoid-1 inverse agonist, in humans

J. Chodakewitz, D. Dean, Sanjeev Kumar, 2010, Xenobiotica; the fate of foreign compounds in biological systems.

Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.

Yun-ping Zhou, J. Berger, N. Thornberry, 2010, Bioorganic & medicinal chemistry letters.

Synthesis of imine-pyrazolopyrimidinones and their mechanistic interventions on anticancer activity.

Raj Kumar, U. Banerjee, Sanjeev Kumar, 2013, Bioorganic & medicinal chemistry.

2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.

L. Gantert, R. DeVita, R. Hargreaves, 2013, Journal of medicinal chemistry.

Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.

L. Shearman, D. Marsh, Sanjeev Kumar, 2010, Bioorganic & medicinal chemistry letters.

Substituted biaryl pyrazoles as sodium channel blockers.

V. Warren, Sanjeev Kumar, M. Fisher, 2010, Bioorganic & medicinal chemistry letters.

Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.

V. Warren, Sanjeev Kumar, M. Fisher, 2010, Bioorganic & medicinal chemistry letters.

Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.

L. V. D. van der Ploeg, L. Shearman, D. Marsh, 2006, Journal of medicinal chemistry.

Discovery of a highly potent, selective, and bioavailable soluble epoxide hydrolase inhibitor with excellent ex vivo target engagement.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Journal of medicinal chemistry.

p38MAP kinase inhibitors. Part 1: design and development of a new class of potent and highly selective inhibitors based on 3,4-dihydropyrido[3,2-d]pyrimidone scaffold.

D. Zaller, D. Schmatz, S. O'keefe, 2003, Bioorganic & medicinal chemistry letters.

p38 Inhibitors: piperidine- and 4-aminopiperidine-substituted naphthyridinones, quinolinones, and dihydroquinazolinones.

A. Woods, D. Zaller, S. O'keefe, 2003, Bioorganic & medicinal chemistry letters.

Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.

W. Hagmann, K. Samuel, Sanjeev Kumar, 2003, Journal of mass spectrometry : JMS.

Approaches for minimizing metabolic activation of new drug candidates in drug discovery.

T. Baillie, Sanjeev Kumar, K. Kassahun, 2010, Handbook of experimental pharmacology.

Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.

Bernard K. Choi, A. Woods, D. Zaller, 2003, Journal of medicinal chemistry.

Synthesis and xanthine oxidase inhibitory activity of 5,6-dihydropyrazolo/pyrazolo[1,5-c]quinazoline derivatives.

Raj Kumar, A. Negi, Sanjeev Kumar, 2014, Bioorganic chemistry.

Conversion of the 2,2,6,6-tetramethylpiperidine moiety to a 2,2-dimethylpyrrolidine by cytochrome P450: evidence for a mechanism involving nitroxide radicals and heme iron.

T. Baillie, Sanjeev Kumar, R. Stearns, 2004, Biochemistry.

Yue Feng, Donald J. Marsh, Hongbo Qi, 2006, Journal of medicinal chemistry.

Drug disposition in the maternal-fetal unit : studies with diphenhydramine and valproic acid in pregnant sheep

Sanjeev Kumar, 1998 .

Pharmacokinetics and Interactions of a Novel Antagonist of Chemokine Receptor 5 (CCR5) with Ritonavir in Rats and Monkeys: Role of CYP3A and P-Glycoprotein

T. Baillie, Sanjeev Kumar, P. Pearson, 2002, Journal of Pharmacology and Experimental Therapeutics.

Application of Chimeric Mice with Humanized Liver for Study of Human-Specific Drug Metabolism

Sanjeev Kumar, Y. Morikawa, T. Bateman, 2014, Drug Metabolism and Disposition.

A novel P450-catalyzed transformation of the 2,2,6,6-tetramethyl piperidine moiety to a 2,2-dimethyl pyrrolidine in human liver microsomes: characterization by high resolution quadrupole-time-of-flight mass spectrometry and 1H-NMR.

Sanjeev Kumar, C. Hop, G. Doss, 2003, Drug metabolism and disposition: the biological fate of chemicals.

A NOVEL P 450-CATALYZED TRANSFORMATION OF THE 2 , 2 , 6 , 6-TETRAMETHYL PIPERIDINE MOIETY TO A 2 , 2-DIMETHYL PYRROLIDINE IN HUMAN LIVER MICROSOMES : CHARACTERIZATION BY HIGH RESOLUTION QUADRUPOLE-TIME-OF-FLIGHT MASS SPECTROMETRY AND 1 H-NMR

Sanjeev Kumar, C. Hop, G. Doss, 2003 .

Minimizing metabolic activation during pharmaceutical lead optimization: progress, knowledge gaps and future directions.

T. Baillie, Sanjeev Kumar, Thomas A Baillie, 2008, Current opinion in drug discovery & development.

p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones.

D. Zaller, S. O'keefe, Sanjeev Kumar, 2006, Bioorganic & medicinal chemistry letters.

Discovery of spirocyclic secondary amine-derived tertiary ureas as highly potent, selective and bioavailable soluble epoxide hydrolase inhibitors.

J. Berger, Gaochao Zhou, Sanjeev Kumar, 2009, Bioorganic & medicinal chemistry letters.

Disposition into Adipose Tissue Determines Accumulation and Elimination Kinetics of the Cholesteryl Ester Transfer Protein Inhibitor Anacetrapib in Mice

F. Gheyas, D. Johns, Sanjeev Kumar, 2016, Drug Metabolism and Disposition.

Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.

R. DeVita, R. Hargreaves, K. Tsao, 2009, Journal of medicinal chemistry.

Atypical Kinetics of Valproic Acid Glucuronidation In vitro and In vivo inHumans

H. Wong, Sanjeev Kumar, J. Kenny, 2012 .

Kinetics of Valproic Acid Glucuronidation: Evidence for in Vivo Autoactivation

H. Wong, Sanjeev Kumar, D. Rurak, 2007, Drug Metabolism and Disposition.

Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Peptide Substrates

Sanjeev Kumar, Y. Morikawa, Zhengqi Ye, 2020 .

Discovery of N-{(1S,2S)-2-(3-cyanophenyl)- 3-[4-(2-[18F]fluoroethoxy)phenyl]-1-methylpropyl}- 2-methyl-2-[(5-methylpyridin-2-yl)oxy]propanamide, a cannabinoid-1 receptor positron emission tomography tracer suitable for clinical use.

H. Burns, R. Hargreaves, W. Hagmann, 2007, Journal of medicinal chemistry.

Potent and selective proline derived dipeptidyl peptidase IV inhibitors.

N. Thornberry, B. Leiting, Sanjeev Kumar, 2004, Bioorganic & Medicinal Chemistry Letters.

Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.

V. Warren, Sanjeev Kumar, M. Fisher, 2010, Bioorganic & medicinal chemistry letters.

Simultaneous determination of diphenhydramine, its N-oxide metabolite and their deuterium-labeled analogues in ovine plasma and urine using liquid chromatography/electrospray tandem mass spectrometry.

Sanjeev Kumar, D. Rurak, K. Riggs, 1998, Journal of mass spectrometry : JMS.

The conceptual understanding of nutrikinetics

Sandeep Mann, Harsimran Riar, Sunil Kumar Khatkar, 2019 .

Metabolism and Excretion of Anacetrapib, a Novel Inhibitor of the Cholesteryl Ester Transfer Protein, in Humans

D. Dean, Sanjeev Kumar, A. Bergman, 2010, Drug Metabolism and Disposition.