A. Rostami-Hodjegan

发表

A mechanistic pharmacokinetic model to assess modified oral drug bioavailability post bariatric surgery in morbidly obese patients: interplay between CYP3A gut wall metabolism, permeability and dissolution

M. Jamei, D. Ashcroft, A. Darwich, 2012, The Journal of pharmacy and pharmacology.

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.

J. Wiśniewski, P. Artursson, T. Andersson, 2017, Molecular pharmaceutics.

A framework for assessing inter-individual variability in pharmacokinetics using virtual human populations and integrating general knowledge of physical chemistry, biology, anatomy, physiology and genetics: A tale of 'bottom-up' vs 'top-down' recognition of covariates.

M. Jamei, A. Rostami-Hodjegan, G. Dickinson, 2009, Drug metabolism and pharmacokinetics.

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model

M. Jamei, A. Rostami-Hodjegan, K. Rowland-Yeo, 2016, Drug Metabolism and Disposition.

Identification and quantification of blood–brain barrier transporters in isolated rat brain microvessels

A. Rostami-Hodjegan, B. Achour, Narciso Couto, 2018, Journal of neurochemistry.

GASP and FASP are Complementary for LC–MS/MS Proteomic Analysis of Drug‐Metabolizing Enzymes and Transporters in Pig Liver

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2018, Proteomics.

Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption.

A Rostami-Hodjegan, G. Warhurst, A. Rostami-Hodjegan, 2013, Biopharmaceutics & drug disposition.

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

Leon Aarons, Nikolaos Tsamandouras, Aleksandra Galetin, 2014, Pharmaceutical Research.

Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance

A. Galetin, A. Darwich, A. Rostami-Hodjegan, 2018, The Journal of Pharmacology and Experimental Therapeutics.

The Constraints, Construction, and Verification of a Strain-Specific Physiologically Based Pharmacokinetic Rat Model.

Masoud Jamei, David B Turner, Amin Rostami-Hodjegan, 2017, Journal of pharmaceutical sciences.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 3: Identifying gaps in system parameters by analysing In Silico performance across different compound classes

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

M. Jamei, M. Rowland, A. Rostami-Hodjegan, 2015, The AAPS Journal.

Application of a Physiologically Based Pharmacokinetic Model to Predict OATP1B1-Related Variability in Pharmacodynamics of Rosuvastatin

A Rostami-Hodjegan, M Jamei, M. Jamei, 2014, CPT: pharmacometrics & systems pharmacology.

Application of permeability-limited physiologically-based pharmacokinetic models: part I-digoxin pharmacokinetics incorporating P-glycoprotein-mediated efflux.

Masoud Jamei, David B Turner, Amin Rostami-Hodjegan, 2013, Journal of pharmaceutical sciences.

The Simcyp® Population-based ADME Simulator

Kairui Feng, Masoud Jamei, Steve Marciniak, 2009 .

Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics

P. Magni, A. Darwich, A. Rostami-Hodjegan, 2019, Journal of Pharmacokinetics and Pharmacodynamics.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom‐up PBPK prediction success part 2: An introduction to the simulation exercise and overview of results

Amitava Mitra, Jian Lin, Mai Anh Nguyen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Development of a Novel Simplified PBPK Absorption Model to Explain the Higher Relative Bioavailability of the OROS® Formulation of Oxybutynin

Avijit Ghosh, Andrés Olivares-Morales, Leon Aarons, 2016, The AAPS Journal.

The nested enzyme‐within‐enterocyte (NEWE) turnover model for predicting dynamic drug and disease effects on the gut wall

A. Darwich, A. Rostami-Hodjegan, H. Burt, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

IMI – oral biopharmaceutics tools project – evaluation of bottom‐up PBPK prediction success part 1: Characterisation of the OrBiTo database of compounds

Xavier Pepin, Leon Aarons, Hans Lennernäs, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

L. Aarons, H. Lennernäs, A. Rostami-Hodjegan, 2015, The AAPS Journal.

The Simcyp Population Based Simulator: Architecture, Implementation, and Quality Assurance

Kairui Feng, Masoud Jamei, Steve Marciniak, 2013, In Silico Pharmacology.

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling Within a Bayesian Framework to Identify Poor Metabolizers of Efavirenz (PM), Using a Test Dose of Efavirenz

M. Jamei, A. Rostami-Hodjegan, M. Chetty, 2018, Front. Pharmacol..

Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives

M. Bolger, B. Hens, T. Heimbach, 2020, Pharmaceutical Research.

Physiologically Based Pharmacokinetics Is Impacting Drug Development and Regulatory Decision Making

A Rostami-Hodjegan, LJ Lesko, M Rowland, 2015, CPT: pharmacometrics & systems pharmacology.

Proteomic Quantification of Human Blood-Brain Barrier SLC and ABC Transporters in Healthy Individuals and Dementia Patients.

A. Rostami-Hodjegan, B. Achour, S. Neuhoff, 2019, Molecular pharmaceutics.

The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

Andrés Olivares-Morales, Leon Aarons, Aleksandra Galetin, 2013, Pharmaceutical Research.

Considerations and Caveats when Applying Global Sensitivity Analysis Methods to Physiologically Based Pharmacokinetic Models

M. Jamei, F. Bois, A. Rostami-Hodjegan, 2020, The AAPS Journal.

Role of pharmacokinetic modeling and simulation in precision dosing of anticancer drugs

K. Ogungbenro, A. Darwich, A. Rostami-Hodjegan, 2017 .

Quantification of Proteins Involved in Drug Metabolism and Disposition in the Human Liver Using Label-Free Global Proteomics.

P. Wright, A. Rostami-Hodjegan, B. Achour, 2019, Molecular pharmaceutics.

Running title : Determinants of human liver microsomal protein

J. Lipscomb, A. Rostami-Hodjegan, J. Snawder, 2008 .

Modelling and simulation in prediction of human xenobiotic absorption, distribution, metabolism and excretion (ADME): in vitro–in vivo extrapolations (IVIVE)

A. Rostami-Hodjegan, G. Gibson, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

Disparity in Holoprotein/Apoprotein Ratios of Different Standards Used for Immunoquantification of Hepatic Cytochrome P450 Enzymes

H. Yamazaki, G. Tucker, A. Rostami-Hodjegan, 2007, Drug Metabolism and Disposition.

The Proton Pump Inhibitor, Omeprazole, but Not Lansoprazole or Pantoprazole, Is a Metabolism-Dependent Inhibitor of CYP2C19: Implications for Coadministration with Clopidogrel

A. Rostami-Hodjegan, A. Parkinson, B. Ogilvie, 2011, Drug Metabolism and Disposition.

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies.

M. Jamei, L. Aarons, M. Bolger, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Quantitative Proteomics of Clinically Relevant Drug-Metabolizing Enzymes and Drug Transporters and Their Intercorrelations in the Human Small Intestine

Pamela J Davies, G. Warhurst, A. Rostami-Hodjegan, 2020, Drug Metabolism and Disposition.

The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery

B. van Ramshorst, A. Darwich, A. Rostami-Hodjegan, 2015, Pharmaceutical Research.

Clinical Investigation on Endogenous Biomarkers to Predict Strong OAT-Mediated Drug–Drug Interactions

A. Galetin, M. Monshouwer, A. Rostami-Hodjegan, 2021, Clinical Pharmacokinetics.

Identification of the Effect of Multiple Polymorphisms on the Pharmacokinetics of Simvastatin and Simvastatin Acid Using a Population‐Modeling Approach

L. Aarons, A. Galetin, A. Rostami-Hodjegan, 2014, Clinical pharmacology and therapeutics.

Implications of intercorrelation between hepatic CYP3A4‐CYP2C8 enzymes for the evaluation of drug–drug interactions: a case study with repaglinide

J. Backman, A. Darwich, A. Rostami-Hodjegan, 2018, British journal of clinical pharmacology.

Application of proteomic data in the translation of in vitro observations to associated clinical outcomes

A. Rostami-Hodjegan, B. Achour, S. Neuhoff, 2021, Drug Discovery Today: Technologies.

Mass Spectrometry of Human Transporters.

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2020, Annual review of analytical chemistry.

Scaling Factors for Clearance in Adult Liver Cirrhosis

A. Rostami-Hodjegan, B. Achour, V. Athwal, 2020, Drug Metabolism and Disposition.

Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

Ruedi Aebersold, Tom Dunkley, Aleksandra Galetin, 2014, Pharmaceutical Research.

Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance

A. Galetin, A. Rostami-Hodjegan, D. Scotcher, 2017, Drug Metabolism and Disposition.

In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells

G. Warhurst, A. Rostami-Hodjegan, B. Achour, 2016, Drug Metabolism and Disposition.

Mass spectrometry‐based abundance atlas of ABC transporters in human liver, gut, kidney, brain and skin

N. Couto, A. Rostami-Hodjegan, B. Achour, 2020, FEBS letters.

Response to “The Link Between Pharmacodynamics and Physiologically Based Pharmacokinetic Models”

A. Rostami-Hodjegan, 2013, Clinical pharmacology and therapeutics.

Global Proteomic Analysis of Human Liver Microsomes: Rapid Characterization and Quantification of Hepatic Drug-Metabolizing Enzymes

A. Rostami-Hodjegan, B. Achour, Francesco Lanucara, 2017, Drug Metabolism and Disposition.

Characterization of CYP2B6 K262R allelic variants by quantitative allele-specific proteomics using a QconCAT standard.

A. Rostami-Hodjegan, B. Achour, M. Russell, 2020, Journal of pharmaceutical and biomedical analysis.

Application of a physiologically based pharmacokinetic model for the evaluation of single-point plasma phenotyping method of CYP2D6.

P. Hu, A. Rostami-Hodjegan, Jun Shi, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Population-Based Mechanistic Prediction of Oral Drug Absorption

Sebastian Polak, Masoud Jamei, Amin Rostami-Hodjegan, 2009, The AAPS Journal.

Virtual bioequivalence for achlorhydric subjects: The use of PBPK modelling to assess the formulation‐dependent effect of achlorhydria

N. Patel, A. Darwich, A. Rostami-Hodjegan, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Prediction of the in vivo behaviour of modified release formulations of metoprolol from in vitro dissolution profiles using the ADAM model (Simcyp V8)

M. Jamei, S. Polak, G. Tucker, 2008 .

DMD058446 1766..1772

G. Warhurst, A. Rostami-Hodjegan, S. Neuhoff, 2014 .

Altered Bioavailability and Pharmacokinetics in Crohn’s Disease: Capturing Systems Parameters for PBPK to Assist with Predicting the Fate of Orally Administered Drugs

Yuan Chen, J. Mao, A. Rostami-Hodjegan, 2022, Clinical Pharmacokinetics.

In vitro evaluation of 99mTc‐sultamicillin for infection imaging

F. Yurt, A. Rostami-Hodjegan, K. Durkan, 2021, Biopharmaceutics & drug disposition.

Label-Free Quantitative Proteomics and Substrate-Based Mass Spectrometry Imaging of Xenobiotic Metabolizing Enzymes in Ex Vivo Human Skin and a Human Living Skin Equivalent Model

M. Clench, J. Sidaway, Esther Karunakaran, 2020, Drug Metabolism and Disposition.

Altered Bioavailability and Pharmacokinetics in Crohn’s Disease: Capturing Systems Parameters for PBPK to Assist with Predicting the Fate of Orally Administered Drugs

Yuan Chen, J. Mao, A. Rostami-Hodjegan, 2022, Clinical Pharmacokinetics.

Quantitative Assessment of the Impact of Crohn's Disease on Protein Abundance of Human Intestinal Drug-Metabolising Enzymes and Transporters.

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2022, Journal of pharmaceutical sciences.

Quantitative Proteomics of Hepatic Drug‐Metabolizing Enzymes and Transporters in Patients With Colorectal Cancer Metastasis

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2022, Clinical pharmacology and therapeutics.

M. Jamei, A. Rostami-Hodjegan, G. Dickinson, 2009, Drug metabolism and pharmacokinetics.

Hepatic Scaling Factors for In Vitro–In Vivo Extrapolation of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis

S. Peters, A. Rostami-Hodjegan, B. Achour, 2021, Drug Metabolism and Disposition.

Accounting for inter-correlation between enzyme abundance: a simulation study to assess implications on global sensitivity analysis within physiologically-based pharmacokinetics

P. Magni, A. Darwich, A. Rostami-Hodjegan, 2019, Journal of Pharmacokinetics and Pharmacodynamics.

The Simcyp Population Based Simulator: Architecture, Implementation, and Quality Assurance

M. Jamei, A. Rostami-Hodjegan, S. Marciniak, 2013, In Silico Pharmacology.

Prediction of concentration-time profile and its inter-individual variability following the dermal drug absorption.

Sebastian Polak, Masoud Jamei, Malidi Ahamadi, 2012, Journal of pharmaceutical sciences.

Application of permeability-limited physiologically-based pharmacokinetic models: part II - prediction of P-glycoprotein mediated drug-drug interactions with digoxin.

Masoud Jamei, David B Turner, Amin Rostami-Hodjegan, 2013, Journal of pharmaceutical sciences.

PBPK models for the prediction of in vivo performance of oral dosage forms.

Martin Bergstrand, Xavier Pepin, Erik Sjögren, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Quantitative mass spectrometry-based proteomics in the era of model-informed drug development: Applications in translational pharmacology and recommendations for best practice.

Jill Barber, Amin Rostami-Hodjegan, Brahim Achour, 2019, Pharmacology & therapeutics.

Application of the MechPeff model to predict passive effective intestinal permeability in the different regions of the rodent small intestine and colon

D B Turner, A Rostami-Hodjegan, M Jamei, 2017, Biopharmaceutics & drug disposition.

The Simcyp population-based ADME simulator.

Kairui Feng, Masoud Jamei, Steve Marciniak, 2009, Expert opinion on drug metabolism & toxicology.

Application of the Nested Enzyme‐Within‐Enterocyte (NEWE) Turnover Model for Predicting the Time Course of Pharmacodynamic Effects

A. Darwich, A. Rostami-Hodjegan, H. Takita, 2020, CPT: pharmacometrics & systems pharmacology.

Accounting for Transporters in Renal Clearance: Towards a Mechanistic Kidney Model (Mech KiM)

Lu Gaohua, Masoud Jamei, Amin Rostami-Hodjegan, 2013 .

Trends in oral drug bioavailability following bariatric surgery: examining the variable extent of impact on exposure of different drug classes.

D. Ashcroft, A. Darwich, B. Ammori, 2012, British journal of clinical pharmacology.

Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination

A. Ungell, A. Rostami-Hodjegan, S. Peters, 2016, The AAPS Journal.

Deciding on Success Criteria for Predictability of Pharmacokinetic Parameters from In Vitro Studies: An Analysis Based on In Vivo Observations

Khaled Abduljalil, Amin Rostami-Hodjegan, A. Rostami-Hodjegan, 2014, Drug Metabolism and Disposition.

Novel minimal physiologically-based model for the prediction of passive tubular reabsorption and renal excretion clearance

Aleksandra Galetin, Amin Rostami-Hodjegan, A. Galetin, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation

A. Galetin, M. Posada, A. Rostami-Hodjegan, 2016, The AAPS Journal.

In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition

K. Ogungbenro, A. Rostami-Hodjegan, S. Neuhoff, 2022, The AAPS Journal.

Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

T. Goosen, A. Rostami-Hodjegan, B. Achour, 2017, Drug Metabolism and Disposition.

Systems Toxicology: Real World Applications and Opportunities

Gary R. Mirams, Imran Shah, Paul Jennings, 2017, Chemical research in toxicology.

Application of a Systems Approach to the Bottom-Up Assessment of Pharmacokinetics in Obese Patients

M. Jamei, A. Rostami-Hodjegan, T. Johnson, 2011, Clinical pharmacokinetics.

Meta-Analysis of the Turnover of Intestinal Epithelia in Preclinical Animal Species and Humans

Umair Aslam, Adam S Darwich, Amin Rostami-Hodjegan, 2014, Drug Metabolism and Disposition.

Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors

A. Galetin, A. Rostami-Hodjegan, O. Hatley, 2017, Biopharmaceutics & drug disposition.

Application of an LC-MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique.

G. Warhurst, A. Rostami-Hodjegan, B. Achour, 2015, Journal of pharmaceutical and biomedical analysis.

Are Physiologically Based Pharmacokinetic Models Reporting the Right Cmax? Central Venous Versus Peripheral Sampling Site

M. Jamei, M. Rowland, A. Rostami-Hodjegan, 2015, The AAPS Journal.

Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

Leon Aarons, Amin Rostami-Hodjegan, Nikolaos Tsamandouras, 2015, British journal of clinical pharmacology.

Liquid Biopsy Enables Quantification of the Abundance and Interindividual Variability of Hepatic Enzymes and Transporters

K. Lea, J. Schageman, A. Rostami-Hodjegan, 2020, Clinical pharmacology and therapeutics.

Quantitative prediction of formulation-specific food effects and their population variability from in vitro data with the physiologically-based ADAM model: a case study using the BCS/BDDCS Class II drug nifedipine.

Sebastian Polak, Masoud Jamei, David B Turner, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Six years of progress in the oral biopharmaceutics area - a summary from the IMI OrBiTo project.

H Lennernäs, A Lindahl, E Sjögren, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Proof of Concept in Assignment of Within-Subject Variability During Virtual Bioequivalence Studies: Propagation of Intra-Subject Variation in Gastrointestinal Physiology Using Physiologically Based Pharmacokinetic Modeling

N. Patel, A. Rostami-Hodjegan, Rodrigo Cristofoletti, 2022, The AAPS Journal.

Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Intercorrelations: A Meta-Analysis

Jill Barber, Amin Rostami-Hodjegan, Brahim Achour, 2014, Drug Metabolism and Disposition.

Past, Present, and Future of Bioequivalence: Improving Assessment and Extrapolation of Therapeutic Equivalence for Oral Drug Products.

Malcolm Rowland, Rodrigo Cristofoletti, Amin Rostami-Hodjegan, 2018, Journal of pharmaceutical sciences.

Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry

A. Rostami-Hodjegan, B. Achour, J. Barber, 2011, Drug Metabolism and Disposition.

Quantifying gut wall metabolism: methodology matters

A. Galetin, A. Rostami-Hodjegan, O. Hatley, 2017, Biopharmaceutics & drug disposition.

Variation in Methodologies – Isolation of Intestinal Microsomes

A. Galetin, A. Rostami-Hodjegan, O. Hatley, 2016 .

Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2021, Molecular pharmaceutics.

Prediction of plasma protein binding displacement and its implications for quantitative assessment of metabolic drug-drug interactions from in vitro data.

G. Tucker, A. Rostami-Hodjegan, H. Christensen, 2006, Journal of pharmaceutical sciences.

Toward a Consensus on Applying Quantitative Liquid Chromatography‐Tandem Mass Spectrometry Proteomics in Translational Pharmacology Research: A White Paper

Jill Barber, Bhagwat Prasad, Amin Rostami-Hodjegan, 2019, Clinical pharmacology and therapeutics.

Translational value of liquid chromatography coupled with tandem mass spectrometry-based quantitative proteomics for in vitro–in vivo extrapolation of drug metabolism and transport and considerations in selecting appropriate techniques

A. Rostami-Hodjegan, B. Achour, Hajar Al Feteisi, 2015, Expert opinion on drug metabolism & toxicology.

Choice of LC-MS Methods for the Absolute Quantification of Drug-Metabolizing Enzymes and Transporters in Human Tissue: a Comparative Cost Analysis

A. Rostami-Hodjegan, B. Achour, Hajar Al Feteisi, 2015, The AAPS Journal.

Simultaneous Quantification of the Abundance of Several Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzymes in Human Liver Microsomes Using Multiplexed Targeted Proteomics

A. Rostami-Hodjegan, B. Achour, M. Russell, 2014, Drug Metabolism and Disposition.

Oral biopharmaceutics tools - time for a new initiative - an introduction to the IMI project OrBiTo.

H Lennernäs, A Lindahl, B Abrahamsson, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

L. Aarons, A. Galetin, A. Darwich, 2015, The AAPS Journal.

Quantitative Proteomic Map of Enzymes and Transporters in the Human Kidney: Stepping Closer to Mechanistic Kidney Models to Define Local Kinetics

A. Galetin, A. Rostami-Hodjegan, B. Achour, 2021, Clinical pharmacology and therapeutics.

Key to Opening Kidney for In Vitro-In Vivo Extrapolation Entrance in Health and Disease: Part II: Mechanistic Models and In Vitro-In Vivo Extrapolation

Aleksandra Galetin, Amin Rostami-Hodjegan, A. Galetin, 2016, The AAPS Journal.

Cytochrome p450 turnover: regulation of synthesis and degradation, methods for determining rates, and implications for the prediction of drug interactions.

Masoud Jamei, Amin Rostami-Hodjegan, Geoffrey T Tucker, 2008, Current drug metabolism.

Meta-Analysis of Expression of Hepatic Organic Anion–Transporting Polypeptide (OATP) Transporters in Cellular Systems Relative to Human Liver Tissue

Aleksandra Galetin, Amin Rostami-Hodjegan, Brahim Achour, 2015, Drug Metabolism and Disposition.

Proteomic quantification of receptor tyrosine kinases involved in the development and progression of colorectal cancer liver metastasis

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2023, Frontiers in Oncology.

Proteomics of colorectal cancer liver metastasis: A quantitative focus on drug elimination and pharmacodynamics effects

S. Peters, A. Rostami-Hodjegan, B. Achour, 2021, British journal of clinical pharmacology.

Proteomic quantification of perturbation to pharmacokinetic target proteins in liver disease.

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2022, Journal of Proteomics.

A family of QconCATs (Quantification conCATemers) for the quantification of human pharmacological target proteins.

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2022, Journal of proteomics.

Quantification of Proteins Involved in Intestinal Epithelial Handling of Xenobiotics

G. Warhurst, A. Rostami-Hodjegan, B. Achour, 2020, Clinical pharmacology and therapeutics.

Toward Systems-Informed Models for Biologics Disposition: Covariates of the Abundance of the Neonatal Fc Receptor (FcRn) in Human Tissues and Implications for Pharmacokinetic Modelling.

A. Rostami-Hodjegan, B. Achour, Narciso Couto, 2023, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process

N. Patel, M. Jamei, A. Rostami-Hodjegan, 2016, The AAPS Journal.

Alternative fusion protein strategies to express recalcitrant QconCAT proteins for quantitative proteomics of human drug metabolizing enzymes and transporters.

A. Rostami-Hodjegan, B. Achour, M. Russell, 2013, Journal of proteome research.

Assessment of inter-individual variability in predicted phenytoin clearance

Sebastian Polak, John O. Miners, Amin Rostami-Hodjegan, 2009, European Journal of Clinical Pharmacology.

Microsoft Word-90450945-file00.docx

A. Galetin, A. Rostami-Hodjegan, B. Achour, 2014 .

Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy.

Y. Daali, J. Aronson, L. Lesko, 2020, Annual review of pharmacology and toxicology.

Evaluation of an In Silico PBPK Post-Bariatric Surgery Model through Simulating Oral Drug Bioavailability of Atorvastatin and Cyclosporine

K Rowland-Yeo, A Rostami-Hodjegan, M Jamei, 2013, CPT: pharmacometrics & systems pharmacology.

Proteomic characterisation of drug metabolising enzymes and drug transporters in pig liver

A. Rostami-Hodjegan, B. Achour, Hajar Al Feteisi, 2020, Xenobiotica; the fate of foreign compounds in biological systems.

Lost in Centrifugation: Accounting for Transporter Protein Losses in Quantitative Targeted Absolute Proteomics

G. Warhurst, A. Rostami-Hodjegan, S. Neuhoff, 2014, Drug Metabolism and Disposition.

Protein expression of various hepatic uridine 5′‐diphosphate glucuronosyltransferase (UGT) enzymes and their inter‐correlations: a meta‐analysis

A. Rostami-Hodjegan, B. Achour, J. Barber, 2014, Biopharmaceutics & drug disposition.

Sources of interindividual variability in IVIVE of clearance: an investigation into the prediction of benzodiazepine clearance using a mechanistic population-based pharmacokinetic model

Amin Rostami-Hodjegan, A. Rostami-Hodjegan, E. Howgate, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling

J. Lipscomb, A. Rostami-Hodjegan, J. Snawder, 2008, Drug Metabolism and Disposition.

Interplay of metabolism and transport in determining oral drug absorption and gut wall metabolism: a simulation assessment using the "Advanced Dissolution, Absorption, Metabolism (ADAM)" model.

A Rostami-Hodjegan, M Jamei, M. Jamei, 2010, Current drug metabolism.

Mechanism-based inactivation of human cytochrome P450 enzymes: strategies for diagnosis and drug–drug interaction risk assessment

R. Obach, K. Venkatakrishnan, A. Rostami-Hodjegan, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

Can We Rationalize Oral Drug Exposure Following Bariatric Surgery to Meet the Pharmacotherapeutic Needs of a Growing Patient Population? Commentary on: “Lithium Toxicity Following Roux-en-Y Gastric Bypass”.

A. Darwich, A. Rostami-Hodjegan, 2014 .

Translating Human Effective Jejunal Intestinal Permeability to Surface-Dependent Intrinsic Permeability: a Pragmatic Method for a More Mechanistic Prediction of Regional Oral Drug Absorption

L. Aarons, H. Lennernäs, A. Rostami-Hodjegan, 2015, The AAPS Journal.

In Vitro–In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition

Amin Rostami-Hodjegan, Gordon Carlson, Brahim Achour, 2016, Drug Metabolism and Disposition.

Analysis of the impact of controlled release formulations on oral drug absorption, gut wall metabolism and relative bioavailability of CYP3A substrates using a physiologically-based pharmacokinetic model.

Andrés Olivares-Morales, Leon Aarons, Adam S Darwich, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Ontogeny of Hepatic Drug Transporters and Relevance to Drugs Used in Pediatrics

A. Rostami-Hodjegan, J. Barber, Yasmine Elmorsi, 2016, Drug Metabolism and Disposition.

Translational Modeling Strategies for Orally Administered Drug Products: Academic, Industrial and Regulatory Perspectives

M. Bolger, B. Hens, T. Heimbach, 2020, Pharmaceutical Research.

Comment on "In Silico Modeling of Gastrointestinal Drug Absorption: Predictive Performance of Three Physiologically-Based Absorption Models".

N. Patel, M. Jamei, S. Polak, 2017, Molecular pharmaceutics.

Effect of Chronic Kidney Disease on the Renal Secretion via Organic Anion Transporters 1/3: Implications for Physiologically‐Based Pharmacokinetic Modeling and Dose Adjustment

A. Galetin, A. Rostami-Hodjegan, S. P. F. Tan, 2022, Clinical pharmacology and therapeutics.

Quantitative translation of microfluidic transporter in vitro data to in vivo reveals impaired albumin-facilitated indoxyl sulfate secretion in chronic kidney disease.

Aleksandra Galetin, Amin Rostami-Hodjegan, Rosalinde Masereeuw, 2019, Molecular pharmaceutics.

Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach

L. Aarons, A. Galetin, A. Rostami-Hodjegan, 2015, Pharmaceutical Research.

Incorporation of stochastic variability in mechanistic population pharmacokinetic models: handling the physiological constraints using normal transformations

L. Aarons, A. Galetin, A. Rostami-Hodjegan, 2015, Journal of Pharmacokinetics and Pharmacodynamics.

Biopharmaceutics data management system for anonymised data sharing and curation: First application with orbito IMI project

Philip Hayward, Xavier Pepin, Kristin Lacy-Jones, 2017, Comput. Methods Programs Biomed..

Deconvolution and IVIVC: Exploring the Role of Rate-Limiting Conditions

L. Aarons, A. Galetin, A. Darwich, 2015, The AAPS Journal.

Ten years of QconCATs: Application of multiplexed quantification to small medically relevant proteomes

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2015 .

Prediction of the Pharmacokinetics, Pharmacodynamics, and Efficacy of a Monoclonal Antibody, Using a Physiologically Based Pharmacokinetic FcRn Model

Masoud Jamei, Amin Rostami-Hodjegan, Iain Gardner, 2015, Front. Immunol..

Sex differences in the clearance of CYP3A4 substrates: exploring possible reasons for the substrate dependency and lack of consensus.

Amin Rostami-Hodjegan, Donald Mattison, D. Mattison, 2012, Current drug metabolism.

Interaction Between Domperidone and Ketoconazole: Toward Prediction of Consequent QTc Prolongation Using Purely In Vitro Information

M. Jamei, S. Polak, A. Rostami-Hodjegan, 2014, CPT: pharmacometrics & systems pharmacology.

Determination of a quantitative relationship between hepatic CYP3A5*1/*3 and CYP3A4 expression for use in the prediction of metabolic clearance in virtual populations

A. Rostami-Hodjegan, A. Rostami-Hodjegan, M. Lennard, 2010, Biopharmaceutics & drug disposition.

Choice of LC-MS Methods for the Absolute Quantification of Drug-Metabolizing Enzymes and Transporters in Human Tissue: a Comparative Cost Analysis

A. Rostami-Hodjegan, B. Achour, Hajar Al Feteisi, 2015, The AAPS Journal.

Label-Free but Still Constrained: Assessment of Global Proteomic Strategies for the Quantification of Hepatic Enzymes and Transporters

N. Couto, A. Rostami-Hodjegan, B. Achour, 2022, Drug Metabolism and Disposition.

Proteomic Quantification of Changes in Abundance of Drug-Metabolizing Enzymes and Drug Transporters in Human Liver Cirrhosis: Different Methods, Similar Outcomes

A. Rostami-Hodjegan, B. Achour, Zubida M. Al-Majdoub, 2021, Drug Metabolism and Disposition.

Data Generated by Quantitative Liquid Chromatography-Mass Spectrometry Proteomics Are Only the Start and Not the Endpoint: Optimization of Quantitative Concatemer-Based Measurement of Hepatic Uridine-5′-Diphosphate–Glucuronosyltransferase Enzymes with Reference to Catalytic Activity

T. Goosen, A. Rostami-Hodjegan, B. Achour, 2018, Drug Metabolism and Disposition.

Methodologies for investigating drug metabolism at the early drug discovery stage: prediction of hepatic drug clearance and P450 contribution.

Hiroshi Yamazaki, Amin Rostami-Hodjegan, Chie Emoto, 2010, Current drug metabolism.

Key to Opening Kidney for In Vitro–In Vivo Extrapolation Entrance in Health and Disease: Part I: In Vitro Systems and Physiological Data

A. Galetin, M. Posada, A. Rostami-Hodjegan, 2016, The AAPS Journal.

Quantitative ADME Proteomics – CYP and UGT Enzymes in the Beagle Dog Liver and Intestine

R. Aebersold, P. Cutler, A. Galetin, 2014, Pharmaceutical Research.

Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters

A. Galetin, K. Ogungbenro, A. Rostami-Hodjegan, 2021, CPT: pharmacometrics & systems pharmacology.

Using Prior Knowledge on Systems Through PBPK to Gain Further Insight into Routine Clinical Data on Trough Concentrations: The Case of Tacrolimus in Chronic Kidney Disease.

P. Kalra, A. Darwich, A. Rostami-Hodjegan, 2023, Therapeutic drug monitoring.

The Use of ROC Analysis for the Qualitative Prediction of Human Oral Bioavailability from Animal Data

L. Aarons, A. Galetin, A. Rostami-Hodjegan, 2013, Pharmaceutical Research.

Utilization of estimated physicochemical properties as an integrated part of predicting hepatic clearance in the early drug-discovery stage: Impact of plasma and microsomal binding

A Rostami-Hodjegan, H. Yamazaki, A. Rostami-Hodjegan, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine

M. Jamei, F. Bajot, A. Rostami-Hodjegan, 2013, Clinical Pharmacokinetics.

Liquid Biopsy for Patient Characterization in Cardiovascular Disease: Verification against Markers of Cytochrome P450 and P‐Glycoprotein Activities

Y. Daali, J. Reny, A. Rostami-Hodjegan, 2022, Clinical pharmacology and therapeutics.

Is Liquid Biopsy Only Restricted to Diagnostics or Can it Go Beyond the Confines of Genotyping and Phenotyping for Quantitative Pharmacology?

A. Rostami-Hodjegan, B. Achour, 2022, Clinical pharmacology and therapeutics.

In‐depth analysis of patterns in selection of different physiologically based pharmacokinetic modeling tools: Part I – Applications and rationale behind the use of open source‐code software

A. Rostami-Hodjegan, Arham Jamaal Rajput, Hamza Khaled Abdelmajed Aldibani, 2023, Biopharmaceutics & drug disposition.

Towards a quantitative framework for the prediction of DDIs arising from cytochrome P450 induction.

M Jamei, M. Jamei, G. Tucker, 2009, Current drug metabolism.

A Mechanistic Model for the Prediction of Equilibrium Blood-to-Plasma Concentration Ratio (B/P) in Human Blood: Basic and Neutral Drugs

M. Jamei, A. Rostami-Hodjegan, D. Turner, 2011 .

The Pharmacokinetics of the CYP3A Substrate Midazolam in Morbidly Obese Patients Before and One Year After Bariatric Surgery

B. van Ramshorst, A. Darwich, A. Rostami-Hodjegan, 2015, Pharmaceutical Research.

CPT: Pharmacometrics & Systems Pharmacology

Ghent, M. Jamei, D. Ashcroft, 2013, CPT: pharmacometrics & systems pharmacology.

Examining the Use of a Mechanistic Model to Generate an In Vivo/In Vitro Correlation: Journey Through a Thought Process

Nikunjkumar Patel, Marilyn N. Martinez, Masoud Jamei, 2016, The AAPS Journal.

Cytochrome P450 Pig Liver Pie: Determination of Individual Cytochrome P450 Isoform Contents in Microsomes from Two Pig Livers Using Liquid Chromatography in Conjunction with Mass Spectrometry

A. Rostami-Hodjegan, J. Barber, Brahim Achour, 2011, Drug Metabolism and Disposition.

Variability in Mass Spectrometry-based Quantification of Clinically Relevant Drug Transporters and Drug Metabolizing Enzymes.

J. Wiśniewski, P. Artursson, H. Wortelboer, 2017, Molecular pharmaceutics.

Drug Metabolism and Disposition META-ANALYSIS OF THE TURNOVER OF INTESTINAL EPITHELIA IN PRE-CLINICAL ANIMAL SPECIES AND HUMAN

D. Ashcroft, A. Darwich, A. Rostami-Hodjegan, 2009 .

Quantitative Characterization of Major Hepatic UDP-Glucuronosyltransferase Enzymes in Human Liver Microsomes: Comparison of Two Proteomic Methods and Correlation with Catalytic Activity

T. Goosen, A. Rostami-Hodjegan, J. Barber, 2017, Drug Metabolism and Disposition.

Understanding Discordance between In Vitro Dissolution, Local Gut and Systemic Bioequivalence of Budesonide in Healthy and Crohn’s Disease Patients through PBPK Modeling

F. Bois, A. Rostami-Hodjegan, Siri Kalyan Chirumamilla, 2023, Pharmaceutics.

Expression of Hepatic Drug-Metabolizing Cytochrome P450 Enzymes and Their Intercorrelations: A Meta-Analysis

A. Rostami-Hodjegan, J. Barber, Brahim Achour, 2014, Drug Metabolism and Disposition.

Hepatic Scaling Factors for In Vitro-In Vivo Extrapolation (IVIVE) of Metabolic Drug Clearance in Patients with Colorectal Cancer with Liver Metastasis

A. Rostami-Hodjegan, D. Scotcher, Areti-Maria Vasilogianni, 2021 .

A. Rostami-Hodjegan, Hajar Al Feteisi, J. Barber, 2015, Expert opinion on drug metabolism & toxicology.

Why Has Model‐Informed Precision Dosing Not Yet Become Common Clinical Reality? Lessons From the Past and a Roadmap for the Future

Y. Daali, L. Lesko, L. Aarons, 2017, Clinical pharmacology and therapeutics.

Dealing With Variable Drug Exposure Due to Variable Hepatic Metabolism: A Proof-of-Concept Application of Liquid Biopsy in Renal Impairment.

A. Rostami-Hodjegan, K. Yee, Zubida M. Al-Majdoub, 2024, Clinical pharmacology and therapeutics.