G. Tonn

发表

An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing

G. Tonn, S. Wong, Sylvia C. Wong, 2009, Drug Metabolism and Disposition.

SAR and mode of action of novel non-nucleoside inhibitors of hepatitis C NS5b RNA polymerase.

N. Walker, James M. Chen, Zhulun Wang, 2006, Journal of medicinal chemistry.

A formulation strategy for gamma secretase inhibitor ELND006, a BCS class II compound: development of a nanosuspension formulation with improved oral bioavailability and reduced food effects in dogs.

E. Merisko-Liversidge, G. Liversidge, G. Tonn, 2012, Journal of pharmaceutical sciences.

Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3.

Feng Xu, T. Schall, Qingge Xu, 2007, Bioorganic & medicinal chemistry letters.

Sequential Metabolism of AMG 487, a Novel CXCR3 Antagonist, Results in Formation of Quinone Reactive Metabolites That Covalently Modify CYP3A4 Cys239 and Cause Time-Dependent Inhibition of the Enzyme

D. Rock, R. Subramanian, G. Tonn, 2012, Drug Metabolism and Disposition.

Discovery of potent and specific CXCR3 antagonists.

B. Lemon, S. Miao, T. Sullivan, 2012, Bioorganic & medicinal chemistry letters.

AMG 837: a potent, orally bioavailable GPR40 agonist.

Ying Sun, J. Reagan, Rajiv Sharma, 2012, Bioorganic & medicinal chemistry letters.

DNL104, a Centrally Penetrant RIPK1 Inhibitor, Inhibits RIP1 Kinase Phosphorylation in a Randomized Phase I Ascending Dose Study in Healthy Volunteers

S. Mosesova, K. Scearce-Levie, M. Moerland, 2020, Clinical pharmacology and therapeutics.

AMG 837: A Novel GPR40/FFA1 Agonist that Enhances Insulin Secretion and Lowers Glucose Levels in Rodents

L. Tang, J. Reagan, G. Tonn, 2011, PloS one.

A novel series of IKKβ inhibitors part II: description of a potent and pharmacologically active series of analogs.

N. Walker, R. C. Hawley, C. Broka, 2011, Bioorganic & medicinal chemistry letters.

Pharmacological inhibition of polo like kinase 2 (PLK2) does not cause chromosomal damage or result in the formation of micronuclei.

M. Bergeron, G. Tonn, A. Olaharski, 2013, Toxicology and applied pharmacology.

Optimization of 2-aminothiazole derivatives as CCR4 antagonists.

T. Schall, Qingge Xu, G. Tonn, 2006, Bioorganic & medicinal chemistry letters.

Discovery and optimization of CRTH2 and DP dual antagonists.

T. Sullivan, G. Tonn, J. Medina, 2009, Bioorganic & medicinal chemistry letters.

Optimization of GPR40 Agonists for Type 2 Diabetes.

Sean P. Brown, Ying Sun, Rajiv Sharma, 2014, ACS medicinal chemistry letters.

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.

G. Tóth, H. Sham, N. Yao, 2011, Bioorganic & medicinal chemistry letters.

Design and optimization of imidazole derivatives as potent CXCR3 antagonists.

B. Lemon, S. Miao, T. Sullivan, 2008, Bioorganic & medicinal chemistry letters.

Optimization of a series of quinazolinone-derived antagonists of CXCR3.

T. Sullivan, G. Tonn, Andrew P. Marcus, 2009, Bioorganic & medicinal chemistry letters.

Estimation of transplacental and nonplacental diphenhydramine clearances in the fetal lamb: the impact of fetal first-pass hepatic drug uptake.

G. Tonn, D. Rurak, K. Riggs, 1997, The Journal of pharmacology and experimental therapeutics.

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

Chuang Lu, Heidi J Einolf, Y. Wong, 2009, Drug Metabolism and Disposition.

Optimization of the heterocyclic core of the quinazolinone-derived CXCR3 antagonists.

B. Lemon, T. Sullivan, G. Tonn, 2008, Bioorganic & medicinal chemistry letters.

In vitro protein binding of propafenone and 5-hydroxypropafenone in serum, in solutions of isolated serum proteins, and to red blood cells.

G. Tonn, C. Kerr, J. Axelson, 1992, Journal of pharmaceutical sciences.

Application of stable isotope labeled diphenhydramine to study the pharmacokinetics and metabolism of diphenhydramine in pregnant, non-pregnant, and fetal sheep

G. Tonn, 1995 .

Simultaneous analysis of diphenylmethoxyacetic acid, a metabolite of diphenhydramine, and its deuterium-labeled stable isotope analog in ovine plasma and urine.

G. Tonn, D. Rurak, F. Abbott, 1995, Journal of chromatography. B, Biomedical applications.

Simultaneous analysis of diphenhydramine and a stable isotope analog (2H10)diphenhydramine using capillary gas chromatography with mass selective detection in biological fluids from chronically instrumented pregnant ewes.

A. Mutlib, G. Tonn, D. Rurak, 1993, Biological mass spectrometry.

Bioactivation of a Novel 2-Methylindole-Containing Dual Chemoattractant Receptor-Homologous Molecule Expressed on T-Helper Type-2 Cells/d-Prostanoid Receptor Antagonist Leads to Mechanism-Based CYP3A Inactivation: Glutathione Adduct Characterization and Prediction of In Vivo Drug-Drug Interaction

R. Subramanian, G. Tonn, Michael G. Johnson, 2010, Drug Metabolism and Disposition.

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

Kent Fitzgerald, Paul Beroza, Lee Latimer, 2013, ChemMedChem.

Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.

P. Beroza, R. Motter, R. Neitz, 2013, Bioorganic & medicinal chemistry letters.

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit.

N. Walker, R. C. Hawley, C. Broka, 2011, Bioorganic & medicinal chemistry letters.

Discovery of the imidazole-derived GPR40 agonist AM-3189.

Rajiv Sharma, Zhihua Ma, G. Tonn, 2016, Bioorganic & medicinal chemistry letters.

Application of Virtual Screening to the Identification of New LpxC Inhibitor Chemotypes, Oxazolidinone and Isoxazoline.

W. Shu, C. Bellamacina, G. Tonn, 2018, Journal of medicinal chemistry.

Diphenhydramine disposition in the sheep maternal-placental-fetal unit: gestational age, plasma drug protein binding, and umbilical blood flow effects on clearance.

G. Tonn, D. Rurak, K. Riggs, 2000, Drug Metabolism And Disposition.

Bioactivation of sitaxentan in liver microsomes, hepatocytes, and expressed human P450s with characterization of the glutathione conjugate by liquid chromatography tandem mass spectrometry.

M. Svensson, G. Tonn, Shawn Gauby, 2013, Chemical research in toxicology.

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.

H. Sham, L. Latimer, M. Bova, 2013, Bioorganic & medicinal chemistry letters.

Imidazo-pyrazine derivatives as potent CXCR3 antagonists.

B. Lemon, Zhulun Wang, S. Miao, 2009, Bioorganic & medicinal chemistry letters.