J. Rautio

J. Leppänen, A. Poso, M. Lahtela-Kakkonen, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pharmacological characterization of potent and selective Free Fatty Acid Receptor 1 ( FFA 1 / GPR 40 ) agonists for the treatment of type 2 diabetes View project

R. Oliyai, T. Heimbach, T. Järvinen, 2022 .

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-3

C. Hulme, A. Mangoni, M. Gütschow, 2017, Molecules.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–4

F. J. Luque, C. Hulme, A. Mangoni, 2018, Molecules.

Synthesis and antileishmanial activity of novel buparvaquone oxime derivatives.

S. Croft, T. Nevalainen, T. Järvinen, 2004, Bioorganic & medicinal chemistry.

Inhibitors of LRRK2 kinase activity to probe the treatment option in Parkinson's disease.

J. Rautio, 2012, Journal of medicinal chemistry.

Determination of metformin and its prodrugs in human and rat blood by hydrophilic interaction liquid chromatography.

J. Leppänen, J. Rautio, P. Keski-Rahkonen, 2009, Journal of pharmaceutical and biomedical analysis.

Convenient microwave-assisted synthesis of lipophilic sulfenamide prodrugs of metformin.

J. Leppänen, J. Rautio, J. Vepsäläinen, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–2

F. J. Luque, C. Hulme, A. Mangoni, 2017, Molecules.

Species differences in the intra-brain distribution of an L-type amino acid transporter 1 (LAT1) -utilizing compound between mice and rats.

M. Lehtonen, J. Rautio, M. Forsberg, 2021, International journal of pharmaceutics.

Diclofenac readily penetrates the cerebrospinal fluid in children.

H. Kokki, E. Kumpulainen, M. Lehtonen, 2008, British journal of clinical pharmacology.

Design, synthesis, and evaluation of novel cyclic phosphates of 5-aminosalicylic acid as cytochrome p450-activated prodrugs.

J. Rautio, H. Raunio, R. Juvonen, 2013, Molecular pharmaceutics.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes

F. J. Luque, C. Hulme, K. Chibale, 2017, Molecules.

Diclofenac readily penetrates the cerebrospinal fluid in

H. Kokki, E. Kumpulainen, M. Lehtonen, 2008 .

Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy-2-naphthyl)propionic acid (Naproxen) for topical drug delivery.

T. Nevalainen, T. Järvinen, J. Gynther, 2000, Journal of medicinal chemistry.

How Readily Does Ketorolac Penetrate Cerebrospinal Fluid in Children?

H. Kokki, E. Kumpulainen, M. Lehtonen, 2008, Journal of clinical pharmacology.

Development of Sesamol Carbamate-L-Phenylalanine Prodrug Targeting L-Type Amino Acid Transporter1 (LAT1) as a Potential Antiproliferative Agent against Melanoma

J. Rautio, Juri M. Timonen, N. Weerapreeyakul, 2022, International journal of molecular sciences.

Molecular characteristics supporting l-Type amino acid transporter 1 (LAT1)-mediated translocation.

A. Poso, T. Laitinen, M. Lehtonen, 2021, Bioorganic chemistry.

Quantitative Insight into the Design of Compounds Recognized by the L‐Type Amino Acid Transporter 1 (LAT1)

J. Leppänen, A. Poso, M. Lahtela-Kakkonen, 2014, ChemMedChem.

Inefficient central nervous system delivery limits the use of ibuprofen in neurodegenerative diseases.

T. Järvinen, Anne Mannila, M. Lehtonen, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Prodrugs – Recent approvals and a glimpse of the pipeline

J. Rautio, K. Sloan, Jussi Kärkkäinen, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design, synthesis and in vitro/in vivo evaluation of orally bioavailable prodrugs of a catechol-O-methyltransferase inhibitor.

J. Leppänen, M. Lehtonen, J. Rautio, 2010, Bioorganic & medicinal chemistry letters.

Cytochrome P450-activated prodrugs: targeted drug delivery.

J. Rautio, H. Raunio, K. Huttunen, 2008, Current medicinal chemistry.

Synthesis and In Vitro Evaluation of a Set of 6-Deoxy-6-thio-carboranyl d-Glucoconjugates Shed Light on the Substrate Specificity of the GLUT1 Transporter

M. Sarparanta, E. Hey‐Hawkins, J. Rautio, 2022, ACS omega.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–5

F. J. Luque, R. Capasso, C. Hulme, 2019, Molecules.

The first bioreversible prodrug of metformin with improved lipophilicity and enhanced intestinal absorption.

J. Leppänen, T. Järvinen, Anne Mannila, 2009, Journal of medicinal chemistry.

Prodrugs: design and clinical applications

Tycho Heimbach, Tomi Järvinen, Jarkko Rautio, 2008, Nature Reviews Drug Discovery.

Amino acids as promoieties in prodrug design and development.

B. Vig, J. Rautio, K. Huttunen, 2013, Advanced drug delivery reviews.

Erratum to: Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine

J. Leppänen, J. Rautio, M. Forsberg, 2013, Pharmaceutical Research.

Design for Optimized Topical Delivery: Prodrugs and a Paradigm Change

Kenneth B. Sloan, Jarkko Rautio, J. Rautio, 2006, Pharmaceutical Research.

In vitro evaluation of acyloxyalkyl esters as dermal prodrugs of ketoprofen and naproxen.

T. Nevalainen, J. Gynther, J. Rautio, 1998, Journal of pharmaceutical sciences.

Discovery of polar spirocyclic orally bioavailable urea inhibitors of soluble epoxide hydrolase.

J. Leppänen, E. Proschak, S. Auriola, 2018, Bioorganic chemistry.

Intranasal Nanoemulsions for Direct Nose-to-Brain Delivery of Actives for CNS Disorders

Dinesh M Pardhi, J. Rosenholm, J. Rautio, 2020, Pharmaceutics.

Prodrug approach for posterior eye drug delivery: synthesis of novel ganciclovir prodrugs and in vitro screening with cassette dosing.

J. Leppänen, A. Urtti, Kati-Sisko Vellonen, 2020, Molecular pharmaceutics.

Role of L-Type Amino Acid Transporter 1 (LAT1) for the Selective Cytotoxicity of Sesamol in Human Melanoma Cells

J. Rautio, N. Weerapreeyakul, Tarapong Srisongkram, 2019, Molecules.

Brain Pharmacokinetics of Ganciclovir in Rats with Orthotopic BT4C Glioma

J. Hakkarainen, S. Ylä-Herttuala, M. Lehtonen, 2015, Drug Metabolism and Disposition.

Secondary carbamate linker can facilitate the sustained release of dopamine from brain-targeted prodrug.

J. Rautio, K. Huttunen, K. Sloan, 2018, Bioorganic & medicinal chemistry letters.

Amino acid prodrugs for oral delivery: challenges and opportunities.

B. Vig, J. Rautio, 2011, Therapeutic delivery.

Prodrugs Designed to Target Transporters for Oral Drug Delivery

J. Rautio, M. S. Warren, 2011 .

Synthesis, in vitro and in vivo characterization of novel ethyl dioxy phosphate prodrug of propofol.

J. Leppänen, T. Nevalainen, Anne Mannila, 2008, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Prodrug Approaches for CNS Delivery

Mikko Gynther, Jarkko Rautio, J. Rautio, 2008, The AAPS Journal.

Aminocarbonyloxymethyl Ester Prodrugs of Flufenamic Acid and Diclofenac: Suppressing the Rearrangement Pathway in Aqueous Media

R. Moreira, H. Mota-Filipe, J. Rautio, 2007, Archiv der Pharmazie.

Prodrugs in medicinal chemistry and enzyme prodrug therapies

Jarkko Rautio, A. Zelikin, J. Rautio, 2017, Advanced drug delivery reviews.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

G. Rastelli, P. Fossa, A. Mangoni, 2020, Molecules.

Midazolam Exhibits Characteristics of a Highly Permeable P-Glycoprotein Substrate

J. Polli, J. Polli, J. Rautio, 2003, Pharmaceutical Research.

Prodrug Strategies in Drug Design

J. Rautio, 2011 .

Amino Acid Promoieties Alter Valproic Acid Pharmacokinetics and Enable Extended Brain Exposure

J. Leppänen, M. Lehtonen, J. Rautio, 2016, Neurochemical Research.

Large amino acid transporter 1 (LAT1) prodrugs of valproic acid: new prodrug design ideas for central nervous system delivery.

J. Leppänen, J. Rautio, K. Laine, 2011, Molecular pharmaceutics.

A novel D2‐dopaminergic and α2‐adrenoceptor receptor agonist induces substantial and prolonged IOP decrease in normotensive rabbits

J. Rautio, J. Savolainen, R. Razzetti, 2003, The Journal of pharmacy and pharmacology.

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

F. J. Luque, R. Capasso, C. Hulme, 2019, Molecules.

Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

R. Wheelhouse, A. Ross, J. Rautio, 2015 .

Exploring the Biochemical Foundations of a Successful GLUT1-Targeting Strategy to BNCT: Chemical Synthesis and In Vitro Evaluation of the Entire Positional Isomer Library of ortho-Carboranylmethyl-Bearing Glucoconjugates.

Mikael P. Johansson, M. Sarparanta, A. Airaksinen, 2020, Molecular pharmaceutics.

Prodrugs - an efficient way to breach delivery and targeting barriers.

J. Rautio, K. Huttunen, 2011, Current topics in medicinal chemistry.

Design, synthesis and in vitro evaluation of novel water-soluble prodrugs of buparvaquone.

T. Nevalainen, J. Rautio, P. Keski-Rahkonen, 2004, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Piperazinylalkyl prodrugs of naproxen improve in vitro skin permeation.

T. Nevalainen, J. Gynther, J. Rautio, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Addressing the Biochemical Foundations of a Glucose-Based “Trojan Horse”-Strategy to Boron Neutron Capture Therapy: From Chemical Synthesis to In Vitro Assessment

Mikael P. Johansson, M. Sarparanta, A. Airaksinen, 2020, Molecular pharmaceutics.

High-accuracy mass spectrometry for identification of sulphur-containing bioactive constituents and flavonoids in extracts of Raphanus sativus var. caudatus Alef (Thai rat-tailed radish)

J. Leppänen, M. Lehtonen, J. Rautio, 2017 .

Prodrugs and Targeted Delivery: Towards Better ADME Properties

J. Rautio, 2010 .

Brain uptake of ketoprofen-lysine prodrug in rats.

J. Leppänen, M. Lehtonen, J. Rautio, 2010, International journal of pharmaceutics.

Structural Features Affecting the Interactions and Transportability of LAT1-Targeted Phenylalanine Drug Conjugates

A. Poso, T. Laitinen, M. Reinisalo, 2022, Molecular pharmaceutics.

Large neutral amino acid transporter enables brain drug delivery via prodrugs.

J. Leppänen, T. Nevalainen, Anne Mannila, 2008, Journal of medicinal chemistry.

Free fatty acid receptor 1 (GPR40) agonists containing spirocyclic periphery inspired by LY2881835.

I. Tikhonova, M. Lehtonen, J. Rautio, 2016, Bioorganic & medicinal chemistry.

Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine

J. Leppänen, J. Rautio, M. Forsberg, 2013, Pharmaceutical Research.

Structural properties for selective and efficient l‐type amino acid transporter 1 (LAT1) mediated cellular uptake

M. Lahtela-Kakkonen, T. Kokkola, S. Auriola, 2018, International journal of pharmaceutics.

Glucose promoiety enables glucose transporter mediated brain uptake of ketoprofen and indomethacin prodrugs in rats.

J. Leppänen, J. Rautio, K. Laine, 2009, Journal of medicinal chemistry.

Tyrosine–Chlorambucil Conjugates Facilitate Cellular Uptake through L-Type Amino Acid Transporter 1 (LAT1) in Human Breast Cancer Cell Line MCF-7

J. Leppänen, J. Rautio, Juri M. Timonen, 2020, International journal of molecular sciences.

Amino acid ester prodrugs conjugated to the α-carboxylic acid group do not display affinity for the L-type amino acid transporter 1 (LAT1).

J. Rautio, K. Huttunen, Mikko Gynther, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Sweet Battle of the Epimers—Continued Exploration of Monosaccharide-Derived Delivery Agents for Boron Neutron Capture Therapy

M. Sarparanta, E. Hey‐Hawkins, J. Rautio, 2023, Molecular pharmaceutics.

Evaluation of hydroxyimine as cytochrome P450-selective prodrug structure.

J. Rautio, H. Raunio, R. Juvonen, 2006, Journal of medicinal chemistry.

Cerebrospinal Fluid Distribution of Ibuprofen After Intravenous Administration in Children

H. Kokki, E. Kumpulainen, M. Lehtonen, 2007, Pediatrics.

Synthesis and In Vitro Evaluation of Aminoacyloxyalkyl Esters of 2-(6-methoxy-2-naphthyl)propionic Acid as Novel Naproxen Prodrugs for Dermal Drug Delivery

T. Nevalainen, J. Gynther, J. Rautio, 1999, Pharmaceutical Research.

The University of Bradford Institutional Repository

R. Wheelhouse, A. Ross, J. Rautio, 2015 .

Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth Original Citation Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

R. Wheelhouse, A. Ross, J. Rautio, 2022 .

Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

R. Wheelhouse, A. Ross, J. Rautio, 2015 .

Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

R. Wheelhouse, A. Ross, J. Rautio, 2015 .

Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

R. Wheelhouse, A. Ross, J. Rautio, 2015 .

Evaluation of Novel Imidazotetrazine Analogues Designed to Overcome Temozolomide Resistance and Glioblastoma Regrowth

R. Wheelhouse, A. Ross, J. Rautio, 2015 .

Glutathione-S-transferase selective release of metformin from its sulfonamide prodrug.

J. Rautio, K. Huttunen, Imke Aufderhaar, 2014, Bioorganic & medicinal chemistry letters.

In vitro and in vivo evaluation of a sulfenamide prodrug of basic metformin.

J. Leppänen, J. Rautio, J. Sirviö, 2012, Journal of pharmaceutical sciences.

Towards Metformin Prodrugs

J. Leppänen, J. Rautio, J. Vepsäläinen, 2008 .

Erratum to: Design, Synthesis and Brain Uptake of LAT1-Targeted Amino Acid Prodrugs of Dopamine

J. Leppänen, J. Rautio, M. Forsberg, 2013, Pharmaceutical Research.

Tetrazine Glycoconjugate for Pretargeted Positron Emission Tomography Imaging of trans-Cyclooctene-Functionalized Molecular Spherical Nucleic Acids

A. Airaksinen, H. Liljenbäck, J. Rautio, 2023, ACS Omega.

In-vitro dynamic dissolution/bioconversion/permeation of fosamprenavir using a novel tool with an artificial biomimetic permeation barrier and microdialysis-sampling.

M. Brandl, A. Bauer-Brandl, J. Rautio, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.