T. Utsuki

发表

Preclinical Investigation of the Topical Administration of Phenserine: Transdermal Flux, Cholinesterase Inhibition, and Cognitive Efficacy

N. Greig, D. Ingram, Qian-sheng Yu, 2007, Journal of Pharmacology and Experimental Therapeutics.

An Iron-responsive Element Type II in the 5′-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript*

Xudong Huang, Debomoy K Lahiri, Rudolph E Tanzi, 2002, The Journal of Biological Chemistry.

Cytoprotective effects of phlorofucofuroeckol A isolated from Ecklonia stolonifera against tacrine-treated HepG2 cells.

T. Utsuki, Min-Sup Lee, Hyeung‐Rak Kim, 2012, Fitoterapia.

Phlorofucofuroeckol A inhibits the LPS-stimulated iNOS and COX-2 expressions in macrophages via inhibition of NF-κB, Akt, and p38 MAPK.

D. Ingram, T. Shin, B. Jang, 2011, Toxicology in vitro : an international journal published in association with BIBRA.

6,6′-Bieckol suppresses inflammatory responses by down-regulating nuclear factor-κB activation via Akt, JNK, and p38 MAPK in LPS-stimulated microglial cells

Bonggi Lee, T. Utsuki, Hyeung‐Rak Kim, 2016, Immunopharmacology and immunotoxicology.

Different photodimerization behaviour of tranilast in α-, β- and γ-cyclodextrin complexes: cavity-size and stoichiometry dependence

F. Hirayama, K. Uekama, T. Utsuki, 1993 .

Nicotine lowers the secretion of the Alzheimer's amyloid β-protein precursor that contains amyloid β-peptide in rat

N. Greig, V. Haroutunian, D. Ingram, 2002 .

Nicotine lowers the secretion of the Alzheimer's amyloid beta-protein precursor that contains amyloid beta-peptide in rat.

N. Greig, V. Haroutunian, D. Ingram, 2002, Journal of Alzheimer's disease : JAD.

Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions.

K. Davis, N. Greig, V. Haroutunian, 1997, Brain research. Molecular brain research.

Interstitial delivery of carboplatin via biodegradable Polymers is effective against experimental glioma in the rat

D. Brat, A. Olivi, M. Ewend, 1996, Cancer Chemotherapy and Pharmacology.

An Avocado Extract Enriched in Mannoheptulose Prevents the Negative Effects of a High-Fat Diet in Mice

D. Ingram, P. Pistell, G. Roth, 2021, Nutrients.

Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins.

N. Greig, D. Ingram, M. Farlow, 2002, Annals of the New York Academy of Sciences.

Sargachromenol protects against vascular inflammation by preventing TNF‐&agr;‐induced monocyte adhesion to primary endothelial cells via inhibition of NF‐&kgr;B activation

T. Utsuki, Hyeung‐Rak Kim, Eun‐Ji Joung, 2017, International immunopharmacology.

Anti-Inflammatory Effect of Ethanolic Extract of Sargassum serratifolium in Lipopolysaccharide-Stimulated BV2 Microglial Cells.

Bonggi Lee, T. Utsuki, Hyeung‐Rak Kim, 2016, Journal of medicinal food.

Butyrylcholinesterase: a new therapeutic target in AD treatment?

N. Greig, D. Ingram, Qian-sheng Yu, 2001 .

Potentiation of anticancer effects of microencapsulated carboplatin by hydroxypropyl α-cyclodextrin

A. Olivi, H. Brem, B. Tyler, 1996 .

Stoichiometry-dependent photodimerization of tranilast in a γ-cyclodextrin inclusion complex

F. Hirayama, K. Uekama, T. Utsuki, 1991 .

Cholinesterase inhibitors, β‐amyloid precursor protein and amyloid β‐peptides in Alzheimer's disease

N. Greig, M. Farlow, D. Lahiri, 2000 .

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

N. Greig, D. Ingram, Qian-sheng Yu, 2005 .

Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease.

N. Greig, Qian-sheng Yu, H. Holloway, 1999, Journal of medicinal chemistry.

Stoichiometry-dependent changes of solubility and photoreactivity of an antiulcer agent, 2′-carboxymethoxy-4,4′-bis(3-methyl-2-butenyloxy) chalcone, in cyclodextrin inclusion complexes

F. Hirayama, K. Uekama, T. Utsuki, 1993 .

Inhibitory effect of guest molecules on acid-catalysed ring-opening of β-cyclodextrin

F. Hirayama, K. Uekama, T. Utsuki, 1993 .

A New Therapeutic Target in Alzheimer's Disease Treatment: Attention to Butyrylcholinesterase

Xiaoxiang Zhu, Nigel H. Greig, Donald K. Ingram, 2001, Current medical research and opinion.

Prominent inclusion effect of dimethyl-beta-cyclodextrin on photoisomerization of the thromboxane synthetase inhibitor (E)-4-(1-imidazoylmethyl)cinnamic acid.

K. Harata, F. Hirayama, T. Utsuki, 1992, Journal of pharmaceutical sciences.

Inclusion complexation of p-hydroxybenzoic acid esters with 2-hydroxypropyl-beta-cyclodextrins. On changes in solubility and antimicrobial activity.

F. Hirayama, K. Uekama, T. Utsuki, 1993, Chemical & pharmaceutical bulletin.

Polylactic acid (PLA) controlled delivery carriers for biomedical applications.

Henry Brem, Betty Tyler, A. Mangraviti, 2016, Advanced drug delivery reviews.

Nicotine Reduces the Secretion of Alzheimer's β‐Amyloid Precursor Protein Containing β‐Amyloid Peptide in the Rat without Altering Synaptic Proteins

N. Greig, D. Ingram, M. Farlow, 2002 .

Genomic Diversification in Strains of Rickettsia felis Isolated from Different Arthropods

A. Azad, Timothy P. Driscoll, Joseph J Gillespie, 2014, Genome biology and evolution.

Specific and nontoxic silencing in mammalian cells with expressed long dsRNAs

T. Giordano, Y. Odaka, T. Utsuki, 2006, Nucleic acids research.

Targets for AD treatment: conflicting messages from γ‐secretase inhibitors

N. Greig, D. Lahiri, N. Bhat, 2011, Journal of neurochemistry.

Differential Rickettsial Transcription in Bloodfeeding and Non-Bloodfeeding Arthropod Hosts

T. Utsuki, V. I. Verhoeve, K. Macaluso, 2016, PloS one.

Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2-MAPK signalling pathway in HepG2 cells.

T. Shin, Bonggi Lee, T. Utsuki, 2015, Food chemistry.

Isolation and identification of phlorotannins from Ecklonia stolonifera with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells.

T. Shin, T. Utsuki, Min-Sup Lee, 2012, Journal of agricultural and food chemistry.

Identification of Novel Small Molecule Inhibitors of Amyloid Precursor Protein Synthesis as a Route to Lower Alzheimer's Disease Amyloid-β Peptide

N. Greig, Qian-sheng Yu, H. Holloway, 2006, Journal of Pharmacology and Experimental Therapeutics.

Optimizing Drugs for Brain Action

N. Greig, D. Ingram, Qian-sheng Yu, 2001 .

PHENSERINE REGULATES TRANSLATION OF J3-AMYLOID PRECURSOR PROTEIN MESSAGE A Novel Drug Target for Alzheimer's Disease

T. Utsuki, J. Rogers, K. Sambamurti, 2002 .

Phenserine Regulates Translation of ß—Amyloid Precursor Protein Message

N. Greig, M. Farlow, D. Lahiri, 2002 .

Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse

O. Arancio, Apostolia Tzekou, T. Utsuki, 2018, Alzheimer's & dementia.

Dissociation Between the Potent β-Amyloid Protein Pathway Inhibition and Cholinergic Actions of the Alzheimer Drug Candidates Phenserine and Cymserine

N. Greig, M. Kamal, Qian-sheng Yu, 2008 .

The Experimental Alzheimer's Disease Drug Posiphen [(+)-Phenserine] Lowers Amyloid-β Peptide Levels in Cell Culture and Mice

N. Greig, Qian-sheng Yu, H. Holloway, 2007, Journal of Pharmacology and Experimental Therapeutics.

The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics

N. Greig, D. Ingram, H. Holloway, 2000, Acta neurologica Scandinavica. Supplementum.

Phenserine: A Selective, Long-Acting and Brain-Directed Acetylcholinesterase Inhibitor Affecting Cognition and β-APP Processing

N. Greig, V. Haroutunian, D. Ingram, 1997 .

Meroterpinoid-rich fraction of the ethanol extract from Sargassum serratifolium suppresses TNF-α-induced monocytes adhesion to vascular endothelium and vascular inflammation in high cholesterol-fed C57BL/6J mice

T. Shin, T. Utsuki, Hyeung‐Rak Kim, 2018, Journal of Functional Foods.

Racemic N1-norphenserine and its enantiomers: Unpredicted inhibition of human acetyl- and butyrylcholinesterase and β-amyloid precursor protein in vitro

N. Greig, Qian-sheng Yu, H. Holloway, 2003 .

Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development

N. Greig, Qian-sheng Yu, A. Brossi, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Meroterpenoid-Rich Fraction of the Ethanol Extract of Sargassum Serratifolium Suppresses Collagen-Induced Rheumatoid Arthritis in DBA/1J Mice Via Inhibition of Nuclear Factor κB Activation.

T. Utsuki, Hyeung‐Rak Kim, Lei Cao, 2020, Molecular nutrition & food research.

Phlorofucofuroeckol A Suppresses Expression of Inducible Nitric Oxide Synthase, Cyclooxygenase-2, and Pro-inflammatory Cytokines via Inhibition of Nuclear Factor-κB, c-Jun NH2-Terminal Kinases, and Akt in Microglial Cells

B. Jang, T. Utsuki, Min-Sup Lee, 2013, Inflammation.

A novel fluorogenic reporter substrate for 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCγ2): Application to high-throughput screening for activators to treat Alzheimer’s disease

A. Mesecar, Zhon-Yin Zhang, T. Utsuki, 2023, SLAS discovery : advancing life sciences R & D.

Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease.

N. Greig, M. Farlow, D. Lahiri, 2000, Acta neurologica Scandinavica. Supplementum.

Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide.

N. Greig, Qian-sheng Yu, H. Holloway, 2006, The Journal of pharmacology and experimental therapeutics.