K. Laine

发表

Entacapone Increases Levodopa Exposure and Reduces Plasma Levodopa Variability When Used With Sinemet CR

R. Huupponen, O. Paija, K. Laine, 2005, Clinical neuropharmacology.

Identifying high risk medications causing potential drug-drug interactions in outpatients: A prescription database study based on an online surveillance system.

K. Laine, M. Airaksinen, T. Toivo, 2016, Research in social & administrative pharmacy : RSAP.

Failure of Oral Activated Charcoal to Accelerate the Elimination of Amiodarone and Chloroquine

P. Neuvonen, K. Laine, K. Kivistö, 1992, Human & experimental toxicology.

Effects of the Antifungals Voriconazole and Fluconazole on the Pharmacokinetics of S-(+)- and R-(−)-Ibuprofen

P. Neuvonen, K. Laine, K. Olkkola, 2006, Antimicrobial Agents and Chemotherapy.

Frequency and Clinical Outcome of Potentially Harmful Drug Metabolic Interactions in Patients Hospitalized on Internal and Pulmonary Medicine Wards: Focus on Warfarin and Cisapride

M. Kailajärvi, M. Scheinin, J. Forsström, 2000, Therapeutic drug monitoring.

St John's wort greatly reduces the concentrations of oral oxycodone

P. Neuvonen, K. Laine, M. Neuvonen, 2010, European journal of pain.

Rifampin Greatly Reduces the Plasma Concentrations of Intravenous and Oral Oxycodone

P. Neuvonen, A. Pertovaara, K. Laine, 2009, Anesthesiology.

Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone.

P. Neuvonen, K. Laine, K. Olkkola, 2010, British journal of clinical pharmacology.

Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone

O. Pelkonen, Tuomas Korhonen, M. Turpeinen, 2008, The Journal of Steroid Biochemistry and Molecular Biology.

The Effect of Oral Contraceptives on the Pharmacokinetics of Melatonin in Healthy Subjects With CYP1A2 g.‐163C>A Polymorphism

S. Mattila, J. Hokkanen, Tuomas Korhonen, 2008, Journal of clinical pharmacology.

St John’s wort greatly decreases the plasma concentrations of oral S‐ketamine

P. Neuvonen, K. Laine, K. Olkkola, 2012, Fundamental & clinical pharmacology.

Clarithromycin, a potent inhibitor of CYP3A, greatly increases exposure to oral S‐ketamine

P. Neuvonen, K. Laine, K. Olkkola, 2010, European journal of pain.

A screening study on the liability of eight different female sex steroids to inhibit CYP2C9, 2C19 and 3A4 activities in human liver microsomes.

U. Yasar, K. Laine, J. Widén, 2003, Pharmacology & toxicology.

Effect of voriconazole on the pharmacokinetics of diclofenac

P. Neuvonen, K. Laine, K. Olkkola, 2007, Fundamental & clinical pharmacology.

The role of CYP2C and CYP3A in the disposition of 3-keto-desogestrel after administration of desogestrel.

J. Jalonen, Tuomas Korhonen, K. Laine, 2005, British journal of clinical pharmacology.

The role of organic cation transporters (OCTs) in the transfer of metformin in the dually perfused human placenta.

T. Rönnemaa, U. Ekblad, K. Laine, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction

P. Neuvonen, M. Scheinin, M. Turpeinen, 2012, European Journal of Clinical Pharmacology.

S-ketamine concentrations are greatly increased by grapefruit juice

P. Neuvonen, K. Laine, K. Olkkola, 2012, European Journal of Clinical Pharmacology.

Grapefruit juice enhances the exposure to oral oxycodone.

P. Neuvonen, K. Laine, M. Neuvonen, 2010, Basic & clinical pharmacology & toxicology.

Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half‐life

P. Neuvonen, K. Laine, K. Olkkola, 2006, Clinical pharmacology and therapeutics.

Influence of adenosine triphosphate and ABCB1 (MDR1) genotype on the P-glycoprotein-dependent transfer of saquinavir in the dually perfused human placenta

O. Wallerman, C. Wadelius, J. Hakkola, 2008, Human & experimental toxicology.

Frequency and Clinical Relevance of Drug Interactions with Lovastatin and Simvastatin

R. Huupponen, T. Vahlberg, T. Klaukka, 2008, Drug safety.

Genetic polymorphism of cytochrome P450s and P‐glycoprotein in the Finnish population

L. Bertilsson, K. Laine, A. Rane, 2007, Fundamental & clinical pharmacology.

Effect of the novel anxiolytic drug deramciclane on cytochrome P450 2D6 activity as measured by desipramine pharmacokinetics

H. Scheinin, M. Anttila, K. Laine, 2004, European Journal of Clinical Pharmacology.

Effects of caffeine intake on the pharmacokinetics of melatonin, a probe drug for CYP1A2 activity.

L. Bertilsson, K. Laine, S. Härtter, 2003, British journal of clinical pharmacology.

CYP2C19 polymorphism is not important for the in vivo metabolism of selegiline

L. Bertilsson, M. Anttila, K. Laine, 2001, European Journal of Clinical Pharmacology.

Voriconazole drastically increases exposure to oral oxycodone

P. Neuvonen, K. Laine, M. Neuvonen, 2009, European Journal of Clinical Pharmacology.

Exposure to Oral S‐ketamine Is Unaffected by Itraconazole but Greatly Increased by Ticlopidine

P. Neuvonen, M. Turpeinen, K. Laine, 2011, Clinical pharmacology and therapeutics.

L. Bertilsson, K. Laine, G. Tybring, 2000, Clinical pharmacology and therapeutics.

The Effect of pH on the In‐vitro Dissolution of Three Second‐generation Sulphonylurea Preparations: Mechanism of Antacid‐sulphonylurea Interaction

P. Neuvonen, K. Laine, P. Lehto, 1996, The Journal of pharmacy and pharmacology.

Placental transfer of quetiapine in relation to P-glycoprotein activity

O. Wallerman, C. Wadelius, J. Hakkola, 2007, Journal of psychopharmacology.

Transfer of repaglinide in the dually perfused human placenta and the role of organic anion transporting polypeptides (OATPs).

M. Niemi, T. Rönnemaa, U. Ekblad, 2011, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Transfer of Proinflammatory Cytokines Across Term Placenta

K. Laine, A. Alanen, T. Heikkinen, 2005, Obstetrics and gynecology.

Lack of adverse interactions between concomitantly administered selegiline and citalopram.

R. Huupponen, M. Scheinin, M. Anttila, 1997, Clinical neuropharmacology.

Oral voriconazole and miconazole oral gel produce comparable effects on the pharmacokinetics and pharmacodynamics of etoricoxib

P. Neuvonen, K. Laine, K. Olkkola, 2008, European Journal of Clinical Pharmacology.

Inhibition of cytochrome P4502D6 activity with paroxetine normalizes the ultrarapid metabolizer phenotype as measured by nortriptyline pharmacokinetics and the debrisoquin test

L. Bertilsson, K. Laine, S. Härtter, 2001, Clinical pharmacology and therapeutics.

Voriconazole Increases while Itraconazole Decreases Plasma Meloxicam Concentrations

P. Neuvonen, L. Bertilsson, T. Korhonen, 2008, Antimicrobial Agents and Chemotherapy.

Epidemiology of CYP3A4-mediated clopidogrel drug-drug interactions and their clinical consequences.

R. Huupponen, T. Vahlberg, K. Laine, 2013, Cardiovascular therapeutics.

Effect of Inhibition of Cytochrome P 450 Enzymes 2 D 6 and 3 A 4 on the Pharmacokinetics of Intravenous Oxycodone A Randomized , Three-Phase , Crossover , Placebo-Controlled Study

P. Neuvonen, K. Laine, K. Olkkola, 2012 .

Effect of Inhibition of Cytochrome P450 Enzymes 2D6 and 3A4 on the Pharmacokinetics of Intravenous Oxycodone

P. Neuvonen, K. Laine, K. Olkkola, 2011, Clinical drug investigation.

Development and pilot testing of PHARAO—a decision support system for pharmacological risk assessment in the elderly

Tuomas Korhonen, K. Laine, Tero Shemeikka, 2017, European Journal of Clinical Pharmacology.

Associations between Use of Benzodiazepines or Related Drugs and Health, Physical Abilities and Cognitive Function

T. Vahlberg, S. Kivelä, J. Puustinen, 2007, Drugs & aging.

Effect of caffeine intake 12 or 24 hours prior to melatonin intake and CYP1A2*1F polymorphism on CYP1A2 phenotyping by melatonin.

Tuomas Korhonen, M. Turpeinen, K. Laine, 2006, Basic & clinical pharmacology & toxicology.

The Effect of Activated Charcoal on the Absorption and Elimination of Astemizole

P. Neuvonen, K. Laine, K. Kivistö, 1994, Human & experimental toxicology.

Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam

P. Neuvonen, K. Laine, K. Olkkola, 2006 .

Rifampicin has a Profound Effect on the Pharmacokinetics of Oral S‐Ketamine and Less on Intravenous S‐Ketamine

P. Neuvonen, K. Laine, K. Olkkola, 2012, Basic & clinical pharmacology & toxicology.

Miconazole Oral Gel Increases Exposure to Oral Oxycodone by Inhibition of CYP2D6 and CYP3A4

P. Neuvonen, K. Laine, K. Olkkola, 2010, Antimicrobial Agents and Chemotherapy.

Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir

P. Neuvonen, K. Laine, M. Neuvonen, 2010, European Journal of Clinical Pharmacology.

Effect of Telithromycin on the Pharmacokinetics and Pharmacodynamics of Oral Oxycodone

P. Neuvonen, K. Laine, K. Olkkola, 2010, Journal of clinical pharmacology.

Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone

P. Neuvonen, K. Laine, M. Neuvonen, 2010, European Journal of Clinical Pharmacology.

Lack of clinically significant interactions between concomitantly administered rasagiline and escitalopram

Tuomas Korhonen, K. Laine, J. Hilli, 2009, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Voriconazole greatly increases the exposure to oral buprenorphine

P. Neuvonen, J. Backman, K. Laine, 2018, European Journal of Clinical Pharmacology.

Pharmacokinetics of fluoxetine and norfluoxetine in pregnancy and lactation

U. Ekblad, K. Laine, P. Palo, 2003, Clinical pharmacology and therapeutics.

Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta

U. Ekblad, K. Laine, T. Heikkinen, 2002, BJOG : an international journal of obstetrics and gynaecology.

The transplacental transfer of the macrolide antibiotics erythromycin, roxithromycin and azithromycin

P. Neuvonen, U. Ekblad, K. Laine, 2000, BJOG : an international journal of obstetrics and gynaecology.

The effect of probenecid and MK-571 on the feto-maternal transfer of saquinavir in dually perfused human term placenta.

K. Laine, T. Heikkinen, K. Hakala, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Citalopram in pregnancy and lactation

U. Ekblad, P. Kero, K. Laine, 2002, Clinical pharmacology and therapeutics.

Effect of renal impairment on the pharmacokinetics of bupropion and its metabolites.

O. Pelkonen, M. Turpeinen, K. Laine, 2007, British journal of clinical pharmacology.

The effect of ethinyloestradiol and levonorgestrel on the CYP2C19-mediated metabolism of omeprazole in healthy female subjects.

K. Laine, G. Tybring, S. Palovaara, 2003, British journal of clinical pharmacology.

Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects

P. Neuvonen, J. Backman, K. Laine, 2016, Pharmacology research & perspectives.

Effect of Terbinafine and Voriconazole on the Pharmacokinetics of the Antidepressant Venlafaxine

L. Bertilsson, K. Laine, P. Neuvonen, 2008, Clinical pharmacology and therapeutics.

Effects of exposure to selective serotonin reuptake inhibitors during pregnancy on serotonergic symptoms in newborns and cord blood monoamine and prolactin concentrations.

U. Ekblad, P. Kero, K. Laine, 2003, Archives of general psychiatry.

Prevention of amlodipine absorption by activated charcoal: effect of delay in charcoal administration.

I. Laakso, K. Laine, K. Kivistö, 1997, British journal of clinical pharmacology.

Prevention of Chloroquine Absorption by Activated Charcoal

K. Laine, K. Kivistö, P. Neuvonen, 1992, Human & experimental toxicology.

Potential CYP2C9‐mediated drug–drug interactions in hospitalized type 2 diabetes mellitus patients treated with the sulphonylureas glibenclamide, glimepiride or glipizide

R. Huupponen, K. Laine, T. Tirkkonen, 2010, Journal of internal medicine.

Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam.

P. Neuvonen, K. Laine, K. Olkkola, 2006, Clinical pharmacology and therapeutics.

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

P. Neuvonen, J. Backman, M. Scheinin, 2015, European Journal of Clinical Pharmacology.

Effects of terbinafine and itraconazole on the pharmacokinetics of orally administered tramadol

P. Neuvonen, J. Backman, M. Scheinin, 2015, European Journal of Clinical Pharmacology.

MAO-A and COMT genotypes as possible regulators of perinatal serotonergic symptoms after in utero exposure to SSRIs

T. Lehtimäki, L. Bertilsson, T. Vahlberg, 2009, European Neuropsychopharmacology.

Transplacental transfer of amitriptyline and nortriptyline in isolated perfused human placenta

U. Ekblad, K. Laine, T. Heikkinen, 2001, Psychopharmacology.

Rifampicin markedly decreases the exposure to oral and intravenous tramadol

P. Neuvonen, M. Scheinin, K. Laine, 2013, European Journal of Clinical Pharmacology.

The effect of drug interactions on bleeding risk associated with warfarin therapy in hospitalized patients

T. Vahlberg, K. Laine, Milka Hauta-aho, 2009, Annals of medicine.

SFINX—a drug-drug interaction database designed for clinical decision support systems

Tuomas Korhonen, Kari Laine, Lars L. Gustafsson, 2009, European Journal of Clinical Pharmacology.

Drug interactions with the potential to prevent prodrug activation as a common source of irrational prescribing in hospital inpatients

Kari Laine, Tuire Tirkkonen, K. Laine, 2004, Clinical pharmacology and therapeutics.

Effect of Clopidogrel and Ticlopidine on Cytochrome P450 2B6 Activity as Measured by Bupropion Hydroxylation

O. Pelkonen, J. Jalonen, M. Turpeinen, 2005, Clinical pharmacology and therapeutics.

Voriconazole greatly increases the exposure to oral buprenorphine

P. Neuvonen, J. Backman, K. Laine, 2018, European Journal of Clinical Pharmacology.

Functional role of P‐glycoprotein in the human blood‐placental barrier

Kari Laine, Claes Wadelius, Mia Wadelius, 2005, Clinical pharmacology and therapeutics.

Dose linearity study of selegiline pharmacokinetics after oral administration: evidence for strong drug interaction with female sex steroids.

R. Huupponen, M. Anttila, A. Helminen, 1999, British journal of clinical pharmacology.

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

P. Neuvonen, J. Backman, K. Laine, 2016, European Journal of Clinical Pharmacology.

Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl

P. Neuvonen, K. Laine, M. Neuvonen, 2007, European Journal of Clinical Pharmacology.

Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction

P. Neuvonen, J. Backman, K. Laine, 2016, European Journal of Clinical Pharmacology.

Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects.

P. Neuvonen, K. Laine, K. Olkkola, 2007, British journal of clinical pharmacology.

The degree of fetal metformin exposure does not influence fetal outcome in gestational diabetes mellitus

V. Rinne, T. Rönnemaa, U. Ekblad, 2014, Acta Diabetologica.

The bioavailability of sustained release nicotinic acid formulations.

K. Laine, P. Neuvonen, O. Sundholm, 1991, British journal of clinical pharmacology.

Effect of activated charcoal on the pharmacokinetics of pholcodine, with special reference to delayed charcoal ingestion.

P. Neuvonen, K. Laine, K. Kivistö, 1997, Therapeutic Drug Monitoring.

Effect of delayed administration of activated charcoal on the absorption of conventional and slow-release verapamil.

P. Neuvonen, K. Laine, K. Kivistö, 1997, Journal of toxicology. Clinical toxicology.

The effect of activated charcoal on the absorption of fluoxetine, with special reference to delayed charcoal administration.

P. Neuvonen, K. Laine, K. Kivistö, 1996, Acta Pharmacologica et Toxicologica.

Plasma tacrine concentrations are significantly increased by concomitant hormone replacement therapy

K. Laine, P. Tapanainen, Sanna Palovaara, 1999, Clinical pharmacology and therapeutics.

Inhibition of cytochrome P450 2B6 activity by hormone replacement therapy and oral contraceptive as measured by bupropion hydroxylation

O. Pelkonen, K. Laine, J. Uusitalo, 2003, Clinical pharmacology and therapeutics.

Voriconazole and fluconazole increase the exposure to oral diazepam

P. Neuvonen, L. Bertilsson, K. Laine, 2007, European Journal of Clinical Pharmacology.

Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy.

L. Bertilsson, K. Laine, J. Kytölä, 2004, Therapeutic drug monitoring.

S-ketamine concentrations are greatly increased by grapefruit juice

P. Neuvonen, K. Laine, K. Olkkola, 2012, European Journal of Clinical Pharmacology.

NCT01110291: induction of CYP3A activity and lowered exposure to docetaxel in patients with primary breast cancer

K. Laine, S. Pyrhönen, L. Sailas, 2011, Cancer Chemotherapy and Pharmacology.

Ticlopidine inhibits both O-demethylation and renal clearance of tramadol, increasing the exposure to it, but itraconazole has no marked effect on the ticlopidine-tramadol interaction

P. Neuvonen, M. Scheinin, M. Turpeinen, 2012, European Journal of Clinical Pharmacology.

Effect of concomitant hormone replacement therapy containing estradiol and levonorgestrel on the pharmacokinetics of selegiline

M. Anttila, K. Laine, L. Nyman, 2002, European Journal of Clinical Pharmacology.

SFINX—a drug-drug interaction database designed for clinical decision support systems

L. Gustafsson, Tuomas Korhonen, K. Laine, 2009, European Journal of Clinical Pharmacology.

Effect of the novel anxiolytic drug deramciclane on the pharmacokinetics and pharmacodynamics of the CYP3A4 probe drug buspirone

R. Huupponen, M. Anttila, K. Laine, 2003, European Journal of Clinical Pharmacology.

Rifampicin markedly decreases the exposure to oral and intravenous tramadol

P. Neuvonen, M. Scheinin, K. Laine, 2012, European Journal of Clinical Pharmacology.

Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone

P. Neuvonen, K. Laine, M. Neuvonen, 2010, European Journal of Clinical Pharmacology.

Pharmacokinetics and Disposition

F. Nosten, K. Stepniewska, E. Ashley, 2009 .