D. Underwood

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Antiinflammatory Activity in Animal Models Receptor That Demonstrates Antagonist of the Anaphylatoxin C3a Identification of a Selective Nonpeptide

McCafferty, J. Adams, K. Ward, 2001 .

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung.

John C. Lee, J. Adams, J. Adams, 2000, American journal of physiology. Lung cellular and molecular physiology.

Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.

B. Undem, D. Underwood, R. Osborn, 1993, The Journal of pharmacology and experimental therapeutics.

New phosphodiesterase inhibitors as therapeutics for the treatment of chronic lung disease.

D. Underwood, M. Barnette, David C. Underwood, 2000, Current opinion in pulmonary medicine.

Chapter 1 – Pharmacology and Pathophysiology of 5-Lipoxygenase Products

D. Underwood, M. Wasserman, M. Barnette, 1991 .

In vivo modeling systems for chronic obstructive pulmonary disease

Christopher S. Stevenson, C. Stevenson, D. Underwood, 2006 .

Food Restriction–Mediated Adrenal Influences on Antigen–Induced Bronchoconstriction and Airway Eosinophil Influx in the Guinea Pig

D. Underwood, R. Osborn, D. Hay, 1998, International Archives of Allergy and Immunology.

Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody.

D. Underwood, R. Osborn, T. Torphy, 1996, American journal of respiratory and critical care medicine.

Dose-dependent mediation of leukotriene D4-induced airway microvascular leakage and bronchoconstriction in the guinea pig.

D. Underwood, S. Bochnowicz, 1995, Prostaglandins, leukotrienes, and essential fatty acids.

Phosphodiesterase IV inhibitors as therapy for eosinophil-induced lung injury in asthma.

D. Underwood, T. Torphy, D. Hay, 1994, Environmental health perspectives.

The influence of endogenous catecholamines on the inhibitory effects of rolipram against early- and late-phase response to antigen in the guinea pig.

D. Underwood, R. Osborn, T. Torphy, 1997, The Journal of pharmacology and experimental therapeutics.

Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic.

S. Christensen, R. Nieman, D. Underwood, 1999, Pulmonary pharmacology & therapeutics.

Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.

H. Sarau, J. Foley, F. Barone, 2002, The Journal of pharmacology and experimental therapeutics.

The antitussive activity of delta-opioid receptor stimulation in guinea pigs.

D. Underwood, G. Dondio, P. Petrillo, 2000, The Journal of pharmacology and experimental therapeutics.

The bronchopulmonary pharmacology of SK&F 104353 in anesthetized guinea pigs: demonstration of potent and selective antagonism of responses to peptidoleukotrienes.

D. Underwood, R. Osborn, T. Torphy, 1989, The Journal of pharmacology and experimental therapeutics.

DIFFERENCES IN TIME-RELATED CARDIOPULMONARY RESPONSES TO HYPOXIA IN THREE RAT STRAINS

D. Underwood, R. Osborn, C. Louden, 2000, Clinical and experimental hypertension.

Interleukin-8 Receptor (CXCR2) Antagonists

H. Sarau, Surname, J. R. White, 2001 .

Chronic obstructive pulmonary disease

D. Underwood, 1999 .

Antiinflammatory Activity in Animal Models Receptor That Demonstrates Antagonist of the Anaphylatoxin C3a Identification of a Selective Nonpeptide

McCafferty, J. Adams, K. Ward, 2001 .

Lack of late-phase airway responses in conscious guinea pigs after a variety of antigen challenges

D. Underwood, R. Osborn, J. M. Hand, 1992, Agents and Actions.

Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.

D. Underwood, R. Osborn, T. Torphy, 1994, The Journal of pharmacology and experimental therapeutics.

Chronic hypoxia-induced cardiopulmonary changes in three rat strains: inhibition by the endothelin receptor antagonist SB 217242.

E. Ohlstein, D. Underwood, R. Osborn, 1998, Journal of cardiovascular pharmacology.

Hypoxia-induced pulmonary hypertension in an optimized environment for the guineapig

D. Underwood, R. Osborn, D. Hay, 1997, Laboratory animals.

Silk gland-specific tRNA(Ala) genes are tightly clustered in the silkworm genome

D. Underwood, K. U. Sprague, H. Knickerbocker, 1988, Molecular and cellular biology.

Inhibition of A23187‐Induced Bronchoconstriction by Dazoxiben, a Thromboxane Synthetase Inhibitor

D. Underwood, P. Kadowitz, T. Kriseman, 1987 .

Inhibition of p38 MAP Kinase

D. Underwood, D. Griswold, 2001 .

In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity.

H. Sarau, J. Foley, S. Van Horn, 1999, Prostaglandins, leukotrienes, and essential fatty acids.

Differential antagonism of airway contractile responses to prostaglandin (PG)D2 and 9 alpha, 11 beta-PGF2 by atropine, SK&F 88046 and SQ 29,548 in the guinea pig.

D. Underwood, T. Torphy, M. Wasserman, 1994, The Journal of pharmacology and experimental therapeutics.

Inhibition of p38 MAP kinase as a therapeutic strategy.

D E Griswold, John C. Lee, J. Adams, 2000, Immunopharmacology.

Inhibition of pulmonary thromboxane A2 synthase activity and airway responses by CGS 13080

D. Underwood, P. Kadowitz, D. B. McNamara, 1989, Molecular and Cellular Biochemistry.

Blockade of thromboxane responses in the airway of the cat by SQ 29,548.

D. Underwood, P. Kadowitz, A. Hyman, 1987, Journal of applied physiology.

Identification of a Selective Nonpeptide Antagonist of the Anaphylatoxin C3a Receptor That Demonstrates Antiinflammatory Activity in Animal Models

J. Adams, K. Ward, H. Sarau, 2001, The Journal of Immunology.

1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.

S. Christensen, P. Bender, J. Bartus, 1998, Journal of medicinal chemistry.

Effects of OKY 1581 on bronchoconstrictor responses to arachidonic acid and PGH2.

D. Underwood, P. Kadowitz, S. Tilden, 1987, Journal of applied physiology.

SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence.

R R Osborn, D E Griswold, J. Adams, 2000, The Journal of pharmacology and experimental therapeutics.

Nonpeptide endothelin receptor antagonists. X. Inhibition of endothelin-1- and hypoxia-induced pulmonary pressor responses in the guinea pig by the endothelin receptor antagonist, SB 217242.

D. Underwood, R. Osborn, D. Hay, 1997, The Journal of pharmacology and experimental therapeutics.

Substituted pyrrolidin-2-one biphenyltetrazoles as angiotensin II antagonists

D. Underwood, A. Gill, W. Murray, 1992 .

1,3- And 1,5-bisbiphenylyl substituted 3-metcaptotriazoles as angiotensin II receptor antagonists

D. Underwood, A. Gill, W. Murray, 1993 .

Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig.

S. Christensen, D. Underwood, R. Osborn, 1998, The Journal of pharmacology and experimental therapeutics.

Nonpeptide endothelin receptor antagonists. X. Inhibition of endothelin-1- and hypoxia-induced pulmonary pressor responses in the guinea pig by the endothelin receptor antagonist, SB 217242.

D. Underwood, R. Osborn, S. Bochnowicz, 1997, The Journal of pharmacology and experimental therapeutics.

Analysis of bronchoconstrictor responses to platelet-activating factor in the cat.

D. Underwood, P. Kadowitz, 1989, Journal of applied physiology.