R. Osborn

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Antiinflammatory Activity in Animal Models Receptor That Demonstrates Antagonist of the Anaphylatoxin C3a Identification of a Selective Nonpeptide

McCafferty, J. Adams, K. Ward, 2001 .

4-Phenyl-7-azaindoles as potent, selective and bioavailable IKK2 inhibitors demonstrating good in vivo efficacy.

P. Bamborough, W. Rumsey, C. Chung, 2012, Bioorganic & medicinal chemistry letters.

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung.

John C. Lee, J. Adams, J. Adams, 2000, American journal of physiology. Lung cellular and molecular physiology.

Inhibition of antigen-induced bronchoconstriction and eosinophil infiltration in the guinea pig by the cyclic AMP-specific phosphodiesterase inhibitor, rolipram.

B. Undem, D. Underwood, R. Osborn, 1993, The Journal of pharmacology and experimental therapeutics.

Food Restriction–Mediated Adrenal Influences on Antigen–Induced Bronchoconstriction and Airway Eosinophil Influx in the Guinea Pig

D. Underwood, R. Osborn, D. Hay, 1998, International Archives of Allergy and Immunology.

Persistent airway eosinophilia after leukotriene (LT) D4 administration in the guinea pig: modulation by the LTD4 receptor antagonist, pranlukast, or an interleukin-5 monoclonal antibody.

D. Underwood, R. Osborn, T. Torphy, 1996, American journal of respiratory and critical care medicine.

Pharmacologic and pharmacokinetic profile of SK&F S-106203, a potent, orally active peptidoleukotriene receptor antagonist, in guinea-pig.

H. Sarau, J. Gleason, R. Osborn, 1991, Pulmonary pharmacology.

The influence of endogenous catecholamines on the inhibitory effects of rolipram against early- and late-phase response to antigen in the guinea pig.

D. Underwood, R. Osborn, T. Torphy, 1997, The Journal of pharmacology and experimental therapeutics.

Canine airway responses to acetylcholine, prostaglandin F2alpha, histamine, and serotonin after chronic antigen exposure.

L. W. Chakrin, R. Osborn, R. Krell, 1976, The Journal of allergy and clinical immunology.

The bronchopulmonary pharmacology of SK&F 104353 in anesthetized guinea pigs: demonstration of potent and selective antagonism of responses to peptidoleukotrienes.

D. Underwood, R. Osborn, T. Torphy, 1989, The Journal of pharmacology and experimental therapeutics.

2-nor-leukotriene analogs: antagonists of the airway and vascular smooth muscle effects of leukotriene C4, D4 and E4.

J. Gleason, R. Osborn, M. McCarthy, 1983, Biochemical and biophysical research communications.

Contraction of isolated airway smooth muscle by synthetic leukotrienes C4 and D4.

J. Gleason, R. Osborn, R. Krell, 1981, Prostaglandins.

DIFFERENCES IN TIME-RELATED CARDIOPULMONARY RESPONSES TO HYPOXIA IN THREE RAT STRAINS

D. Underwood, R. Osborn, C. Louden, 2000, Clinical and experimental hypertension.

Evidence for a Thromboxane Antagonist in Selected In Vitro and In Vivo Systems

R. Osborn, M. Wasserman, P. E. Malo, 1985 .

Antiinflammatory Activity in Animal Models Receptor That Demonstrates Antagonist of the Anaphylatoxin C3a Identification of a Selective Nonpeptide

McCafferty, J. Adams, K. Ward, 2001 .

Lack of late-phase airway responses in conscious guinea pigs after a variety of antigen challenges

D. Underwood, R. Osborn, J. M. Hand, 1992, Agents and Actions.

Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.

D. Underwood, R. Osborn, T. Torphy, 1994, The Journal of pharmacology and experimental therapeutics.

Chronic hypoxia-induced cardiopulmonary changes in three rat strains: inhibition by the endothelin receptor antagonist SB 217242.

E. Ohlstein, D. Underwood, R. Osborn, 1998, Journal of cardiovascular pharmacology.

Hypoxia-induced pulmonary hypertension in an optimized environment for the guineapig

D. Underwood, R. Osborn, D. Hay, 1997, Laboratory animals.

In vitro and in vivo mechanisms of leukotriene-mediated bronchoconstriction in the guinea pig.

J. Gleason, R. Osborn, M. Wasserman, 1982, The Journal of pharmacology and experimental therapeutics.

Enhancement of isolated airway responses to bronchoconstrictive agonists by the slow-reacting substance of anaphylaxis antagonist FPL 55712.

R. Osborn, R. Krell, L. Vickery, 1981, Prostaglandins.

Effect of inhibition of thromboxane production on the leukotriene D4-mediated bronchoconstriction in the guinea pig.

R. Osborn, R. Muccitelli, B. Weichman, 1983, Prostaglandins.

SK&F 104353, a selective leukotriene receptor antagonist, inhibits leukotriene D4- and antigen-induced bronchoconstriction in cynomolgus monkeys.

R. Osborn, T. Torphy, M. Wasserman, 1992, Pulmonary pharmacology.

Antagonism of the pulmonary effects of the peptidoleukotrienes by a leukotriene D4 analog.

J. Gleason, R. Osborn, M. Wasserman, 1983, The Journal of pharmacology and experimental therapeutics.

Identification of a Selective Nonpeptide Antagonist of the Anaphylatoxin C3a Receptor That Demonstrates Antiinflammatory Activity in Animal Models

J. Adams, K. Ward, H. Sarau, 2001, The Journal of Immunology.

1,4-Cyclohexanecarboxylates: potent and selective inhibitors of phosophodiesterase 4 for the treatment of asthma.

S. Christensen, P. Bender, J. Bartus, 1998, Journal of medicinal chemistry.

SB 239063, a potent p38 MAP kinase inhibitor, reduces inflammatory cytokine production, airways eosinophil infiltration, and persistence.

R R Osborn, D E Griswold, J. Adams, 2000, The Journal of pharmacology and experimental therapeutics.

Effects of airborne toxicants on pulmonary function and mitochondrial DNA damage in rodent lungs

W. Rumsey, R. Osborn, B. Bolognese, 2016, Mutagenesis.

Nonpeptide endothelin receptor antagonists. X. Inhibition of endothelin-1- and hypoxia-induced pulmonary pressor responses in the guinea pig by the endothelin receptor antagonist, SB 217242.

D. Underwood, R. Osborn, D. Hay, 1997, The Journal of pharmacology and experimental therapeutics.

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent.

J. Boehm, P. Bamborough, Wei-Chang Fu, 2018, ACS medicinal chemistry letters.

Antiasthmatic activity of the second-generation phosphodiesterase 4 (PDE4) inhibitor SB 207499 (Ariflo) in the guinea pig.

S. Christensen, D. Underwood, R. Osborn, 1998, The Journal of pharmacology and experimental therapeutics.

Pharmacologic profile of SK&F 104353, a novel, highly potent and selective peptidoleukotriene antagonist.

R. Hall, K. Erhard, K. A. Wilson, 1987, Advances in prostaglandin, thromboxane, and leukotriene research.

Nonpeptide endothelin receptor antagonists. X. Inhibition of endothelin-1- and hypoxia-induced pulmonary pressor responses in the guinea pig by the endothelin receptor antagonist, SB 217242.

D. Underwood, R. Osborn, S. Bochnowicz, 1997, The Journal of pharmacology and experimental therapeutics.