A. Cohen

发表

Effects of intravenous temazepam. II. A study of the long‐term reproducibility of pharmacokinetics, pharmacodynamics, and concentration‐effect parameters

J. Hartigh, A. Van Steveninck, H. Schoemaker, 1994, Clinical pharmacology and therapeutics.

The pharmacokinetics of recombinant double‐chain t‐PA (duteplase): Effects of bolus injection, infusions, and administration by weight in patients with myocardial infarction

B. Weatherley, A. Cohen, R. Koster, 1991, Clinical pharmacology and therapeutics.

Clinical research in a developing country

A. Cohen, J. Posner, 1995 .

A Novel Tumor-Specific Agent for Intraoperative Near-Infrared Fluorescence Imaging: A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer

Philip S Low, Cornelis J H van de Velde, Alexander L Vahrmeijer, 2016, Clinical Cancer Research.

Saccadic peak velocity and EEG as end‐points for a serotonergic challenge test

Robbert Jan Verkes, Adam F Cohen, Joop M A van Gerven, 2002, Human psychopharmacology.

Biomarkers for the effects of selective serotonin reuptake inhibitors (SSRIs) in healthy subjects.

A F Cohen, G. Dumont, A. Cohen, 2005, British journal of clinical pharmacology.

Pharmacokinetic‐pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite α‐hydroxymidazolam in healthy volunteers

Meindert Danhof, Bert Tuk, M. Danhof, 1992, Clinical pharmacology and therapeutics.

The Future of Clinical Trial Design: The Transition from Hard Endpoints to Value-Based Endpoints.

A. Cohen, G. Groeneveld, M. Kruizinga, 2019, Handbook of experimental pharmacology.

The transition to a sustainable system of drug development requires reformation of the regulatory and patent systems, and a shift of responsibility to open-access discovery and clinical evaluation of innovative drugs to the public sector.

E. Moors, A. Cohen, H. Schellekens, 2014 .

Hyposomatotropism blunts lipolysis in abdominally obese women.

H. Pijl, J. Romijn, H. Sauerwein, 2002, The Journal of clinical endocrinology and metabolism.

Influence of obesity and body fat distribution on growth hormone kinetics in humans.

H. Pijl, C. Roelen, M. Frölich, 1999, American journal of physiology. Endocrinology and metabolism.

Influence of obesity and body fat distribution on growth hormone kinetics in humans.

H. Pijl, C. Roelen, M. Frölich, 1999, The American journal of physiology.

Pharmacokinetics and Pharmacodynamics of the Erythropoietin Mimetibody™ Construct CNTO 528 in Healthy Subjects

J. Pérez-Ruixo, Honghui Zhou, A. Cohen, 2009, Clinical pharmacokinetics.

Implications of the BIA‐102474‐101 study for review of first‐into‐human clinical trials

M. Eddleston, A. Cohen, David J Webb, 2016, British journal of clinical pharmacology.

Biomarkers for the effects of antipsychotic drugs in healthy volunteers.

A F Cohen, J. V. van Gerven, M. Pieters, 2001, British journal of clinical pharmacology.

The use of biomarkers in human pharmacology (Phase I) studies.

J. V. van Gerven, M. Moerland, A. Cohen, 2015, Annual review of pharmacology and toxicology.

Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia

A. Masclee, A. Cohen, J. Burggraaf, 2004, Alimentary pharmacology & therapeutics.

Monitoring the recovery time of children after tonsillectomy using commercial activity trackers

J. N. van den Anker, A. Cohen, T. Welzel, 2021, European Journal of Pediatrics.

Population Pharmacokinetic Model of THC Integrates Oral, Intravenous, and Pulmonary Dosing and Characterizes Short- and Long-term Pharmacokinetics

P. Morrison, T. Beumer, J. Freijer, 2015, Clinical Pharmacokinetics.

Estimation of growth hormone secretion rate: impact of kinetic assumptions intrinsic to the analytical approach.

H. Pijl, J. Veldhuis, A. Meinders, 2001, American journal of physiology. Regulatory, integrative and comparative physiology.

Improving the quality of drug research or simply increasing its cost? An evidence-based study of the cost for data monitoring in clinical trials.

A. Cohen, E. Pronker, B. Geerts, 2011, British journal of clinical pharmacology.

Integrating data from the Investigational Medicinal Product Dossier/investigator's brochure. A new tool for translational integration of preclinical effects

J. V. van Gerven, A. Cohen, 2018, British journal of clinical pharmacology.

A Pilot Study Evaluating the Physiological Parameters of Performance-Induced Stress in Undergraduate Music Students

A. Cohen, P. Gal, G. Jacobs, 2018, Digital Biomarkers.

Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: An exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis

A. Cohen, M. Dröge, M. Kruizinga, 2020, British journal of clinical pharmacology.

The bioavailability of digoxin from three oral formulations measured by a specific h.p.l.c. assay.

H. Schoemaker, D. Breimer, A. Cohen, 1993, British journal of clinical pharmacology.

Editors' pick 2011

J. Ritter, Y. Loke, A. Somogyi, 2012 .

The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients

E. Lentjes, A. Cohen, R. Schoemaker, 1995, Clinical pharmacology and therapeutics.

Assessment of changes in liver blood flow after food intake--comparison of ICG clearance and echo-Doppler.

H. Schoemaker, A. Cohen, J. Burggraaf, 1996, British journal of clinical pharmacology.

Variability of splanchnic blood flow measurements using MR velocity mapping under fasting and post-prandial conditions--comparison with echo-Doppler.

L. S. Schultze Kool, A. de Roos, G. J. Lycklama À Nijeholt, 1997, Journal of hepatology.

Pharmacokinetics of the Recombinant Thrombolytic Agents

A. Cohen, 1999, BioDrugs.

Lamotrigine (BW430C), a potential anticonvulsant. Effects on the central nervous system in comparison with phenytoin and diazepam.

A. Cohen, A. A. Miller, L. Ashby, 1985, British journal of clinical pharmacology.

Carbamazepine and Lamotrigine in Healthy Volunteers: Relevance to Early Tolerance and Clinical Trial Dosage

B. Weatherley, A. Cohen, A. Yuen, 1993, Epilepsia.

Endothelial Binding of Recombinant Tissue Plasminogen Activator: Quantification In Vivo Using a Recirculatory Model

M. Moerland, A. Cohen, C. Kluft, 2003, Journal of Pharmacokinetics and Pharmacodynamics.

Glucose homeostasis in abdominal obesity: hepatic hyperresponsiveness to growth hormone action.

H. Pijl, M. D. de Kam, M. Frölich, 2004, American journal of physiology. Endocrinology and metabolism.

Plasma amino acid ratios related to brain serotonin synthesis in response to food intake in bulimia nervosa

H. Pijl, R. Verkes, M. Frölich, 1995, Biological Psychiatry.

New EU clinical trials regulation

A. Cohen, A. Westra, W. Bos, 2014, BMJ : British Medical Journal.

Influence of food on the bioavailability of metoprolol from an OROS system; a study in healthy volunteers

H. Schoemaker, A. Cohen, A. Boer, 1990, European Journal of Clinical Pharmacology.

Clinical Pharmacology Research Internships at the Interface between Academia and Industry: Students’ Perceptions and Scientific Output

A. Cohen, K. Franson, S. Goulooze, 2017, Basic & clinical pharmacology & toxicology.

Evidence for brain serotonin-mediated control of carbohydrate consumption in normal weight and obese humans.

H. Pijl, M. Frölich, A. Meinders, 1993, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

Futility of current urine salbutamol doping control

A. Cohen, J. Heuberger, Sven C van Dijkman, 2018, British journal of clinical pharmacology.

First proof of pharmacology in humans of a novel glucagon receptor antisense drug

J. Romijn, S. Bhanot, M. D. de Kam, 2015, Journal of clinical pharmacology.

Plasmin inhibitors in the prevention of systemic effects during thrombolytic therapy: specific role of the plasminogen-binding form of alpha 2-antiplasmin.

F. Leebeek, A. Cohen, C. Kluft, 1990, Journal of the American College of Cardiology.

Increased impact of a contraceptive vaginal ring with ethinyl estradiol and nestorone on C-reactive protein

A. Cohen, C. Kluft, J. Burggraaf, 2012, Steroids.

Creating a culture of thoughtful prescribing

M. D. de Kam, A. Cohen, K. Franson, 2009, Medical teacher.

Efficacy and safety of RPL554, a dual PDE3 and PDE4 inhibitor, in healthy volunteers and in patients with asthma or chronic obstructive pulmonary disease: findings from four clinical trials.

M. Cazzola, Dave Singh, M. D. de Kam, 2013, The Lancet. Respiratory medicine.

Low-dose infusion of recombinant tissue-type plasminogen activator in healthy volunteers to investigate the biodistribution of t-PA in the early phase of infusion

L. Huisman, H. Schoemaker, A. Cohen, 1997 .

Metabolic profile of a continuous versus a cyclic low-dose combined oral contraceptive after one year of use

M. D. de Kam, A. Cohen, C. Kluft, 2011, The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.

Influence of skinfold thickness on heparin absorption

A. Cohen, C. Kroon, A. Boer, 1991, The Lancet.

Effect of an NK1/NK2 receptor antagonist on airway responses and inflammation to allergen in asthma.

P. Sterk, A. Cohen, J. Burggraaf, 2007, American journal of respiratory and critical care medicine.

Relationship between airway responsiveness to neurokinin A and methacholine in asthma.

P. Sterk, A. Cohen, J. Burggraaf, 2005, Pulmonary pharmacology & therapeutics.

Reversal of the late asthmatic response increases exhaled nitric oxide.

P. Sterk, A. Cohen, Z. Diamant, 2005, Respiratory medicine.

A review of current approaches for evaluating impaired performance in around-the-clock medical professionals.

P. J. Marang-van de Mheen, K. V. D. van der Bogt, A. Cohen, 2019, Sleep medicine reviews.

Stimulation programs for pediatric drug research – do children really benefit?

J. Wit, A. Cohen, J. Burggraaf, 2007, European Journal of Pediatrics.

Sofosbuvir and daclatasvir

A. Cohen, M. Hessel, R. Rissmann, 2016, British journal of clinical pharmacology.

Industrialized research in the BJCP: a neo-Luddite view.

J. Ritter, A. Cohen, 2012, British journal of clinical pharmacology.

Denosumab: New Drug Mechanisms

A. Cohen, R. Rissmann, E. Dubois, 2011 .

Injection site reactions after subcutaneous oligonucleotide therapy

M. Moerland, J. Gallagher, E. Prens, 2016, British journal of clinical pharmacology.

Effects of liver blood flow on the pharmacokinetics of tissue‐type plasminogen activator (alteplase) during thrombolysis in patients with acute myocardial infarction

L. Huisman, A. Cohen, R. Koster, 1998, Clinical pharmacology and therapeutics.

Influence of gastric acidity on the bioavailability of digoxin.

A. Cohen, R. Schoemaker, A. V. van Vliet, 1991, Annals of internal medicine.

Evaluating Fitness to Perform in Surgical Residents after Night Shifts and Alcohol Intoxication: The development of a "Fit-to-Perform" test.

J. V. van Gerven, H. Stockmann, M. D. de Kam, 2018, Journal of surgical education.

A cross-over comparison of the anti-clotting effects of three low molecular weight heparins and glycosaminoglycuronan.

A. Cohen, T. van Dinther, J. Stiekema, 1993, British journal of clinical pharmacology.

Circadian rhythm of plasma leptin levels in upper and lower body obese women: influence of body fat distribution and weight loss.

H. Pijl, J. Doornbos, A. Meinders, 1998, The Journal of clinical endocrinology and metabolism.

A comparison of the concentration-effect relationships of midazolam for EEG-derived parameters and saccadic peak velocity.

M. Danhof, J. G. van Dijk, A. Van Steveninck, 1993, British journal of clinical pharmacology.

Intraindividual Variability in Nifedipine Pharmacokinetics and Effects in Healthy Subjects

H. Schoemaker, D. Breimer, A. Cohen, 1992, Journal of clinical pharmacology.

MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers.

A. Cohen, Z. Diamant, J. V. van Gerven, 2008, Pulmonary pharmacology & therapeutics.

Endothelial function in patients with hyperthyroidism before and after treatment with propranolol and thiamazol.

H. Pijl, A. Cohen, S. Lalezari, 2001, Thyroid : official journal of the American Thyroid Association.

A Comparison of the Gastrointestinal Effects of the Nitrogen‐Containing Bisphosphonates Pamidronate, Alendronate, and Olpadronate in Humans

M. Kam, A. Cohen, J. Burggraaf, 2006, Journal of clinical pharmacology.

Assessment of hepatic blood flow using continuous infusion of high clearance drugs.

A. Cohen, J. Burggraaf, R. Schoemaker, 2002, British journal of clinical pharmacology.

Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial.

A. Levin, M. Moerland, A. Cohen, 2015, British journal of clinical pharmacology.

Characterization of glutathione conjugation in humans: Stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)‐ and (S)‐2‐bromoisovalerylurea in healthy volunteers

G. Mulder, D. Breimer, A. Cohen, 1993, Clinical pharmacology and therapeutics.

The pharmacokinetic and pharmacodynamic interactions of ramipril with propranolol

H. Schoemaker, A. Cohen, M. Seibert-Grafe, 2004, European Journal of Clinical Pharmacology.

Food choice in hyperthyroidism: potential influence of the autonomic nervous system and brain serotonin precursor availability.

H. Pijl, A. Meinders, A. Cohen, 2001, Journal of Clinical Endocrinology and Metabolism.

Organised crime against the academic peer review system

R. Bies, A. de Boer, A. Cohen, 2016, British journal of clinical pharmacology.

Specific stimulation of brain serotonin mediated neurotransmission by dexfenfluramine does not restore growth hormone responsiveness in obese women

H. Pijl, H. Schoemaker, A. Cohen, 1996, Clinical endocrinology.

Clinically Important Interaction Between Tedisamil and Verapamil

A. Cohen, J. Burggraaf, R. Schoemaker, 2009, Journal of clinical pharmacology.

No Influence of acute hypertriglyceridemia on plasma t-PA in healthy male volunteers.

A. Cohen, J. Burggraaf, M. Kemme, 2001, Thrombosis research.

Retinal oximetry and fractal analysis of capillary maps in sickle cell disease patients and matched healthy volunteers

J. V. van Meurs, A. Cohen, L. van Manen, 2019, Graefe's Archive for Clinical and Experimental Ophthalmology.

Pharmacokinetics, pharmacodynamics and bioavailability of the ACE inhibitor ramipril

A. Cohen, R. Schoemaker, M. Seibert-Grafe, 2004, European Journal of Clinical Pharmacology.

From pharmacology to immunopharmacology.

A. Cohen, 2006, British journal of clinical pharmacology.

Sensitivity and specificity of detection methods for erythropoietin doping in cyclists

P. Van Eenoo, A. Cohen, J. Burggraaf, 2019, Drug testing and analysis.

Liver Blood Flow as a Major Determinant of the Clearance of Recombinant Human Tissue-Type Plasminogen Activator

H. Schoemaker, D. Breimer, A. Cohen, 1992, Thrombosis and Haemostasis.

Pharmacokinetics of PC‐SOD, a Lecithinized Recombinant Superoxide Dismutase, After Single‐ and Multiple‐Dose Administration to Healthy Japanese and Caucasian Volunteers

A. Cohen, J. Burggraaf, Y. Mizushima, 2008, Journal of clinical pharmacology.

The pharmacokinetics and effects of a long-acting preparation of superoxide dismutase (PC-SOD) in man.

H. Schoemaker, A. Cohen, J. Burggraaf, 2008, British journal of clinical pharmacology.

Cardiovascular side effects of inhaled salbutamol in hypoxic asthmatic patients

P. Sterk, R. Westendorp, A. Cohen, 2001, Thorax.

Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue‐type plasminogen activator

G. Dooijewaard, L. Huisman, A. Cohen, 1996, Clinical pharmacology and therapeutics.

Effects of changing liver blood flow by exercise and food on kinetics and dynamics of saruplase

L. Huisman, A. Cohen, R. Schoemaker, 1995, Clinical pharmacology and therapeutics.

Self-selection for personality variables among healthy volunteers.

A. Jennekens‐Schinkel, H. Schoemaker, M. Pieters, 1992, British journal of clinical pharmacology.

Technical validity and usability of a novel smartphone‐connected spirometry device for pediatric patients with asthma and cystic fibrosis

A. Cohen, H. Janssens, M. Nuijsink, 2020, Pediatric pulmonology.

Absence of an interaction between the synthetic pentasaccharide fondaparinux and oral warfarin.

A. Cohen, J. Burggraaf, R. Schoemaker, 2002, British journal of clinical pharmacology.

Editors' Report for 2015, December 2015.

Albert Ferro, Yoon K Loke, Sarah Ross, 2016, British journal of clinical pharmacology.

Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes

M. Moerland, H. ten Cate, A. Cohen, 2020, European Journal of Applied Physiology.

Lack of Interaction Between Tramadol and Coumarins

A. Cohen, E. Meegen, R. Ende, 1998, Journal of clinical pharmacology.

Postdischarge Recovery after Acute Pediatric Lung Disease Can Be Quantified with Digital Biomarkers

A. Cohen, M. Nuijsink, M. Kruizinga, 2021, Respiration.

Assessment of hepatic blood flow in healthy subjects by continuous infusion of indocyanine green.

D. Breimer, A. Cohen, A. D. De Boer, 1991, British journal of clinical pharmacology.

Lomitapide: New drug mechanisms: lomitapide

A. Cohen, S. Goulooze, R. Rissmann, 2015 .

Abstracts of papers clinical pharmacological meeting

D. J. Veldhuisen, J. Remon, J. Ottervanger, 2005, Pharmacy World and Science.

The oral bioavailability of pentosan polysulphate sodium in healthy volunteers

A. Cohen, C. Kluft, J. Burggraaf, 1999, European Journal of Clinical Pharmacology.

The influence of reduced liver blood flow on the pharmacokinetics and pharmacodynamics of recombinant tissue factor pathway inhibitor

E. Lentjes, A. Cohen, J. Burggraaf, 2000, Clinical pharmacology and therapeutics.

Interaction study between nifedipine and recombinant tissue-type plasminogen activator in healthy subjects.

H. Schoemaker, D. Breimer, A. Cohen, 1993, British Journal of Clinical Pharmacology.

Tolvaptan: New Drug Mechanisms

A. Cohen, R. Rissmann, E. Dubois, 2012 .

Clearance of Plasminogen Activators—A Major Determinant of Plasma Concentration: Therapeutic and Diagnostic Implications

A. Cohen, C. Kluft, A. Cohen, 1992 .

The effects of acrivastine (BW825C), diphenhydramine and terfenadine in combination with alcohol on human CNS performance

A. Cohen, A. W. Peck, M. Hamilton, 2004, European Journal of Clinical Pharmacology.

Developing drug prototypes: pharmacology replaces safety and tolerability?

A. Cohen, 2010, Nature Reviews Drug Discovery.

The influence of cisapride and clarithromycin on QT intervals in healthy volunteers

A. Cohen, J. Burggraaf, R. Schoemaker, 1998, Clinical pharmacology and therapeutics.

The influence of cilazapril on anticoagulation in hypertensive patients treated with coumarins

A. Cohen, D. Breimer, C. Kleinbloesem, 1993 .

Life style and blood fibrinolytic activity: a comment on clearance of plasminogen activators

A. Cohen, C. Kluft, A. D. Boer, 1990 .

and pharmacokinetic effects of m r subtype selective agonist, compared to lorazepam and placebo in healthy volunteers

J. Gerven, M. Pieters, A. Cohen, 2014 .

ch a pter 4 Central nervous system effects of ethanol at a pseudo-steady state concentration using ethanol clamping in healthy volunteers

J. Gerven, A. Cohen, A. Dahan, 2012 .

Pharmacodynamic and pharmacokinetic effects of the intravenous CB1 receptor agonist Org 26828 in healthy male volunteers

A. Cohen, L. Zuurman, J. V. van Gerven, 2010, Journal of psychopharmacology.

Gerven healthy male volunteers Pharmacodynamic and pharmacokinetic effects of the intravenous CB 1 receptor agonist Org 26828 in

A. Cohen, L. Zuurman, H. Kleijn, 2010 .

Pharmacodynamic and pharmacokinetic effects of the intravenously administered CB1 receptor agonist Org 28611 in healthy male volunteers

J. V. van Gerven, A. Cohen, L. Zuurman, 2009, Journal of psychopharmacology.

Pharmacodynamic and pharmacokinetics of BW 825C: A new antihistamine

J. W. Findlay, S. Liao, A. Cohen, 2004, European Journal of Clinical Pharmacology.

A study of the effects of long-term use on individual sensitivity to temazepam and lorazepam in a clinical population.

M. Danhof, A. Van Steveninck, M. Pieters, 2003, British journal of clinical pharmacology.

The effects of clonazepam and vigabatrin in hyperekplexia

J. G. Dijk, H. Schoemaker, A. Cohen, 1997, Journal of the Neurological Sciences.

Pharmacodynamic response profiles of anxiolytic and sedative drugs

J. V. van Gerven, J. Baas, M. D. de Kam, 2017, British journal of clinical pharmacology.

How to expedite early‐phase SARS‐CoV‐2 vaccine trials in pandemic setting—A practical perspective

A. Cohen, M. Roestenberg, I. Kamerling, 2020, British journal of clinical pharmacology.

The Synthetic Pentasaccharide Fondaparinux Sodium Does Not Interact with Oral Warfarin

A. Cohen, J. Burggraaf, R. Schoemaker, 2002, Clinical pharmacokinetics.

Absence of Interaction of Fondaparinux Sodium with Aspirin and Piroxicam in Healthy Male Volunteers

A. Cohen, J. Burggraaf, R. Schoemaker, 2002, Clinical pharmacokinetics.

Central nervous system effects of alcohol at a pseudo-steady-state concentration using alcohol clamping in healthy volunteers.

A. Dahan, J. V. van Gerven, R. Zoethout, 2009, British journal of clinical pharmacology.

Pharmacokinetic and pharmacodynamic interactions of bretazenil and diazepam with alcohol.

R. Gieschke, A. Van Steveninck, M. Pieters, 2003, British journal of clinical pharmacology.

Motilin effects on the proximal stomach in patients with functional dyspepsia and healthy volunteers.

A. Masclee, A. Cohen, J. Burggraaf, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Early stage development of the glycine-1 re-uptake inhibitor SCH 900435: central nervous system effects compared with placebo in healthy men.

J. V. van Gerven, G. Holder, M. D. de Kam, 2013, British journal of clinical pharmacology.

The acute effects of acrivastine (BW825C), a new antihistamine, compared with triprolidine on measures of central nervous system performance and subjective effects

A. Cohen, A. W. Peck, M. Hamilton, 1985, Clinical pharmacology and therapeutics.

Influence of a Microemulsion Vehicle on Cutaneous Bioequivalence of a Lipophilic Model Drug Assessed by Microdialysis and Pharmacodynamics

A. Cohen, J. Burggraaf, R. Schoemaker, 2001, Pharmaceutical Research.

Methods in clinical pharmacology--a tale of two worlds.

A. Cohen, 2008, British journal of clinical pharmacology.

Effects of a nonpeptide motilin receptor antagonist on proximal gastric motor function.

A. Masclee, M. D. de Kam, A. Cohen, 2004, British journal of clinical pharmacology.

The effect of motilin on the rectum in healthy volunteers.

A. Masclee, H. Schoemaker, A. Cohen, 2003, British journal of clinical pharmacology.

Hydrolyzed Casein Decreases Postprandial Glucose Concentrations in T2DM Patients Irrespective of Leucine Content

J. Romijn, M. Moerland, A. Cohen, 2011, Journal of dietary supplements.

Tinnitus suppression by intravenous lidocaine in relation to its plasma concentration

J. Hartigh, A. Cohen, R. Schoemaker, 1993, Clinical pharmacology and therapeutics.

A comparative study of two methods for attaining constant alcohol levels.

Albert Dahan, Adam F Cohen, Joop M A van Gerven, 2008, British journal of clinical pharmacology.

The influence of the hand circulation on the assessment of venous distensibility of the human forearm with venous occlusion plethysmography.

A. Cohen, J. Burggraaf, M. Kemme, 2008, British journal of clinical pharmacology.

Dexamethasone concentration in the subretinal fluid after a subconjunctival injection, a peribulbar injection, or an oral dose.

J. V. van Meurs, F. Romijn, E. Lentjes, 2000, Ophthalmology.

Biomarkers for the effects of antipsychotic drugs in healthy volunteers.

J. V. van Gerven, M. Pieters, A. Cohen, 2001, British journal of clinical pharmacology.

A Guide to Clinical Drug Research

A. Cohen, J. Posner, 2000, Springer Netherlands.

Effects of erythropoietin on cycling performance of well trained cyclists: a double-blind, randomised, placebo-controlled trial.

M. D. de Kam, M. Moerland, A. Cohen, 2017, The Lancet. Haematology.

Bioavailability and bioequivalence of etonogestrel from two oral formulations of desogestrel: Cerazette® and Liseta®

A. Cohen, T. Dieben, C. Timmer, 1999, European Journal of Drug Metabolism and Pharmacokinetics.

The sugar absorption test in the evaluation of the gastrointestinal intolerance to bisphosphonates: Studies with oral pamidronate

J. Hartigh, A. Cohen, J. Burggraaf, 2001, Clinical pharmacology and therapeutics.

Editors' pick 2009.

A. Somogyi, A. Cohen, A. Ferro, 2010, British journal of clinical pharmacology.

The South London and Maudsley NHS Foundation Trust and Oxleas NHS Foundation Trust Prescribing Guidelines, 9th Edition

A. Cohen, G. Jacobs, 2008 .

The influence of nifedipine and captopril on liver blood flow in healthy subjects.

A. Cohen, J. Burggraaf, R. Schoemaker, 2002, British journal of clinical pharmacology.

Absence of tolerance and toxicity to high-dose continuous intravenous furosemide in haemodynamically unstable infants after cardiac surgery.

A. J. van der Heijden, J. den Hartigh, A. Cohen, 2007, British journal of clinical pharmacology.

Development of an optimal furosemide infusion strategy in infants with modeling and simulation

A. Cohen, J. Burggraaf, R. Schoemaker, 2002, Clinical pharmacology and therapeutics.

Continuous intravenous furosemide in haemodynamically unstable children after cardiac surgery

J. den Hartigh, A. Cohen, J. Burggraaf, 2001, Intensive Care Medicine.

Estimating impossible curves using NONMEM.

A F Cohen, A. Cohen, R. Schoemaker, 2003, British journal of clinical pharmacology.

Interaction Study between Org 10172, a Low Molecular Weight Heparinoid, and Acetylsalicylic Acid in Healthy Male Volunteers

M. Danhof, D. Breimer, A. Cohen, 1991, Thrombosis and Haemostasis.

No evidence of the usefulness of eye blinking as a marker for central dopaminergic activity

J. Gerven, A. Cohen, J. V. van Gerven, 2004, Journal of psychopharmacology.

Pharmacodynamic interactions of diazepam and intravenous alcohol at pseudo steady state

R. Gieschke, H. Schoemaker, M. Pieters, 2005, Psychopharmacology.

The sensitivity of pharmacodynamic tests for the central nervous system effects of drugs on the effects of sleep deprivation

J. Gerven, A. Van Steveninck, D. Breimer, 1999, Journal of psychopharmacology.

A comparison of the sensitivities of adaptive tracking, eye movement analysis, and visual analog lines to the effects of incremental doses of temazepam in healthy volunteers

H. Schoemaker, M. Pieters, D. Breimer, 1991, Clinical pharmacology and therapeutics.

Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects.

A. Vollmar, R. Gebhardt, V. Dirsch, 2006, The American journal of clinical nutrition.

Pharmacokinetics and systemic endocrine effects of the phyto-oestrogen 8-prenylnaringenin after single oral doses to postmenopausal women.

M. Hümpel, W. Schleuning, A. Cohen, 2006, British journal of clinical pharmacology.

Intraocular penetration and systemic absorption after topical application of dexamethasone disodium phosphate.

J. V. van Meurs, F. Romijn, E. Lentjes, 2002, Ophthalmology.

High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection.

J. V. van Meurs, F. Romijn, E. Lentjes, 1999, American journal of ophthalmology.

Dexamethasone concentration in vitreous and serum after oral administration.

J. V. van Meurs, F. Romijn, E. Lentjes, 1998, American journal of ophthalmology.

Peribulbar corticosteroid injection: vitreal and serum concentrations after dexamethasone disodium phosphate injection.

J. V. van Meurs, F. Romijn, E. Lentjes, 1997, American journal of ophthalmology.

Vaccination during myeloid cell depletion by cancer chemotherapy fosters robust T cell responses

S. H. van der Burg, G. Kenter, M. Welters, 2016, Science Translational Medicine.

A pharmacodynamic Markov mixed‐effect model for the effect of temazepam on sleep

Meindert Danhof, Bert Tuk, M. Danhof, 2000, Clinical pharmacology and therapeutics.

Self-medication of a single headache episode with ketoprofen, ibuprofen or placebo, home-monitored with an electronic patient diary.

A F Cohen, A. Cohen, R C Schoemaker, 1996, British journal of clinical pharmacology.

Review of WADA Prohibited Substances: Limited Evidence for Performance-Enhancing Effects

A. Cohen, J. Heuberger, 2018, Sports Medicine.

Pharmacokinetics and central nervous system effects of the novel dopamine D2 receptor antagonist JNJ-37822681

J. V. van Gerven, M. D. de Kam, M. Moerland, 2012, Journal of psychopharmacology.

The pharmacokinetics of lamotrigine (BW430C) in healthy subjects with unconjugated hyperbilirubinaemia (Gilbert's syndrome).

A. Cohen, J. Posner, G. Land, 1989, British journal of clinical pharmacology.

Lamotrigine, a new anticonvulsant: Pharmacokinetics in normal humans

A. Cohen, D. Breimer, W. Yuen, 1987, Clinical pharmacology and therapeutics.

Pharmacokinetics of the conventional and microemulsion formulations of cyclosporine in pancreas-kidney transplant recipients with gastroparesis.

A. Cohen, J. Burggraaf, F. J. van der Woude, 1996, Transplantation.

Concentration-effect relationships of two infusion rates of the imidazoline antihypertensive agent rilmenidine for blood pressure and development of side-effects in healthy subjects.

A. Cohen, S. D. de Visser, J. V. van Gerven, 2002, British journal of clinical pharmacology.

Central nervous system effects of moxonidine experimental sustained release formulation in patients with mild to moderate essential hypertension.

J. V. van Gerven, A. Cohen, R. Schoemaker, 2003, British journal of clinical pharmacology.

Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans

B. Edgar, H. Schoemaker, D. Breimer, 1991, Clinical pharmacology and therapeutics.

Erythropoietin doping in cycling: lack of evidence for efficacy and a negative risk–benefit

A. Cohen, J. Burggraaf, J. Rotmans, 2013, British journal of clinical pharmacology.

Olaparib: New drug mechanisms: Olaparib

A. Cohen, S. Goulooze, R. Rissmann, 2016 .

Studies of interaction of a low-molecular-weight heparinoid (Org 10172) with cloxacillin and ticarcillin in healthy male volunteers

M. Danhof, D. Breimer, A. Cohen, 1991, Antimicrobial Agents and Chemotherapy.

Evaluation of tests of central nervous system performance after hypoxemia for a model for cognitive impairment

J. V. van Gerven, J. Gerven, A. Cohen, 2002, Journal of psychopharmacology.

Rate-controlled rectal absorption enhancement of cefoxitin by co-administration of sodium salicylate or sodium octanoate in healthy volunteers.

D. Breimer, A. Cohen, A. Wackwitz, 1989, British journal of clinical pharmacology.

Urinary kidney biomarkers for early detection of nephrotoxicity in clinical drug development

M. Moerland, A. Cohen, J. Burggraaf, 2014, British journal of clinical pharmacology.

Sympathovagal imbalance in hyperthyroidism.

H. Pijl, A. Meinders, A. Cohen, 2001, American journal of physiology. Endocrinology and metabolism.

COVID‐19 vaccines: the importance of transparency and fact‐based education

S. Cremers, J. V. van Gerven, W. van Eden, 2020, British journal of clinical pharmacology.

A Comparison of the Effects of Propofol and Midazolam on Memory During Two Levels of Sedation by Using Target-Controlled Infusion

J. V. van Gerven, A. Cohen, J. Bovill, 2000, Anesthesia and analgesia.

Integrated pharmacokinetics and pharmacodynamics of Ro 48-6791, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects.

A. Cohen, M. Zell, J. V. van Gerven, 2003, British journal of clinical pharmacology.

Integrated pharmacokinetics and pharmacodynamics of Ro 48-8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects.

J. Gerven, A. Cohen, M. Zell, 2003, British journal of clinical pharmacology.

Quantification of heparin-induced TFPI release: a maximum release at low heparin dose.

A. Cohen, C. Kluft, J. Burggraaf, 2002, British journal of clinical pharmacology.

Finding Suitable Clinical Endpoints for a Potential Treatment of a Rare Genetic Disease: the Case of ARID1B

M. D. de Kam, G. Santen, A. Cohen, 2020, Neurotherapeutics.

Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers.

J. van der Greef, A. Tas, J. Vogels, 2007, British journal of clinical pharmacology.

Rare disease specialists and clinical pharmacologists unite: Increase collection of longitudinal data!

G. Santen, A. Cohen, 2019, British journal of clinical pharmacology.

Biomarkers for the effects of benzodiazepines in healthy volunteers.

A F Cohen, A. Cohen, J M A van Gerven, 2002, British journal of clinical pharmacology.

A. Van Steveninck, H. Schoemaker, M. Pieters, 1993, British journal of clinical pharmacology.

The gastrointestinal passage and release of beclomethasone dipropionate from oral delivery systems in ileostomy volunteers.

P. Fockens, H. Schoemaker, A. Cohen, 1998, British journal of clinical pharmacology.

A comparison of the central nervous system effects of alcohol at pseudo-steady state in Caucasian and expatriate Japanese healthy male volunteers.

A. Dahan, J. V. van Gerven, M. D. de Kam, 2012, Alcohol.

A placebo-controlled parallel study of the effect of two types of coffee oil on serum lipids and transaminases: identification of chemical substances involved in the cholesterol-raising effect of coffee.

A. Cohen, J. Burggraaf, J. V. van Rooij, 1995, The American journal of clinical nutrition.

Blunted lipolytic response to fasting in abdominally obese women: evidence for involvement of hyposomatotropism.

H. Pijl, C. Wijbrandts, J. Romijn, 2003, The American journal of clinical nutrition.

Editors' pick 2010.

J. Ritter, Y. Loke, A. Somogyi, 2011, British journal of clinical pharmacology.

Rilonacept and canakinumab.

A. Cohen, R. Rissmann, E. Dubois, 2011, British journal of clinical pharmacology.

Estimating Potency for the Emax-Model Without Attaining Maximal Effects

J. V. van Gerven, A. Cohen, R. Schoemaker, 1998, Journal of Pharmacokinetics and Biopharmaceutics.

Physical Exercise Induces Enhancement of Urokinase-Type Plasminogen Activator (u-PA) Levels in Plasma

G. Dooijewaard, D. Breimer, A. Cohen, 1991, Thrombosis and Haemostasis.

Impact of (chemo)radiotherapy on immune cell composition and function in cervical cancer patients

S. H. van der Burg, G. Kenter, M. Welters, 2016, Oncoimmunology.

Measuring learning from the TRC pharmacology E-Learning program.

M. D. de Kam, A. Cohen, K. Franson, 2008, British journal of clinical pharmacology.

SIX MONTHS TREATMENT WITH IBOPAMINE IN PATIENTS WITH HYPOTONY AFTER VITREORETINAL SURGERY FOR RETINAL DETACHMENT, UVEITIS OR PENETRATING TRAUMA

P. Mulder, J. V. van Meurs, A. Cohen, 2012, Retina.

Pharmacodynamic and pharmacokinetic effects of TPA023, a GABAA α2,3 subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers

J. Gerven, A. Cohen, M. Murphy, 2007 .

Editors' pick 2013.

J. Ritter, Y. Loke, A. Somogyi, 2014, British journal of clinical pharmacology.

The central nervous system effects, pharmacokinetics and safety of the NAALADase-inhibitor GPI 5693.

D. Hilt, J. Gerven, E. Bortey, 2005, British journal of clinical pharmacology.

Pharmacokinetic and pharmacodynamic profile of oral and intravenous meta-chlorophenylpiperazine in healthy volunteers.

M. Ferrari, J. V. van Gerven, M. Pieters, 1998, Journal of clinical psychopharmacology.

Evaluation of lecithinized human recombinant super oxide dismutase as cardioprotectant in anthracycline-treated breast cancer patients.

Jeroen J. Bax, M. D. de Kam, F. D. de Jongh, 2014, British journal of clinical pharmacology.

Pharmacokinetic and pharmacodynamic profiles of sumatriptan in migraine patients with headache recurrence or no response

A F Cohen, J Burggraaf, M. Ferrari, 1996, Clinical pharmacology and therapeutics.

Effect of Isotretinoin on Endogenous Tissue-Type Plasminogen Activator (t-PA) and Plasminogen Activator Inhibitor 1 (PAI-1) in Humans

T. Kooistra, W. Lambert, H. Schoemaker, 1993, Thrombosis and Haemostasis.

Clinical pharmacology--providing tools and expertise for translational medicine.

J. Aronson, A. Cohen, L. Lewis, 2008, British journal of clinical pharmacology.

The impact of the global COVID‐19 pandemic on the conduct of clinical trials: Return to normalcy by considering the practical impact of a structured ethical analysis

J. V. van Gerven, A. Cohen, M. Vissers, 2020, British journal of clinical pharmacology.

Towards a sustainable system of drug development.

E. Moors, A. Cohen, H. Schellekens, 2014, Drug discovery today.

Pharmacokinetics of Saruplase, a Recombinant Unglycosylated Human Single-Chain Urokinase-Type Plasminogen Activator and Its Effects on Fibrinolytic and Haemostatic Parameters in Healthy Male Subjects

G. Dooijewaard, A. Cohen, C. Kluft, 1993, Thrombosis and Haemostasis.

Pronounced Effects of the Combination of a New Thromboxane Antagonist (GR32191) and Heparin on Bleeding Time in Man

H. Schoemaker, D. Breimer, A. Cohen, 1992, Thrombosis and Haemostasis.

Highly Variable Anticoagulant Response After Subcutaneous Administration of High‐Dose (12,500 IU) Heparin in Patients With Myocardial Infarction and Healthy Volunteers

H. Schoemaker, A. Cohen, F. V. D. van der Meer, 1992, Circulation.

Diurnal Rhythm in Anticoagulant Effect of Heparin during a Low Dose Constant Rate Infusion

A. Meinders, H. Schoemaker, A. Cohen, 1992, Thrombosis and Haemostasis.

Discriminant analysis of the metabolic effects of a new combined contraceptive vaginal ring containing Nestorone/EE vs. a second-generation oral contraceptive containing levonorgestrel/EE.

M. D. de Kam, A. Cohen, C. Kluft, 2012, Contraception.

Effects of intravenous temazepam. I. Saccadic eye movements and electroencephalogram after fast and slow infusion to pseudo steady state

J. Hartigh, A. Van Steveninck, H. Schoemaker, 1994, Clinical pharmacology and therapeutics.

De‐risking Clinical Trials: The BIAL Phase I Trial in Foresight

A. Cohen, J. van Smeden, David J. Webb, 2021, Clinical pharmacology and therapeutics.

Central nervous system effects of the interaction between risperidone (single dose) and the 5-HT6 antagonist SB742457 (repeated doses) in healthy men.

J. V. van Gerven, E. Pich, A. Cohen, 2011, British journal of clinical pharmacology.

Evaluation of biomarkers for cardiotoxicity of anthracyclin-based chemotherapy

H. J. Ritsema van Eck, A. Cohen, J. Burggraaf, 2008, Journal of Cancer Research and Clinical Oncology.

Pharmacokinetic differences between Caucasian and Japanese subjects after single and multiple doses of a potential combined oral contraceptive (Org 30659 and EE).

A. Cohen, E. Uchida, S. D. de Visser, 2003, Contraception.

No evidence for functional involvement of 5-HT2B receptors in serotonin-induced vasodilatation in the human forearm.

A. Cohen, G. Blauw, J. Burggraaf, 2000, Journal of cardiovascular pharmacology.

Digoxin and mortality: lessons for observational studies

A. Cohen, A. Boer, 2016, British journal of clinical pharmacology.

BJCP 40th anniversary: moving forward, looking back.

J. Ritter, Y. Loke, A. Somogyi, 2014, British journal of clinical pharmacology.

Improving public health by improving clinical trial guidelines and their application

Adam Cohen, Jeroen J. Bax, Marc Buyse, 2017, European heart journal.

In vivo quantification of striatal dopamine D2 receptor occupancy by JNJ-37822681 using [11C]raclopride and positron emission tomography

A. Lammertsma, J. V. van Gerven, A. Windhorst, 2012, Journal of psychopharmacology.

Exogenous Motilin Affects Postprandial Proximal Gastric Motor Function and Visceral Sensation

A. Masclee, A. Cohen, J. Burggraaf, 2002, Digestive Diseases and Sciences.

Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABAA α2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers

R. Ramakrishnan, A. Cohen, M. Murphy, 2008, Journal of psychopharmacology.

The Psychomotor Effects of Carbamazepine in Epileptic Patients and Healthy Volunteers

M. Pieters, A. Cohen, J. V. van Gerven, 2003, Journal of psychopharmacology.

Local tissue factor pathway inhibitor release in the human forearm

D. Webb, D. Newby, A. Cohen, 2003, Thrombosis and Haemostasis.

Disagreement between bedside and laboratory activated partial thromboplastin time and international normalized ratio for various novel anticoagulants

A. Cohen, C. Kluft, P. Meijer, 2001, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Pharmacokinetics and Pharmacodynamics of Orally Administered Clonidine: A Model-Based Approach

J. Wit, J. Freijer, A. Cohen, 2013, Hormone Research in Paediatrics.

Risk Assessment in Extrapolation of Pharmacokinetics from Preclinical Data to Humans

T. Lavé, J. Freijer, A. Cohen, 2010, Clinical pharmacokinetics.

Growth hormone blunts protein oxidation and promotes protein turnover to a similar extent in abdominally obese and normal-weight women.

H. Pijl, J. Romijn, M. D. de Kam, 2002, The Journal of clinical endocrinology and metabolism.

Question-based Drug Development for psilocybin.

A. Cohen, G. Jacobs, Francis M. Dijkstra, 2016, The lancet. Psychiatry.

Immunomonitoring of Tacrolimus in Healthy Volunteers: The First Step from PK- to PD-Based Therapeutic Drug Monitoring?

M. D. de Kam, A. D. de Vries, M. Moerland, 2019, International journal of molecular sciences.

Objective Assessment of Fitness to Perform (FTOP) After Surgical Night Shifts in the Netherlands: An Observational Study Using the Validated FTOP Self-Test in Daily Surgical Practice.

J. Hamming, H. Stockmann, K. V. D. van der Bogt, 2019, Annals of surgery.

Comparative effects of felodipine, nitrendipine and nifedipine in healthy subjects: concentration-effect relationships of racemic drugs and enantiomers

D. Breimer, A. Cohen, P. Soons, 2004, European Journal of Clinical Pharmacology.

Renal Effects of Antisense-Mediated Inhibition of SGLT2

M. D. de Kam, M. Moerland, A. Cohen, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Effects of temazepam on saccadic eye movements: Concentration‐effect relationships in individual volunteers

H. Schoemaker, M. Pieters, D. Breimer, 1992, Clinical pharmacology and therapeutics.

REM Sleep Effects as a Biomarker for the Effects of Antidepressants in Healthy Volunteers

A. Cohen, K. Franson, S. D. de Visser, 2003, Journal of psychopharmacology.

Sputum RNA signature in allergic asthmatics following allergen bronchoprovocation test

A. Cohen, J. Burggraaf, Z. Diamant, 2016, European clinical respiratory journal.

Evaluation of simulated driving in comparison to laboratory-based tests to assess the pharmacodynamics of alprazolam and alcohol

J. V. van Gerven, M. D. de Kam, A. Cohen, 2019, Journal of psychopharmacology.

Abstracts of papers Pharmacological meeting

N. Ramsey, J. M. Ree, M. Danhof, 1985, Pharmaceutisch Weekblad.

The effects of moclobemide on the pharmacokinetics of the 5-HT1B/1D agonist rizatriptan in healthy volunteers.

A. Sterrett, M. Goldberg, A. Cohen, 1999, British journal of clinical pharmacology.

Towards remote monitoring in pediatric care and clinical trials—Tolerability, repeatability and reference values of candidate digital endpoints derived from physical activity, heart rate and sleep in healthy children

M. Kam, A. Cohen, M. Kruizinga, 2021, PloS one.

Repeatability and predictive value of lactate threshold concepts in endurance sports

A. Cohen, F. Stuurman, J. Heuberger, 2018, PloS one.

A. Masclee, H. Schoemaker, A. Cohen, 2002, Alimentary pharmacology & therapeutics.

Placebo-Controlled Comparison of Three Dose-Regimens of 5-Hydroxytryptophan Challenge Test in Healthy Volunteers

J. V. van Gerven, M. D. de Kam, M. Pieters, 2002, Journal of clinical psychopharmacology.

Pharmacokinetics of the recombinant thrombolytic agents: what is the clinical significance of their different pharmacokinetic parameters?

A. Cohen, 1999, BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy.

Acceptable risks and burdens for children in research without direct benefit: a systematic analysis of the decisions made by the Dutch Central Committee

J. Wit, A. Cohen, I. D. de Beaufort, 2010, Journal of Medical Ethics.

Intraoperative imaging of folate receptor alpha positive ovarian and breast cancer using the tumor specific agent EC17

Charlotte E. S. Hoogstins, P. Low, C. V. D. van de Velde, 2016, Oncotarget.

Tolrestat pharmacokinetic and pharmacodynamic effects on red blood cell sorbitol levels in normal volunteers and in patients with insulin‐dependent diabetes

W. Jusko, A. Cohen, S. Chiang, 1995, Clinical pharmacology and therapeutics.

Clinical ophtalmo‐pharmacology. Looking ahead

J. V. van Meurs, A. Cohen, 2021, British journal of clinical pharmacology.

Reproducibility of biomarkers in induced sputum and in serum from chronic smokers.

M. D. de Kam, A. Cohen, J. Burggraaf, 2015, Pulmonary pharmacology & therapeutics.

Development of Novel, Value-Based, Digital Endpoints for Clinical Trials: A Structured Approach Toward Fit-for-Purpose Validation

M D Kruizinga, F E Stuurman, V Exadaktylos, 2020, Pharmacological Reviews.

Novel Tumor-Speci fi c Agent for Intraoperative Near-Infrared Fluorescence Imaging : A Translational Study in Healthy Volunteers and Patients with Ovarian Cancer

Charlotte E. S. Hoogstins, P. Low, A. Vahrmeijer, 2016 .

The Application of the Principles of Clinical Drug Development to Pharmacological Challenge Tests of the Serotonergic System

J. Gerven, A. Cohen, H. Gijsman, 2004, Journal of psychopharmacology.

Good Clinical Trials by removing defensive interpretation of Good Clinical Practice guidelines

A. Cohen, J. Burggraaf, G. Groeneveld, 2021, British journal of clinical pharmacology.

Development of Visual Pharmacology Education Across an Integrated Medical School Curriculum

Adam F Cohen, Kari L Franson, Eline A Dubois, 2007, Journal of visual communication in medicine.

[New drugs; exenatide and sitagliptin].

H. Pijl, A. Cohen, H. van Bronswijk, 2008, Nederlands tijdschrift voor geneeskunde.

Re-engineering the European Union Clinical Trials Directive

A. Cohen, M. Kenter, 2012, The Lancet.

How reliable are commercially available trackers in detecting daytime sleep

J. N. van den Anker, A. Cohen, V. Ziesenitz, 2018, British journal of clinical pharmacology.

The effect of m-CPP on tics and obsessive-compulsive phenomena in Gilles de la Tourette syndrome

D. Cath, A. Cohen, H. Gijsman, 1999, Psychopharmacology.

Altered neuroregulation of GH secretion in viscerally obese premenopausal women.

H. Pijl, J. Veldhuis, A. Meinders, 2001, The Journal of clinical endocrinology and metabolism.

Novel SGLT2 inhibitor: first‐in‐man studies of antisense compound is associated with unexpected renal effects

M. D. de Kam, M. Moerland, A. Cohen, 2017, Pharmacology research & perspectives.

Gallbladder volume as a biomarker for the motilin effect in healthy volunteers and patients with functional dyspepsia

A. Masclee, A. Cohen, I. Kamerling, 2004 .

Development and Technical Validation of a Smartphone-Based Cry Detection Algorithm

A. Cohen, V. Exadaktylos, R. Doll, 2021, Frontiers in Pediatrics.

The Neurotoxicity Scale: The validity of a patient-based scale, assessing neurotoxicity

G. Baker, A. Aldenkamp, H. Schoemaker, 1995, Epilepsy Research.

Adherence to HAART therapy measured by electronic monitoring in newly diagnosed HIV patients in Botswana

B. Vrijens, P. Kristanto, A. Cohen, 2007, European Journal of Clinical Pharmacology.

Objectives of Biomarkers in Early Drug Development Biomarkers for Pharmacological Effects Biomarkers for (patho)physiological Principle Biomarkers for Therapeutic Principle Table 1 Number of Tests within Individual Domains Neuropsychological Domains Neuroleptics Selective Serotonin Re-uptake Inhibit

M. Ferrari, F. Zitman, D. Hilt, 2022 .

Theoretical Performance of Nonlinear Mixed-Effect Models Incorporating Saliva as an Alternative Sampling Matrix for Therapeutic Drug Monitoring in Pediatrics: A Simulation Study

A. Cohen, M. Kruizinga, F. Stuurman, 2021, Therapeutic drug monitoring.

Stereoselective pharmacokinetics of oral felodipine and nitrendipine in healthy subjects: correlation with nifedipine pharmacokinetics

H. Schoemaker, D. Breimer, A. Cohen, 2004, European Journal of Clinical Pharmacology.

Spotlight Commentary: Medicines use during pregnancy and harmful effects on offspring.

A. Cohen, Li Wei, 2019, British journal of clinical pharmacology.

The specificity of different selective and non-selective gabaa (partial) agonists in healthy volunteers

A. Cohen, 2008 .

Hypoxia‐Induced Arterial Endothelin Does Not Influence Peripheral Vascular Tone

R. Westendorp, A. Meinders, A. Cohen, 1995, Journal of cardiovascular pharmacology.

Reversal of mecamylamine‐induced effects in healthy subjects by nicotine receptor agonists: Cognitive and (electro) physiological responses

J. V. van Gerven, M. D. de Kam, A. Cohen, 2018, British journal of clinical pharmacology.

A comparison of methods for assessing the sedative effects of diphenhydramine on skills related to car driving

A. Cohen, J. Posner, L. Ashby, 2004, European Journal of Clinical Pharmacology.

Recombinant human erythropoietin does not affect several microvascular parameters in well‐trained cyclists

A. Cohen, J. Burggraaf, F. Stuurman, 2018, Physiological reports.

A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development.

J. V. van Gerven, A. Cohen, E. Hart, 2019, Journal of visualized experiments : JoVE.

Pharmacological vs. classical approaches in the design of first in man clinical drug trials

J. V. van Gerven, H. Leufkens, A. Cohen, 2017, British journal of clinical pharmacology.

Is there interaction between tramadol and phenprocoumon?

A. Cohen, E. Meegen, R. Ende, 1997, The Lancet.

Good clinical practice: a question of balance.

A. Cohen, A. Wallnöfer, 1993, British journal of clinical pharmacology.

Editors' pick 2012.

J. Ritter, Y. Loke, A. Somogyi, 2013, British journal of clinical pharmacology.

Sorbitol as a marker for drug-induced decreases of variable duration in liver blood flow in healthy volunteers.

E. Lentjes, A. Cohen, J. Burggraaf, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Influence of 1-desamino-8-D-vasopressin on endogenous fibrinolysis, haemodynamics and liver blood flow in healthy subjects.

L. Huisman, H. Schoemaker, A. Cohen, 1994, Clinical science.

Hypothalamic glutamate levels following serotonergic stimulation: A pilot study using 7-Tesla magnetic resonance spectroscopy in healthy volunteers

F. G. Zitman, F. Zitman, W. Teeuwisse, 2010, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

European drug market entries 2015 with new mechanisms of action.

A. Cohen, R. Rissmann, Titus W P van den Heuvel, 2016, Clinical medicine.

Pharmacokinetic/pharmacodynamic Assessment of Tolerance to Central Nervous System Effects of a 3 mg Sustained Release Tablet of Rilmenidine in Hypertensive Patients

A. Cohen, S. D. de Visser, J. V. van Gerven, 2004, Journal of psychopharmacology.

Vanishing clinical psychopharmacology.

J. V. van Gerven, A. Cohen, 2011, British journal of clinical pharmacology.

Clinical pharmacology in neuroscience drug discovery: quo vadis?

A. Cohen, D. Trist, A. Bye, 2014, Current opinion in pharmacology.

The first administration of a new active substance to humans

A. Cohen, J. Posner, 1995 .

Pharmacokinetic and Pharmacodynamic Data to be Derived from Early-Phase Drug Development

Adam Cohen, A. Cohen, 2008, Clinical pharmacokinetics.

A comparison of the effects of propofol and midazolam on memory during two levels of sedation by using target-controlled infusion.

A. Cohen, J. Bovill, R. Schoemaker, 2000 .

Pharmacodynamics of temazepam in primary insomnia: Assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep

Meindert Danhof, Bert Tuk, M. Danhof, 1997, Clinical pharmacology and therapeutics.

Icatibant.

A. Cohen, E. Dubois, 2010, British journal of clinical pharmacology.

Bedaquiline.

A. Cohen, S. Goulooze, R. Rissmann, 2015, British journal of clinical pharmacology.