D. Verotta

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The pharmacokinetics and pharmacodynamics of diltiazem and its metabolites in healthy adults after a single oral dose

K. Giacomini, L. Sheiner, R. Boyd, 1989, Clinical pharmacology and therapeutics.

Non-linear dynamics models characterizing long-term virological data from AIDS clinical trials.

Davide Verotta, D. Verotta, F. Schaedeli, 2002, Mathematical biosciences.

Comparative tissue concentration profiles of fentanyl and alfentanil in humans predicted from tissue/blood partition data obtained in rats.

H Harashima, D R Stanski, D Verotta, 1990, Anesthesiology.

Models and estimation methods for clinical HIV-1 data

Davide Verotta, D. Verotta, 2005 .

LINEAR MIXED-EFFECT MULTIVARIATE ADAPTIVE REGRESSION SPLINES APPLIED TO NONLINEAR PHARMACOKINETICS DATA

D. Verotta, J. Gries, 2000, Journal of biopharmaceutical statistics.

Mechanistic pharmacokinetic modelling of ephedrine, norephedrine and caffeine in healthy subjects.

N. Benowitz, C. Csajka, D. Verotta, 2005, British Journal of Clinical Pharmacology.

Estimation and model selection in constrained deconvolution

D. Verotta, 1993, Annals of Biomedical Engineering.

Fractional Kinetics Compartmental Models

D. Verotta, 2011 .

Age effects on interrelationships between lung volume and heart rate during standing.

Davide Verotta, D. Verotta, N. Craft, 1997, American journal of physiology. Heart and circulatory physiology.

Two Constrained Deconvolution Methods Using

D. Verotta, Spline Functions, 1993 .

Population Analyses of Atorvastatin Clearance in Patients Living in the Community and in Nursing Homes

D. Verotta, J. Schwartz, J. Schwartz, 2009, Clinical pharmacology and therapeutics.

Passive versus electrotransport‐facilitated transdermal absorption of ketorolac

L. Sheiner, S. Gupta, Suneel K. Gupta, 1998, Clinical pharmacology and therapeutics.

Mean time parameters for generalized physiological flow models (semihomogeneous linear systems)

L. Sheiner, D. Verotta, S. Beal, 1991, Journal of pharmacokinetics and biopharmaceutics.

Comments on two recent deconvolution methods

D. Verotta, 1990, Journal of Pharmacokinetics and Biopharmaceutics.

Title Fractional compartmental models and multi-term Mittag-Leffler response functions Permalink

D. Verotta, 2010 .

Pharmacokinetic and pharmacodynamic modelling of metoprolol in rabbits with liver failure

M. Bonati, D. Verotta, A. Bortolotti, 1989, European Journal of Drug Metabolism and Pharmacokinetics.

Population pharmacokinetics of unbound mycophenolic acid in adult allogeneic haematopoietic cell transplantation: effect of pharmacogenetic factors

D. Verotta, P. Jacobson, A. Frymoyer, 2013 .

Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin.

E. Eger, L. Benet, P. Ionescu, 1992, Anesthesiology.

Nevirapine pharmacokinetics and risk of rash and hepatitis among HIV-infected sub-Saharan African women

M. Hughes, S. Lockman, J. Currier, 2012, AIDS.

Gentamicin Pharmacokinetics and Dosing in Neonates with Hypoxic Ischemic Encephalopathy Receiving Hypothermia

B. Guglielmo, S. Bonifacio, Lina Meng, 2013, Pharmacotherapy.

Every 36-hour Gentamicin Dosing in Neonates with Hypoxic Ischemic Encephalopathy Receiving Hypothermia

B. Guglielmo, S. Bonifacio, Lina Meng, 2013, Journal of Perinatology.

Oral heroin in opioid-dependent patients: pharmacokinetic comparison of immediate and extended release tablets.

K. Rentsch, G. Kullak-Ublick, K. Fattinger, 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Differential postnatal development of -, d- and ?-opioid binding sites in rat brain

D. Verotta, A. Tavani, P. Petrillo, 1987 .

Differential postnatal development of mu-, delta- and kappa-opioid binding sites in rat brain.

D. Verotta, A. Tavani, P. Petrillo, 1987, Brain research.

Further notes on physiologic indirect response models

L. Sheiner, D. Verotta, 1995, Clinical pharmacology and therapeutics.

Building population pharmacokineticpharmacodynamic models. I. Models for covariate effects

Lewis B. Sheiner, Jaap W. Mandema, Davide Verotta, 1992, Journal of Pharmacokinetics and Biopharmaceutics.

An application of the D-optimal criterion to define the experimental design for a particular class of semi-parametric models.

D Verotta, D. Verotta, 1990, Computer methods and programs in biomedicine.

A new criterion for selection of pharmacokinetic multiexponential equations.

B. Imbimbo, D. Verotta, G. Bassotti, 1988, Journal of pharmaceutical sciences.

Software for experimental design: the computer program EXCAD.

D Verotta, D. Verotta, 1988, Computer methods and programs in biomedicine.

D-optimal design applied to binding saturation curves of an enkephalin analog in rat brain.

M Rocchetti, D Verotta, M. Rocchetti, 1988, Life sciences.

A new method to explore the distribution of interindividual random effects in non-linear mixed effects models.

L B Sheiner, D Verotta, L. Sheiner, 1995, Biometrics.

Influence of Arterial vs. Venous Sampling Site on Nicotine Tolerance Model Selection and Parameter Estimation

N. Benowitz, D. Verotta, S. Gourlay, 2002, Journal of Pharmacokinetics and Pharmacodynamics.

Determination of meropenem in bacterial media by LC-MS/MS.

F. Aweeka, D. Verotta, Liusheng Huang, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Down-regulation models and modeling of testosterone production induced by recombinant human choriogonadotropin.

A. Munafo, D. Verotta, J. Gries, 1999, The Journal of pharmacology and experimental therapeutics.

Pharmacokinetics of saquinavir, zidovudine, and zalcitabine in combination therapy

T. Blaschke, L. Sheiner, K. Squires, 1997, Antimicrobial agents and chemotherapy.

Exposure-response relationships for saquinavir, zidovudine, and zalcitabine in combination therapy

L B Sheiner, T F Blaschke, D Verotta, 1997, Antimicrobial agents and chemotherapy.

Modeling Nicotine Arterial–Venous Differences to Predict Arterial Concentrations and Input Based on Venous Measurements: Application to Smokeless Tobacco and Nicotine Gum

N. Benowitz, D. Verotta, S. Gourlay, 2002, Journal of Pharmacokinetics and Pharmacodynamics.

Pharmacodynamics of acute tolerance to multiple nicotinic effects in humans.

N. Benowitz, K. Fattinger, D. Verotta, 1997, The Journal of pharmacology and experimental therapeutics.

A Method to Quantify Illicit Intake of Drugs from Urine: Methamphetamine

G. Galloway, M. Baggott, D. Verotta, 2011, Journal of Pharmacology and Experimental Therapeutics.

Spatiotemporal pharmacodynamics of meropenem- and tobramycin-treated Pseudomonas aeruginosa biofilms

A. Spormann, J. Engel, D. Verotta, 2017, The Journal of antimicrobial chemotherapy.

Additive Inhibition of Nicotinic Acetylcholine Receptors by Corticosteroids and the Neuromuscular Blocking Drug Vecuronium

A. Gray, C. Kindler, D. Verotta, 2000, Anesthesiology.

Pharmacokinetic–Pharmacodynamic Modelling: History and Perspectives

Davide Verotta, Chantal Csajka, C. Csajka, 2006, Journal of Pharmacokinetics and Pharmacodynamics.

The Use of a Sum of Inverse Gaussian Functions to Describe the Absorption Profile of Drugs Exhibiting Complex Absorption

Davide Verotta, Chantal Csajka, C. Csajka, 2005, Pharmaceutical Research.

Input Characteristics and Bioavailability after Administration of Immediate and a New Extended-release Formulation of Hydromorphone in Healthy Volunteers

D. Stanski, M. Angst, D. Verotta, 2002, Anesthesiology.

A mechanistic model for the sex-specific response to nalbuphine and naloxone in postoperative pain

J. Levine, D. Verotta, R. Gear, 2008, Journal of Pharmacokinetics and Pharmacodynamics.

Simultaneous modeling of pharmacokinetics and pharmacodynamics: an improved algorithm

Lewis B. Sheiner, D. Verotta, L. Sheiner, 1987, Comput. Appl. Biosci..

Reversal of neuromuscular blockade in humans by neostigmine and edrophonium: A mathematical model

L. Sheiner, Ronald D. Miller, D. Verotta, 1991, Journal of Pharmacokinetics and Biopharmaceutics.

A descriptive tool to characterize nonlinear kinetics, with applications to meperidine and lidocaine.

R. Upton, D. Verotta, J. Gries, 1996, Journal of pharmaceutical sciences.

Pharmacodynamic modeling of the EEG effects of ketamine and its enantiomers in man

Paul F. White, Jürgen Schüttler, L. B. Sheiner, 1987, Journal of Pharmacokinetics and Biopharmaceutics.

Population analyses of sustained‐release verapamil in patients: Effects of sex, race, and smoking

S. Gupta, D. Verotta, N. Modi, 2003, Clinical pharmacology and therapeutics.

Volterra Series in Pharmacokinetics and Pharmacodynamics

Davide Verotta, D. Verotta, 2003, Journal of Pharmacokinetics and Pharmacodynamics.

Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations

R. Eastell, R. Jorde, M. Holick, 2018, The Journal of clinical endocrinology and metabolism.

Sample Size Computations for PK/PD Population Models

Dongwoo Kang, Davide Verotta, D. Verotta, 2005, Journal of Pharmacokinetics and Pharmacodynamics.

A sample size computation method for non‐linear mixed effects models with applications to pharmacokinetics models

Dongwoo Kang, Davide Verotta, D. Verotta, 2004, Statistics in medicine.

A predictive model for exemestane pharmacokinetics/pharmacodynamics incorporating the effect of food and formulation.

M. Rocchetti, I. Poggesi, D. Verotta, 2005, British journal of clinical pharmacology.

New In Vitro Model To Study the Effect of Human Simulated Antibiotic Concentrations on Bacterial Biofilms

A. Spormann, D. Verotta, Liusheng Huang, 2015, Antimicrobial Agents and Chemotherapy.

CSF quinolinic acid levels are determined by local HIV infection: cross-sectional analysis and modelling of dynamics following antiretroviral therapy.

R. Price, M. Heyes, D. Verotta, 2004, Brain : a journal of neurology.

Improving Data Reliability Using a Non-Compliance Detection Method versus Using Pharmacokinetic Criteria

Lewis B. Sheiner, Davide Verotta, Terrence F. Blaschke, 2007, Journal of Pharmacokinetics and Pharmacodynamics.

Two constrained deconvolution methods using spline functions

Davide Verotta, D. Verotta, 1993, Journal of Pharmacokinetics and Biopharmaceutics.

Reversible Jump Markov Chain Monte Carlo for Deconvolution

D. Verotta, D. Kang, 2007, Journal of Pharmacokinetics and Pharmacodynamics.

Chronopharmacokinetics of nicotine

D Verotta, D. Verotta, J M Gries, 1996, Clinical pharmacology and therapeutics.

Mathematical Modeling of Biofilm Structures Using COMSTAT Data

Alfred Spormann, Davide Verotta, Janus Haagensen, 2017, Comput. Math. Methods Medicine.

Nasal mucosal versus gastrointestinal absorption of nasally administered cocaine

R. Jones, N. Benowitz, K. Fattinger, 2000, European Journal of Clinical Pharmacology.

Modeling a bivariate control system: LH and testosterone response to the GnRH antagonist antide.

L B Sheiner, D Verotta, A. Munafo, 1996, The American journal of physiology.

A Non-linear Mixed Effect Dynamic Model Incorporating Prior Exposure and Adherence to Treatment to Describe Long-term Therapy Outcome in HIV-patients

Davide Verotta, D. Verotta, Line Labbé, 2006, Journal of Pharmacokinetics and Pharmacodynamics.

Selecting Reliable Pharmacokinetic Data for Explanatory Analyses of Clinical Trials in the Presence of Possible Noncompliance

L. Sheiner, D. Verotta, Jianfeng Lu, 2001, Journal of Pharmacokinetics and Pharmacodynamics.

1 Fractional Kinetics Compartmental Models

D. Verotta, 2018 .

Fractional dynamics pharmacokinetics–pharmacodynamic models

Davide Verotta, D. Verotta, 2010, Journal of Pharmacokinetics and Pharmacodynamics.

Fractional compartmental models and multi-term Mittag–Leffler response functions

Davide Verotta, D. Verotta, 2010, Journal of Pharmacokinetics and Pharmacodynamics.

Title Fractional dynamics pharmacokinetics-pharmacodynamic models

D. Verotta, 2010 .

Semiparametric models for antagonistic drug interactions.

L B Sheiner, I F Troconiz, D Verotta, 1994, Journal of applied physiology.

An inequality-constrained least-squares deconvolution method

Davide Verotta, D. Verotta, 1989, Journal of Pharmacokinetics and Biopharmaceutics.

Characterizing the Variability of System Kernel and Input Estimates

D. Verotta, 1998, Annals of Biomedical Engineering.

Pharmacodynamic modeling of verapamil effects under steady-state and nonsteady-state conditions.

L. Sheiner, D. Verotta, J. Schwartz, 1989, The Journal of pharmacology and experimental therapeutics.

A semiparametric approach to physiological flow models

L. Sheiner, W. Ebling, D. Stanski, 1989, Journal of Pharmacokinetics and Biopharmaceutics.

Mechanistic Pharmacokinetic and Pharmacodynamic Modeling of CHF3381 (2-[(2,3-Dihydro-1H-inden-2-yl)amino]acetamide Monohydrochloride), a Novel N-Methyl-d-aspartate Antagonist and Monoamine Oxidase-A Inhibitor in Healthy Subjects

P. Dostert, C. Csajka, B. Imbimbo, 2005, Journal of Pharmacology and Experimental Therapeutics.

Effects of interleukin 3 and interleukin 6 on platelet recovery in mice treated with 5-fluorouracil.

D. Verotta, R. Hill, J. Levin, 1992, Experimental Hematology.

A Semiparametric Method for Describing Noisy Population Pharmacokinetic Data

Lewis B. Sheiner, Davide Verotta, Terrence F. Blaschke, 1997, Journal of Pharmacokinetics and Biopharmaceutics.

A semiparametric deconvolution model to establish in vivo-in vitro correlation applied to OROS oxybutynin.

D. Verotta, S. Gupta, M. Pitsiu, 2001, Journal of pharmaceutical sciences.

Age and autonomic effects on interrelationships between lung volume and heart rate.

D Verotta, D. Verotta, N. Craft, 1996, The American journal of physiology.

A general solution for nonparametric control of a linear system using computer-controlled infusion pumps

D. Verotta, D. Verotta, 1999, IEEE Transactions on Biomedical Engineering.

Covariate Modeling in Population PK/PD Models: an Open Problem

Davide Verotta, D. Verotta, 2012 .

Semiparametric approach to pharmacokinetic-pharmacodynamic data.

L B Sheiner, S L Beal, D Verotta, 1989, The American journal of physiology.

Concepts, properties, and applications of linear systems to describe distribution, identify input, and control endogenous substances and drugs in biological systems.

D Verotta, D. Verotta, 1996, Critical reviews in biomedical engineering.

Population analyses of amlodipine in patients living in the community and patients living in nursing homes

D. Verotta, D. Kang, J. Schwartz, 2006, Clinical pharmacology and therapeutics.

Use of a Pharmacokinetic/Pharmacodynamic Model to Design an Optimal Dose Input Profile

Lewis B. Sheiner, Davide Verotta, Kyungsoo Park, 1998, Journal of Pharmacokinetics and Biopharmaceutics.

A pooled analysis of CD4 response to zidovudine and zalcitabine treatment in patients with AIDS and AIDS‐related complex

L. Sheiner, M. Jacobson, D. Verotta, 1997, Clinical pharmacology and therapeutics.

A nonparametric subject-specific population method for deconvolution: I. Description, internal validation, and real data examples

Davide Verotta, K. Fattinger, D. Verotta, 1995, Journal of Pharmacokinetics and Biopharmaceutics.

Nevirapine pharmacokinetics and risk of rash and hepatitis among HIV-infected sub-Saharan African women

M. Hughes, S. Lockman, J. Currier, 2012, AIDS.

Aging effects on stereoselective pharmacokinetics and pharmacodynamics of verapamil.

D. Verotta, J. Schwartz, I. Trocóniz, 1993, The Journal of pharmacology and experimental therapeutics.

Pharmacokinetic/Pharmacodynamic Models and Methods

L. Sheiner, D. Verotta, 1993 .