H. Ishikura

T. Egawa, H. Ishikura, Yoshihiko Nakamura, 2017, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

Japan COVID-19 Task Force: a nation-wide consortium to elucidate host genetics of COVID-19 pandemic in Japan

M. Kanai, Y. Okada, S. Fuke, 2021, medRxiv.

Sepsis-Associated Delirium: A Narrative Review

H. Kamijo, H. Ishikura, Hiroyuki Ohbe, 2023, Journal of clinical medicine.

Phosphorylation of ERK in the spinal dorsal horn following pancreatic pronociceptive stimuli with proteinase‐activated receptor‐2 agonists and hydrogen sulfide in rats: Evidence for involvement of distinct mechanisms

H. Ishikura, A. Kawabata, H. Nishikawa, 2010, Journal of neuroscience research.

Activation of neutrophil function by recombinant human granulocyte colony-stimulating factor improves the survival of rats with peritonitis

N. Takeyama, H. Ishikura, K. Yamagami, 1996, Surgery Today.

Nitrite/nitrate (NOx) levels and hemodynamics during septic shock

Seidai Sato, G. Wakabayashi, H. Ishikura, 2010, Surgery Today.

A CASE OF FULMINANT AMEBIC COLITIS

H. Ishikura, Takaya Tanaka, A. Hirakawa, 2003 .

Usefulness of presepsin in the diagnosis of sepsis in a multicenter prospective study

H. Ishikura, Tsuyoshi Nojima, G. Takahashi, 2012, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

[Posttraumatic pseudoaneurysm of the middle meningeal artery: a case report].

H. Ishikura, K. Sako, E. Takeuchi, 1995, No shinkei geka. Neurological surgery.

Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis

M. Nishibori, Keyue Liu, H. Ishikura, 2017, Journal of Neuroimmune Pharmacology.

Polymyxin B Hemoperfusion in Septic Shock: Finding the Right Patients by Analyzing Real-World Big Data

H. Ishikura, 2022, Blood Purification.

The clinical usefulness of extravascular lung water and pulmonary vascular permeability index to diagnose and characterize pulmonary edema: a prospective multicenter study on the quantitative differential diagnostic definition for acute lung injury/acute respiratory distress syndrome

S. Kushimoto, K. Okuchi, T. Tagami, 2012, Critical Care.

HMGB1 and its membrane receptors as therapeutic targets in an intravesical substance P-induced bladder pain syndrome mouse model.

M. Nishibori, H. Ishikura, H. Wake, 2020, Journal of pharmacological sciences.

Enhanced effect of recombinant human soluble thrombomodulin by ultrasound irradiation in acute liver failure

K. Tachibana, H. Ishikura, Yoshihiko Nakamura, 2020, Scientific Reports.

Involvement of high mobility group box 1 in the development and maintenance of chemotherapy-induced peripheral neuropathy in rats.

M. Nishibori, Keyue Liu, H. Ishikura, 2016, Toxicology.

Adrenal myelolipoma: A case report and review of the literature

N. Takeyama, N. Matsuo, D. Takagi, 1989, The Japanese journal of surgery.

Comparison of accuracy of presepsin and procalcitonin concentrations in diagnosing sepsis in patients with and without acute kidney injury.

H. Ishikura, Yoshihiko Nakamura, F. Kiyomi, 2019, Clinica chimica acta; international journal of clinical chemistry.

Limitations of global end-diastolic volume index as a parameter of cardiac preload in the early phase of severe sepsis: a subgroup analysis of a multicenter, prospective observational study

S. Kushimoto, K. Okuchi, T. Tagami, 2013, Journal of Intensive Care.

Clinical course and outcome of disseminated intravascular coagulation diagnosed by Japanese Association for Acute Medicine criteria

S. Kushimoto, D. Saitoh, H. Ishikura, 2008, Thrombosis and Haemostasis.

A case of airway obstruction and cardiac compression as a complication of esophageal achalasia

H. Ishikura, T. Sugimura, A. Saka, 2011 .

Adsorption of Nafamostat Mesilate on AN69ST Membranes: A Single‐Center Retrospective and In Vitro Study

H. Ishikura, Yoshihiko Nakamura, S. Hara, 2017, Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.

Usefulness of plasminogen activator inhibitor-1 as a predictive marker of mortality in sepsis

H. Ishikura, Yoshihiko Nakamura, T. Kitamura, 2017, Journal of Intensive Care.

Early recognition of sepsis-induced coagulopathy using the C2PAC index: a ratio of soluble type C lectin-like receptor 2 (sCLEC-2) level and platelet count

H. Ishikura, Yoshihiko Nakamura, K. Suzuki-Inoue, 2022, Platelets.

Usefulness of Early Diagnosis of Sepsis-Induced Coagulopathy by Measuring Novel Platelet Activation Marker Soluble Type C Lectin-Like Receptor 2 (CLEC-2)

H. Ishikura, Yoshihiko Nakamura, K. Suzuki-Inoue, 2021 .

Presepsin as a powerful monitoring tool for the prognosis and treatment of sepsis: a multicenter prospective study.

H. Ishikura, Tsuyoshi Nojima, G. Takahashi, 2014, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

Post-marketing surveillance data of thrombomodulin alfa: sub-analysis in patients with sepsis-induced disseminated intravascular coagulation

R. Tsujita, J. Mimuro, Y. Sakata, 2014, Journal of Intensive Care.

Vancomycin Bactericidal Activity as a Predictor of 30-Day Mortality in Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia

H. Ishikura, A. Matsunaga, B. Tsuji, 2011, Antimicrobial Agents and Chemotherapy.

Presence of both heterogeneous vancomycin-intermediate resistance and β-lactam antibiotic-induced vancomycin resistance phenotypes is associated with the outcome in methicillin-resistant Staphylococcus aureus bloodstream infection

T. Ishikawa, H. Ishikura, A. Matsunaga, 2013, Scandinavian journal of infectious diseases.

36th International Symposium on Intensive Care and Emergency Medicine

R. Pizov, E. Mancini, G. Van den Berghe, 2016, Critical Care.

Rhodanese, but not cystathionine-gamma-lyase, is associated with dextran sulfate sodium-evoked colitis in mice: a sign of impaired colonic sulfide detoxification?

H. Ishikura, A. Kawabata, F. Sekiguchi, 2009, Toxicology.

The SIRS criteria have better performance for predicting infection than qSOFA scores in the emergency department

T. Hifumi, S. Kushimoto, S. Fujishima, 2020, Scientific Reports.

Variations in infection sites and mortality rates among patients in intensive care units with severe sepsis and septic shock in Japan

H. Okudera, Kenichi Yoshida, N. Takeyama, 2019, Journal of Intensive Care.

Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H3

S. Yamada, Takashi Ito, I. Maruyama, 2018, Journal of Intensive Care.

Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study

H. Okudera, N. Takeyama, T. Hifumi, 2018, Critical Care.

Coagulopathy of lower gastrointestinal perforation in the elderly

H. Ishikura, T. Kitamura, Y. Irie, 2019, Journal of the Japanese Society of Intensive Care Medicine.

Natural history of disseminated intravascular coagulation diagnosed based on the newly established diagnostic criteria for critically ill patients: Results of a multicenter, prospective survey*

S. Kushimoto, D. Saitoh, H. Ishikura, 2008, Critical care medicine.

Presepsin in the prognosis of infectious diseases and diagnosis of infectious disseminated intravascular coagulation: A prospective, multicentre, observational study

H. Ishikura, G. Takahashi, S. Endo, 2015, European journal of anaesthesiology.

Characteristics of Coagulation/Fibrinolysis Abnormalities in Serious Corona Virus Disease 2019 (COVID-19) Patients Complicated with Stroke: Case Series

H. Ishikura, Yoshihiko Nakamura, K. Takayama, 2020 .

Characteristics of coagulation/fibrinolysis abnormalities in severe novel coronavirus disease 2019 (COVID-19) patients —Case series—

H. Ishikura, Yoshihiko Nakamura, Y. Irie, 2020 .

Recombinant human soluble thrombomodulin ameliorates cerebral ischemic injury through a high-mobility group box 1 inhibitory mechanism without hemorrhagic complications in mice

Tomomitsu Satho, H. Ishikura, Yoshihiko Nakamura, 2016, Journal of the Neurological Sciences.

A randomized, controlled, multicenter trial of the effects of antithrombin on disseminated intravascular coagulation in patients with sepsis

S. Kushimoto, Y. Inoue, D. Saitoh, 2013, Critical Care.

A case of simultaneous idiopathic spinal epidural hematoma and spinal subdural hematoma in gravidas

H. Ishikura, T. Sugimura, T. Kitamura, 2010 .

Disseminated intravascular coagulation (DIC) diagnosed based on the Japanese Association for Acute Medicine criteria is a dependent continuum to overt DIC in patients with sepsis.

S. Kushimoto, D. Saitoh, H. Ishikura, 2009, Thrombosis research.

Treatment Results of Combined Endovascular Coil Embolization Ruptured Anterior Communicating Artery Aneurysm and Endoscopic Surgery for Intracerebral and/or Intraventricular Hematoma

H. Ishikura, Tooru Inoue, K. Fukuda, 2014 .

Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis

H. Okudera, Kenichi Yoshida, N. Takeyama, 2020, Scientific Reports.

Potential use of procalcitonin as biomarker for bacterial sepsis in patients with or without acute kidney injury.

H. Ishikura, Yoshihiko Nakamura, D. Ohta, 2015, Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.

New diagnostic strategy for sepsis-induced disseminated intravascular coagulation: a prospective single-center observational study

H. Ishikura, Yoshihiko Nakamura, Y. Irie, 2014, Critical Care.

Usefulness of presepsin in the diagnosis of sepsis in patients with or without acute kidney injury

H. Ishikura, Yoshihiko Nakamura, Y. Nakamura, 2014, BMC Anesthesiology.

Limaprost reduces motor disturbances by increasing the production of insulin-like growth factor I in rats subjected to spinal cord injury.

H. Ishikura, N. Harada, K. Okajima, 2010, Translational research : the journal of laboratory and clinical medicine.

Relationship between serum zinc level and sepsis-induced coagulopathy

H. Ishikura, Ryo Hokama, Y. Irie, 2021, International Journal of Hematology.

Outcomes in patients with infections and augmented renal clearance: A multicenter retrospective study

H. Ishikura, Ryo Hokama, K. Hoshino, 2018, PloS one.

Augmented renal clearance in Japanese intensive care unit patients: a prospective study

H. Ishikura, K. Hoshino, T. Nishida, 2016, Journal of Intensive Care.

Global end-diastolic volume is an important contributor to increased extravascular lung water in patients with acute lung injury and acuterespiratory distress syndrome: a multicenter observational study

S. Kushimoto, K. Okuchi, T. Tagami, 2014, Journal of Intensive Care.

A CASE OF ALCOHOL INDUCED RHABDOMYOLYSIS

N. Takeyama, H. Ishikura, T. Arai, 1992 .

Impact of respiratory bacterial infections on mortality in Japanese patients with COVID-19: a retrospective cohort study

S. Miyano, S. Imoto, S. Ogawa, 2023, BMC Pulmonary Medicine.

Risk modifiers of acute respiratory distress syndrome in patients with non-pulmonary sepsis: a retrospective analysis of the FORECAST study

H. Okudera, N. Takeyama, T. Hifumi, 2020, Journal of Intensive Care.

The current status of the therapeutic approach for severe sepsis in Japan and its comparison to the international guidelines

H. Ishikura, T. Iba, T. Mayumi, 2009 .

Intravenous immunoglobulin improves sepsis-induced coagulopathy: A retrospective, single-center observational study.

H. Ishikura, Yoshihiko Nakamura, D. Ohta, 2015, Journal of critical care.

Characteristics and outcomes of bacteremia among ICU-admitted patients with severe sepsis

H. Okudera, Kenichi Yoshida, N. Takeyama, 2020, Scientific Reports.

Macrophage-derived HMGB1 as a Pain Mediator in the Early Stage of Acute Pancreatitis in Mice: Targeting RAGE and CXCL12/CXCR4 Axis

M. Nishibori, Keyue Liu, H. Ishikura, 2017, Journal of Neuroimmune Pharmacology.

Diagnostic significance of secondary bacteremia in patients with COVID-19

S. Miyano, S. Imoto, S. Ogawa, 2023, Journal of Infection and Chemotherapy.

A multicenter prospective cohort study of volume management after subarachnoid hemorrhage: circulatory characteristics of pulmonary edema after subarachnoid hemorrhage.

H. Ishikura, E. Isotani, T. Matsui, 2016, Journal of neurosurgery.

Fibrinogen and base excess levels as predictive markers of the need for massive blood transfusion after blunt trauma

H. Ishikura, Yoshihiko Nakamura, K. Hoshino, 2015, Surgery Today.

The Psychological States of the Family of Suicide Attempters Admitted to the Emergency Department of Fukuoka University Hospital and the Effectiveness of Psycho-Education

H. Ishikura, N. Kawano, Yuta Yoshimura, 2015 .

Time to Initiation of Treatment with Polymyxin B Cartridge Hemoperfusion in Septic Shock Patients

N. Takeyama, H. Ishikura, H. Noguchi, 2012, Blood Purification.

Role of disseminated intravascular coagulation in severe sepsis.

H. Okudera, N. Takeyama, T. Hifumi, 2019, Thrombosis research.

Validating plasminogen activator inhibitor‐1 as a poor prognostic factor in sepsis

H. Ishikura, Y. Irie, K. Hoshino, 2020, Acute medicine & surgery.

Significance of body temperature in elderly patients with sepsis

H. Okudera, Kenichi Yoshida, N. Takeyama, 2020, Critical Care.

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

R. Pizov, E. Mancini, G. Van den Berghe, 2016, Critical Care.

Surveillance of Extended-Spectrum β-Lactamase-producing Enterobacteriaceae Carriage in a Japanese Intensive Care Unit: a Retrospective Analysis

H. Ishikura, A. Togawa, Y. Irie, 2016 .

Emerging resistance to beta-lactams in Pantoea ananatis isolated from an immunocompetent patient with bacteremia.

J. Maruyama, H. Ishikura, A. Togawa, 2022, Diagnostic microbiology and infectious disease.

Differences in coagulopathy and massive transfusion strategy based on trauma type.

H. Ishikura, Yoshihiko Nakamura, T. Kitamura, 2020, The American journal of emergency medicine.

Can Early Aggressive Administration of Fresh Frozen Plasma Improve Outcomes in Patients with Severe Blunt Trauma?—a Report by the Japanese Association for the Surgery of Trauma

S. Kushimoto, D. Saitoh, H. Yokota, 2016, Shock.

Therapeutic Dose Monitoring for Linezolid in a Patient with MRSA Pneumonia with Bacteremia in Diabetes Insipidus

H. Ishikura, Yoshihiko Nakamura, T. Takata, 2015, Infectious Diseases and Therapy.

Relationship between extravascular lung water and severity categories of acute respiratory distress syndrome by the Berlin definition.

S. Kushimoto, K. Okuchi, T. Tagami, 2013 .

Enhanced effect of recombinant human soluble thrombomodulin by ultrasound irradiation in acute liver failure

K. Tachibana, H. Ishikura, Yoshihiko Nakamura, 2020, Scientific Reports.

CG02N Analyzer Accurately Measures Fibrinogen Level in Whole Blood in the Presence of Low- or High-Dose Heparin

H. Ishikura, Y. Irie, K. Hoshino, 2023, Indian Journal of Hematology and Blood Transfusion.

Mapping the human genetic architecture of COVID-19

Mattia G. Bergomi, Christopher M. DeBoever, Matthew A. Wiles, 2021, Nature.

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

M. Kanai, Y. Okada, S. Fuke, 2023, Nature Genetics.

Potential survival benefit of polymyxin B hemoperfusion in patients with septic shock: a propensity-matched cohort study

Tsuyoshi Nakashima, H. Ishikura, N. Saito, 2017, Critical Care.

A second update on mapping the human genetic architecture of COVID-19

M. A. Hakim Newton, Jack D. Sanders, Jonathan H. Morgan, 2022, Nature.

Association between low body mass index and increased 28-day mortality of severe sepsis in Japanese cohorts

H. Okudera, N. Takeyama, T. Hifumi, 2021, Scientific Reports.

Transfusion of platelets with severe trauma patients

H. Ishikura, 2016 .

Net reclassification index in comparison of prognostic value of disseminated intravascular coagulation diagnostic criteria by Japanese Society on Thrombosis and Hemostasis and International Society on Thrombosis and Haemostasis: a multicenter prospective cohort study

T. Ikezoe, H. Ishikura, M. Hayakawa, 2023, Thrombosis Journal.

Usefulness of presepsin in the diagnosis of sepsis in patients with or without acute 1 kidney injury 2

H. Ishikura, Y. Nakamura, T. Nishida, 2014 .

Comparison of the cytokine adsorption ability in continuous renal replacement therapy using polyethyleneimine-coated polyacrylonitrile (AN69ST) or polymethylmethacrylate (PMMA) hemofilters: a pilot single-center open-label randomized control trial

H. Ishikura, Yoshihiko Nakamura, F. Kiyomi, 2023, European Journal of Medical Research.

Daily combined measurement of platelet count and presepsin concentration can predict in-hospital death of patients with severe coronavirus disease 2019 (COVID-19)

H. Ishikura, T. Kitamura, K. Hoshino, 2023, International Journal of Hematology.

The SIRS criteria have better performance for predicting infection than qSOFA scores in the emergency department

T. Hifumi, S. Kushimoto, S. Fujishima, 2020, Scientific Reports.

Soluble fibrin is a useful marker for predicting extracorporeal membrane oxygenation circuit exchange because of circuit clots

H. Ishikura, Yoshihiko Nakamura, K. Hoshino, 2018, Journal of Artificial Organs.

Oral Health of COVID-19 Patients Using Extracorporeal Membrane Oxygenation: A Clinical Study of 19 Cases

H. Ishikura, Yoshihiko Nakamura, T. Takata, 2021, Journal of clinical medicine.

Soluble Fas and soluble Fas L levels in patients with acute pancreatitis.

G. Wakabayashi, H. Ishikura, K. Inada, 2000, Research communications in molecular pathology and pharmacology.

Assessment of the usefulness of presepsin (soluble CD14 subtype) in septic patients

R. Bellomo, M. Bailey, S. Finfer, 2011, Critical Care.

Assessment of the usefulness of presepsin (soluble CD14 subtype) in septic patients

H. Ishikura, T. Nishida, A. Murai, 2011, Critical Care.

High D-Dimer Levels Predict a Poor Outcome in Patients with Severe Trauma, Even with High Fibrinogen Levels on Arrival: A Multicenter Retrospective Study

S. Kushimoto, D. Saitoh, H. Ishikura, 2016, Shock.

Propensity-Score Matched Analysis of the Effectiveness of Baricitinib in Patients With Coronavirus Disease 2019 (COVID-19) Using Nationwide Real-World Data: An Observational Matched Cohort Study From the Japan COVID-19 Task Force

S. Miyano, S. Imoto, S. Ogawa, 2023, Open forum infectious diseases.

Fibrinogen level on admission is a predictor for massive transfusion in patients with severe blunt trauma: Analyses of a retrospective multicentre observational study.

S. Kushimoto, D. Saitoh, H. Ishikura, 2017, Injury.

The Association between the Oral-Gut Axis and the Outcomes of Severe COVID-19 Patients Receiving Extracorporeal Membrane Oxygenation: A Case-Control Study

H. Ishikura, T. Takata, A. Yoshino, 2022, Journal of clinical medicine.