A. Dalpiaz

L. Ferraro, C. Bignozzi, S. Beggiato, 2010, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Research Article Caffeine intake induces an alteration in human neutrophil A 2A adenosine receptors

K. Varani, F. Portaluppi, A. Dalpiaz, 2005 .

Thermodynamics of full agonist, partial agonist, and antagonist binding to wild-type and mutant adenosine A1 receptors.

P. Schofield, A. IJzerman, M. Beukers, 1998, Biochemical pharmacology.

Solid lipid microparticles for the stability enhancement of the polar drug N6-cyclopentyladenosine.

A. Dalpiaz, S. Scalia, A. Scatturin, 2008, International journal of pharmaceutics.

Quantitative determination of zolmitriptan in rat blood and cerebrospinal fluid by reversed phase HPLC-ESI-MS/MS analysis: application to in vivo preclinical pharmacokinetic study.

L. Ferraro, S. Beggiato, S. Velaga, 2012, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Potential therapeutic effects of odorants through their ectopic receptors in pigmented cells.

A. Dalpiaz, B. Pavan, A. Capuzzo, 2017, Drug discovery today.

Thermodynamic In Vitro Studies as a Method to Investigate the Pharmacodynamic Behavior of Adenosine A1 Receptor Ligands

A. IJzerman, K. Varani, A. Dalpiaz, 1999, Pharmaceutical Research.

Full and partial agonistic behaviour and thermodynamic binding parameters of adenosine A1 receptor ligands.

A. IJzerman, K. Varani, E. Fabbri, 1994, European journal of pharmacology.

Retinal pigment epithelial cells as a therapeutic tool and target against retinopathies.

A. Dalpiaz, B. Pavan, 2018, Drug discovery today.

Synthesis and in vitro stability of nucleoside 5'-phosphonate derivatives.

L. Ferraro, K. Varani, A. Dalpiaz, 2012, European journal of medicinal chemistry.

Bile salt-coating modulates the macrophage uptake of nanocores constituted by a zidovudine prodrug and enhances its nose-to-brain delivery.

L. Ferraro, S. Beggiato, E. Leo, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Application of the “in-oil nanoprecipitation” method in the encapsulation of hydrophilic drugs in PLGA nanoparticles

E. Leo, A. Dalpiaz, B. Pavan, 2016 .

Fabrication via a nonaqueous nanoprecipitation method, characterization and in vitro biological behavior of N(6)-cyclopentyladenosine-loaded nanoparticles.

E. Leo, E. Vighi, A. Dalpiaz, 2009, Journal of pharmaceutical sciences.

Binding thermodynamics of adenosine A2a receptor ligands.

K. Varani, A. Dalpiaz, G. Gilli, 1995, Biochemical pharmacology.

Targeting Systems to the Brain Obtained by Merging Prodrugs, Nanoparticles, and Nasal Administration

A. Dalpiaz, B. Pavan, Giada Botti, 2021, Pharmaceutics.

The Role of Combined Penetration Enhancers in Nasal Microspheres on In Vivo Drug Bioavailability

L. Ferraro, P. Giunchedi, E. Gavini, 2018, Pharmaceutics.

Solid microparticles based on chitosan or methyl-β-cyclodextrin: a first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate.

L. Ferraro, P. Giunchedi, E. Gavini, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Nuclear retinoic acid receptor beta as a tool in chemoprevention trials.

A. Dalpiaz, C. Biondi, B. Pavan, 2006, Current medicinal chemistry.

Studies on human neutrophil biological functions by means of formyl-peptide receptor agonists and antagonists.

A. Dalpiaz, M. E. Ferretti, C. Biondi, 2003, Current drug targets. Immune, endocrine and metabolic disorders.

Immunoheterogeneity of serum calcitonin in heroin addicts.

R. Miori, A. Dalpiaz, M. Mattarei, 1988, Drug and alcohol dependence.

Effects of Microencapsulated Ferulic Acid or Its Prodrug Methyl Ferulate on Neuroinflammation Induced by Muramyl Dipeptide

F. Spizzo, A. Dalpiaz, L. Del Bianco, 2022, International journal of environmental research and public health.

Development and characterization of biodegradable nanospheres as delivery systems of anti-ischemic adenosine derivatives.

F. Forni, M. Vandelli, E. Leo, 2005, Biomaterials.

Vitamin C and 6-amino-vitamin C conjugates of diclofenac: synthesis and evaluation.

A. Dalpiaz, S. Manfredini, C. Biondi, 2005, International journal of pharmaceutics.

Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs.

L. Ferraro, S. Tanganelli, P. Prasad, 2005, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design, synthesis and in vitro evaluation on HRPE cells of ascorbic and 6-bromoascorbic acid conjugates with neuroactive molecules.

P. Prasad, A. Dalpiaz, S. Manfredini, 2004, Bioorganic & medicinal chemistry.

Transporter-mediated effects of diclofenamic acid and its ascorbyl pro-drug in the in vivo neurotropic activity of ascorbyl nipecotic acid conjugate.

L. Ferraro, S. Tanganelli, P. Prasad, 2004, Journal of pharmaceutical sciences.

Temperature dependence of the affinity enhancement of selective adenosine A1 receptor agonism: a thermodynamic analysis.

A. IJzerman, A. Dalpiaz, B. Pavan, 2002, European journal of pharmacology.

Can thermodynamic measurements of receptor binding yield information on drug affinity and efficacy?

K. Varani, A. Dalpiaz, G. Gilli, 2000, Biochemical pharmacology.

Receptor binding thermodynamics as a tool for linking drug efficacy and affinity.

K. Varani, A. Dalpiaz, S. Gessi, 1998, Farmaco.

Binding thermodynamics at A1 and A2A adenosine receptors.

K. Varani, A. Dalpiaz, S. Gessi, 1996, Life sciences.

Conjugation of aspirin with vitamin C: uptake and stability studies

A. Dalpiaz, S. Manfredini, C. Biondi, 2009 .

Cocrystals of Nitrofurantoin: How Coformers Can Modify Its Solubility and Permeability Across Intestinal Cell Monolayers

F. Spizzo, A. Dalpiaz, M. Pastore, 2022, Crystal Growth & Design.

Synthesis and biological evaluation of pro-drugs of GW196771, a potent glycine antagonist acting at the NMDA receptor.

R. Barnaby, A. Dalpiaz, S. Manfredini, 2005, Farmaco.

Influence of chitosan glutamate on the in vivo intranasal absorption of rokitamycin from microspheres.

L. Ferraro, A. Brunetti, P. Giunchedi, 2011, Journal of pharmaceutical sciences.

Influence of secondary preparative parameters and aging effects on PLGA particle size distribution: a sedimentation field flow fractionation investigation

E. Leo, E. Vighi, C. Contado, 2012, Analytical and Bioanalytical Chemistry.

Pharmacokinetic and Permeation Studies in Rat Brain of Natural Compounds Led to Investigate Eugenol as Direct Activator of Dopamine Release in PC12 Cells

L. Ferraro, A. Dalpiaz, E. Spisni, 2023, International journal of molecular sciences.

A concerted study using binding measurements, X-ray structural data, and molecular modeling on the stereochemical features responsible for the affinity of 6-arylpyrrolo[2,1-d][1,5]benzothiazepines toward mitochondrial benzodiazepine receptors.

E. Novellino, G. Greco, G. Campiani, 1995, Journal of medicinal chemistry.

Nasal biocompatible powder of geraniol oil complexed with cyclodextrins for neurodegenerative diseases: Physicochemical characterization and in vivo evidences of nose to brain delivery.

L. Ferraro, S. Beggiato, E. Leo, 2021, Journal of controlled release : official journal of the Controlled Release Society.

Uptake in the Central Nervous System of Geraniol Oil Encapsulated in Chitosan Oleate Following Nasal and Oral Administration

L. Ferraro, S. Beggiato, M. C. Bonferoni, 2019, Pharmaceutics.

Preparation and characterization of starch/cyclodextrin bioadhesive microspheres as platform for nasal administration of Gabexate Mesylate (Foy) in allergic rhinitis treatment.

P. Ascenzi, R. Cortesi, E. Menegatti, 2004, Biomaterials.

Indomethacin co-crystals and their parent mixtures: does the intestinal barrier recognize them differently?

L. Ferraro, S. Beggiato, F. Spizzo, 2015, Molecular pharmaceutics.

Particulate formulations based on chitosan for nose-to-brain delivery of drugs. A review

P. Giunchedi, E. Gavini, A. Dalpiaz, 2016 .

Brain uptake of an anti-ischemic agent by nasal administration of microparticles.

L. Ferraro, S. Tanganelli, P. Russo, 2008, Journal of pharmaceutical sciences.

Nasal chitosan microparticles target a zidovudine prodrug to brain HIV sanctuaries.

L. Ferraro, A. Salis, P. Giunchedi, 2015, Antiviral research.

Brain uptake of a Zidovudine prodrug after nasal administration of solid lipid microparticles.

L. Ferraro, S. Beggiato, E. Leo, 2014, Molecular pharmaceutics.

Compost use in viticulture: Effect on heavy metal levels in soil and plants

F. Pinamonti, G. Stringari, G. Zorzi, 1999 .

Brain targeting of resveratrol by nasal administration of chitosan‐coated lipid microparticles

L. Ferraro, S. Beggiato, A. Dalpiaz, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Cationic liposomes as potential carriers for ocular administration of peptides with anti-herpetic activity.

R. Manservigi, R. Cortesi, E. Esposito, 2006, International journal of pharmaceutics.

Estrogen metabolites in the release of inflammatory mediators from human amnion-derived cells.

A. Dalpiaz, G. Paganetto, C. Biondi, 2011, Life sciences.

Polymeric nanomicelles based on inulin D α-tocopherol succinate for the treatment of diabetic retinopathy

D. Mandracchia, P. Giunchedi, E. Gavini, 2021 .

Adenylyl cyclases as innovative therapeutic goals.

A. Dalpiaz, C. Biondi, B. Pavan, 2009, Drug discovery today.

Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinson's disease.

L. Ferraro, S. Beggiato, E. Leo, 2020, Journal of controlled release : official journal of the Controlled Release Society.

Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activity.

L. Ferraro, S. Tanganelli, P. Prasad, 2002, Journal of medicinal chemistry.

Biochemical and pharmacological characterization of periodate-oxidized adenosine analogues at adenosine A1 receptors.

C. Martini, K. Varani, G. Chiellini, 1995, Biochimica et biophysica acta.

Zidovudine and ursodeoxycholic acid conjugation: design of a new prodrug potentially able to bypass the active efflux transport systems of the central nervous system.

S. Beggiato, A. Dalpiaz, A. Medici, 2012, Molecular pharmaceutics.

An RPE cell line as a useful in vitro model for studying retinoic acid receptor beta: expression and affinity.

A. De Luca, P. Prasad, A. Dalpiaz, 2008, Bioscience reports.

Cancer stem cells and nanomedicine: new opportunities to combat multidrug resistance?

A. Dalpiaz, G. Paganetto, B. Pavan, 2020, Drug discovery today.

Pharmacological and biochemical characterization of purified A2a adenosine receptors in human platelet membranes by [3H]‐CGS 21680 binding

K. Varani, A. Dalpiaz, S. Gessi, 1996, British journal of pharmacology.

Expression and characterization of vitamin C transporter in the human trophoblast cell line HTR-8/SVneo: effect of steroids, flavonoids and NSAIDs.

A. Dalpiaz, C. Biondi, B. Pavan, 2007, Molecular human reproduction.

Exploring the use of spray congealing to produce solid dispersions with enhanced indomethacin bioavailability: In vitro characterization and in vivo study

L. Ferraro, S. Beggiato, A. Dalpiaz, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Geraniol Pharmacokinetics, Bioavailability and Its Multiple Effects on the Liver Antioxidant and Xenobiotic-Metabolizing Enzymes

Fabio Vivarelli, Moreno Paolini, Donatella Canistro, 2018, Front. Pharmacol..

Complementary use of flow and sedimentation field-flow fractionation techniques for size characterizing biodegradable poly(lactic acid) nanospheres.

E. Leo, M. Zborowski, C. Contado, 2007, Journal of chromatography. A.

Dopamine-sensitive adenylyl cyclases in neuronal development: physiopathological and pharmacological implications.

A. Dalpiaz, G. Paganetto, B. Pavan, 2011, Drug discovery today.

Stereochemistry of serotonin receptor ligands from crystallographic data. Crystal structures of NAN-190.HBr, 1-phenylbiguanide, MDL 72222 and mianserin.HCl and selectivity criteria towards 5-HT1, 5-HT2, and 5-HT3 receptor subtypes.

A. Dalpiaz, V. Bertolasi, P. Gilli, 1996, Acta crystallographica. Section B, Structural science.

Influence of polymeric microcarriers on the in vivo intranasal uptake of an anti-migraine drug for brain targeting.

L. Ferraro, S. Beggiato, S. Velaga, 2013, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Characterization of A2A adenosine receptors in human lymphocyte membranes by [3H]‐SCH 58261 binding

E. Ongini, K. Varani, A. Dalpiaz, 1997, British journal of pharmacology.

Development and characterization of PLGA nanoparticles as delivery systems of a prodrug of zidovudine obtained by its conjugation with ursodeoxycholic acid

E. Leo, E. Vighi, C. Contado, 2014, Drug delivery.

Molecular mechanism involved in the transport of a prodrug dopamine glycosyl conjugate.

P. Prasad, A. Dalpiaz, C. Biondi, 2007, International journal of pharmaceutics.

Effect of a Fiber D-Limonene-Enriched Food Supplement on Intestinal Microbiota and Metabolic Parameters of Mice on a High-Fat Diet

S. Turroni, L. Ferraro, F. D’Amico, 2021, Pharmaceutics.

Progress in Drug Delivery to the Central Nervous System by the Prodrug Approach

A. Dalpiaz, S. Manfredini, C. Biondi, 2008, Molecules.

Nanoparticle formulation may affect the stabilization of an antiischemic prodrug.

G. Tosi, E. Leo, C. Contado, 2006, International journal of pharmaceutics.

Soil management effects on nutritional status and grapevine performance

M. Stefanini, A. Dalpiaz, F. Pinamonti, 1996 .

Odorants could elicit repair processes in melanized neuronal and skin cells

A. Dalpiaz, B. Pavan, 2017, Neural regeneration research.

Caffeine intake induces an alteration in human neutrophil A2A adenosine receptors

K. Varani, F. Portaluppi, A. Dalpiaz, 2005, Cellular and Molecular Life Sciences CMLS.

Conjugation, Prodrug, and Co-Administration Strategies in Support of Nanotechnologies to Improve the Therapeutic Efficacy of Phytochemicals in the Central Nervous System

M. C. Bonferoni, P. Giunchedi, E. Gavini, 2023, Pharmaceutics.

Prodrugs and endogenous transporters: are they suitable tools for drug targeting into the central nervous system?

A. Dalpiaz, B. Pavan, 2011, Current pharmaceutical design.

Oxcarbazepine free or loaded PLGA nanoparticles as effective intranasal approach to control epileptic seizures in rodents

L. Ferraro, G. Sancini, M. Serapide, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

A novel conjugated agent between dopamine and an A2A adenosine receptor antagonist as a potential anti-Parkinson multitarget approach.

S. Federico, G. Spalluto, B. Cacciari, 2012, Molecular pharmaceutics.

A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach.

L. Ferraro, R. Baruchello, A. Dalpiaz, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Crystal and molecular structures of two adenosine receptor ligands: 1,3-dimethylxanthine-7-riboside monohydrate (DMX-7R), a partial A1 agonist, and 9-chloro-2-(furyl)[1,2,4]triazolo[1,5-c]quinazolin-5-amine methane sulfonate (CGS 15943), a selective A2a antagonist

A. Dalpiaz, V. Bertolasi, V. Ferretti, 1997 .

Versatile Nasal Application of Cyclodextrins: Excipients and/or Actives?

L. Ferraro, M. C. Bonferoni, P. Giunchedi, 2021, Pharmaceutics.

From Physical Mixtures to Co-Crystals: How the Coformers Can Modify Solubility and Biological Activity of Carbamazepine.

Antonio Monari, Valerio Bertolasi, Valeria Ferretti, 2018, Molecular pharmaceutics.

Physicochemical stability of cabazitaxel and docetaxel solutions

S. Salvadori, A. Dalpiaz, R. Guerrini, 2014 .

Synthesis and Study of 5′-Ester Prodrugs of N6-Cyclopentyladenosine, a Selective A1 Receptor Agonist

E. Menegatti, A. Dalpiaz, S. Manfredini, 2001, Pharmaceutical Research.

Solid lipid microparticles for the stability enhancement of a dopamine prodrug.

B. Cacciari, A. Dalpiaz, S. Scalia, 2010, Journal of pharmaceutical sciences.

Conformational Aspects of Human Formyl-peptide Receptor Agonists

K. Varani, A. Dalpiaz, F. Vitali, 2003, Arzneimittelforschung.

Binding thermodynamics of serotonin to rat-brain 5-HT1A, 5HT2A and 5-HT3 receptors.

A. Dalpiaz, S. Gessi, G. Gilli, 1995, Life sciences.

Binding thermodynamics of 5-HT1A receptor ligands.

A. Dalpiaz, S. Gessi, G. Gilli, 1996, European journal of pharmacology.

Thermodynamics of 5-HT3 receptor binding discriminates agonistic from antagonistic behaviour.

A. Dalpiaz, S. Gessi, G. Gilli, 1996, European journal of pharmacology.

Drug Release from Pharmaceutical Co-Crystals: Are Therapeutic and Safety Properties of Active Pharmaceutical Substances Retained?

A. Dalpiaz, B. Pavan, V. Ferretti, 2019, Current drug delivery.

Chitosan/heparin polyelectrolyte complexes as ion-paring approach to encapsulate heparin in orally administrable SLN: In vitro evaluation

M. Montanari, E. Leo, A. Dalpiaz, 2021 .

Responses of peripheral blood mononucleated cells from non-celiac gluten sensitive patients to various cereal sources.

M. Campieri, A. Dalpiaz, E. Spisni, 2015, Food chemistry.

Indomethacin co-crystals and their parent mixtures: does the intestinal barrier recognize them differently?

L. Ferraro, S. Beggiato, F. Spizzo, 2015, Molecular pharmaceutics.

Synthesis of naringenin-betaine cocrystal by gas antisolvent technique and cell models for in vitro permeation studies

A. Dalpiaz, L. Lerin, A. Siebel, 2024, Journal of Drug Delivery Science and Technology.

A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approach.

L. Ferraro, R. Baruchello, A. Dalpiaz, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Dimeric ferulic acid conjugate as a prodrug for brain targeting after nasal administration of loaded solid lipid microparticles

S. Beggiato, M. C. Bonferoni, L. Catenacci, 2023, Expert opinion on drug delivery.

In Vitro Studies to Evaluate the Intestinal Permeation of an Ursodeoxycholic Acid-Conjugated Oligonucleotide for Duchenne Muscular Dystrophy Treatment

A. Dalpiaz, B. Pavan, E. Marchesi, 2024, Pharmaceutics.

Delivering hydrosoluble compounds through the skin: what are the chances?

P. Giunchedi, E. Gavini, A. Dalpiaz, 2023, International journal of pharmaceutics.

Supramolecular eutectogel as new oral paediatric delivery system to enhance benznidazole bioavailability.

B. Perissutti, S. Beggiato, A. Dalpiaz, 2024, International journal of pharmaceutics.

Conformational Aspects of Human Formylpeptide Receptor Antagonists

A. Dalpiaz, R. Pecoraro, A. Scatturin, 1999, Arzneimittelforschung.

Chlorogenic acid permeation across intestinal cell monolayers: Influence by circadian rhythms in the presence of other natural polyphenols and by dopaminergic neuronal-like cells

S. Beggiato, V. Bertagnolo, A. Dalpiaz, 2024, Journal of Functional Foods.