M. Koziolek

发表

Lipids in the Stomach – Implications for the Evaluation of Food Effects on Oral Drug Absorption

C. Porter, F. Carrière, M. Koziolek, 2018, Pharmaceutical Research.

Intragastric volume changes after intake of a high-caloric, high-fat standard breakfast in healthy human subjects investigated by MRI.

J. Kühn, M. Grimm, W. Weitschies, 2014, Molecular pharmaceutics.

Investigation of pH and Temperature Profiles in the GI Tract of Fasted Human Subjects Using the Intellicap(®) System.

M. Grimm, W. Weitschies, M. Koziolek, 2015, Journal of pharmaceutical sciences.

Navigating the human gastrointestinal tract for oral drug delivery: Uncharted waters and new frontiers.

Michael Grimm, Jens-Peter Kühn, Werner Weitschies, 2016, Advanced drug delivery reviews.

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

Christine M. Madla, L. Marciani, D. V. van Riet-Nales, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Comparison of In Vitro and In Vivo Results Using the GastroDuo and the Salivary Tracer Technique: Immediate Release Dosage Forms under Fasting Conditions

W. Weitschies, M. Tzvetkov, M. Wendler, 2019, Pharmaceutics.

A dynamic system for the simulation of fasting luminal pH-gradients using hydrogen carbonate buffers for dissolution testing of ionisable compounds.

W. Weitschies, M. Koziolek, G. Garbacz, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Application of In Vivo Imaging Techniques and Diagnostic Tools in Oral Drug Delivery Research

L. Marciani, H. Lennernäs, W. Weitschies, 2022, Pharmaceutics.

In vivo characterization of enTRinsic™ Drug Delivery Technology capsule after intake in fed state: A cross-validation approach using salivary tracer technique in comparison to MRI.

M. Grimm, W. Weitschies, M. Tzvetkov, 2019, Journal of controlled release : official journal of the Controlled Release Society.

In Vitro and In Vivo Test Methods for the Evaluation of Gastroretentive Dosage Forms

W. Weitschies, M. Koziolek, F. Schneider, 2019, Pharmaceutics.

Automated small-scale in vitro transfer model as screening tool for the prediction of in vivo-dissolution and precipitation of poorly solubles.

W. Weitschies, M. Koziolek, C. Wagner, 2019, International journal of pharmaceutics.

Application of an automated small-scale in vitro transfer model to predict in vivo precipitation inhibition.

W. Weitschies, M. Koziolek, C. Wagner, 2019, International journal of pharmaceutics.

Improved prediction of in vivo supersaturation and precipitation of poorly soluble weakly basic drugs using a biorelevant bicarbonate buffer in a GI transfer model.

W. Weitschies, M. Koziolek, C. Wagner, 2019, Molecular pharmaceutics.

Controlled release of acidic drugs in compendial and physiological hydrogen carbonate buffer from polymer blend-coated oral solid dosage forms.

C. Leopold, M. Koziolek, G. Garbacz, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Characterization of gastrointestinal transit and luminal conditions in pigs using a telemetric motility capsule.

Niklas J. Koehl, B. Griffin, M. Grimm, 2020, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Interindividual and intraindividual variability of fasted state gastric fluid volume and gastric emptying of water

J. Kühn, M. Grimm, W. Weitschies, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Release Characteristics of Quetiapine Fumarate Extended Release Tablets Under Biorelevant Stress Test Conditions

W. Weitschies, M. Koziolek, G. Garbacz, 2013, AAPS PharmSciTech.

Simulating the postprandial stomach: physiological considerations for dissolution and release testing.

W. Weitschies, M. Koziolek, G. Garbacz, 2013, Molecular pharmaceutics.

Application of tiny-TIM as a mechanistic tool to investigate the in vitro performance of different itraconazole formulations under physiologically relevant conditions.

M. Koziolek, A. Wahl, Kerstin A. Sauer, 2022, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design and optimization of a novel strategy for the local treatment of Helicobacter pylori infections.

M. Grimm, W. Weitschies, R. Haas, 2020, Journal of pharmaceutical sciences.

Simulating the postprandial stomach: biorelevant test methods for the estimation of intragastric drug dissolution.

W. Weitschies, M. Koziolek, G. Garbacz, 2013, Molecular pharmaceutics.

An Automated System for Monitoring and Regulating the pH of Bicarbonate Buffers

Werner Weitschies, Grzegorz Garbacz, Mirko Koziolek, 2013, AAPS PharmSciTech.

In vitro simulation of realistic gastric pressure profiles

W. Weitschies, M. Koziolek, F. Schneider, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Effect of Coadministered Water on the In Vivo Performance of Oral Formulations Containing N-Acetylcysteine: An In Vitro Approach Using the Dynamic Open Flow-Through Test Apparatus.

W. Weitschies, M. Koziolek, F. Schneider, 2017, Molecular pharmaceutics.

In vitro models for the prediction of in vivo performance of oral dosage forms: Recent progress from partnership through the IMI OrBiTo collaboration

Anette Müllertz, Filippos Kesisoglou, Christos Reppas, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Assessment of food effects during clinical development.

P. Augustijns, Z. Vinarov, M. Koziolek, 2023, International journal of pharmaceutics.

Impact of gastrointestinal tract variability on oral drug absorption and pharmacokinetics: an UNGAP review.

Clive G. Wilson, Christine M. Madla, B. Griffin, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Current challenges and future perspectives in oral absorption research: An opinion of the UNGAP network.

Clive G. Wilson, B. Griffin, P. Artursson, 2021, Advanced drug delivery reviews.

Low dose caffeine as a salivary tracer for the determination of gastric water emptying in fed and fasted state: A MRI validation study

Michael Grimm, Mahmoud Hasan, Werner Weitschies, 2018, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Impact of regional differences along the gastrointestinal tract of healthy adults on oral drug absorption: An UNGAP review.

Clive G. Wilson, M. Grimm, W. Weitschies, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Gastric Water Emptying under Fed State Clinical Trial Conditions Is as Fast as under Fasted Conditions.

Michael Grimm, Jens-Peter Kühn, Werner Weitschies, 2017, Molecular pharmaceutics.

Study of radial die-wall pressure during high speed tableting: effect of formulation variables

Gabriele Betz, Mirko Koziolek, M. Koziolek, 2012, Drug development and industrial pharmacy.

Application of biorelevant in vitro assays for the assessment and optimization of ASD-based formulations for pediatric patients.

M. Koziolek, A. Wahl, Julia T. Schiele, 2023, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Gastric Emptying and Small Bowel Water Content after Administration of Grapefruit Juice Compared to Water and Isocaloric Solutions of Glucose and Fructose: A Four-Way Crossover MRI Pilot Study in Healthy Subjects.

Michael Grimm, Jens-Peter Kühn, Werner Weitschies, 2018, Molecular pharmaceutics.

Integration of advanced methods and models to study drug absorption and related processes: An UNGAP perspective.

Clive G. Wilson, L. Aarons, P. Augustijns, 2021, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Dissolution of mesalazine modified release tablets under standard and bio‐relevant test conditions

W. Weitschies, M. Koziolek, G. Garbacz, 2015, The Journal of pharmacy and pharmacology.

Resolving the physiological conditions in bioavailability and bioequivalence studies: Comparison of fasted and fed state.

M. Grimm, W. Weitschies, M. Koziolek, 2016, European journal of pharmaceutics and biopharmaceutics.

Intragastric pH and pressure profiles after intake of the high-caloric, high-fat meal as used for food effect studies.

M. Grimm, W. Weitschies, M. Koziolek, 2015, Journal of controlled release : official journal of the Controlled Release Society.

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities.

Roelof J Bennink, Clive G. Wilson, Bart Hens, 2017, International journal of pharmaceutics.

Effect of obesity on gastrointestinal transit, pressure and pH using a wireless motility capsule.

J. Raes, G. Falony, S. Vieira-Silva, 2021, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Ingestible devices for studying the gastrointestinal physiology and their application in oral biopharmaceutics.

M. Grimm, W. Weitschies, M. Koziolek, 2021, Advanced drug delivery reviews.

Design and characterization of a novel 3D printed pressure-controlled drug delivery system.

W. Weitschies, M. Koziolek, F. Schneider, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Application of the GastroDuo to study the interplay of drug release and gastric emptying in case of immediate release Aspirin formulations.

W. Weitschies, M. Koziolek, Maximilian Sager, 2020, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

The application of the GastroDuo as an in vitro dissolution tool to simulate the gastric emptying of the postprandial stomach.

Werner Weitschies, Mirko Koziolek, W. Weitschies, 2019, Molecular pharmaceutics.

Physiological Considerations and In Vitro Strategies for Evaluating the Influence of Food on Drug Release from Extended-Release Formulations

M. Koziolek, E. Kostewicz, M. Vertzoni, 2018, AAPS PharmSciTech.

Development of a bio-relevant dissolution test device simulating mechanical aspects present in the fed stomach.

Werner Weitschies, Grzegorz Garbacz, Mirko Koziolek, 2014, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

In Vitro Biopredictive Methods: A Workshop Summary Report.

Amitava Mitra, Sandra Suarez-Sharp, Erik Sjögren, 2020, Journal of pharmaceutical sciences.

Physiological Considerations and In Vitro Strategies for Evaluating the Influence of Food on Drug Release from Extended-Release Formulations

M. Koziolek, E. Kostewicz, M. Vertzoni, 2018, AAPS PharmSciTech.

An Automated System for Monitoring and Regulating the pH of Bicarbonate Buffers

W. Weitschies, M. Koziolek, G. Garbacz, 2013, AAPS PharmSciTech.

Simulating the Postprandial Stomach: Biorelevant Test Methods for the Estimation of Intragastric Drug Dissolution

W. Weitschies, M. Koziolek, G. Garbacz, 2013 .

A novel mechanical antrum model for the prediction of the gastroretentive potential of dosage forms.

W. Weitschies, M. Koziolek, G. Garbacz, 2017, International journal of pharmaceutics.

Combined Application of MRI and the Salivary Tracer Technique to Determine the in Vivo Disintegration Time of Immediate Release Formulation Administered to Healthy, Fasted Subjects.

M. Grimm, W. Weitschies, M. Tzvetkov, 2019, Molecular pharmaceutics.

Characterization of the GI transit conditions in Beagle dogs with a telemetric motility capsule

M. Grimm, W. Weitschies, S. Blattner, 2019, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Release Characteristics of Quetiapine Fumarate Extended Release Tablets Under Biorelevant Stress Test Conditions

W. Weitschies, M. Koziolek, G. Garbacz, 2014, AAPS PharmSciTech.

Challenges in Permeability Assessment for Oral Drug Product Development

J. Polli, W. Weitschies, P. Augustijns, 2023, Pharmaceutics.

Gastric Water Emptying under Fed State Clinical Trial Conditions Is as Fast as under Fasted Conditions.

J. Kühn, M. Grimm, W. Weitschies, 2017, Molecular pharmaceutics.

The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.

Christine M. Madla, L. Marciani, D. V. van Riet-Nales, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Mucin-Protected Caco-2 Assay to Study Drug Permeation in the Presence of Complex Biorelevant Media

M. Mezler, M. Koziolek, Dong Ye, 2022, Pharmaceutics.

Prolongation of the gastric residence time of caffeine after administration in fed state: Comparison of effervescent granules with an extended release tablet.

M. Grimm, M. Koziolek, M. Kromrey, 2024, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Comparing the gastric emptying of 240 mL and 20 mL water by MRI and caffeine salivary tracer technique.

M. Grimm, W. Weitschies, M. Tzvetkov, 2023, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Influence of Postprandial Intragastric Pressures on Drug Release from Gastroretentive Dosage Forms

W. Weitschies, M. Koziolek, Melanie Hoppe, 2018, AAPS PharmSciTech.