S. Mason

发表

Elongation factor NusG interacts with termination factor rho to regulate termination and antitermination of transcription.

Joyce Li, J. Greenblatt, J. Li, 1993, Genes & development.

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Malina A. Bakowski, Chunlong Ma, Jun Wang, 2021, Nature Communications.

Preclinical Profile of BI 224436, a Novel HIV-1 Non-Catalytic-Site Integrase Inhibitor

J. Duan, M. Garneau, P. Bonneau, 2014, Antimicrobial Agents and Chemotherapy.

Novel inhibitor binding site discovery on HIV-1 capsid N-terminal domain by NMR and X-ray crystallography.

J. Mercier, J. Rancourt, S. Titolo, 2013, ACS chemical biology.

Inhibition of HIV-1 capsid assembly: optimization of the antiviral potency by site selective modifications at N1, C2 and C16 of a 5-(5-furan-2-yl-pyrazol-1-yl)-1H-benzimidazole scaffold.

J. Duan, O. Hucke, M. Garneau, 2012, Bioorganic & medicinal chemistry letters.

An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19

K. Gajiwala, A. Kalgutkar, P. Verhoest, 2021, Science.

RNA polymerase I transcription termination: similar mechanisms are employed by yeast and mammals.

I. Grummt, S. Mason, M. Wallisch, 1997, Journal of molecular biology.

Identification of a transcript release activity acting on ternary transcription complexes containing murine RNA polymerase I

I. Grummt, S. Mason, E. Sander, 1997, The EMBO journal.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 1: addressing configurational instability through scaffold modification.

O. Hucke, P. Bonneau, S. Morin, 2013, Bioorganic & medicinal chemistry letters.

The amino-terminal domain of the transcription termination factor TTF-I causes protein oligomerization and inhibition of DNA binding.

I. Grummt, S. Mason, E. Sander, 1996, Nucleic acids research.

Minimizing the Contribution of Enterohepatic Recirculation to Clearance in Rat for the NCINI Class of Inhibitors of HIV.

J. Duan, M. Garneau, C. Yoakim, 2014, ACS medicinal chemistry letters.

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly.

O. Hucke, P. Bonneau, C. Yoakim, 2011, Bioorganic & medicinal chemistry letters.

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

Jean-François Mercier, Wesley I. Sundquist, Stephen W. Mason, 2013, Antimicrobial Agents and Chemotherapy.

Discovery and structural characterization of a new inhibitor series of HIV-1 nucleocapsid function: NMR solution structure determination of a ternary complex involving a 2:1 inhibitor/NC stoichiometry.

O. Hucke, P. Bonneau, S. Titolo, 2013, Journal of molecular biology.

Optimization of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of HIV capsid assembly inhibitors 2: structure-activity relationships (SAR) of the C3-phenyl moiety.

J. Duan, O. Hucke, M. Garneau, 2013, Bioorganic & medicinal chemistry letters.

Monitoring Binding of HIV‐1 Capsid Assembly Inhibitors Using 19F Ligand‐and 15N Protein‐Based NMR and X‐ray Crystallography: Early Hit Validation of a Benzodiazepine Series

Jean-François Mercier, Yves Bousquet, J. Mercier, 2013, ChemMedChem.

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

Wesley I. Sundquist, Stephen W. Mason, W. Sundquist, 2012, Journal of Virology.

Cloning and functional characterization of PTRF, a novel protein which induces dissociation of paused ternary transcription complexes

U. Hoffmann‐Rohrer, I. Grummt, S. Mason, 1998, The EMBO journal.

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1.

Araz Jakalian, Sébastien Morin, Yves Bousquet, 2014, ACS medicinal chemistry letters.

Polyadenylation-dependent screening assay for respiratory syncytial virus RNA transcriptase activity and identification of an inhibitor.

B. Simoneau, S. Mason, M. Liuzzi, 2004, Nucleic acids research.

Inhibitors of Respiratory Syncytial Virus Replication Target Cotranscriptional mRNA Guanylylation by Viral RNA-Dependent RNA Polymerase

J. Rancourt, M. Massariol, S. Landry, 2005, Journal of Virology.

Aligning Potency and Pharmacokinetic Properties for Pyridine-Based NCINIs.

J. Duan, M. Garneau, P. Bonneau, 2016, ACS medicinal chemistry letters.

Transcriptional antitermination

J. Greenblatt, J. Nodwell, S. Mason, 1993, Nature.

Host factor requirements for processive antitermination of transcription and suppression of pausing by the N protein of bacteriophage lambda.

J. Greenblatt, J. Li, S. Mason, 1992, The Journal of biological chemistry.

Assembly of transcription elongation complexes containing the N protein of phage lambda and the Escherichia coli elongation factors NusA, NusB, NusG, and S10.

J. Greenblatt, S. Mason, 1991, Genes & development.

Direct interaction between two Escherichia coli transcription antitermination factors, NusB and ribosomal protein S10.

Joyce Li, J. Greenblatt, J. Li, 1992, Journal of molecular biology.

Interaction between Human Respiratory Syncytial Virus (RSV) M2-1 and P Proteins Is Required for Reconstitution of M2-1-Dependent RSV Minigenome Activity

S. Mason, M. Liuzzi, Erika Åberg, 2003, Journal of Virology.

A novel inhibitor-binding site on the HIV-1 capsid N-terminal domain leads to improved crystallization via compound-mediated dimerization.

P. Bonneau, S. Titolo, A. Faucher, 2013, Acta crystallographica. Section D, Biological crystallography.

Transcriptase Inhibitor Series ReverseNovel HIV-1 Nucleotide-Competing Identification and Characterization of a

A. Pelletier, L. Bourgon, S. Mason, 2013 .

Discovery of Novel Small-Molecule HIV-1 Replication Inhibitors That Stabilize Capsid Complexes

W. Sundquist, J. Mercier, C. Aiken, 2013, Antimicrobial Agents and Chemotherapy.