L. R. Hoth

发表

Spontaneous alpha-N-6-phosphogluconoylation of a "His tag" in Escherichia coli: the cause of extra mass of 258 or 178 Da in fusion proteins.

P. Lemotte, K. Geoghegan, H. Dixon, 1999, Analytical biochemistry.

Identification, Characterization, and Crystal Structure of the Omega Class Glutathione Transferases*

G Chelvanayagam, G. Chelvanayagam, D. Danley, 2000, The Journal of Biological Chemistry.

Crystal structures of interleukin 17A and its complex with IL-17 receptor A

Xi Song, L. R. Hoth, E. Marr, 2013, Nature Communications.

Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists

Li Xing, Guoyun Bai, Atli Thorarensen, 2016, Scientific Reports.

Kinetic analysis of estrogen receptor/ligand interactions

Rebecca L Rich, David G Myszka, Preston Hensley, 2002, Proceedings of the National Academy of Sciences of the United States of America.

The 2.0 Å crystal structure of the ERα ligand‐binding domain complexed with lasofoxifene

M. Ammirati, P. Lemotte, D. Danley, 2007, Protein Science.

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

R. Kurumbail, M. Harris, Hong Wang, 2014, Structure.

Escherichia coli expression, purification and characterization of functional full-length recombinant alpha2beta2gamma3 heterotrimeric complex of human AMP-activated protein kinase.

R. Kurumbail, M. Harris, K. Geoghegan, 2010, Protein expression and purification.

Expression and protein chemistry yielding crystallization of the catalytic domain of ADAM17 complexed with a hydroxamate inhibitor.

I. Wang, K. Geoghegan, L. R. Hoth, 2007, Protein expression and purification.

Probing the enzyme kinetics, allosteric modulation and activation of α1- and α2-subunit-containing AMP-activated protein kinase (AMPK) heterotrimeric complexes by pharmacological and physiological activators

R. Kurumbail, L. R. Hoth, P. Sahasrabudhe, 2015, The Biochemical journal.

Development of a high-throughput crystal structure-determination platform for JAK1 using a novel metal-chelator soaking system.

R. Kurumbail, K. Geoghegan, L. R. Hoth, 2016, Acta crystallographica. Section F, Structural biology communications.

Expression and functional characterization of human lysosomal acid lipase gene (LIPA) mutation responsible for cholesteryl ester storage disease (CESD) phenotype.

R. Kurumbail, L. R. Hoth, N. Caspers, 2015, Protein expression and purification.

Cyclization of N-terminal S-carbamoylmethylcysteine causing loss of 17 Da from peptides and extra peaks in peptide maps.

J. Boyd, K. Geoghegan, L. R. Hoth, 2002, Journal of proteome research.

Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue.

A. Gopalsamy, E. Hett, L. R. Hoth, 2017, ACS chemical biology.

Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides.

Jeffrey B. Sperry, Hua Zhou, L. R. Hoth, 2018, Organic letters.

Synthesis and biological activity of selective pipecolic acid-based TNF-alpha converting enzyme (TACE) inhibitors.

Dennis E Danley, D. Danley, G. Schulte, 2002, Bioorganic & medicinal chemistry letters.

Crystal structure of cholesteryl ester transfer protein reveals a long tunnel and four bound lipid molecules

Ing-Kae Wang, Xiayang Qiu, Dennis E Danley, 2007, Nature Structural &Molecular Biology.

Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies

M. Ehlers, D. Krainc, P. Saftig, 2017, Nature Communications.

Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia

Xiayang Qiu, Dennis E Danley, S. Shenolikar, 2007, Nature Structural &Molecular Biology.

Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1β Posttranslational Processing*

C. Gabel, K. Geoghegan, P. Rosner, 2003, The Journal of Biological Chemistry.

A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.

A. Mathiowetz, J. Fortin, D. Hepworth, 2014, Nature chemical biology.

Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing.

C. Gabel, K. Geoghegan, P. Rosner, 2003, The Journal of biological chemistry.

Crystal structure of human lysosomal acid lipase and its implications in cholesteryl ester storage disease[S]

R. Kurumbail, Adam G Schwaid, L. R. Hoth, 2020, Journal of Lipid Research.

Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line.

Xi Song, Xidong Feng, K. Geoghegan, 2013, Protein expression and purification.

Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry.

Scott A. Busby, M. J. Chalmers, R. Kurumbail, 2013, Structure.

Structural basis for AMPK activation: natural and synthetic ligands regulate kinase activity from opposite poles by different molecular mechanisms.

R. Kurumbail, M. Harris, Hong Wang, 2014, Structure.

Description of additional supplementary files

William W. Greenwald, K. Frazer, Siddarth Selvaraj, 2017 .

Chemical and biochemical issues related to X-ray crystallography of the ligand-binding domain of estrogen receptor alpha.

L. R. Hoth, Steven Wayne Goldstein, Jon Bordner, 2001, Bioconjugate chemistry.

Unexpected mucin-type O-glycosylation and host-specific N-glycosylation of human recombinant interleukin-17A expressed in a human kidney cell line.

K. Geoghegan, L. R. Hoth, D. Luxenberg, 2013, Protein expression and purification.