R. Gonsky

发表

Down syndrome phenotypes: the consequences of chromosomal imbalance.

C. Disteche, X. Chen, J. Korenberg, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells.

S. Targan, R. Gonsky, R. Deem, 2013, Cytokine.

A Distal Region in the Interferon-γ Gene Is a Site of Epigenetic Remodeling and Transcriptional Regulation by Interleukin-2*

S. Targan, W. Leonard, J. O’Shea, 2004, Journal of Biological Chemistry.

Distinct Methylation of IFNG in the Gut.

S. Targan, R. Gonsky, R. Deem, 2009, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Involvement of protein kinase Cepsilon (PKCepsilon) in thyroid cell death. A truncated chimeric PKCepsilon cloned from a thyroid cancer cell line protects thyroid cells from apoptosis.

X. Chen, J. Korenberg, J. Fagin, 1999, The Journal of biological chemistry.

Activation of the CD2 pathway in lamina propria T cells up-regulates functionally active AP-1 binding to the IL-2 promoter, resulting in messenger RNA transcription and IL-2 secretion.

S. Targan, C. Hughes, R. Gonsky, 1998, Journal of immunology.

Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo

S. Targan, K. Michelsen, R. Gonsky, 2018, Scientific Reports.

Transforming DNA sequences present in human prolactin-secreting pituitary tumors.

J. Fagin, S. Melmed, R. Gonsky, 1991, Molecular endocrinology.

Mucosa-Specific Targets for Regulation of IFN-γ Expression: Lamina Propria T Cells Use Different cis-Elements than Peripheral Blood T Cells to Regulate Transactivation of IFN-γ Expression1

S. Targan, H. Young, R. Gonsky, 2000, The Journal of Immunology.

Mucosa-specific targets for regulation of IFN-gamma expression: lamina propria T cells use different cis-elements than peripheral blood T cells to regulate transactivation of IFN-gamma expression.

S. Targan, H. Young, R. Gonsky, 2000, Journal of immunology.

Enhancer Role of STAT5 in CD2 Activation of IFN-γ Gene Expression1

S. Targan, H. Young, R. Gonsky, 2004, The Journal of Immunology.

CD28 costimulation augments IL-2 secretion of activated lamina propria T cells by increasing mRNA stability without enhancing IL-2 gene transactivation.

S. Targan, R. Gonsky, A. Chen, 1999, Journal of immunology.

CD 28 Costimulation Augments IL-2 Secretion of Activated Lamina Propria T Cells by Increasing mRNA Stability Without Enhancing IL-2 Gene Transactivation 1

S. Targan, R. Gonsky, R. Deem, 1999 .

CD2 mediates activation of the IFN‐γ intronic STAT binding region in mucosal T cells

S. Targan, H. Young, R. Gonsky, 2003 .

Enhancer role of STAT5 in CD2 activation of IFN-gamma gene expression.

S. Targan, H. Young, R. Gonsky, 2004, Journal of immunology.

Binding of ATP and messenger RNA by the beta-subunit of eukaryotic initiation factor 2.

R. Kaempfer, R. Gonsky, D. Itamar, 1992, Biochimie.

Intracellular Pathogen Promoter Function in Disease Due to an g Element-Binding Proteins and IFN--Monophospate Response ¢ Adenosine 5 Reduced Expression of Nuclear Cyclic

H. Young, U. Pendurthi, P. Barnes, 2002 .

Environmental Interaction of Resolved Human Cytomegalovirus Infection With Crohn's Disease Location.

S. Kugathasan, Dalin Li, L. Denson, 2022, Inflammatory bowel diseases.

IFNG rs1861494 Polymorphism Is Associated with IBD Disease Severity and Functional Changes in Both IFNG Methylation and Protein Secretion

S. Targan, T. Haritunians, Shaohong Yang, 2014, Inflammatory bowel diseases.

Clonal origin of pituitary adenomas.

K. Kovacs, J. Fagin, S. Melmed, 1990, The Journal of clinical endocrinology and metabolism.

Microbial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells

S. Targan, C. Elson, R. Gonsky, 2009, European journal of immunology.

TLR4 and MD-2 Expression Is Regulated by Immune-mediated Signals in Human Intestinal Epithelial Cells*

M. Abreu, R. Gonsky, M. Arditi, 2002, The Journal of Biological Chemistry.

From amplification to gene in thyroid cancer: a high-resolution mapped bacterial-artificial-chromosome resource for cancer chromosome aberrations guides gene discovery after comparative genome hybridization.

X. Chen, J. Korenberg, S. Chissoe, 1998, American journal of human genetics.

Reexpression of thyroid peroxidase in a derivative of an undifferentiated thyroid carcinoma cell line by introduction of wild-type p53.

R. Lauro, A. Fusco, J. Fagin, 1996, Cancer research.

Binding of ATP to eukaryotic initiation factor 2. Differential modulation of mRNA-binding activity and GTP-dependent binding of methionyl-tRNAMetf.

Y. Banai, R. Kaempfer, R. Gonsky, 1990, The Journal of biological chemistry.

Diagnostic and therapeutic potential of RNASET2 in Crohn’s disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion

Simon G. Coetzee, Dennis J. Hazelett, S. Targan, 2022, Frontiers in Immunology.

Association of Ribonuclease T2 Gene Polymorphisms With Decreased Expression and Clinical Characteristics of Severity in Crohn's Disease.

Alka A. Potdar, S. Targan, D. McGovern, 2017, Gastroenterology.

Identification of rapid turnover transcripts overexpressed in thyroid tumors and thyroid cancer cell lines: use of a targeted differential RNA display method to select for mRNA subsets.

J. Fagin, J. Knauf, R. Gonsky, 1997, Nucleic acids research.

Molecular screening of pituitary adenomas for gene mutations and rearrangements.

S. Melmed, R. Gonsky, V. Herman, 1993, The Journal of clinical endocrinology and metabolism.

Distinct IFNG methylation in a subset of ulcerative colitis patients based on reactivity to microbial antigens

S. Targan, D. McGovern, R. Gonsky, 2011, Inflammatory bowel diseases.

Mutations of the adenomatous polyposis coli gene in sporadic thyroid neoplasms.

J. Fagin, R. Gonsky, N. Sharifi, 1994, The Journal of clinical endocrinology and metabolism.

An IFNG SNP with an estrogen-like response element selectively enhances promoter expression in peripheral but not lamina propria T cells

S. Targan, H. Young, R. Gonsky, 2006, Genes and Immunity.

Reduced Expression of Nuclear Cyclic Adenosine 5′-Monophospate Response Element-Binding Proteins and IFN-γ Promoter Function in Disease Due to an Intracellular Pathogen1

H. Young, B. Samten, U. Pendurthi, 2002, The Journal of Immunology.

Functional signaling of membrane‐bound TL1A induces IFN‐γ expression

S. Targan, R. Gonsky, B. Ko, 2010, FEBS letters.

Relief of cytotoxicity and enhancement of interferon inducer activity of double-stranded RNA by eukaryotic initiation factor 2.

R. Kaempfer, R. Gonsky, D. Itamar, 1990, Virology.

Linkage of Crohn’s disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-κB activation

S. Targan, E. Vasiliauskas, K. Taylor, 2008, Gut.

The nature of the interaction of eukaryotic initiation factor 2 with double-stranded RNA.

R. Kaempfer, R. Gonsky, M. Lebendiker, 1984, European journal of biochemistry.

Dampened SOCS: An altered balance between STAT activating and SOCS inhibitory signals regulate interferon-γ expression in LPMC

S. Targan, H. Young, R. Gonsky, 2001 .

Insights into TL1A and IBD pathogenesis.

S. Targan, K. Michelsen, R. Gonsky, 2011, Advances in experimental medicine and biology.

CD2 mediates activation of the IFN-gamma intronic STAT binding region in mucosal T cells.

S. Targan, H. Young, R. Gonsky, 2003, European Journal of Immunology.

Tu1926 Functional Characterization of the CD40 IBD Risk SNP rs6074022: Integrated Gwas, eQTL, and mQTL Defines IBD Patient Subgroups With Altered Pathobiology and Distinct Natural History of Disease

S. Targan, D. McGovern, Y. Kakuta, 2014 .

Multiple activating and repressive cis-promoter regions regulate TNFSF15 expression in human primary mononuclear cells.

S. Targan, R. Gonsky, R. Deem, 2013, Cytokine.

A blood-based transcriptomic signature stratifies severe Crohn’s disease and defines potentially targetable therapeutic pathways

Alka A. Potdar, S. Targan, D. McGovern, 2023, Frontiers in Gastroenterology.