S. Harris

发表

The crystal structure of the carboxy-terminal dimerization domain of htpG, the Escherichia coli Hsp90, reveals a potential substrate binding site.

D. Agard, A. Shiau, S. Harris, 2004, Structure.

Outcome of the First wwPDB/CCDC/D3R Ligand Validation Workshop.

Haruki Nakamura, Evan Bolton, Zukang Feng, 2016, Structure.

Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.

Taraneh Mirzadegan, Klaus Klumpp, S. Tsing, 2008, Journal of medicinal chemistry.

Structural Analysis of E. coli hsp90 Reveals Dramatic Nucleotide-Dependent Conformational Rearrangements

David A. Agard, Andrew K. Shiau, D. Agard, 2006, Cell.

Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.

Masaki Tomimoto, Charles Kissinger, Anthony M Giannetti, 2008, Bioorganic & medicinal chemistry letters.

De novo fragment design: a medicinal chemistry approach to fragment-based lead generation.

A. M. Giannetti, S. Harris, J. D. de Vicente, 2013, Journal of medicinal chemistry.

OX40R (TNFRSF4) bound to Fab 1A7

Wadim L. Matochko, G. A. Lazar, M. Ultsch, 2019 .

Tetravalent biepitopic targeting enables intrinsic antibody agonism of tumor necrosis factor receptor superfamily members

Wadim L. Matochko, G. A. Lazar, M. Ultsch, 2019, mAbs.

Discovery of S-[5-amino-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-[3-(2,3-dihydroxypropoxy)phenyl]methanone (RO3201195), an orally bioavailable and highly selective inhibitor of p38 MAP kinase.

D. Rotstein, C. Ramesha, M. Browner, 2006, Journal of medicinal chemistry.

Discovery of highly potent, selective, and brain-penetrable leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2012, Journal of medicinal chemistry.

Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.

Benjamin D. Sellers, Rohan V Mendonca, Sanjeev Kumar, 2020, ACS medicinal chemistry letters.

Biochemical characterization of the inhibition of the dengue virus RNA polymerase by beta-d-2'-ethynyl-7-deaza-adenosine triphosphate.

D. Swinney, A. Kutach, D. Shaw, 2010, Antiviral research.

Inhibitors of the Hepatitis C Virus Palm-Binding Nonnucleoside Polymerase Variants Dually Resistant to Thumb-and Selection and Characterization of Replicon

Than, C. Oshiro, A. M. Giannetti, 2006 .

Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.

Kevin Chen, Ping Wu, Stephen Schmidt, 2015, ACS medicinal chemistry letters.

MAP4K4 regulates integrin-FERM binding to control endothelial cell motility

A. Crow, P. Vitorino, J. Eastham‐Anderson, 2015, Nature.

Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.

D. Davis, A. Railkar, Amy D. Fung, 2014, Journal of medicinal chemistry.

1 Slow-binding inhibition and mechanism of resistance of non-nucleoside polymerase inhibitors of hepatitis C virus

A. M. Giannetti, S. Harris, S. Pogam, 2009 .

Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.

Amy D. Fung, S. Harris, S. Le Pogam, 2013, Journal of medicinal chemistry.

Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors.

K. Scearce-Levie, A. Beresford, A. Medhurst, 2014, Journal of medicinal chemistry.

Quantitative Determination of Protein-Ligand Affinity by Size Exclusion Chromatography Directly Coupled to High-Resolution Native Mass Spectrometry.

Melinda M. Mulvihill, W. Sandoval, A. Bailey, 2018, Analytical chemistry.

Antibody interfaces revealed through structural mining

Lipika R. Pal, J. Moult, G. Lazar, 2022, Computational and structural biotechnology journal.

Novel Antibody Interfaces Revealed Through Structural Mining

Lipika R. Pal, J. Moult, G. Lazar, 2022, bioRxiv.

Developments in the Implementation of Acoustic Droplet Ejection for Protein Crystallography

M. Ultsch, C. Noland, Ping Wu, 2016, Journal of laboratory automation.

Design and Evaluation of Highly-Selective Human Immunoproteasome Inhibitors Reveals a Compensatory Process that Preserves Immune Cell Viability.

S. Steinbacher, M. Augustin, Celine Eidenschenk, 2019, Journal of medicinal chemistry.

Synthesis and biological activity of new pyridone diaryl ether non-nucleoside inhibitors of HIV-1 reverse transcriptase

N. Arora, S. Harris, Mark Smith, 2010 .

Diphenyl Ether Non‐Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties

Y. Li, D. Stefanidis, N. Arora, 2009, ChemMedChem.

Discovery and optimization of pyridazinone non-nucleoside inhibitors of HIV-1 reverse transcriptase.

Y. Li, W. Huber, T. Mirzadegan, 2008, Bioorganic & medicinal chemistry letters.

Nanolitre-scale crystallization using acoustic liquid-transfer technology

T. Donohue, A. Kuglstatter, S. Harris, 2012, Acta crystallographica. Section D, Biological crystallography.

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).

K. Scearce-Levie, Jianping Yin, Xingrong Liu, 2015, Journal of medicinal chemistry.

Discovery of Clinical Candidate (1 R,4 r)-4-(( R)-2-(( S)-6-Fluoro-5 H-imidazo[5,1- a]isoindol-5-yl)-1-hydroxyethyl)cyclohexan-1-ol (Navoximod), a Potent and Selective Inhibitor of Indoleamine 2,3-Dioxygenase 1.

Sanjeev Kumar, S. Harris, R. Metz, 2019, Journal of medicinal chemistry.

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Connie Oshiro, Klaus Klumpp, Anthony M. Giannetti, 2006, Journal of Virology.

Sca ff old-Hopping and Structure-Based Discovery of Potent , Selective , And Brain Penetrant N ‐ ( 1 H ‐ Pyrazol-3-yl ) pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase ( DLK , MAP 3 K 12 )

K. Scearce-Levie, Jianping Yin, Xingrong Liu, 2015 .

Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors

C. Lemmen, S. Steinbacher, P. Beroza, 2022, Nature Communications.

Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

April Wong, Klaus Klumpp, Hannah J. Whittington, 2009, The Journal of Biological Chemistry.

VH-VL orientation prediction for antibody humanization candidate selection: A case study

Guy Georges, Alexander Bujotzek, Florian Lipsmeier, 2016, mAbs.

Fragment-based identification and optimization of a class of potent pyrrolo[2,1-f][1,2,4]triazine MAP4K4 inhibitors.

Anthony M Giannetti, Ping Wu, Brandon J. Bravo, 2014, Bioorganic & medicinal chemistry letters.

Identification of Noncompetitive Protein-Ligand Interactions for Structural Optimization

Robin Taylor, B. Kuhn, J. Cole, 2020, J. Chem. Inf. Model..

Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.

Jianping Yin, M. Starovasnik, E. Dueber, 2015, Structure.

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Jianping Yin, Xingrong Liu, J. Lyssikatos, 2017, Journal of medicinal chemistry.

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.

April Wong, J. E. Robinson, Jim Li, 2009, Bioorganic & medicinal chemistry letters.

Discovery of selective 4-Amino-pyridopyrimidine inhibitors of MAP4K4 using fragment-based lead identification and optimization.

Anthony M Giannetti, Ping Wu, Brandon J. Bravo, 2014, Journal of medicinal chemistry.

3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models.

Alam Jahangir, Johannes C. Hermann, Seth Harris, 2013, Journal of medicinal chemistry.

Acoustic matrix microseeding: improving protein crystal growth with minimal chemical bias.

A. Kuglstatter, S. Harris, A. Wong, 2010, Acta crystallographica. Section D, Biological crystallography.

Structure Based Design of Potent Selective Inhibitors of Protein Kinase D1 (PKD1).

Jianwen A. Feng, P. McEwan, R. Godemann, 2019, ACS medicinal chemistry letters.

Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.

Xianfeng Lin, Taraneh Mirzadegan, Klaus Klumpp, 2010, Bioorganic & medicinal chemistry letters.

Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies.

B. Nelson, Zhijian Li, A. Kuglstatter, 2018, Journal of molecular biology.

Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.

Amy D. Fung, N. Arora, S. Harris, 2010, Bioorganic & medicinal chemistry letters.

Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration* ♦

J. Stinson, G. Fuh, Sarah Sanowar, 2015, The Journal of Biological Chemistry.

Design of annulated pyrazoles as inhibitors of HIV-1 reverse transcriptase.

S. Tsing, T. Mirzadegan, S. Harris, 2008, Journal of medicinal chemistry.

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.

J. E. Robinson, J. Blake, C. Oshiro, 2009, Bioorganic & medicinal chemistry letters.

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.

J. E. Robinson, J. Blake, C. Oshiro, 2009, Bioorganic & medicinal chemistry letters.