P. Brough

发表

Structure-based discovery of a new class of Hsp90 inhibitors.

X. Barril, M. Drysdale, R. Hubbard, 2005, Bioorganic & medicinal chemistry letters.

Synthesis of 2-iodo- and 2-phenyl-[11C]melatonin: potential PET tracers for melatonin binding sites.

V. Snieckus, P. Brough, G. Firnau, 1998, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.

X. Barril, B. Davis, M. Drysdale, 2009, Journal of Medicinal Chemistry.

Off-rate screening (ORS) by surface plasmon resonance. An efficient method to kinetically sample hit to lead chemical space from unpurified reaction products.

J. Murray, P. Brough, S. Roughley, 2014, Journal of medicinal chemistry.

4,5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer.

Mike Wood, Brian Dymock, Xavier Barril, 2007, Journal of medicinal chemistry.

NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.

L. Pearl, X. Barril, M. Drysdale, 2008, Cancer research.

Hsp90 inhibitors and drugs from fragment and virtual screening.

R. Hubbard, A. Massey, P. Brough, 2011, Topics in current chemistry.

Preclinical Antitumor Activity of the Orally Available Heat Shock Protein 90 Inhibitor NVP-BEP800

J. Brueggen, M. Drysdale, M. Jensen, 2010, Molecular Cancer Therapeutics.

Molecular Cancer Therapeutics Preclinical Antitumor Activity of the Orally Available Heat Shock Protein 90 Inhibitor NVP-BEP 800

J. Brueggen, M. Drysdale, M. Jensen, 2010 .

Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.

Xavier Barril, Paul Workman, Roderick E Hubbard, 2005, Journal of medicinal chemistry.

Two isostructural triboluminescent lanthanide complexes.

I. Sage, P. Brough, I. Oswald, 2000, Acta Crystallographica Section C: Crystal Structure Communications.

Anatoxin-a is a potent agonist of the nicotinic acetylcholine receptor of bovine adrenal chromaffin cells.

S. Wonnacott, P. Brough, T. Gallagher, 1995, European journal of pharmacology.

Determination of anatoxin-a and homoanatoxin in blue—green algal extracts by high-performance liquid chromatography and gas chromatography—mass spectrometry

P. Brough, T. Jefferies, T. Gallagher, 1993 .

3-(5-Chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone.

X. Barril, M. Drysdale, P. Workman, 2005, Bioorganic & medicinal chemistry letters.

Discovery and development of pyrazole-scaffold Hsp90 inhibitors.

M. Drysdale, P. Workman, P. Brough, 2006, Current topics in medicinal chemistry.

Targeting Hsp90 for the treatment of cancer.

M. Drysdale, M. Jensen, J. Schoepfer, 2006, Current opinion in drug discovery & development.

Determination of Anatoxin-a, Homoanatoxin and Propylanatoxin in Cyanobacterial Extracts by HPLC, GC-Mass Spectrometry and Capillary Electrophoresis

P. Brough, T. Jefferies, T. Gallagher, 1994 .

Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization.

B. Davis, M. Drysdale, N. Foloppe, 2012, Bioorganic & medicinal chemistry.

Lindane neurotoxicity

P. Brough, M. Boffa, R.D. Ead, 1995, The British journal of dermatology.

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues

L. Pearl, X. Barril, M. Drysdale, 2007, Molecular Cancer Therapeutics.

Application of Off-Rate Screening in the Identification of Novel Pan-Isoform Inhibitors of Pyruvate Dehydrogenase Kinase.

Mike Wood, Ben Davis, Terry Shaw, 2017, Journal of medicinal chemistry.

Complex induced proximity effect enhancement in α-silyl carbanion generation. A general conversion of 2-silyl benzamides into 2-fluorosilylacetophenones

V. Snieckus, P. Brough, B. Zhao, 1996 .

Complex Induced Proximity Effect Enhancement in α-Silyl Carbanion Generation. A General Conversion of 2-Silyl Benzamides into 2-Fluorosilylacetophenones.

V. Snieckus, P. Brough, B. Zhao, 1996 .

VER-246608, a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase, disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells

J. Murray, B. Davis, P. Brough, 2014, Oncotarget.

Medicinal chemistry of Hsp90 inhibitors.

M. Drysdale, P. Brough, 2008, Current topics in medicinal chemistry.

The role of synthetic chemistry in the production of standards for toxin analysis

S. Wonnacott, P. Brough, T. Jefferies, 1994 .