Mei Chen

发表

Extracellular heat shock protein‐90α: linking hypoxia to skin cell motility and wound healing

Wei Li, Yong Li, Shengxi Guan, 2007, The EMBO journal.

The anti-motility signaling mechanism of TGFβ3 that controls cell traffic during skin wound healing

Wei Li, D. Sahu, Mei Chen, 2012, Biology Open.

Heat shock protein-90alpha (Hsp90α) stabilizes hypoxia-inducible factor-1α (HIF-1α) in support of spermatogenesis and tumorigenesis

A. Schönthal, Wei Li, Xinlei Tang, 2021, Cancer Gene Therapy.

Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.

Wei Li, Yong Li, Jianhua Fan, 2006, The Journal of investigative dermatology.

Characterization of Molecular Mechanisms Underlying Mutations in Dystrophic Epidermolysis Bullosa Using Site-directed Mutagenesis*

Wei Li, Mei Chen, D. Woodley, 2008, Journal of Biological Chemistry.

The Carboxyl Terminus of Type VII Collagen Mediates Antiparallel Dimer Formation and Constitutes a New Antigenic Epitope for Epidermolysis Bullosa Acquisita Autoantibodies*

D. Keene, Mei Chen, D. Woodley, 2001, The Journal of Biological Chemistry.

Heat Shock Protein 90 Versus Conventional Growth Factors in Acute and Diabetic Wound Healing

Wei Li, Mei Chen, D. Woodley, 2012 .

A fragment of secreted Hsp90α carries properties that enable it to accelerate effectively both acute and diabetic wound healing in mice.

Wei Li, D. Sahu, Yong Li, 2011, The Journal of clinical investigation.

Autoimmune bullous skin disorders

D. Zillikens, E. Laffitte, L. Borradori, 2001 .

Reduced Toxicity Conditioning and Allogeneic Hematopoietic Progenitor Cell Transplantation for Recessive Dystrophic Epidermolysis Bullosa.

K. Radhakrishnan, J. Uitto, J. McGrath, 2015, The Journal of pediatrics.

Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients.

D. Keene, Mei Chen, D. Woodley, 2006, The Journal of investigative dermatology.

The cartilage matrix protein subdomain of type VII collagen is pathogenic for epidermolysis bullosa acquisita.

Mei Chen, D. Woodley, Yingping Hou, 2007, The American journal of pathology.

Evidence that anti-type VII collagen antibodies are pathogenic and responsible for the clinical, histological, and immunological features of epidermolysis bullosa acquisita.

Mei Chen, D. Woodley, P. Saadat, 2005, The Journal of investigative dermatology.

Autoantibodies to Type VII Collagen Have Heterogeneous Subclass and Light Chain Compositions and Their Complement-Activating Capacities Do Not Correlate with the Inflammatory Clinical Phenotype

S. Aasi, Mei Chen, D. Woodley, 2000, Journal of Clinical Immunology.

Identification of the Critical Therapeutic Entity in Secreted Hsp90α That Promotes Wound Healing in Newly Re-Standardized Healthy and Diabetic Pig Models

Wei Li, Mei Chen, D. Woodley, 2014, PloS one.

Participation of the lipoprotein receptor LRP1 in hypoxia-HSP90α autocrine signaling to promote keratinocyte migration

G. Bu, Wei Li, Yong Li, 2009, Journal of Cell Science.

Keratinocyte-Secreted Heat Shock Protein-90alpha: Leading Wound Reepithelialization and Closure.

Wei Li, Mei Chen, D. Woodley, 2016, Advances in wound care.

Extracellular Heat Shock Protein 90 Signals through Subdomain II and the NPVY Motif of LRP-1 Receptor to Akt1 and Akt2: a Circuit Essential for Promoting Skin Cell Migration In Vitro and Wound Healing In Vivo

N. Hay, B. Stiles, Wei Li, 2013, Molecular and Cellular Biology.

Vivo In and Wound Healing In Vitro Migration Circuit Essential for Promoting Skin Cell of LRP-1 Receptor to Akt 1 and Akt 2 : a through Subdomain II and the NPVY Motif Extracellular Heat Shock Protein 90 Signals

N. Hay, B. Stiles, Wei Li, 2013 .

Hypoxia induces epidermal keratinocyte matrix metalloproteinase‐9 secretion via the protein kinase C pathway

Mei Chen, D. Woodley, E. O’Toole, 2008, Journal of cellular physiology.

Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa

M. Barcová, D. Keene, P. Cannon, 2002, Nature Genetics.

A role for Collagen VII in matrix protein secretion.

J. McGrath, Mei Chen, A. South, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Heterogeneous Responses and Isoform Compensation Dim the Therapeutic Window of Hsp90 ATP-Binding Inhibitors in Cancer

A. Schönthal, Wei Li, Xinlei Tang, 2021, Molecular and cellular biology.

Gentamicin induces LAMB3 nonsense mutation readthrough and restores functional laminin 332 in junctional epidermolysis bullosa

M. De Luca, L. De Rosa, Mei Chen, 2018, Proceedings of the National Academy of Sciences.

Duplicating autoimmune bullous diseases by passively transferring autoantibodies into animals.

Mei Chen, D. Woodley, 2008, The Journal of investigative dermatology.

Fibroblasts as target cells for DEB gene therapy.

Mei Chen, D. Woodley, 2006, The Journal of investigative dermatology.

LRP-1 receptor combines EGFR signalling and eHsp90α autocrine to support constitutive breast cancer cell motility in absence of blood supply

A. Schönthal, Wei Li, Xinlei Tang, 2022, Scientific Reports.

After Conventional Wisdom Has Failed, What Drives Wound Healing?

Wei Li, Xinlei Tang, Mei Chen, 2019, European Medical Journal.

Over‐expression of stromal periostin correlates with poor prognosis of cutaneous squamous cell carcinomas

D. Murrell, A. Wysong, Mei Chen, 2021, Experimental dermatology.

Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice.

L. Guey, J. Uitto, D. Keene, 2015, The Journal of investigative dermatology.

Mesenchymal Stromal Cells Isolated from Irradiated Human Skin Have Diminished Capacity for Proliferation, Differentiation, Colony Formation, and Paracrine Stimulation

Sun Young Park, Charles Wang, Wei Li, 2019, Stem cells translational medicine.

α2β1 Integrin Mediates Dermal Fibroblast Attachment to Type VII Collagen via a 158-Amino-Acid Segment of the NC1 Domain

Mei Chen, D. Woodley, E. O’Toole, 1999 .

Wound-healing perspectives.

Wei Li, W. Garner, T. Phillips, 2005, Dermatologic clinics.

Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa

Wei Li, D. Keene, Mei Chen, 2004, Nature Medicine.

A “traffic control” role for TGFβ3: orchestrating dermal and epidermal cell motility during wound healing

Wei Li, Jianhua Fan, Mei Chen, 2006, The Journal of Cell Biology.

Keratinocyte Migration and a Hypothetical New Role for Extracellular Heat Shock Protein 90 Alpha in Orchestrating Skin Wound Healing.

Wei Li, A. Wysong, Mei Chen, 2015, Advances in wound care.

A “trafﬁ c control” role for TGF β 3: orchestrating dermal and epidermal cell motility during wound healing

Yong Li, Shengxi Guan, Jianhua Fan, 2006 .

PKCdelta clustering at the leading edge and mediating growth factor-enhanced, but not ecm-initiated, dermal fibroblast migration.

Wei Li, Shengxi Guan, Jianhua Fan, 2006, The Journal of investigative dermatology.

Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa.

J. Uitto, J. McGrath, M. Prisco, 2017, The Journal of investigative dermatology.

Systemic collagen VII replacement therapy for advanced recessive dystrophic epidermolysis bullosa.

C. Gretzmeier, Mei Chen, D. Woodley, 2021, The Journal of investigative dermatology.

A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing.

Wei Li, Yong Li, Shengxi Guan, 2006, The Journal of cell biology.

Collagen VII maintains proteostasis in dermal fibroblasts by scaffolding TANGO1 cargo

J. McGrath, Mei Chen, A. South, 2022, Matrix biology : journal of the International Society for Matrix Biology.

Epidermolysis bullosa acquisita.

Mei Chen, D. Woodley, Rishu Gupta, 2012, Clinics in dermatology.

Autoimmunity to type VII collagen: epidermolysis bullosa acquisita.

Mei Chen, D. Woodley, J. Remington, 2008, Current directions in autoimmunity.

Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen.

C. Prins, J. Saurat, J. Desmeules, 2002, Journal of the American Academy of Dermatology.

Canine epidermolysis bullosa acquisita: circulating autoantibodies target the aminoterminal non-collagenous (NC1) domain of collagen VII in anchoring fibrils.

Dawn A. D. Chasse, N. Monteiro-Riviere, Mei Chen, 1998, Veterinary dermatology.

Clinical and immunological heterogeneity of canine subepidermal blistering dermatoses with anti-laminin-332 (laminin-5) auto-antibodies.

Mei Chen, T. Olivry, M. Marinkovich, 2010, Veterinary dermatology.

Epidermolysis bullosa acquisita: Autoimmunity to anchoring fibril collagen

Mei Chen, D. Woodley, Gene H. Kim, 2012, Autoimmunity.

Cloning of the cDNA encoding canine skin basement membrane bullous pemphigoid antigen 2 reveals molecular and immunologic identities in the human and canine NC16A domains

Luting Xu, Mei Chen, T. Olivry, 1998 .

Bullous systemic lupus erythematosus with IgG and IgA autoantibodies targeting multiple skin basement membrane zone components

A. Paller, Mei Chen, D. Woodley, 1998 .

Autoimmunity to Type VII Collagen: Epidermolysis Bullosa Acquisita

Mei Chen, D. Woodley, J. Remington, 2007, Clinical reviews in allergy & immunology.

TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites

R. Schekman, V. Malhotra, Huilin Zhou, 2009, Cell.

A patient with both bullous pemphigoid and epidermolysis bullosa acquisita: an example of intermolecular epitope spreading.

Mei Chen, D. Woodley, J. Fairley, 2004, Journal of the American Academy of Dermatology.

The epidermolysis bullosa acquisita antigen (type VII collagen) is present in human colon and patients with crohn's disease have autoantibodies to type VII collagen.

D. Kelleher, Mei Chen, D. Woodley, 2002, The Journal of investigative dermatology.

Increased invasive behaviour in cutaneous squamous cell carcinoma with loss of basement-membrane type VII collagen

J. McGrath, K. Purdie, A. Storey, 2009, Journal of Cell Science.

Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa.

J. Uitto, D. Keene, Mei Chen, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

Patients with recessive dystrophic epidermolysis bullosa develop squamous-cell carcinoma regardless of type VII collagen expression.

J. McGrath, I. Leigh, H. Fassihi, 2007, The Journal of investigative dermatology.

Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healing.

Wei Li, D. Keene, Mei Chen, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

The Recombinant Expression of Full-length Type VII Collagen and Characterization of Molecular Mechanisms Underlying Dystrophic Epidermolysis Bullosa*

Mei Chen, D. Woodley, Yuanping Han, 2002, The Journal of Biological Chemistry.

Wound Healing Driver Gene (WDG) and Therapeutic Development: Political and Scientific Hurdles.

D. Armstrong, Wei Li, Xinlei Tang, 2020, Advances in wound care.

Dual therapeutic functions of F-5 fragment in burn wounds: preventing wound progression and promoting wound healing in pigs

Wei Li, W. Garner, Mei Chen, 2016, Molecular therapy. Methods & clinical development.

Congenital epidermolysis bullosa acquisita: vertical transfer of maternal autoantibody from mother to infant.

Mei Chen, D. Woodley, A. Mancini, 2011, Archives of dermatology.

Bone marrow transplantation for recessive dystrophic epidermolysis bullosa.

Jakub Tolar, John E Wagner, Mei Chen, 2010, The New England journal of medicine.

Gentamicin induces functional type VII collagen in recessive dystrophic epidermolysis bullosa patients

D. Keene, Mei Chen, D. Woodley, 2017, The Journal of clinical investigation.

Aminoglycosides restore full-length type VII collagen by overcoming premature termination codons: therapeutic implications for dystrophic epidermolysis bullosa.

Mei Chen, D. Woodley, Sabrina Martin, 2014, Molecular therapy : the journal of the American Society of Gene Therapy.

Topical Application of Recombinant Type VII Collagen Incorporates Into the Dermal-Epidermal Junction and Promotes Wound Closure.

J. Uitto, D. Keene, Mei Chen, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo.

D. Keene, Mei Chen, D. Woodley, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Epidermolysis bullosa: then and now.

Mei Chen, D. Woodley, 2004, Journal of the American Academy of Dermatology.

Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone.

D. Keene, G. Krueger, Mei Chen, 2003, The Journal of investigative dermatology.

Mechanism of human dermal fibroblast migration driven by type I collagen and platelet-derived growth factor-BB.

G. Bokoch, Wei Li, Shengxi Guan, 2003, Molecular biology of the cell.

Extracellular heat shock protein‐90α: linking hypoxia to skin cell motility and wound healing

Wei Li, Yong Li, Shengxi Guan, 2011 .

Molecular and Clinical Outcomes After Intravenous Gentamicin Treatment for Patients With Junctional Epidermolysis Bullosa Caused by Nonsense Variants.

Xinlei Tang, Mei Chen, D. Woodley, 2022, JAMA dermatology.

The Distinct Assignments for Hsp90α and Hsp90β: More Than Skin Deep

Wei Li, Xinlei Tang, Mei Chen, 2023, Cells.

A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α–positive tumors

P. Conti, Wei Li, R. Park, 2012, Molecular biology of the cell.

Transforming Growth Factor (TGF )-Stimulated Secretion of HSP90 : Using the Receptor LRP-1/CD91 To Promote Human Skin Cell Migration against a TGF -Rich Environment during Wound Healing †

Wei Li, Yong Li, Shengxi Guan, 2008 .

TβRI/Alk5-independent TβRII signaling to ERK1/2 in human skin cells according to distinct levels of TβRII expression

Wei Li, Yong Li, Jianhua Fan, 2011, Journal of Cell Science.

Non-compensating roles between Nckalpha and Nckbeta in PDGF-BB signaling to promote human dermal fibroblast migration.

Wei Li, Shengxi Guan, Jianhua Fan, 2009, The Journal of investigative dermatology.

Profiling motility signal-specific genes in primary human keratinocytes.

D. Mock, Wei Li, Shengxi Guan, 2008, The Journal of investigative dermatology.

Nckβ Adapter Controls Neuritogenesis by Maintaining the Cellular Paxillin Level

Wei Li, Shengxi Guan, Mei Chen, 2007, Molecular and Cellular Biology.

Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa.

J. McGrath, I. Leigh, F. Hogg, 2012, Cancer research.

Extracellular HSP90α Versus Intracellular HSP90β in Wound Healing and Cancer

Wei Li, Xinlei Tang, Mei Chen, 2019, Heat Shock Proteins.

Extracellular Hsp90 (eHsp90) as the actual target in clinical trials: intentionally or unintentionally.

Wei Li, D. Sahu, G. Multhoff, 2013, International review of cell and molecular biology.

Hsp90&agr; and Hsp90&bgr; together operate a hypoxia and nutrient paucity stress‐response mechanism during wound healing

Wei Li, Mei Chen, D. Woodley, 2015, Journal of Cell Science.

Gentamicin Induces Laminin 332 and Improves Wound Healing in Junctional Epidermolysis Bullosa Patients with Nonsense Mutations

Mei Chen, D. Woodley, Qiuyang Chen, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

Extracellular and Non-Chaperone Function of Heat Shock Protein-90α Is Required for Skin Wound Healing.

Mei Chen, Wei Li, Mei Chen, 2017, The Journal of investigative dermatology.

Breast Cancer MDA-MB-231 Cells Use Secreted Heat Shock Protein-90alpha (Hsp90α) to Survive a Hostile Hypoxic Environment

Wei Li, Qi-Long Ying, Mei Chen, 2016, Scientific Reports.

Interactions of the Amino-terminal Noncollagenous (NC1) Domain of Type VII Collagen with Extracellular Matrix Components

C. N. Rao, Mei Chen, D. Woodley, 1997, The Journal of Biological Chemistry.

A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion

S. Przyborski, Mei Chen, J. Armstrong, 2015, Molecular Cancer Therapeutics.

Intravenously Injected Recombinant Human Type VII Collagen Homes to Skin Wounds and Restores Skin Integrity of Dystrophic Epidermolysis Bullosa

J. Uitto, D. Keene, Mei Chen, 2013, The Journal of investigative dermatology.

Safety and early efficacy outcomes for lentiviral fibroblast gene therapy in recessive dystrophic epidermolysis bullosa.

F. Reid, J. Tolar, M. del Río, 2019, JCI insight.

Lentiviral Engineered Fibroblasts Expressing Codon-Optimized COL7A1 Restore Anchoring Fibrils in RDEB

J. R. McMillan, J. McGrath, F. Farzaneh, 2016, The Journal of investigative dermatology.

Recessive Dystrophic Epidermolysis Bullosa: Advances in the Laboratory Leading to New Therapies.

Mei Chen, D. Woodley, 2015, The Journal of investigative dermatology.

Lentiviral Engineered Fibroblasts Expressing Codon Optimized COL7A1 Restore Anchoring Fibrils in RDEB.

J. R. McMillan, J. McGrath, F. Farzaneh, 2015, The Journal of investigative dermatology.

PRAS40 Connects Microenvironmental Stress Signaling to Exosome-Mediated Secretion

M. Fabbri, Wei Li, Mei Chen, 2017, Molecular and Cellular Biology.

Tumour-Secreted Hsp90α on External Surface of Exosomes Mediates Tumour - Stromal Cell Communication via Autocrine and Paracrine Mechanisms

Wei Li, Xinlei Tang, Mei Chen, 2019, Scientific Reports.

An Important Role for Protein Kinase C-δ in Human Keratinocyte Migration on Dermal Collagen

Wei Li, Mei Chen, D. Woodley, 2002 .

An important role for protein kinase C-delta in human keratinocyte migration on dermal collagen.

Wei Li, Mei Chen, D. Woodley, 2002, Experimental cell research.

Development and Characterization of A Recombinant Truncated Type VII Collagen “Minigene”

Mei Chen, D. Woodley, N. Kasahara, 2000, The Journal of Biological Chemistry.

Signals that initiate, augment, and provide directionality for human keratinocyte motility.

Wei Li, W. Garner, Jianhua Fan, 2004, The Journal of investigative dermatology.

Extracellular heat shock protein‐90α: linking hypoxia to skin cell motility and wound healing

Wei Li, Yong Li, Shengxi Guan, 2013 .

De Novo Anti-Type VII Collagen Antibodies in Patients With Recessive Dystrophic Epidermolysis Bullosa

D. Keene, Mei Chen, D. Woodley, 2013, The Journal of investigative dermatology.

Characterization of mutant type VII collagens underlying the inversa subtype of recessive dystrophic epidermolysis bullosa.

K. Yim, Mei Chen, D. Woodley, 2021, Journal of dermatological science.

NC1 domain of type VII (anchoring fibril) collagen binds to the β3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats

Mei Chen, D. Woodley, M. Marinkovich, 1998 .

Familial epidermolysis bullosa acquisita.

M. Noe, Mei Chen, D. Woodley, 2008, Dermatology online journal.

Bullous systemic lupus erythematosus with autoantibodies recognizing multiple skin basement membrane components, bullous pemphigoid antigen 1, laminin-5, laminin-6, and type VII collagen.

A. Paller, T. Traczyk, Mei Chen, 1999, Archives of dermatology.

Epitope spreading: lessons from autoimmune skin diseases.

T. Nishikawa, S. Miller, K. Gordon, 1998, The Journal of investigative dermatology.

Epidermolysis bullosa acquisita: update and review.

Mei Chen, D. Woodley, M. Chen, 2001, Clinics in dermatology.

NC1 domain of type VII collagen binds to the beta3 chain of laminin 5 via a unique subdomain within the fibronectin-like repeats.

J. C. Jones, Mei Chen, D. Woodley, 1999, The Journal of investigative dermatology.

Development of an ELISA for rapid detection of anti-type VII collagen autoantibodies in epidermolysis bullosa acquisita.

Mei Chen, D. Woodley, J. Sample, 1997, The Journal of investigative dermatology.

Mechanisms of human skin cell motility.

Wei Li, W. Li, J. Fan, 2004, Histology and histopathology.

High levels of type VII collagen expression in recessive dystrophic epidermolysis bullosa cutaneous squamous cell carcinoma keratinocytes increases PI3K and MAPK signalling, cell migration and invasion

J. McGrath, I. Leigh, Mei Chen, 2014, The British journal of dermatology.

Topical application of recombinant type VII collagen incorporates into the dermal-epidermal junction and promotes wound closure.

J. Uitto, D. Keene, Mei Chen, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.

J. McGrath, V. Kähäri, D. Murrell, 2016, Journal of the National Cancer Institute.

Topical Fibronectin Improves Wound Healing of Irradiated Skin

Wei Li, Mei Chen, Young-Kwon Hong, 2017, Scientific Reports.

FC004 Type VII (anchoring fibril) collagen exists in human intestine and serves as an antigenic target in patients with inflammatory bowel disease

D. Kelleher, Mei Chen, D. Woodley, 1997 .

Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice.

L. Guey, J. Uitto, D. Keene, 2015, The Journal of investigative dermatology.

Amlexanox Enhances Premature Termination Codon Read-Through in COL7A1 and Expression of Full Length Type VII Collagen: Potential Therapy for Recessive Dystrophic Epidermolysis Bullosa.

J. Uitto, J. McGrath, M. Prisco, 2017, The Journal of investigative dermatology.

Hematopoietic and mesenchymal cell transplantation after myeloablative and non-myeloablative conditioning for recessive dystrophic and junctional epidermolysis bullosa (RDEB, JEB)

J. Tolar, J. McGrath, A. Hovnanian, 2012 .