F. Simorini

发表

TSPO-ligands prevent oxidative damage and inflammatory response in C6 glioma cells by neurosteroid synthesis.

B. Cosimelli, F. Da Settimo, S. Taliani, 2016, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Pyrido[1,2-a]pyrimidin-4-one derivatives as a novel class of selective aldose reductase inhibitors exhibiting antioxidant activity.

E. Novellino, A. Lavecchia, F. Da Settimo, 2007, Journal of medicinal chemistry.

Synthesis of pyrrolo[3,4-c]pyridine derivatives possessing an acid group and their in vitro and in vivo evaluation as aldose reductase inhibitors

G. Primofiore, A. Martinelli, C. L. Motta, 1996 .

Investigation of new 2-aryl substituted Benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors targeting vascular endothelial growth factor receptor 2.

E. Novellino, F. Da Settimo, S. Taliani, 2015, European journal of medicinal chemistry.

1,2-Benzisothiazole Derivatives Bearing 4-, 5-, or 6-Alkyl/arylcarboxamide Moieties Inhibit Carbonic Anhydrase Isoform IX (CAIX) and Cell Proliferation under Hypoxic Conditions.

F. Da Settimo, S. Taliani, C. La Motta, 2016, Journal of medicinal chemistry.

New insights in the structure-activity relationships of 2-phenylamino-substituted benzothiopyrano[4,3-d]pyrimidines as kinase inhibitors.

E. Novellino, F. Da Settimo, S. Taliani, 2018, European journal of medicinal chemistry.

Phenylpyrazolo[1,5-a]quinazolin-5(4H)-one: a suitable scaffold for the development of noncamptothecin topoisomerase I (Top1) inhibitors.

Y. Pommier, E. Novellino, F. Da Settimo, 2013, Journal of medicinal chemistry.

5-amino-2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1-one: a versatile scaffold to obtain potent and selective A3 adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

Novel irreversible fluorescent probes targeting the 18 kDa translocator protein: synthesis and biological characterization.

E. Novellino, B. Cosimelli, G. Greco, 2010, Journal of medicinal chemistry.

Medicinal chemistry of indolylglyoxylamide TSPO high affinity ligands with anxiolytic-like effects.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Current topics in medicinal chemistry.

N,N-dialkyl-2-phenylindol-3-ylglyoxylamides. A new class of potent and selective ligands at the peripheral benzodiazepine receptor.

E. Novellino, G. Greco, G. Primofiore, 2004, Journal of medicinal chemistry.

New fluorescent 2-phenylindolglyoxylamide derivatives as probes targeting the peripheral-type benzodiazepine receptor: design, synthesis, and biological evaluation.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

New antiproliferative agents derived from tricyclic 3,4‐dihydrobenzo[4,5]imidazo[1,2‐a][1,3,5]triazine scaffold: Synthesis and pharmacological effects

F. Vaglini, F. Da Settimo, S. Taliani, 2022, Archiv der Pharmazie.

Dialkylaminoalkylindolonaphthyridines as potential antitumour agents: synthesis, cytotoxicity and DNA binding properties.

A. Da Settimo, G. Primofiore, F. Da Settimo, 2002, European journal of medicinal chemistry.

Synthesis and in vitro antiproliferative activity of new substituted benzo[3',2':5,6]thiopyrano[4,3-d]pyrimidines.

S. Taliani, O. Gia, S. Salerno, 2008 .

Synthesis of New Heterocyclic Ring Systems via [1,3,5]Triazino[1,2-a]benzimidazole Derivatives†

G. Primofiore, A. Marini, C. L. Motta, 2005 .

Novel, highly potent aldose reductase inhibitors: cyano(2-oxo-2,3-dihydroindol-3-yl)acetic acid derivatives.

E. Novellino, G. Greco, A. Lavecchia, 2003, Journal of medicinal chemistry.

Discovery of Pyrido[3',2':5,6]thiopyrano[4,3-d]pyrimidine-Based Antiproliferative Multikinase Inhibitors.

E. Novellino, F. Da Settimo, S. Taliani, 2019, ACS medicinal chemistry letters.

Facile synthesis of 3-substituted [1,2,4]triazino[3,4-f]purine-4,6,8-trione derivatives

G. Primofiore, S. Salerno, A. Marini, 2001 .

Synthesis of a Novel Purine-Containing Heterocyclic Ring System: 8,10-Dimethylindolo[2',3':5,6][1,2,4]triazino[4,3-f]purine-9,11(8H,10H,13H)dione

G. Primofiore, S. Taliani, A. Marini, 2000 .

Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor.

E. Novellino, B. Cosimelli, G. Greco, 2009, Journal of medicinal chemistry.

Tertiary amides with a five-membered heteroaromatic ring as new probes for the translocator protein.

E. Novellino, B. Cosimelli, G. Greco, 2011, European journal of medicinal chemistry.

Refinement of the benzodiazepine receptor site topology by structure-activity relationships of new N-(heteroarylmethyl)indol-3-ylglyoxylamides.

E. Novellino, B. Cosimelli, Marina Ehlardo, 2006, Journal of medicinal chemistry.

Medicinal chemistry of indolylglyoxylamide GABAA/BzR high affinity ligands: identification of novel anxiolytic/non sedative agents.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Current topics in medicinal chemistry.

Novel N-substituted indol-3-ylglyoxylamides probing the LDi and L1/L2 lipophilic regions of the benzodiazepine receptor site in search for subtype-selective ligands.

E. Novellino, B. Cosimelli, G. Greco, 2007, Journal of medicinal chemistry.

Novel, highly potent adenosine deaminase inhibitors containing the pyrazolo[3,4-d]pyrimidine ring system. Synthesis, structure-activity relationships, and molecular modeling studies.

E. Novellino, A. Lavecchia, G. Primofiore, 2005, Journal of medicinal chemistry.

An approach to novel fused triazole or tetrazole derivatives starting from Benzimidazo[1,2-a]quinazoline-5(7H)-one and 5,7-Dihydro-5-oxopyrido[3',2':5,6]pyrimido[1,2-a]benzimidazole

G. Primofiore, A. Marini, F. Simorini, 2002 .

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.

E. Novellino, B. Cosimelli, G. Greco, 2008, Journal of medicinal chemistry.

Benzothiopyranoindole- and pyridothiopyranoindole-based antiproliferative agents targeting topoisomerases.

E. Novellino, F. Da Settimo, S. Taliani, 2019, European journal of medicinal chemistry.

Tricyclic sulfonamides incorporating benzothiopyrano[4,3-c]pyrazole and pyridothiopyrano[4,3-c]pyrazole effectively inhibit α- and β-carbonic anhydrase: X-ray crystallography and solution investigations on 15 isoforms.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.

Naphtho[1,2-d]isothiazole acetic acid derivatives as a novel class of selective aldose reductase inhibitors.

Ettore Novellino, Enrico Boldrini, Sabrina Taliani, 2005, Journal of medicinal chemistry.

Synthesis of novel pyrido[3′,2′:5,6]thiopyrano[3,2‐b]indol‐5(6H)‐ones and 6H‐pyrido[3′,2′:5,6]thiopyrano[4,3‐b]quinolines, two new heterocyclic ring systems

G. Primofiore, S. Salerno, A. Marini, 2002 .

[1,2,4]Triazino[4,3-a]benzimidazole acetic acid derivatives: a new class of selective aldose reductase inhibitors.

E. Novellino, G. Greco, A. Lavecchia, 2001, Journal of medicinal chemistry.

Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors.

Ettore Novellino, Sabrina Taliani, Federico Da Settimo, 2009, Journal of medicinal chemistry.

Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular modeling studies.

E. Novellino, F. Da Settimo, S. Taliani, 2012, Journal of medicinal chemistry.

Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model.

E. Novellino, F. Da Settimo, S. Taliani, 2008, Journal of medicinal chemistry.

Synthesis and benzodiazepine receptor activity of some 4,5-dihydro-1H-pyrazolo[4,3-c][1,8]naphthyridine derivatives.

A. Da Settimo, G. Primofiore, F. Da Settimo, 1994, Drug design and discovery.

Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.

E. Novellino, B. Cosimelli, G. Greco, 2010, Journal of medicinal chemistry.

Sulfonamides incorporating heteropolycyclic scaffolds show potent inhibitory action against carbonic anhydrase isoforms I, II, IX and XII.

F. Da Settimo, S. Taliani, C. La Motta, 2016, Bioorganic & medicinal chemistry.

Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs.

F. Da Settimo, S. Taliani, C. La Motta, 2010, Current medicinal chemistry.

Benzothiopyranoindole-based antiproliferative agents: synthesis, cytotoxicity, nucleic acids interaction, and topoisomerases inhibition properties.

V. Barone, E. Novellino, A. Lavecchia, 2009, Journal of medicinal chemistry.

PIGA (N,N‐Di‐n‐butyl‐5‐chloro‐2‐(4‐chlorophenyl)indol‐3‐ylglyoxylamide), a New Mitochondrial Benzodiazepine‐Receptor Ligand, Induces Apoptosis in C6 glioma Cells

F. Da Settimo, C. Martini, R. Vanacore, 2005, Chembiochem : a European journal of chemical biology.

Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides.

E. Novellino, B. Cosimelli, G. Greco, 2015, Journal of medicinal chemistry.

Anxiolytic properties of a 2-phenylindolglyoxylamide TSPO ligand: Stimulation of in vitro neurosteroid production affecting GABAA receptor activity

S. Taliani, C. Martini, M. Morelli, 2011, Psychoneuroendocrinology.

3-aryl-[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-one: a novel template for the design of highly selective A₂B adenosine receptor antagonists.

E. Novellino, B. Cosimelli, G. Greco, 2012, Journal of medicinal chemistry.

Template for the Design of Highly Selective A 2 B Adenosine Receptor Antagonists

E. Novellino, B. Cosimelli, G. Greco, 2012 .

Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies.

E. Novellino, F. Da Settimo, S. Taliani, 2014, Journal of medicinal chemistry.

F. Da Settimo, S. Taliani, C. La Motta, 2012, Journal of medicinal chemistry.

Novel N2-substituted pyrazolo[3,4-d]pyrimidine adenosine A3 receptor antagonists: inhibition of A3-mediated human glioblastoma cell proliferation.

E. Novellino, B. Cosimelli, G. Greco, 2010, Journal of medicinal chemistry.

Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis.

E. Novellino, B. Cosimelli, G. Greco, 2008, Journal of medicinal chemistry.