D. Patterson

发表

Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13.

D. Driscoll, W. Miller, T. Sugawara, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Mapping of a locus correcting lack of phosphoribosylaminoimidazole carboxylase activity in Chinese hamster ovary cell Ade-D mutants to human chromosome 4.

D. Patterson, I. Hart, J. Barton, 1991, Genomics.

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

J. Haines, M. Pericak-Vance, H. Horvitz, 1993, Nature.

The Use of Mouse Models for Understanding the Biology of Down Syndrome and Aging

D. Patterson, G. Vacano, N. Duval, 2012, Current gerontology and geriatrics research.

Genetic mechanisms involved in the phenotype of Down syndrome.

D. Patterson, 2007, Mental retardation and developmental disabilities research reviews.

A high-resolution physical map of human chromosome 21p using yeast artificial chromosomes.

X. Estivill, A. Kessling, S. Antonarakis, 1999, Genome research.

Glycinamide ribonucleotide synthetase activity in lymphocytes from patients with Alzheimer's disease and normal controls

K. Davis, D. Patterson, Z. Zemishlany, 1990, Biological Psychiatry.

Cloning, sequencing, and mapping of the human chromosome 14 heat shock protein gene (HSPA2).

B. Trask, J. Weber, G. Schellenberg, 1994, Genomics.

The human GARS-AIRS-GART gene encodes two proteins which are differentially expressed during human brain development and temporally overexpressed in cerebellum of individuals with Down syndrome.

G. Brodsky, D. Patterson, T. Barnes, 1997, Human molecular genetics.

RUNX1 Permits E4orf6-Directed Nuclear Localization of the Adenovirus E1B-55K Protein and Associates with Centers of Viral DNA and RNA Synthesis

M. Ohki, D. Patterson, I. Kitabayashi, 2008, Journal of Virology.

E 4 orf 6-Directed Nuclear Localization of the Adenovirus E 1 B-55 K Protein and Associates with Centers of Viral DNA and RNA Synthesis

M. Ohki, D. Patterson, I. Kitabayashi, 2008 .

A humanized mouse model for the reduced folate carrier.

Christina Cherian, L. Matherly, D. Patterson, 2008, Molecular genetics and metabolism.

Induction of Bax-dependent neuronal apoptosis by Amyloid-β Protein Precursor (AβPP) requires its localization to functional mitochondria

R. Swerdlow, D. Linseman, D. Patterson, 2017 .

Purification of, generation of monoclonal antibodies to, and mapping of phosphoribosyl N-formylglycinamide amidotransferase.

D. Patterson, I. Hart, J. Barton, 1994, Biochemistry.

Resistance of Chinese hamster ovary cell chromatin to endonuclease digestion. I. Reversal by cAMP.

T. Puck, D. Patterson, S. Schonberg, 1983, Experimental cell research.

Superoxide dismutase, oxygen radical metabolism, and amyotrophic lateral sclerosis.

Z. Rahmani, D. Patterson, H. Warner, 1994, Molecular genetic medicine.

Protocatechuic Acid Extends Survival, Improves Motor Function, Diminishes Gliosis, and Sustains Neuromuscular Junctions in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

D. Linseman, D. Patterson, A. Winter, 2020, Nutrients.

Rapamycin Treatment Ameliorates Age-Related Accumulation of Toxic Metabolic Intermediates in Brains of the Ts65Dn Mouse Model of Down Syndrome and Aging

D. Patterson, G. Vacano, N. Duval, 2018, Front. Aging Neurosci..

A Cystine-Rich Whey Supplement (Immunocal®) Delays Disease Onset and Prevents Spinal Cord Glutathione Depletion in the hSOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

Erika K. Ross, D. Linseman, D. Patterson, 2014, Antioxidants.

Five new microsatellite polymorphisms at the q21 region of human chromosome 21

X. Estivill, S. Wiemann, W. Ansorge, 2004, Human Genetics.

YAC contig mapping of six expressed sequences encoded by human chromosome 21

J. Yu, D. Patterson, F. Kao, 1995, Somatic cell and molecular genetics.

Analysis of aldehyde oxidase and xanthine dehydrogenase/oxidase as possible candidate genes for autosomal recessive familial amyotrophic lateral sclerosis

M. Brownstein, J. Repine, É. Mezey, 1995, Somatic cell and molecular genetics.

Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells: I. Isolation of a mutant defective in the early steps of de novo pyrimidine synthesis

D. Patterson, D. V. Carnright, Diane V. Carnright, 1977, Somatic cell genetics.

Sublocalization on chromosome 21 of human interferon-alpha receptor gene and the gene for an interferon-gamma response protein

D. Patterson, A. Rashidbaigi, L. Lai, 1990, Somatic cell and molecular genetics.

Expression of a human cDNA encoding a protein containing GAR synthetase, AIR synthetase, and GAR transformylase corrects the defects in mutant Chinese hamster ovary cells lacking these activities

A. Gnirke, D. Schild, D. Patterson, 1991, Somatic cell and molecular genetics.

The human cystathionine beta-synthase (CBS) gene: complete sequence, alternative splicing, and polymorphisms.

W. Ansorge, Č. Vlček, D. Patterson, 1998, Genomics.

Physical mapping of chromosome 21 DNA markers in Alzheimer's disease region using somatic cell hybrids

C. Broeckhoven, H. Backhovens, A. Wehnert, 1990, Somatic cell and molecular genetics.

Two-dimensional electrophoresis of human-CHO cell hybrids containing human chromosome 11

T. Puck, D. Patterson, C. Jones, 1981, Somatic cell genetics.

Two-dimensional electrophoresis of peptides from human-CHO cell hybrids containing human chromosome 21

D. Patterson, C. Scoggin, Y. Miller, 1983, Somatic cell genetics.

Loss of DNA polymerase β induces cellular senescence

D. Patterson, Aqila Ahmed, Cristine Smoczer, 2018, Environmental and molecular mutagenesis.

Adenylosuccinate lyase deficiency.

D. Patterson, R. Colman, E. Spiegel, 2006, Molecular genetics and metabolism.

Folate metabolism and the risk of Down syndrome.

D. Patterson, 2008, Down's syndrome, research and practice : the journal of the Sarah Duffen Centre.

Two Novel Mutant Human Adenylosuccinate Lyases (ASLs) Associated with Autism and Characterization of the Equivalent Mutant Bacillus subtilis ASL*

D. Patterson, R. Colman, Sharmila Sivendran, 2004, Journal of Biological Chemistry.

Cloning and in vivo expression of the human GART gene using yeast artificial chromosomes.

A. Gnirke, M. Olson, D. Schild, 1991, The EMBO journal.

A single base change at a splice acceptor site leads to a truncated CAD protein in Urd−A mutant Chinese hamster ovary cells

D. Patterson, R. Berger, J. Davidson, 1992, Somatic cell and molecular genetics.

Alteration in structure of multifunctional protein from Chinese hamster ovary cells defective in pyrimidine biosynthesis.

D. Patterson, J. Davidson, 1979, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of DNA sequences on human chromosome 21 by application of a recombination-based assay to DNA from flow-sorted chromosomes

G. D. Stewart, S. Latt, H. Drabkin, 1988, Human Genetics.

Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1.

I. Shechter, D. Patterson, I. Hart, 1994, Genomics.

Isolation, characterization, and regional mapping of microclones from a human chromosome 21 microdissection library.

J. Korenberg, J. Yu, R. Gemmill, 1992, American journal of human genetics.

Two Drosophila melanogaster mutations block successive steps of de novo purine synthesis.

S. Henikoff, D. Patterson, J. Woolford, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Identification and localization of DNA alteration in Chinese hamster ovary cell mutants (Urd−) defective in the first three enzymes of de novo pyrimidine synthesis

D. Patterson, L. Niswander, J. Davidson, 1985, Somatic cell and molecular genetics.

Structural gene coding for multifunctional protein carrying orotate phosphoribosyltransferase and OMP decarboxylase activity is located on long arm of human chromosome 3

D. Patterson, P. Rumsby, C. Jones, 1983, Somatic cell genetics.

Multiple purine pathway enzyme activities are encoded at a single genetic locus in Drosophila.

S. Henikoff, M. A. Keene, D. Patterson, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Confirmation of assignment of the human α1-crystallin gene (CRYA1) to chromosome 21 with regional localization to q22.3

J. Piatigorsky, D. Patterson, F. Kao, 1987, Human Genetics.

Molecular genetic analysis of Down syndrome

David Patterson, D. Patterson, 2009, Human Genetics.

Development of a mouse model for the study of human purine metabolism.

G. Brodsky, D. Patterson, T. Barnes, 1994, Advances in experimental medicine and biology.

Localization of the L-glutamine synthetase gene to chromosome 1q23.

D. Patterson, K. Clancy, I. Hart, 1996, Genomics.

Isolation and refined regional mapping of expressed sequences from human chromosome 21.

S. Weissman, J. Yu, D. Patterson, 1994, Genomics.

Isolation of a human cDNA encoding amidophosphoribosyltransferase and functional complementation of a CHO Ade−A mutant deficient in this activity

D. Patterson, J. Barton, J. Bleskan, 1991, Somatic cell and molecular genetics.

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism. VI. Enzymatic studies of two mutants unable to convert inosinic acid to adenylic acid

D. Patterson, A. Tu, 1977, Biochemical Genetics.

Structural and biochemical characterization of human adenylosuccinate lyase (ADSL) and the R303C ADSL deficiency-associated mutation.

K. Ghosh, Lucas Sawle, D. Patterson, 2012, Biochemistry.

Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells: III. Association of carbamyl phosphate synthetase, aspartate transcarbamylase, and dihydroorotase in mutants of cultured Chinese hamster cells

D. Patterson, J. Davidson, D. V. Carnright, 1979, Somatic cell genetics.

Regional mapping of the gene encoding dihydroorotate dehydrogenase, an enzyme involved in UMP synthesis, electron transport, and superoxide generation, to human chromosome region 16q22

M. Minet, D. Patterson, I. Hart, 1993, Somatic cell and molecular genetics.

Isolation and characterization of 5-fluorouracil-resistant mutants of Chinese hamster ovary cells deficient in the activities of orotate phosphoribosyltransferase and orotidine 5′-monophosphate decarboxylase

D. Patterson, 1980, Somatic cell genetics.

Resolution of the intermediates of de novo purine biosynthesis by ion-pair reversed-phase high-performance liquid chromatography.

D. Patterson, R. Hards, 1988, Journal of chromatography.

A multifunctional protein possessing glycinamide ribonucleotide synthetase, glycinamide ribonucleotide transformylase, and aminoimidazole ribonucleotide synthetase activities in de novo purine biosynthesis.

S. Henikoff, S. Benkovic, J. Stubbe, 1985, Biochemistry.

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: Isolation and characterization of a mutant deficient in the activity of phosphoribosylaminoimidazole synthetase

D. Patterson, D. C. Oates, M. Irwin, 1979, Somatic cell genetics.

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: Biochemical analysis of eight mutants

D. Patterson, 1975, Somatic cell genetics.

Localization of TDPX1, a human homologue of the yeast thioredoxin-dependent peroxide reductase gene (TPX), to chromosome 13q12.

P. Pahl, S. Rhee, H. Chae, 1995, Genomics.

Variation of glycinamide ribonucleotide synthetase levels during in vitro aging of human fibroblasts: Implications for gene dosage studies

D. Patterson, R. Hards, 1986, Mechanisms of Ageing and Development.

Use of exhaustive nucleic acid hybridization for determining the amount and size distribution of newly synthesized bacterial message RNA

A. Jacobson, D. Gillespie, D. Patterson, 1973, Biochemical Genetics.

Isolation and characterization of a Chinese hamster ovary cell mutant which accumulates UDP glucuronic acid and requires uridine for growth

D. Patterson, D. Vannais, Diane B. Vannais, 1983, Journal of cellular physiology.

A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment

L. Meltesen, R. Rozen, G. Brodsky, 2010, Molecular genetics and metabolism.

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: Isolation, selection, and characterization of a mutant lacking hypoxanthine-guanine phosphoribosyltransferase activity by nutritional means

D. Patterson, Carol Jones, 1976, Somatic cell genetics.

Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging

D. C. Cabelof, D. Patterson, 2012, Mechanisms of Ageing and Development.

Selection of somatic cell hybrids between HGPRT--and APRT--cells.

D. Patterson, R. Liskay, 1978, Methods in cell biology.

D21S418E identifies a cAMP-regulated gene located on chromosome 21q22.3 that is expressed in placental syncytiotrophoblast and choriocarcinoma cells.

M. Bronner, R. Berger, J. Strauss, 1993, Genomics.

Characterization of a human chromosome 8 cosmid library constructed from flow-sorted chromosomes.

J. Longmire, L. Deaven, H. Drabkin, 1992, Cytogenetics and cell genetics.

Overexpression of amyloid-β protein precursor induces mitochondrial oxidative stress and activates the intrinsic apoptotic cascade.

D. Linseman, D. Patterson, H. Wilkins, 2012, Journal of Alzheimer's disease : JAD.

Mutations of ATIC and ADSL affect purinosome assembly in cultured skin fibroblasts from patients with AICA-ribosiduria and ADSL deficiency.

S. Kmoch, D. Patterson, V. Barešová, 2012, Human molecular genetics.

A gene correcting the defect in the CHO mutant Ade -H, deficient in a branch point enzyme (adenylosuccinate synthetase) of de novo purine biosynthesis, is located on the long arm of chromosome 1.

L. Lai, D. Patterson, I. Hart, 1991, Genomics.

Reduced purine biosynthesis in humans after their divergence from Neandertals

S. Pääbo, P. Khaitovich, T. Maricic, 2020, bioRxiv.

Genetics of somatic mammalian cells: biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism.

T. Puck, D. Patterson, F. Kao, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Mapping of the gene encoding the multifunctional protein carrying out the first three steps of pyrimidine biosynthesis to human chromosome 2

David Patterson, K. Chen, D. Patterson, 1989, Human Genetics.

Biochemical genetic analysis of pyrimidine biosynthesis in mammalian cells. II. Isolation and characterization of a mutant of chinese hamster ovary cells with defective dihydroorotate dehydrogenase (E.C. 1.3.3.1) activity

D. Patterson, T. Stamato, Thomas D. Stamato, 1979, Journal of cellular physiology.

The CRISPR-Cas9 crADSL HeLa transcriptome: A first step in establishing a model for ADSL deficiency and SAICAR accumulation

D. Patterson, G. Vacano, V. Barešová, 2019, Molecular genetics and metabolism reports.

Regional assignment of 64 human gene transcripts on chromosome 8.

C. Auffray, D. Birnbaum, R. Houlgatte, 1997, Cytogenetics and cell genetics.

Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33

J. Haines, H. Horvitz, M. Hamida, 1998, Neurogenetics.

Mutations in SOD1 associated with amyotrophic lateral sclerosis cause novel protein interactions

Eva Mezey, Michael J. Brownstein, David Patterson, 1997, Nature Genetics.

Genetic mapping of a mouse modifier gene that can prevent ALS onset.

J. Haines, C. B. Kunst, D. Patterson, 2000, Genomics.

The CRISPR-Cas9 crGART HeLa transcriptome: A novel cell model of de novo purine synthesis deficiency

D. Patterson, G. Vacano, V. Barešová, 2020, bioRxiv.

Brain Phenotype of Transgenic Mice Overexpressing Cystathionine β-Synthase

J. Billard, J. Bizot, J. Delabar, 2012, PloS one.

Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13.

W. Pearson, D. Patterson, D. Patterson, 1993, American journal of human genetics.

The Production of Transgenic Mice Expressing Human Cystathionine Beta-Synthase to Study Down Syndrome

D. Patterson, A. Knox, C. Butler, 2006, Behavior genetics.

Localization of the gene for the ciliary neurotrophic factor receptor (CNTFR) to human chromosome 9.

C. L. Jackson, D. Patterson, C. Jones, 1993, Genomics.

Assignment of the gene coding for phosphoribosylglycineamide formyltransferase to human chromosome 14

D. Patterson, C. Jones, F. Kao, 1981, Somatic cell genetics.

Identification of two highly polymorphic CA-repeats (D21S1224 and D21S1261) on human chromosome 21q22.3

X. Estivill, S. Wiemann, W. Ansorge, 1995, Human Genetics.

Three CA/GT repeat polymorphisms from loci D21S414 and D21S1234 on human chromosome 21

X. Estivill, S. Wiemann, W. Ansorge, 1994, Human Genetics.

Isolation and regional mapping of NotI and EagI clones from human chromosome 21.

H. Drabkin, D. Patterson, C. Jones, 1991, Genomics.

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism: Characterization of Chinese hamster cell mutants defective in phosphoribosylpyrophosphate amidotransferase and phosphoribosylglycinamide synthetase and an examination of alternatives to the first step of purine bios

D. Patterson, D. C. Oates, Dale C. Oates, 1977, Somatic cell genetics.

Genetic and physical mapping of the GLUR5 glutamate receptor gene on human chromosome 21

J. Haines, H. Horvitz, G. Uhl, 1994, Human Genetics.

Mapping of bovine PRGS and PAIS genes in hybrid somatic cells: Syntenic conservation with human chromosome 21

J. Womack, D. Patterson, J. McAvin, 1988, Biochemical Genetics.

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism III. Isolation and characterization of a mutant unable to convert IMP to AMP

D. Patterson, 1976, Somatic cell genetics.

The CRISPR-Cas9 crATIC HeLa transcriptome: Characterization of a novel cellular model of ATIC deficiency and ZMP accumulation

D. Patterson, G. Vacano, V. Barešová, 2020, bioRxiv.

Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome.

J. Sikela, J. Warrington, J. Wasmuth, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Localization of STCH to human chromosome 21q11.1.

F. Kaye, G. Otterson, G. Brodsky, 1995, Genomics.

A tribute to Dr. Theodore T. Puck

D. Patterson, P. I. Marcus, R. G. Ham, 2006, In Vitro Cellular & Developmental Biology - Animal.

Isolation and characterization of 14 CA-repeat microsatellites from human chromosome 21.

X. Estivill, A. Bosch, D. Patterson, 1993, Genomics.

Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model

D. Patterson, M. Duncan, J. Geiger, 2018, Neurobiology of Aging.

Molecular characterization of the AdeI mutant of Chinese hamster ovary cells: a cellular model of adenylosuccinate lyase deficiency.

S. Kmoch, D. Patterson, G. Vacano, 2011, Molecular genetics and metabolism.

Transcriptome and metabolome analysis of crGART, a novel cell model of de novo purine synthesis deficiency: Alterations in CD36 expression and activity

D. Patterson, G. Vacano, V. Barešová, 2020, PloS one.

Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: cellular models of de novo purine biosynthesis deficiency disorders.

S. Kmoch, D. Patterson, G. Vacano, 2013, Molecular genetics and metabolism.

Mutations in the Chinese hamster ovary cell GART gene of de novo purine synthesis.

G. Brodsky, D. Patterson, A. Knox, 2009, Gene.

Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations.

K. Ghosh, S. Shaheen, D. Patterson, 2013, Biochimica et biophysica acta.

Purification of mammalian glycinamide ribonucleotide (GAR) synthetase.

D. Patterson, S. Graw, R. Hards, 1986, Advances in experimental medicine and biology.

A frequent ala 4 to val superoxide dismutase-1 mutation is associated with a rapidly progressive familial amyotrophic lateral sclerosis.

T. Usdin, Z. Rahmani, É. Mezey, 1994, Human molecular genetics.

Mice transgenic for reduced folate carrier: an animal model of Down syndrome?

G. Lubec, D. Patterson, H. Höger, 2009, Amino Acids.

Characterization of a guanine‐sensitive mutant defective in adenylo‐succinate synthetase activity

D. Patterson, A. Tu, 1978, Journal of cellular physiology.

Assessment of post‐mortem‐induced changes to the mouse brain proteome

S. Hunsucker, D. Patterson, M. Duncan, 2008, Journal of neurochemistry.

Human phosphoribosylformylglycineamide amidotransferase (FGARAT): regional mapping, complete coding sequence, isolation of a functional genomic clone, and DNA sequence analysis.

D. Patterson, K. Gardiner, J. Bleskan, 1999, Gene.

[10] Suicide selection of mammalian cell mutants

D. Patterson, C. Waldren, 1987 .

Molecular and cytogenetic characterization of a Chinese hamster/human hybrid cell line containing a der (21)t(Ypter-->cenY::cen21-->21qter) chromosome.

C. Brahe, F. Tassone, L. Lai, 1993, Genomics.

Isolation and characterization of temperature-sensitive mutants of Chinese hamster ovary cells after treatment with UV and X-irradiation

D. Patterson, C. Waldren, Carolyn Walker, 1976, Somatic cell genetics.

Adenylosuccinate lyase deficiency.

D. Patterson, R. Colman, E. Spiegel, 2006, Molecular Genetics and Metabolism.

Isolation of region specific single-copy probes from human chromosome 1q23-->1q25.

D. Patterson, I. Wieland, G. Schmitz, 1994, Cytogenetics and Cell Genetics.

Folate metabolism and the risk of Down syndrome.

D. Patterson, 2008, Down's syndrome, research and practice : the journal of the Sarah Duffen Centre.

Biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism. IV. Isolation of a mutant which accumulates adenylosuccinic acid and succinylaminoimidazole carboxamide ribotide

D. Patterson, 1976, Somatic cell genetics.

Mutations in the Chinese hamster ovary cell GART gene of de novo purine synthesis.

G. Brodsky, D. Patterson, A. Knox, 2009, Gene.

Genetics of somatic mammalian cells: biochemical genetics of Chinese hamster cell mutants with deviant purine metabolism.

T. Puck, D. Patterson, F. Kao, 1974, Proceedings of the National Academy of Sciences of the United States of America.

Human gene locations achieved by means of human-Chinese hamster (CHO-K1) auxotrophic cell hybridization.

T. Puck, D. Patterson, F. Kao, 1976, Birth defects original article series.

Giemsa-11 technique. Applications in the chromosomal characterization of hematologic specimens

A. Robinson, D. Patterson, T. Hays, 2004, Human Genetics.