M. Didonato

发表

A scaleable and integrated crystallization pipeline applied to mining the Thermotoga maritima proteome

A. Deacon, S. Lesley, H. Klock, 2004, Journal of Structural and Functional Genomics.

Crystal structure of TM1367 from Thermotoga maritima at 1.90 Å resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2006, Proteins.

Crystal structure of an α/β serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 Å resolution

Adam Godzik, Henry van den Bedem, Slawomir K. Grzechnik, 2004 .

Superoxide Dismutase Structures, Stability, Mechanism and Insights into the Human Disease Amyotrophic Lateral Sclerosis from Eukaryotic Thermophile Alvinella pompejana

Greg L. Hura, J. Tainer, E. Getzoff, 2009 .

Crystal structure of a PIN (PilT N‐terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 Å resolution

Adam Godzik, Henry van den Bedem, Slawomir K. Grzechnik, 2004, Proteins.

Comparative structural analysis of a novel glutathioneS‐transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2006, Proteins.

Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 Å resolution

Adam Godzik, Henry van den Bedem, Slawomir K. Grzechnik, 2005, Proteins.

Tuning a Protein Labeling Reaction to Achieve Highly Site-Selective Lysine Conjugation.

Susan E. Cellitti, G. Spraggon, A. Brock, 2018 .

Crystal structure of TM1030 from Thermotoga maritima at 2.3 Å resolution reveals molecular details of its transcription repressor function

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2007, Proteins: Structure, Function, and Bioinformatics.

Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 Å resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2‐hydroxy‐3‐keto‐5‐methylthiopentenyl‐1‐phosphate

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2007, Proteins.

Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 Å resolution reveals a fold similar to the Ran‐binding protein Mog1p

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2006, Proteins.

Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2006, Proteins.

Crystal structure of an alanine‐glyoxylate aminotransferase from Anabaena sp. at 1.70 Å resolution reveals a noncovalently linked PLP cofactor

Adam Godzik, Henry van den Bedem, Slawomir K. Grzechnik, 2005, Proteins.

Crystal structure of an ADP‐ribosylated protein with a cytidine deaminase‐like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 Å resolution

Adam Godzik, Henry van den Bedem, Slawomir K. Grzechnik, 2008, Proteins.

Crystal structure of phosphoribosylformyl‐glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2006, Proteins.

Superoxide dismutase from the eukaryotic thermophile Alvinella pompejana: structures, stability, mechanism, and insights into amyotrophic lateral sclerosis.

John A Tainer, Greg L. Hura, Greg L Hura, 2009, Journal of molecular biology.

Zinc Binding to the NH2-terminal Domain of the Wilson Disease Copper-transporting ATPase

L. Que, M. Didonato, B. Sarkar, 2002, The Journal of Biological Chemistry.

Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.

H. M. Petrassi, P. McNamara, Minhua Qiu, 2020, Journal of medicinal chemistry.

Clinical stage EGFR inhibitors irreversibly alkylate Bmx kinase.

L. Flatauer, Sungjoon Kim, M. Warmuth, 2008, Bioorganic & medicinal chemistry letters.

Manganese Superoxide Dismutase

J. Tainer, M. Stroupe, M. Didonato, 2006 .

Copper transport and its alterations in Menkes and Wilson diseases.

M. Didonato, B. Sarkar, B. Sarkar, 1997, Biochimica et biophysica acta.

Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Ce

Chun Xing Li, S. Bender, G. Spraggon, 2016, Journal of medicinal chemistry.

Expression, purification, and metal binding characteristics of the putative copper binding domain from the Wilson disease copper transporting ATPase (ATP7B).

M. Didonato, B. Sarkar, S. Narindrasorasak, 1999, Advances in experimental medicine and biology.

Expression, Purification, and Metal Binding Properties of the N-terminal Domain from the Wilson Disease Putative Copper-transporting ATPase (ATP7B)*

D. Cox, M. Didonato, J. Forbes, 1997, The Journal of Biological Chemistry.

Overcoming EGFR T790M and C797S resistance with mutant-selective allosteric inhibitors

Haikuo Zhang, Gerald Lelais, Kwok-Kin Wong, 2016 .

EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor.

J. Barretina, Jennifer L. Harris, J. Engelman, 2016, Cancer research.

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation

Austin D. Swafford, P. McNamara, A. Herman, 2015, Nature Communications.

ALS mutants of human superoxide dismutase form fibrous aggregates via framework destabilization.

John A Tainer, J. Tainer, E. Getzoff, 2003, Journal of molecular biology.

Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase.

J. Tainer, E. Getzoff, M. M. Thayer, 2002, Journal of molecular biology.

Biochemical characterization of respiratory syncytial virus RNA-dependent RNA polymerase complex.

G. Spraggon, M. Hekmatnejad, M. Didonato, 2020, ACS infectious diseases.

Structural, Functional, and Immunogenic Insights on Cu,Zn Superoxide Dismutase Pathogenic Virulence Factors from Neisseria meningitidis and Brucella abortus

J. Tainer, E. Getzoff, P. Langford, 2015, Journal of bacteriology.

Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2004, Proteins.

Copper-induced conformational changes in the N-terminal domain of the Wilson disease copper-transporting ATPase.

L. Que, M. Didonato, B. Sarkar, 2000, Biochemistry.

Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 Å resolution reveals a new fold

Mitchell D. Miller, A. Godzik, K. Hodgson, 2005, Proteins.

Crystal structure of a single‐stranded DNA‐binding protein (TM0604) from Thermotoga maritima at 2.60 Å resolution

Adam Godzik, Henry van den Bedem, Slawomir K. Grzechnik, 2006, Proteins.

Towards the Characterization of the Wilson Disease Copper ATpase Metal Binding Domain

M. Didonato, B. Sarkar, 1999 .

Crystal structure of S‐adenosylmethionine:tRNA ribosyltransferase‐isomerase (QueA) from Thermotoga maritima at 2.0 Å resolution reveals a new fold

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2005, Proteins.

Crystal structure of an indigoidine synthase A (IndA)‐like protein (TM1464) from Thermotoga maritima at 1.90 Å resolution reveals a new fold

Mitchell D. Miller, A. Godzik, A. Deacon, 2005, Proteins.

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 Å resolution reveals a new fold

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2005, Proteins: Structure, Function, and Bioinformatics.

Crystal structure of a tandem cystathionine‐β‐synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2004, Proteins.

Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2004, Proteins: Structure, Function, and Bioinformatics.

Crystal structure of a novel manganese‐containing cupin (TM1459) from Thermotoga maritima at 1.65 Å resolution

Mitchell D. Miller, A. Godzik, A. Deacon, 2004, Proteins.

Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2004, Proteins.

Crystal structure of an Udp‐n‐acetylmuramate‐alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 Å resolution

Mitchell D. Miller, A. Godzik, A. Deacon, 2004, Proteins.

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2004, Proteins.

Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77‐Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2004, Proteins.

Crystal structure of a putative PII‐like signaling protein (TM0021) from Thermotoga maritima at 2.5 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2004, Proteins.

Erratum to “ALS Mutants of Human Superoxide Dismutase form Fibrous Aggregates via Framework Destabilization” [J. Mol. Biol. 332 (2003) 601–615]

J. Tainer, E. Getzoff, J. Kelly, 2003 .

Tuning a Protein‐Labeling Reaction to Achieve Highly Site Selective Lysine Conjugation

Susan E. Cellitti, G. Spraggon, A. Brock, 2018, Chembiochem : a European journal of chemical biology.

Abstract 2585: Discovery of a potent covalent mutant-selective EGFR inhibitor - the journey from high throughput screening to EGF816

C. Li, S. Kasibhatla, I. Matushansky, 2015 .

Abstract 1734:In vitrocharacterization of EGF816, a third-generation mutant-selective EGFR inhibitor

Jennifer L. Harris, S. Bender, N. Pathan, 2014 .

Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 Å resolution provides a structural scaffold for nonclassical, eukaryotic‐like phosphatases

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2007, Proteins.

IL-2 Immunotherapy Reveals Potential for Innate Beta Cell Regeneration in the Non-Obese Diabetic Mouse Model of Autoimmune Diabetes

P. McNamara, A. Herman, M. Londei, 2013, PloS one.

Crystal structure of homoserine O‐succinyltransferase from Bacillus cereus at 2.4 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2007, Proteins.

Overcoming EGFR T790M and C797S resistance with mutant-selective allosteric inhibitors

P. Jänne, Jennifer L. Harris, M. Eck, 2016, Nature.

Crystal structure of a putative NADPH‐dependent oxidoreductase (GI: 18204011) from mouse at 2.10 Å resolution

Adam Godzik, Henry van den Bedem, Slawomir K. Grzechnik, 2004, Proteins.

Crystal structure of 2‐phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 Å resolution reveals a new fold with a novel active site

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2006, Proteins.

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 Å resolution

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2006 .

Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 Å resolution reveals a new fold

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2005, Proteins.

Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 Å resolution reveals a new fold

Slawomir K. Grzechnik, Mitchell D. Miller, A. Godzik, 2005, Proteins.