A. Goutopoulos

发表

Novel analogues of arachidonylethanolamide (anandamide): affinities for the CB1 and CB2 cannabinoid receptors and metabolic stability.

A. Makriyannis, Sonyuan Lin, S. Lin, 1998, Journal of medicinal chemistry.

Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors.

A. Bender, A. Goutopoulos, Xiaohua Zhu, 2021, Bioorganic & medicinal chemistry.

Discovery of Covalent Bruton's Tyrosine Kinase Inhibitors with Decreased CYP2C8 Inhibitory Activity

F. Rohdich, A. Follis, K. Georgi, 2021, ChemMedChem.

Identification of Clinical Candidate M2698, a Dual p70S6K and Akt Inhibitor, for Treatment of PAM Pathway-Altered Cancers.

T. E. Richardson, F. Rohdich, B. Huck, 2021, Journal of medicinal chemistry.

Potentiation of the action of anandamide on hippocampal slices by the fatty acid amide hydrolase inhibitor, palmitylsulphonyl fluoride (AM 374).

N. Volkow, A. Makriyannis, Sonyuan Lin, 1999, European journal of pharmacology.

Discovery of Affinity‐Based Probes for Btk Occupancy Assays

Daigen Xu, A. Bender, A. Goutopoulos, 2019, ChemMedChem.

Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk.

A. Follis, A. Goutopoulos, R. Grenningloh, 2018, Bioorganic & medicinal chemistry letters.

Substrate specificity and stereoselectivity of rat brain microsomal anandamide amidohydrolase.

K. Abouzid, A. Makriyannis, Sonyuan Lin, 1999, Journal of medicinal chemistry.

Determination of anandamide amidase activity using ultraviolet-active amine derivatives and reverse-phase high-performance liquid chromatography.

A. Makriyannis, A. Goutopoulos, C. Qin, 1998, Analytical biochemistry.

Optimization of the efflux ratio and permeability of covalent irreversible BTK inhibitors.

A. Goutopoulos, R. Grenningloh, A. Gardberg, 2018, Bioorganic & medicinal chemistry letters.

Discovery of substituted benzamides as follicle stimulating hormone receptor allosteric modulators.

T. E. Richardson, Xuliang Jiang, S. Palmer, 2014, Bioorganic & medicinal chemistry letters.

Effects of Δ9-tetrahydrocannabinol, (R)-methanandamide, SR 141716, and d-amphetamine before and during daily Δ9-tetrahydrocannabinol dosing

A. Makriyannis, A. Goutopoulos, R. Lamb, 2000 .

SAR and evaluation of novel 5H-benzo[c][1,8]naphthyridin-6-one analogs as Aurora kinase inhibitors.

Xuliang Jiang, B. Huck, H. Tian, 2013, Bioorganic & medicinal chemistry letters.

Discovery of Evobrutinib: An Oral, Potent and Highly Selective, Covalent Bruton's Tyrosine Kinase (BTK) Inhibitor for the Treatment of Immunological Diseases.

M. Camps, A. Follis, B. Huck, 2019, Journal of medicinal chemistry.

Stereochemical selectivity of methanandamides for the CB1 and CB2 cannabinoid receptors and their metabolic stability.

A. Makriyannis, S. Lin, A. Khanolkar, 2001, Bioorganic & medicinal chemistry.

Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer*

Xuliang Jiang, S. Arkinstall, A. Goutopoulos, 2014, The Journal of Biological Chemistry.

From cannabis to cannabinergics: new therapeutic opportunities.

A. Makriyannis, A. Goutopoulos, 2002, Pharmacology & therapeutics.

Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172.

D. Fegley, D. Piomelli, A. Makriyannis, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Blockade of the MEK/ERK signalling cascade by AS703026, a novel selective MEK1/2 inhibitor, induces pleiotropic anti‐myeloma activity in vitro and in vivo

N. Munshi, P. Richardson, P. Burger, 2010, British journal of haematology.

Discovery of novel covalent BTK inhibitors with reduced CYP2C8 inhibitory activity.

F. Rohdich, K. Georgi, A. Goutopoulos, 2021, ChemMedChem.

Discovery of potent, highly selective covalent irreversible BTK inhibitors from a fragment hit.

A. Follis, A. Goutopoulos, R. Grenningloh, 2018, Bioorganic & medicinal chemistry letters.

Structural determinants for recognition and translocation by the anandamide transporter.

D. Piomelli, A. Makriyannis, S. Lin, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Pharmacophoric requirements for cannabinoid side chains: multiple bond and C1'-substituted delta 8-tetrahydrocannabinols.

A. Makriyannis, A. Goutopoulos, D. Papahatjis, 1998, Journal of medicinal chemistry.

Δ9-THC training dose as a determinant for (R)-methanandamide generalization in rats

A. Makriyannis, S. Lin, A. Goutopoulos, 1998, Psychopharmacology.

Title Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM 1172

D. Fegley, D. Piomelli, A. Makriyannis, 2004 .

Synthesis and SAR development of quinoline analogs as novel P2X7 receptor antagonists.

A. Goutopoulos, Jeyaprakashnarayanan Seenisamy, B. Sherer, 2019, Bioorganic & medicinal chemistry letters.

Abstract LB-295: Discovery of potent selective oral ACSS2 inhibitors for the treatment of acetate avid tumors

E. Gottlieb, I. Alchanati, A. Goutopoulos, 2020 .

Discovery of 4-Aminopyrimidine Analogs as highly Potent Dual P70S6K/Akt Inhibitors.

Xuliang Jiang, B. Huck, E. Wilker, 2021, Bioorganic & medicinal chemistry letters.