J. Sauer

发表

Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor.

F. Bymaster, G. Nomikos, C. Felder, 2002, The Journal of pharmacology and experimental therapeutics.

The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4-induced liver injury by a single dose of retinol.

I. Sipes, J. Sauer, D. Badger, 1996, Toxicology and applied pharmacology.

A formulation strategy for gamma secretase inhibitor ELND006, a BCS class II compound: development of a nanosuspension formulation with improved oral bioavailability and reduced food effects in dogs.

E. Merisko-Liversidge, G. Liversidge, G. Tonn, 2012, Journal of pharmaceutical sciences.

Improving the permeability of the hydroxyethylamine BACE-1 inhibitors: structure-activity relationship of P2' substituents.

H. Sham, N. Yao, T. Yednock, 2010, Bioorganic & medicinal chemistry letters.

Qualification of translational safety biomarkers

A. Porter, J. Sauer, 2021, Experimental biology and medicine.

Preclinical biomarker qualification

A. Porter, J. Sauer, 2018, Experimental biology and medicine.

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor.

R. Neitz, H. Sham, N. Yao, 2011, Bioorganic & medicinal chemistry letters.

Serum glutamate dehydrogenase activity enables early detection of liver injury in subjects with underlying muscle impairments

J. Aubrecht, A. Porter, J. Sauer, 2020, PloS one.

Simultaneous determination of cyclohexene oxide and its metabolites in rat plasma and urine by gas chromatography.

I. Sipes, J. Sauer, J. Bao, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Absorption, disposition kinetics, and metabolic pathways of cyclohexene oxide in the male Fischer 344 rat and female B6C3F1 mouse.

M. Cunningham, I. Sipes, J. Sauer, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement.

R. Neitz, H. Sham, T. Yednock, 2011, Bioorganic & medicinal chemistry letters.

Design and synthesis of disubstituted thiophene and thiazole based inhibitors of JNK.

G. Tóth, R. Neitz, H. Sham, 2010, Bioorganic & medicinal chemistry letters.

Oral and topical absorption, disposition kinetics, and the metabolic fate of trans-methyl styryl ketone in the male Fischer 344 rat.

I. Sipes, J. Sauer, R. Kuester, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Metabolic and dispositional fate of 1,2-dibromo-2,4-dicyanobutane in the male fischer 344 Rat.

I. Sipes, J. Sauer, R. Kuester, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel

K. Kinnett, L. Cripe, C. Spurney, 2021, Open Heart.

Atomoxetine pharmacokinetics in children and adolescents with attention deficit hyperactivity disorder.

J. Biederman, T. Spencer, T. Wilens, 2003, Journal of child and adolescent psychopharmacology.

Alteration of Kupffer cell function and morphology by low melt point paraffin wax in female Fischer-344 but not Sprague-Dawley rats.

M. Miller, I. Sipes, J. Hensel, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Quantifying Amyloid Beta (Aβ)–Mediated Changes in Neuronal Morphology in Primary Cultures

Mike Lee, W. Zago, M. Bova, 2012, Journal of biomolecular screening.

Gadolinium chloride reduces cytochrome P450: relevance to chemical-induced hepatotoxicity.

I. Sipes, J. Sauer, D. Badger, 1997, Toxicology.

Population pharmacokinetic analysis of atomoxetine in pediatric patients

B. Smith, M. Heathman, J. Sauer, 2004 .

Translatable Biomarkers in Drug Development

E. Walker, A. Porter, J. Sauer, 2016 .

The Predictive Safety Testing Consortium : safety biomarkers biomarkers biomarkers , collaboration , and qualification

E. Walker, A. Porter, J. Sauer, 2015 .

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration.

G. Tóth, H. Sham, N. Yao, 2011, Bioorganic & medicinal chemistry letters.

Effect of hepatic impairment on the pharmacokinetics of atomoxetine and its metabolites

K. Desante, R. Frye, J. Sauer, 2003, Clinical pharmacology and therapeutics.

Amblyomma americanum: characterization of salivary prostaglandins E2 and F2 alpha by RP-HPLC/bioassay and gas chromatography-mass spectrometry.

J. Sauer, J. Ribeiro, J. Sauer, 1992, Experimental parasitology.

Orally available and efficacious α4β1/α4β7 integrin inhibitors.

Zhenmei Liao, L. Mutter, G. Shopp, 2013, Bioorganic & medicinal chemistry letters.

Cytotoxicity and genotoxicity of methyleugenol and related congeners-- a mechanism of activation for methyleugenol.

I. Sipes, J. Sauer, C. Mcqueen, 2000, Mutation research.

1-Nitronaphthalene Causes Ultrastructural Changes Primarily in Nonciliated Bronchiolar Epithelium Followed by Ciliated Epithelium in the Rat

J. Sauer, 1991 .

Monitoring signaling by the p75(NTR) receptor utilizing a caspase-3 activation assay amenable to small-molecule screening.

J. M. Bradshaw, M. Bova, J. Sauer, 2012, Assay and drug development technologies.

Tolerance induced by all-trans-retinol to the hepatotoxic effects of cadmium in rats: role of metallothionein expression.

A. Baines, I. Sipes, M. Waalkes, 1997, Toxicology and applied pharmacology.

Design, synthesis, and structure-activity relationship of novel orally efficacious pyrazole/sulfonamide based dihydroquinoline gamma-secretase inhibitors.

H. Sham, T. Yednock, M. Bova, 2009, Bioorganic & medicinal chemistry letters.

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.

R. Motter, D. Kholodenko, H. Sham, 2010, Bioorganic & medicinal chemistry letters.

Clinical Pharmacokinetics of Atomoxetine

John-Michael Sauer, B. Ring, J. Sauer, 2005, Clinical pharmacokinetics.

Sulfhydryl-dependent biotransformation and macromolecular binding of 1,2-dibromo-2,4-dicyanobutane in blood.

I. Sipes, J. Sauer, R. Kuester, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Suppression of Kupffer cell function prevents cadmium induced hepatocellular necrosis in the male Sprague-Dawley rat.

I. Sipes, M. Waalkes, J. Sauer, 1997, Toxicology.

Candidate biomarkers for the diagnosis and prognosis of drug‐induced liver injury: An international collaborative effort

Jiri Aubrecht, John-Michael Sauer, Simon Kirby, 2018, Hepatology.

Physiology of the Gastrointestinal System

H. Merchant, J. Sauer, 2018 .

Biomarkers of Crohn's Disease to Support the Development of New Therapeutic Interventions.

J. Aubrecht, J. Braun, B. Linggi, 2020, Inflammatory bowel diseases.

Disposition and metabolic fate of atomoxetine hydrochloride: pharmacokinetics, metabolism, and excretion in the Fischer 344 rat and beagle dog.

John-Michael Sauer, F. Kuo, W. J. Wheeler, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Alterations in chemically induced tissue injury related to all-trans-retinol pretreatment in rodents.

A. Baines, I. Sipes, J. Sauer, 1995, Drug metabolism reviews.

The Engineered Antibiotic Peptide PLG0206 Eliminates Biofilms and Is a Potential Treatment for Periprosthetic Joint Infections

J. Sauer, J. Steckbeck, Jonathan D. Steckbeck, 2021, Antibiotics.

An ultrastructural evaluation of acute 1-nitronaphthalene induced hepatic and pulmonary toxicity in the rat.

R. Eversole, J. Sauer, D. Johnson, 1997, Toxicology letters.

The liver as a target for chemical-chemical interactions.

I. Sipes, J. Sauer, L. Gunawardhana, 1997, Advances in pharmacology.

Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism.

John-Michael Sauer, K. Desante, J. Sauer, 2003, Drug metabolism and disposition: the biological fate of chemicals.

Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.

I. Sipes, J. Sauer, J. Halladay, 1999, Drug metabolism and disposition: the biological fate of chemicals.

Modulation of Kupffer cell and peripheral blood monocyte activity by in vivo treatment of rats with all-trans-retinol.

R. McCuskey, I. Sipes, J. Sauer, 2008, Liver.

Pharmacokinetics, Safety, and Tolerability of Atomoxetine and Effect of CYP2D6*10/*10 Genotype in Healthy Japanese Men

K. Desante, J. Azuma, J. Sauer, 2012, Journal of clinical pharmacology.

The interactions between retinol and five different hepatotoxicants in the Swiss Webster mouse.

I. Sipes, J. Sauer, S. Hooser, 1995, Fundamental and applied toxicology : official journal of the Society of Toxicology.

All-trans-retinol alteration of 1-nitronaphthalene-induced pulmonary and hepatic injury by modulation of associated inflammatory responses in the male Sprague-Dawley rat.

I. Sipes, J. Sauer, S. Hooser, 1995, Toxicology and applied pharmacology.

Modulation of chemical-induced lung and liver toxicity by all-trans-retinol in the male Sprague-Dawley rat.

I. Sipes, J. Sauer, 1995, Toxicology.

Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease

R. Motter, D. Kholodenko, R. Barbour, 2010, Alzheimer's Research & Therapy.

Highly selective c-Jun N-terminal kinase (JNK) 2 and 3 inhibitors with in vitro CNS-like pharmacokinetic properties prevent neurodegeneration.

John-Michael Sauer, Zhao Ren, Dean R Artis, 2011, Bioorganic & medicinal chemistry letters.

Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitor

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.

Advancing Risk Assessment through the Application of Systems Toxicology

Manuel C. Peitsch, A. Wallace Hayes, André Kleensang, 2016, Toxicological research.

Systems Toxicology

Thomas B Knudsen, Thomas Hartung, Julia Hoeng, 2015, International journal of toxicology.

Perspectives on statistical strategies for the regulatory biomarker qualification process

Sue-Jane Wang, S. Hendrix, L. McShane, 2021, Biomarkers in medicine.

Absorption, disposition, and metabolism of trans-methyl styryl ketone in female B6C3F1 mice.

I. Sipes, J. Sauer, R. Kuester, 1997, Drug metabolism and disposition: the biological fate of chemicals.

What evidence do we need for biomarker qualification?

Chris Leptak, Joseph P Menetski, John A Wagner, 2017, Science Translational Medicine.

Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition.

Christine R. Wilson, J. Sauer, G. Carlson, 2003, Toxicology.

Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.

H. Sham, L. Latimer, M. Bova, 2013, Bioorganic & medicinal chemistry letters.

Rat Urinary Osteopontin and Neutrophil Gelatinase-Associated Lipocalin Improve Certainty of Detecting Drug-Induced Kidney Injury.

Yi-Zhong Gu, D. Holder, E. Walker, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Atomoxetine Hydrochloride: Clinical Drug-Drug Interaction Prediction and Outcome

J. Gillespie, B. Ring, S. Wrighton, 2004, Journal of Pharmacology and Experimental Therapeutics.

Net Reclassification Index and Integrated Discrimination Index Are Not Appropriate for Testing Whether a Biomarker Improves Predictive Performance.

John-Michael Sauer, Jonathan A Phillips, Peter M Burch, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.

G. Tóth, H. Sham, N. Yao, 2010, Bioorganic & medicinal chemistry letters.

eTRANSAFE: Building a sustainable framework to share reproducible drug safety knowledge with the public domain

N. Blomberg, J. van der Lei, K. Briggs, 2022, F1000Research.

Effect of Potent CYP2D6 Inhibition by Paroxetine on Atomoxetine Pharmacokinetics

C. Ernest, J. Sauer, H. Thomasson, 2002, Journal of clinical pharmacology.

Effects of single and multiple dose oral administration of ELND006, a novel APP-selective gamma-secretase inhibitor, on amyloid-β concentrations in the brain and CSF of cynomolgus monkeys

R. Motter, D. Kholodenko, J. Sauer, 2010, Alzheimer's & Dementia.

Discovery of sulfonamide-pyrazole gamma-secretase inhibitors.

H. Sham, J. Sauer, P. Keim, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.

R. Neitz, M. Adler, H. Sham, 2012, Bioorganic & medicinal chemistry letters.

Simultaneous quantification of atomoxetine as well as its primary oxidative and O-glucuronide metabolites in human plasma and urine using liquid chromatography tandem mass spectrometry (LC/MS/MS).

W. J. Wheeler, J. Sauer, R. Lelacheur, 2005, Journal of pharmaceutical and biomedical analysis.

Discovery of a novel sulfonamide-pyrazolopiperidine series as potent and efficacious gamma-secretase inhibitors.

H. Sham, M. Bova, J. Sauer, 2010, Bioorganic & medicinal chemistry letters.

Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.

H. Sham, M. Bova, J. Sauer, 2011, Bioorganic & Medicinal Chemistry Letters.

Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.

M. Bova, J. Sauer, G. Basi, 2011, Bioorganic & medicinal chemistry letters.

Modeling and simulation for medical product development and evaluation: highlights from the FDA-C-Path-ISOP 2013 workshop

B. Corrigan, Sue-Jane Wang, T. Colatsky, 2014, Journal of Pharmacokinetics and Pharmacodynamics.

Gastrointestinal System: Overview of Physiology

J. Sauer, 2010 .

Taxines: a review of the mechanism and toxicity of yew (Taxus spp.) alkaloids.

Christine R. Wilson, J. Sauer, C. Wilson, 2001, Toxicon : official journal of the International Society on Toxinology.

The Predictive Safety Testing Consortium: safety bio-markers, collaboration, and qualification

John-Michael Sauer, Elizabeth G. Walker, Amy C. Porter, 2016, Journal of Medicines Development Sciences.

Evaluation of the Relative Performance of Drug-Induced Skeletal Muscle Injury Biomarkers in Rats.

R. Higgs, D. Watson, E. Walker, 2016, Toxicological sciences : an official journal of the Society of Toxicology.

N-Bridged bicyclic sulfonamides as inhibitors of gamma-secretase.

H. Sham, M. Bova, J. Sauer, 2009, Bioorganic & medicinal chemistry letters.

Promoting Adoption of the 3Rs through Regulatory Qualification.

John-Michael Sauer, Elizabeth Gribble Walker, Amanda F Baker, 2016, ILAR journal.

R. Motter, D. Kholodenko, H. Sham, 2013, Journal of medicinal chemistry.

The regulatory acceptance of translational safety biomarkers

A. Porter, J. Sauer, 2020 .

The Predictive Safety Testing Consortium: safety bio-markers, collaboration, and qualification

E. Walker, A. Porter, J. Sauer, 2016, Journal of Medicines Development Sciences.

Design and synthesis of cell potent BACE-1 inhibitors: structure-activity relationship of P1' substituents.

John-Michael Sauer, Gergely Toth, G. Tóth, 2009, Bioorganic & medicinal chemistry letters.

The Predictive Safety Testing Consortium and the Coalition Against Major Diseases

J. Sauer, D. Stephenson, 2014, Nature Reviews Drug Discovery.