K. Sharkey

M. van Engeland, W. Boesmans, P. Vanden Berghe, 2017, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors

Hong Zhang, S. Brand, B. Lutz, 2008, Journal of Molecular Medicine.

The effects of glucagon‐like peptide 2 on enteric neurons in intestinal inflammation

L. Wallace, K. Sharkey, D. Sigalet, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Intracisternal TRH analog induces Fos expression in gastric myenteric neurons and glia in conscious rats.

Y. Taché, K. Sharkey, M. Miampamba, 2001, American journal of physiology. Gastrointestinal and liver physiology.

Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?

A. Makriyannis, K. Sharkey, D. Osei-Hyiaman, 2009, Trends in pharmacological sciences.

Area Postrema Neurons Are Modulated by the Adipocyte Hormone Adiponectin

R. Ahima, A. Ferguson, K. Sharkey, 2006, The Journal of Neuroscience.

Accumulation and degranulation of mast cells in experimental neuromas

K. Sharkey, D. Zochodne, C. Nguyen, 1994, Neuroscience Letters.

The neutral cannabinoid CB1 receptor antagonist AM4113 regulates body weight through changes in energy intake in the rat

Lindsay K. Eller, J. Wood, R. Reimer, 2011, Pharmacology Biochemistry and Behavior.

Ileitis alters neuronal and enteroendocrine signalling in guinea pig distal colon

K. Sharkey, G. Mawe, A. Lomax, 2006, Gut.

Activation of neuronal P2X7 receptor-Pannexin-1 mediates death of enteric neurons during colitis

Roger J. Thompson, D. McKay, K. Sharkey, 2012, Nature Medicine.

From Fat to Full: Peripheral and Central Mechanisms Controlling Food Intake and Energy Balance: View from the Chair

K. Sharkey, 2006, Obesity.

Cyclooxygenase‐2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon

D. R. Linden, K. Sharkey, G. Mawe, 2004, The Journal of physiology.

A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice

K. Mackie, D. Saur, B. Göke, 2013, Neuropharmacology.

Enteric glia

Y. Nasser, K. Sharkey, A. Rühl, 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Disruption of the blood–brain barrier during TNBS colitis

Q. Pittman, S. Natah, K. Sharkey, 2005, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

D. Saur, W. Krajewska, J. Timmermans, 2015, Journal of Molecular Medicine.

Effects of capsaicin in rat and pigeon on peripheral nerves containing substance P and calcitonin gene-related peptide

K. Sharkey, F. Pierau, G. Harti, 1989, Cell and Tissue Research.

Cytokines and irritable bowel syndrome: where do we stand?

N. Rezaei, C. Andrews, M. Storr, 2012, Cytokine.

Orally administered indomethacin acutely reduces cellular prion protein in the small intestine and modestly increases survival of mice exposed to infectious prions

F. Jirik, K. Sharkey, G. Martin, 2015, Scandinavian journal of gastroenterology.

Inducible nitric oxide synthase (iNOS) in endotoxemia: chimeric mice reveal different cellular sources in various tissues

P. Kubes, M. Hickey, K. Sharkey, 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Sensory substance P innervation of the stomach and pancreas: Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing

G. Dockray, K. Sharkey, R. G. Williams, 1984 .

S1670 The Identification of Peroxisome Proliferator-Activated Receptor Alpha-Independent Effects of Oleoylethanolamide On Intestinal Transit in Mice

D. Piomelli, B. Lutz, K. Sharkey, 2008 .

Peptides and neuromas: Calcitonin gene‐related peptide, substance P, and mast cells in a mechanosensitive human sural neuroma

C. Cheng, K. Sharkey, D. Zochodne, 1997, Muscle & nerve.

AM 251 produces sustained reductions in food intake and body weight that are resistant to tolerance and conditioned taste aversion

Q. Pittman, K. Sharkey, H. Koopmans, 2006, British journal of pharmacology.

Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice

Q. Pittman, F. Lee, K. Sharkey, 2021, Frontiers in Cellular Neuroscience.

Cytokine imbalance in irritable bowel syndrome: a systematic review and meta‐analysis

L. Chang, L. Öhman, D. McKernan, 2014, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Innervation and mast cells of the rat exorbital lacrimal gland: the effects of age.

K. Sharkey, Jaipaul Singh, R. M. Williams, 1994, Journal of the autonomic nervous system.

Sensory substance P innervation of the stomach and pancreas. Demonstration of capsaicin-sensitive sensory neurons in the rat by combined immunohistochemistry and retrograde tracing.

G. Dockray, K. Sharkey, R. G. Williams, 1984, Gastroenterology.

Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation.

K. Sharkey, P. Beck, D. McCafferty, 2007, Gastroenterology.

A novel receptor for calcitonin gene‐related peptide (CGRP) mediates secretion in the rat colon: implications for secretory function in colitis

R. Quirion, W. MacNaughton, J. Junien, 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Substance P and Calcitonin Gene‐Related Peptide (CGRP) in Gastrointestinal Inflammation a

K. Sharkey, 1992, Annals of the New York Academy of Sciences.

Enteroendocrine cells and 5-HT availability are altered in mucosa of guinea pigs with TNBS ileitis.

D. R. Linden, K. Sharkey, G. Mawe, 2004, American journal of physiology. Gastrointestinal and liver physiology.

ENTEROENDOCRINE CELLS AND SEROTONIN AVAILABILITY ARE ALTERED IN THE MUCOSA OF GUINEA PIGS WITH TNBS ILEITIS

D. R. Linden, K. Sharkey, G. Mawe, 2004 .

Prion diseases and the gastrointestinal tract.

J. Reynolds, F. Jirik, K. Sharkey, 2006, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

Characterization of the inflammatory response to proteinase‐activated receptor‐2 (PAR2)‐activating peptides in the rat paw

J. Wallace, M. Hollenberg, K. Sharkey, 1999, British journal of pharmacology.

Aspirin causes rapid up‐regulation of cyclo‐oxygenase‐2 expression in the stomach of rats

N. Davies, J. Wallace, W. MacNaughton, 1997, Alimentary pharmacology & therapeutics.

Themes Endocannabinoids and Liver Disease . III . Endocannabinoid effects on immune cells : implications for inflammatory liver diseases

Stephen P. H. Alexander, B. Cravatt, Adam D. Thomas, 2008 .

Insights into the role of cannabis in the management of inflammatory bowel disease

G. Kaplan, K. Sharkey, C. Seow, 2019, Therapeutic advances in gastroenterology.

Cannabinoid CB2 receptors in the enteric nervous system modulate gastrointestinal contractility in lipopolysaccharide-treated rats.

K. Mackie, Q. Pittman, N. E. Buckley, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Differential induction of nitric oxide synthase in rat gastric and vascular smooth muscle tissue: distinct tissue distribution and distinctive signaling pathways.

M. Hollenberg, K. Sharkey, Y. Gui, 1999, The Journal of pharmacology and experimental therapeutics.

Induction of nitric oxide synthase in rat gastric smooth muscle preparations.

M. Hollenberg, Xi-Long Zheng, K. Sharkey, 1997, American journal of physiology. Gastrointestinal and liver physiology.

Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway

A. Basbaum, J. Wallace, M. Hollenberg, 2001, Nature Medicine.

Effects of chemical sympathectomy and sensory nerve ablation on experimental colitis in the rat.

J. Wallace, K. Sharkey, D. McCafferty, 1997, The American journal of physiology.

Interleukin-1beta activates specific populations of enteric neurons and enteric glia in the guinea pig ileum and colon.

K. Sharkey, E. Tjwa, A. Kroese, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Interleukin-1B (IL-1B) stimulates fos expression in specific subsets of enteric neurons through a cyclooxygenase-dependent pathway

K. Sharkey, E. Tjwa, A. Kroese, 2000 .

Spontaneously developing chronic colitis in IL-10/iNOS double-deficient mice.

J. Wallace, P. Kubes, K. Sharkey, 2000, American journal of physiology. Gastrointestinal and liver physiology.

Recruitment of α4β7 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior

Q. Pittman, M. Swain, K. Sharkey, 2022, Journal of Neuroinflammation.

The Role of the Endocannabinoid System in the Brain-Gut Axis.

K. Sharkey, J. Wiley, 2016, Gastroenterology.

Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ9-Tetrahydrocannabinol

B. Le Foll, R. Reimer, K. Sharkey, 2015, PloS one.

Beneficial effects of local or systemic lidocaine in experimental colitis.

J. Wallace, K. Sharkey, D. McCafferty, 1994, The American journal of physiology.

The Antidepressant Mirtazapine Inhibits Hepatic Innate Immune Networks to Attenuate Immune-Mediated Liver Injury in Mice

M. Swain, K. Sharkey, A. Shaheen, 2019, Front. Immunol..

Lack of beneficial effect of a tachykinin receptor antagonist in experimental colitis

J. Wallace, K. Sharkey, D. McCafferty, 1998, Regulatory Peptides.

Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis.

J. Wallace, K. Sharkey, W. McKnight, 1995, Gastroenterology.

A monocyte–leptin–angiogenesis pathway critical for repair post-infection

P. Kubes, M. Mack, J. Biernaskie, 2022, Nature.

Altered Brain Excitability and Increased Anxiety in Mice With Experimental Colitis: Consideration of Hyperalgesia and Sex Differences

Q. Pittman, M. Swain, K. Sharkey, 2018, Front. Behav. Neurosci..

Targeting the endocannabinoid system for the treatment of abdominal pain in irritable bowel syndrome

J. Tack, M. Storr, S. Brierley, 2022, Nature reviews. Gastroenterology & hepatology.

Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice

K. Mackie, B. Lutz, C. Hirota, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Multiple mechanisms contribute to myenteric plexus ablation induced by benzalkonium chloride in the guinea-pig ileum

K. Sharkey, E. J. Parr, E. Parr, 1997, Cell and Tissue Research.

Comorbid anxiety-like behavior in a rat model of colitis is mediated by an upregulation of corticolimbic fatty acid amide hydrolase

Q. Pittman, K. Sharkey, M. Hill, 2021, Neuropsychopharmacology.

The expression and role of Fas ligand in intestinal inflammation

W. MacNaughton, K. Sharkey, J. Braun, 2004, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Endogenous cellular prion protein regulates contractility of the mouse ileum

F. Jirik, K. Sharkey, M. Bashashati, 2012, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Cannabinoids Alleviate Experimentally Induced Intestinal Inflammation by Acting at Central and Peripheral Receptors

A. Makriyannis, M. Storr, G. Thakur, 2014, PloS one.

Neonatal immune challenge exacerbates experimental colitis in adult rats: potential role for TNF-alpha.

Q. Pittman, N. Hyland, K. Sharkey, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Neuropeptide y modulates L-type Ca2+ current during heart development.

W. Giles, K. Sharkey, A. Lomax, 2003, Circulation research.

Activation of the cannabinoid 2 receptor (CB2) protects against experimental colitis

Hong Zhang, M. Storr, K. Sharkey, 2009, Inflammatory bowel diseases.

Endocannabinoids: biology, mechanism of action and functions

K. Sharkey, 2006, International Journal of Obesity.

Malabsorption plays a major role in the effects of the biliopancreatic diversion with duodenal switch on energy metabolism in rats.

D. Richard, K. Sharkey, L. Biertho, 2015, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

Visceral sensation and colitis: inflammation and hypersensitivity do not always go hand in hand

K. Sharkey, K. Sharkey, Keith A. Sharkey, 2006, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

The subfornical organ: a novel site of action of cholecystokinin.

A. Ferguson, K. Sharkey, W. Ho, 2014, American journal of physiology. Regulatory, integrative and comparative physiology.

Animal models of bariatric/metabolic surgery shed light on the mechanisms of weight control and glucose homeostasis: view from the chair

K. Sharkey, 2011, International Journal of Obesity.

Effects of cannabinoid receptor‐2 activation on accelerated gastrointestinal transit in lipopolysaccharide‐treated rats

Q. Pittman, K. Sharkey, J. Davison, 2004, British journal of pharmacology.

Enhanced excitability of myenteric AH neurones in the inflamed guinea‐pig distal colon

D. R. Linden, K. Sharkey, G. Mawe, 2003, The Journal of physiology.

Effects of PGE2 in guinea pig colonic myenteric ganglia.

K. Sharkey, G. Mawe, B. Manning, 2002, American journal of physiology. Gastrointestinal and liver physiology.

Modulation of the immune response by helminths: a role for serotonin?

D. McKay, K. Sharkey, S. J. Wang, 2018, Bioscience reports.

Intestinal microbiota shapes gut physiology and regulates enteric neurons and glia

A. Flockton, L. Wallace, J. Cavin, 2020, Microbiome.

The expression levels of cellular prion protein affect copper isotopic shifts in the organs of mice

F. Jirik, K. Sharkey, M. Wieser, 2016 .

THE ENDOCANNABINOID SYSTEM AND THE CONTROL OF GASTROINTESTINAL FUNCTION

K. Sharkey, 2008 .

Interleukin 1β-induced increase in substance P in rat myenteric plexus

S. Collins, K. Sharkey, A. Stanisz, 1993 .

lnterleukin 1 P-Induced Increase in Substance Myenteric Plexus P in Rat

S. Collins, K. Sharkey, A. Stanisz, 1993 .

Compromised neuroimmune status in rats with experimental colitis

Q. Pittman, K. Sharkey, Marja D. Van Sickle, 2003, The Journal of physiology.

Helminth Parasites and the Modulation of Joint Inflammation

J. McDougall, D. McKay, K. Sharkey, 2011, Journal of parasitology research.

Cannabidiol Impairs Brain Mitochondrial Metabolism and Neuronal Integrity

G. Teskey, J. Rho, K. Sharkey, 2022, Cannabis and cannabinoid research.

Cannabinoid (CB)1 receptor antagonist, AM 251, causes a sustained reduction of daily food intake in the rat

K. Sharkey, H. Koopmans, A. P. Chambers, 2004, Physiology & Behavior.

Novel functional roles for enteric glia in the gastrointestinal tract

K. Sharkey, Brian D. Gulbransen, B. Gulbransen, 2012, Nature Reviews Gastroenterology &Hepatology.

Leukocyte - Cerebral Endothelial Cell Interactions in the Brain Lead to Anxiety-like Behaviour in Experimental Colitis

Q. Pittman, M. Swain, K. Sharkey, 2021 .

Cannabinoid 1 receptors are critical for the innate immune response to TLR4 stimulation.

Q. Pittman, D. McKay, K. Sharkey, 2013, American journal of physiology. Regulatory, integrative and comparative physiology.

Cannabinoid ( CB ) 1 receptors are critical for the innate immune response to TLR 4 stimulation

Q. Pittman, D. McKay, K. Sharkey, 2013 .

Identification functional characterization of brainstem cannabinoid CB2 receptors.

K. Mackie, L. Marnett, Q. Pittman, 2022 .

Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis

W. MacNaughton, K. Sharkey, Hailey Cuddihey, 2022, Cellular and molecular gastroenterology and hepatology.

Dextran sodium sulfate-induced colitis reveals nicotinic modulation of ion transport via iNOS-derived NO.

D. McKay, K. Sharkey, W. Ho, 2004, American journal of physiology. Gastrointestinal and liver physiology.

The atypical cannabinoid O‐1602 protects against experimental colitis and inhibits neutrophil recruitment

K. Mackie, D. Saur, D. McHugh, 2011, Inflammatory bowel diseases.

Neuroimmune and epithelial interactions in intestinal inflammation.

K. Sharkey, G. Mawe, 2002, Current opinion in pharmacology.

Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach.

J. Wallace, K. Sharkey, W. McKnight, 2000, American journal of physiology. Gastrointestinal and liver physiology.

Innervation and mast cells of the rat lacrimal gland: the effects of age.

K. Sharkey, R. M. Williams, J. Singh, 1994, Advances in experimental medicine and biology.

Progressive development of a Th1‐type hepatic cytokine profile in rats with experimental cholangitis

M. Swain, K. Sharkey, K. Tjandra, 2000, Hepatology.

Secretion and serotonin release in the isolated rat lacrimal gland: the effects of substance P and calcitonin gene-related peptide.

K. Sharkey, Jaipaul Singh, R. Lea, 1996, Journal of the autonomic nervous system.

Inhibiting Inducible Nitric Oxide Synthase in Enteric Glia Restores Electrogenic Ion Transport in Mice With Colitis.

T. Savidge, W. MacNaughton, K. Sharkey, 2015, Gastroenterology.

Acute gut inflammation reduces neural activity and spine maturity in hippocampus but not basolateral amygdala

R. Gibb, A. Gruber, L. Wallace, 2022, Scientific Reports.

Extrinsic innervation of the rat pancreas: Demonstration of vagal sensory neurones in the rat by retrograde tracing

K. Sharkey, R. G. Williams, 1983, Neuroscience Letters.

In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity

Jordan S. Farrell, I. Soltesz, G. Teskey, 2021, Neuron.

Persistent alterations to enteric neural signaling in the guinea pig colon following the resolution of colitis.

N. Hyland, K. Sharkey, G. Mawe, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Persistent alterations to enteric neural signalling in guinea pig colon following resolution of colitis

N. Hyland, K. Sharkey, G. Mawe, 2006 .

Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis in guinea‐pig

K. Sharkey, G. Mawe, A. Lomax, 2005, The Journal of physiology.

Adaptation of intestinal secretomotor function and nutrient absorption in response to diet‐induced obesity

Q. Pittman, W. MacNaughton, N. Hyland, 2010, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Salvinorin A inhibits colonic transit and neurogenic ion transport in mice by activating κ‐opioid and cannabinoid receptors

A. Janecka, C. Andrews, M. Storr, 2009, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves.

K. Mackie, W. MacNaughton, K. Sharkey, 2004, American journal of physiology. Gastrointestinal and liver physiology.

Stress and immunity — the circuit makes the difference

J. Bains, K. Sharkey, 2022, Nature Immunology.

How does the B-afferent classification apply to vagal afferent neurons?

K. Sharkey, J. Davison, 1990, Behavioral and Brain Sciences.

Peripheral satiety signals: view from the Chair

K. Sharkey, 2009, International Journal of Obesity.

Endocannabinoid signaling at the periphery: 50 years after THC.

S. Dey, T. Bíró, A. Zimmer, 2015, Trends in pharmacological sciences.

Urinary phenotyping indicates weight loss-independent metabolic effects of Roux-en-Y gastric bypass in mice.

J. Nicholson, E. Holmes, Jia V. Li, 2013, Journal of proteome research.

Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: implications for gastrointestinal toxicity.

J. Wallace, W. MacNaughton, K. Sharkey, 1998, Gastroenterology.

Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2.

J. Wallace, A. Buret, K. Sharkey, 1996, The Journal of clinical investigation.

Colitis-associated microbiota drives changes in behaviour in male mice in the absence of inflammation

M. Surette, Q. Pittman, M. Swain, 2022, Brain, Behavior, and Immunity.

The intestinal barrier in multiple sclerosis: implications for pathophysiology and therapeutics.

C. Cámara-Lemarroy, L. Metz, K. Sharkey, 2018, Brain : a journal of neurology.

Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes

Matthew A. Windsor, L. Marnett, K. Sharkey, 2012, ACS medicinal chemistry letters.

Glucagon-like peptide 2 induces vasoactive intestinal polypeptide expression in enteric neurons via phophatidylinositol 3-kinase-γ signaling.

L. Wallace, K. Sharkey, D. Sigalet, 2012, American journal of physiology. Endocrinology and metabolism.

Neurochemistry of visceral afferent neurones.

G. Dockray, K. Sharkey, 1986, Progress in brain research.

Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: role in resistance to damage.

J. Wallace, K. Sharkey, B. Reuter, 1997, Gastroenterology.

Capsaicin treatment blocks development of hyperkinetic circulation in portal hypertensive and cirrhotic rats.

K. Sharkey, S. S. Lee, 1993, The American journal of physiology.

Sensory substance P-innervation of the urinary bladder: Possible site of action of capsaicin in causing urine retention in rats

M. Schultzberg, G. Dockray, K. Sharkey, 1983, Neuroscience.

Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium

D. McKay, K. Sharkey, P. Beck, 2018, Nature Reviews Gastroenterology & Hepatology.

Substance P in the rat parotid gland: evidence for a dual origin from the otic and trigeminal ganglia

K. Sharkey, D. Templeton, 1984, Brain Research.

Hyperdynamic circulation in portal‐hypertensive rats is dependent on central c‐fos gene expression

K. Sharkey, Hongqun Liu, Sam Lee, 2002, Hepatology.

The role of enteric neurons in the development and progression of colorectal cancer.

A. Koch, V. Melotte, K. Sharkey, 2017, Biochimica et biophysica acta. Reviews on cancer.

Colitis-Induced Microbial Perturbation Promotes Postinflammatory Visceral Hypersensitivity

Y. Nasser, L. Basso, C. Altier, 2020, Cellular and molecular gastroenterology and hepatology.

Consequences of intestinal inflammation on the enteric nervous system: Neuronal activation induced by inflammatory mediators

K. Sharkey, A. Kroese, Alfons B.A. Kroese, 2001, The Anatomical record.

Activation of colonic mucosal 5-HT(4) receptors accelerates propulsive motility and inhibits visceral hypersensitivity.

J. Galligan, O. Balemba, G. Swain, 2012, Gastroenterology.

Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis.

D. R. Linden, M. Gershon, K. Sharkey, 2003, American journal of physiology. Gastrointestinal and liver physiology.

Effects of gastrointestinal inflammation on enteroendocrine cells and enteric neural reflex circuits

D. R. Linden, K. Sharkey, G. Mawe, 2006, Autonomic Neuroscience.

Downregulated hypothalamic 5‐HT3 receptor expression and enhanced 5‐HT3 receptor antagonist‐mediated improvement in fatigue‐like behaviour in cholestatic rats

Hong Wang, M. Swain, K. Sharkey, 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

C-Myc antigens in the mammalian enteric nervous system

K. Sharkey, E. J. Parr, A. Gibson, 1994, Neuroscience.

Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a Peripherally Restricted Cannabinoid CB1/CB2 Receptor Agonist, Inhibits Gastrointestinal Motility but Has No Effect on Experimental Colitis in Mice

B. Lutz, K. Sharkey, M. Duncan, 2010, Journal of Pharmacology and Experimental Therapeutics.

Impaired Hypothalamic Microglial Activation in Offspring of Antibiotic-Treated Pregnant/Lactating Rats Is Attenuated by Prebiotic Oligofructose Co-Administration

R. Mychasiuk, Weilan Wang, R. Reimer, 2020, Microorganisms.

Characterization of microglial transcriptomes in the brain and spinal cord of mice in early and late experimental autoimmune encephalomyelitis using a RiboTag strategy

Paul M. K. Gordon, Q. Pittman, M. Workentine, 2021, Scientific Reports.

Endocannabinoid regulation of nausea is mediated by 2-arachidonoylglycerol (2-AG) in the rat visceral insular cortex

B. Cravatt, A. Lichtman, C. Limebeer, 2016, Neuropharmacology.

Ectonucleotidases in the digestive system: focus on NTPDase3 localization.

J. Sévigny, M. Martín-Satué, K. Sharkey, 2011, American journal of physiology. Gastrointestinal and liver physiology.

Emerging roles for enteric glia in gastrointestinal disorders.

K. Sharkey, 2015, The Journal of clinical investigation.

Purinergic neuron-to-glia signaling in the enteric nervous system.

K. Sharkey, Brian D. Gulbransen, B. Gulbransen, 2009, Gastroenterology.

Capsaicin‐sensitive vagal stimulation‐induced gastric acid secretion in the rat: evidence for cholinergic vagal afferents

K. Sharkey, L. D. Oland, J. Davison, 1991, British journal of pharmacology.

Synaptic plasticity in myenteric neurons of the guinea‐pig distal colon: presynaptic mechanisms of inflammation‐induced synaptic facilitation

D. R. Linden, K. Sharkey, G. Mawe, 2007, The Journal of physiology.

Evidence for a role of capsaicin-sensitive mucosal afferent nerves in the regulation of mesenteric blood flow in the dog.

K. Sharkey, Z. Rózsa, G. Jancsó, 1986, Gastroenterology.

Purinergic neuromuscular transmission is selectively attenuated in ulcerated regions of inflamed guinea pig distal colon

J. Hoffman, K. Sharkey, G. Mawe, 2010, The Journal of physiology.

More than just gut feelings about visceral sensation

K. Sharkey, F. Cerveró, 1985, Trends in Neurosciences.

Electrophysiology, shape, and chemistry of neurons that project from guinea pig colon to inferior mesenteric ganglia.

J. Furness, K. Sharkey, P. Bertrand, 1998, Gastroenterology.

Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon

L. Durnin, V. Mutafova-Yambolieva, K. Sharkey, 2013, The Journal of physiology.

Enteric Glia Are Targets of the Sympathetic Innervation of the Myenteric Plexus in the Guinea Pig Distal Colon

J. Bains, K. Sharkey, Brian D. Gulbransen, 2010, The Journal of Neuroscience.

Infection with an intestinal helminth parasite reduces Freund's complete adjuvant-induced monoarthritis in mice.

J. McDougall, D. McKay, K. Sharkey, 2011, Arthritis and rheumatism.

Immunohistochemically-defined subtypes of neurons in the inferior mesenteric ganglion of the guinea-pig.

K. Sharkey, E. Parr, 1996, Journal of the autonomic nervous system.

Distribution of adrenergic receptors in the enteric nervous system of the guinea pig, mouse, and rat

Y. Nasser, K. Sharkey, Yasmin Nasser, 2006, The Journal of comparative neurology.

Functional alterations in jejunal myenteric neurons during inflammation in nematode-infected guinea pigs.

M. Wong-Riley, K. Sharkey, J. Palmer, 1998, The American journal of physiology.

The Enteric Nervous System in Intestinal Inflammation

K. Sharkey, E. Parr, 1996 .

Morphological and immunohistochemical examination of nerves in normal and injured collateral ligaments of rat, rabbit, and human knee joints

J. McDougall, K. Sharkey, R. Bray, 1997, The Anatomical record.

Evidence for CGRP accumulation and activity in experimental neuromas.

K. Hargreaves, K. Sharkey, D. Zochodne, 1995, The American journal of physiology.

Peptide accumulations in proximal endbulbs of transected axons

K. Hargreaves, K. Sharkey, D. Zochodne, 2001, Brain Research.

Reprint of: Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract

T. Savidge, K. Sharkey, 2014, Autonomic Neuroscience.

Role of enteric neurotransmission in host defense and protection of the gastrointestinal tract

T. Savidge, K. Sharkey, 2014, Autonomic Neuroscience.

Vagal involvement in dietary regulation of nutrient transport.

K. Sharkey, J. Meddings, S. Bates, 1998, The American journal of physiology.

Vagal involvement in dietary regulation of nutrient transport.

K. Sharkey, J. Meddings, S. Bates, 1998, American journal of physiology. Gastrointestinal and liver physiology.

Dendritically released transmitters cooperate via autocrine and retrograde actions to inhibit afferent excitation in rat brain

Yannick Schwab, Ken Mackie, K. Mackie, 2004, The Journal of physiology.

The past 10 years of gastroenterology and hepatology—reflections and predictions

J. Sung, S. Friedman, E. Quigley, 2014, Nature Reviews Gastroenterology &Hepatology.

Gastrointestinal Viral Load and Enteroendocrine Cell Number Are Associated with Altered Survival in HIV-1 Infected Individuals

D. Church, M. Gill, K. Sharkey, 2013, PloS one.

Intestinal fungi are causally implicated in microbiome assembly and immune development in mice

K. McCoy, W. MacNaughton, J. Cavin, 2020, Nature Communications.

Antibiotic treatment affects the expression levels of copper transporters and the isotopic composition of copper in the colon of mice

K. Sharkey, M. Wieser, S. Hirota, 2019, Proceedings of the National Academy of Sciences.

Gastric bypass increases energy expenditure in rats.

S. Bloom, C. L. le Roux, M. Bueter, 2010, Gastroenterology.

Magnetic resonance imaging evidence of hippocampal structural changes in patients with primary biliary cholangitis

G. Kaplan, G. MacQueen, B. Goodyear, 2018, Clinical and Translational Gastroenterology.

Microglial activation and TNFα production mediate altered CNS excitability following peripheral inflammation

Q. Pittman, K. Sharkey, J. B. Kuzmiski, 2008, Proceedings of the National Academy of Sciences.

Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig

K. Sharkey, C. Keenan, E. Parr, 1999, The Journal of Neuroscience.

Colonic immune cells in irritable bowel syndrome: A systematic review and meta‐analysis

L. Chang, M. Coëffier, N. Rezaei, 2016, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Antineuronal antibodies in idiopathic achalasia and gastro-oesophageal reflux disease

R. Rothstein, P. Moses, K. Sharkey, 2003, Gut.

Control of exocrine secretion in the guinea-pig pancreas by histamine H3 receptors.

G. Salido, K. Sharkey, J. Pariente, 1996, Canadian journal of physiology and pharmacology.

Consequences of Citrobacter rodentium infection on enteroendocrine cells and the enteric nervous system in the mouse colon

W. MacNaughton, K. Sharkey, A. C. Skinn, 2006, Cellular microbiology.

Impact of major depression and antidepressant use on alcoholic and non‐alcoholic fatty liver disease: A population‐based study

G. Kaplan, M. Swain, K. Sharkey, 2021, Liver international : official journal of the International Association for the Study of the Liver.

Expression, activity and cellular localization of inducible nitric oxide synthase in rat ileum and colon post-irradiation.

M. Miller, W. MacNaughton, K. Sharkey, 1998, International journal of radiation biology.

Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system.

L. Parker, K. Sharkey, N. Darmani, 2014, European journal of pharmacology.

Endogenous prion protein attenuates experimentally induced colitis.

F. Jirik, K. Sharkey, G. Martin, 2011, The American journal of pathology.

Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental colitis?

Q. Pittman, N. Hyland, K. Sharkey, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Immunoreactivity for the Fas ligand in the mammalian enteric nervous system

M. Hanani, K. Riabowol, K. Sharkey, 1997, Cell and Tissue Research.

Alterations to enteric neural signaling underlie secretory abnormalities of the ileum in experimental colitis in the guinea pig.

J. Grider, K. Sharkey, G. Mawe, 2009, American journal of physiology. Gastrointestinal and liver physiology.

Expression of a functional metabotropic glutamate receptor 5 on enteric glia is altered in states of inflammation

Y. Nasser, K. Sharkey, D. McCafferty, 2007, Glia.

Role of enteric glia in intestinal physiology: effects of the gliotoxin fluorocitrate on motor and secretory function.

W. MacNaughton, Y. Nasser, M. Schemann, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Effects of inflammation on cell proliferation in the myenteric plexus of the guinea-pig ileum

K. Sharkey, E. Parr, John S. Bradley Jr., 1997, Cell and Tissue Research.

Cannabinoids inhibit emesis through CB1 receptors in the brainstem of the ferret.

K. Mackie, C. Hillard, K. Sharkey, 2001, Gastroenterology.

The Endocannabinoid System and Its Role in Regulating the Intrinsic Neural Circuitry of the Gastrointestinal Tract.

K. Sharkey, Samantha M Trautmann, 2015, International review of neurobiology.

Central and Peripheral Signaling Mechanisms Involved in Endocannabinoid Regulation of Feeding: A Perspective on the Munchies

Q. Pittman, K. Sharkey, 2005, Science's STKE.

Cannabinoid CB2 Receptors in Health and Disease

Q. Pittman, K. Sharkey, K. Patel, 2010 .

Cannabinoid CB(2) receptors in health and disease.

Q. Pittman, K. Sharkey, K. Patel, 2010, Current medicinal chemistry.

Reduced Microglial Activity and Enhanced Glutamate Transmission in the Basolateral Amygdala in Early CNS Autoimmunity

M. Tremblay, Q. Pittman, K. Sharkey, 2018, The Journal of Neuroscience.

Primary Biliary Cholangitis Alters Functional Connections of the Brain’s Deep Gray Matter

G. Kaplan, G. MacQueen, B. Goodyear, 2017, Clinical and Translational Gastroenterology.

Modulation of ion channels in rod photoreceptors by nitric oxide

R. W. Turner, L. Moroz, S. Barnes, 1994, Neuron.

Distribution and function of monoacylglycerol lipase in the gastrointestinal tract.

Stephen P. H. Alexander, D. Piomelli, B. Lutz, 2008, American journal of physiology. Gastrointestinal and liver physiology.

Contribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice

Richard J. A. Wilson, K. McCoy, H. Ramay, 2019, bioRxiv.

Cannabinoid hyperemesis syndrome in North America: evaluation of health burden and treatment prevalence

Christopher Ma, C. Andrews, Y. Nasser, 2022, Alimentary pharmacology & therapeutics.

Unnecessary Abdominal and Back Surgery in Irritable Bowel Syndrome: Time to Stem the Flood Now?

Coldwell, H. Steinbusch, A. Cuello, 2004 .

Primary biliary cholangitis patients exhibit MRI changes in structure and function of interoceptive brain regions

G. Kaplan, G. MacQueen, B. Goodyear, 2019, PloS one.

Impact of depression and antidepressant use on clinical outcomes of hepatitis B and C: a population-based study

G. Kaplan, M. Swain, K. Sharkey, 2023, Hepatology communications.

Neurons populating the rectal extrinsic nerves in humans express neuronal and Schwann cell markers

M. Lovell, A. Flockton, K. Sharkey, 2020, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

The source and action of histamine in the isolated guinea-pig gallbladder

G. Salido, M. Pozo, K. Sharkey, 1995, Inflammation Research.

Prostaglandin E2 activation of VIP secretomotor neurons in the guinea pig ileum.

W. MacNaughton, K. Sharkey, A. Kroese, 1997, Journal of the autonomic nervous system.

Protective Actions of Epithelial 5-Hydroxytryptamine 4 Receptors in Normal and Inflamed Colon.

R. Wilcox, E. Bonora, W. MacNaughton, 2016, Gastroenterology.

Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial

D. Hart, R. Schachar, R. Reimer, 2021, Trials.

The Intrinsic Reflex Circuitry of the Inflamed Colon.

K. Sharkey, G. Mawe, 2016, Advances in Experimental Medicine and Biology.

Characterization of neurokinin-1 receptors in the submucosal plexus of guinea pig ileum.

S. Vanner, N. Bunnett, K. Sharkey, 1997, The American journal of physiology.

Microglia-Dependent Alteration of Glutamatergic Synaptic Transmission and Plasticity in the Hippocampus during Peripheral Inflammation

Q. Pittman, K. Sharkey, A. C. Kentner, 2015, The Journal of Neuroscience.

Protective Actions of 5‐HT4 Receptors in the Colonic Epithelium

R. Wilcox, E. Bonora, W. MacNaughton, 2016 .

Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis

Q. Pittman, M. Swain, D. McKay, 2020, Brain, Behavior, and Immunity.

Cholecystokinin and Gastrin Forms in the Nervous System

H. Raybould, G. Dockray, K. Sharkey, 1985, Annals of the New York Academy of Sciences.

Involvement of Mast Cells in α7 Nicotinic Receptor Agonist Exacerbation of Freund's Complete Adjuvant–Induced Monoarthritis in Mice

J. McDougall, D. McKay, F. Lopes, 2015, Arthritis & rheumatology.

Proliferative capacity of enterochromaffin cells in guinea-pigs with experimental ileitis

K. Sharkey, J. O’Hara, 2007, Cell and Tissue Research.

Role of 5-HT in cholera toxin-induced mucin secretion in the rat small intestine.

K. Sharkey, B. Moore, M. Mantle, 1996, The American journal of physiology.

Substance P levels in experimental ileitis in guinea pigs: effects of misoprostol.

K. Sharkey, A. Jeng, D. Clark, 1993, The American journal of physiology.

Intestinal distension orchestrates neuronal activity in the enteric nervous system of adult mice

O. Balemba, W. MacNaughton, J. Cavin, 2023, The Journal of physiology.

Key elements of serotonin signaling are altered in IBD and IBS: support for a molecular basis of the irritable bowel syndrome

D. R. Linden, P. Moses, M. Gershon, 2003, American Journal of Gastroenterology.

The use of constitutive nuclear oncoproteins to count neurons in the enteric nervous system of the guinea pig

K. Sharkey, E. Parr, 1994, Cell and Tissue Research.

Behavioral Comorbidities in Dextran Sulphate Sodium (DSS) Colitis, an animal model of Inflammatory Bowel Diseases

Q. Pittman, M. Swain, K. Sharkey, 2016 .

Nitric oxide regulation of colonic epithelial ion transport: a novel role for enteric glia in the myenteric plexus

D. McKay, K. Sharkey, S. MacEachern, 2011, The Journal of physiology.

Behavioral adaptations in a relapsing mouse model of colitis

A. Gruber, K. Sharkey, S. Hirota, 2020, Physiology & Behavior.

Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?

B. Le Foll, Y. Le Strat, K. Sharkey, 2013, Medical hypotheses.

Neurohormonal signalling in the gastrointestinal tract: new frontiers

K. Sharkey, G. Mawe, 2014, Journal of Physiology.

Trigeminal nuclear complex of the ferret: Anatomical and Immunohistochemical studies

K. Sharkey, G. E. Lucier, F. Boissonade, 1993, The Journal of comparative neurology.

Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment

Regina M. Krohn, M. Storr, S. Parsons, 2016, Journal of Inflammation.

Behavioural adaptations after antibiotic treatment in male mice are reversed by activation of the aryl hydrocarbon receptor

Q. Pittman, M. Swain, K. Sharkey, 2021, Brain, Behavior, and Immunity.

Targeting the gut to treat obesity and its metabolic consequences: view from the Chair.

K. Sharkey, K. Sharkey, 2016, International journal of obesity supplements.

Nitric oxide synthase in tiger salamander retina

G. Thurlow, R. W. Turner, L. Moroz, 1995, The Journal of comparative neurology.

Intestinal fungi are causally implicated in microbiome assembly and immune development in mice

Richard J. A. Wilson, K. McCoy, H. Ramay, 2020, Nature Communications.

Suppression of colitis by adoptive transfer of helminth antigen-treated dendritic cells requires interleukin-4 receptor-α signaling

D. McKay, F. Lopes, K. Sharkey, 2017, Scientific Reports.

Nitric oxide participates in the recovery of normal jejunal epithelial ion transport following exposure to the superantigen, Staphylococcus aureus enterotoxin B.

S. Jedrzkiewicz, D. McKay, K. Sharkey, 1999, Journal of immunology.

The origin and distribution of neurons with projections passing through the inferior mesenteric ganglion of the guinea-pig.

S. Davison, K. Sharkey, J. Davison, 1993, Journal of the Autonomic Nervous System.

Interactive effects of oligofructose and obesity predisposition on gut hormones and microbiota in diet‐induced obese rats

Lindsay K. Eller, R. Reimer, K. Sharkey, 2015, Obesity.

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

D. Saur, W. Krajewska, J. Timmermans, 2015, Journal of Molecular Medicine.

Antisecretory effects of neuropeptide Y in the mouse colon are region-specific and are lost in DSS-induced colitis

D. McKay, K. Sharkey, Winnie Ho, 2010, Regulatory Peptides.

Brain CB1 receptor expression following lipopolysaccharide-induced inflammation

K. Mackie, Q. Pittman, K. Sharkey, 2012, Neuroscience.

Neural mediation of cholera toxin-induced mucin secretion in the rat small intestine.

K. Sharkey, B. Moore, M. Mantle, 1993, American Journal of Physiology.

Nausea-Induced 5-HT Release in the Interoceptive Insular Cortex and Regulation by Monoacylglycerol Lipase (MAGL) Inhibition and Cannabidiol

C. Limebeer, E. Rock, L. Parker, 2018, eNeuro.

Visceral and Somatic Afferent Origin of Calcitonin Gene-Related Peptide-Immunoreactivity in the Superficial and Deep Laminae of the Thoracic Dorsal Horn of the Rat

J. Sobrino, K. Sharkey, F. Cerveró, 1989 .

The enteric nervous system.

K. Sharkey, G. Mawe, 2022, Physiological reviews.

Serotonin transporter function and expression are reduced in mice with TNBS‐induced colitis

D. R. Linden, K. Sharkey, G. Mawe, 2005, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

The role of the endocannabinoid system in the pathophysiology and treatment of irritable bowel syndrome

C. Andrews, M. Storr, K. Sharkey, 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

A novel peripherally restricted cannabinoid receptor antagonist, AM6545, reduces food intake and body weight, but does not cause malaise, in rodents

B. Lutz, A. Zimmer, C. Limebeer, 2010, British journal of pharmacology.

Neurogastroenterology in 2011: Emerging concepts in neurogastroenterology and motility

K. Sharkey, G. Mawe, 2012, Nature Reviews Gastroenterology &Hepatology.

The Autonomic Nervous System: Peripheral and Central Integrative Aspects

Q. J. Pittman, Q. Pittman, K. Sharkey, 1996 .

Changes in colonic motility and the electrophysiological properties of myenteric neurons persist following recovery from trinitrobenzene sulfonic acid colitis in the guinea pig

D. R. Linden, K. Sharkey, G. Mawe, 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Indiscriminate loss of myenteric neurones in the TNBS‐inflamed guinea‐pig distal colon

H. Blaszyk, D. R. Linden, K. Sharkey, 2005, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Plasticity of the enteric nervous system during intestinal inflammation

K. Sharkey, A. Lomax, K. A. Sharkey, 2005, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Peptides in the gastrointestinal tract in human immunodeficiency virus infection. The GI/HIV Study Group of the University of Calgary.

D. Church, M. Gill, K. Sharkey, 1992, Gastroenterology.

Distribution of growth-associated protein, B-50 (GAP-43) in the mammalian enteric nervous system

W. Tetzlaff, K. Sharkey, J. Davison, 1990, Neuroscience.

Inhibiting fatty acid amide hydrolase normalizes endotoxin‐induced enhanced gastrointestinal motility in mice

K. Mackie, B. Cravatt, S. Nikas, 2012, British journal of pharmacology.

Serotonin signaling in the mucosa of the human colon

M. Crowell, D. R. Linden, M. Coates, 2003 .

Disordered central cardiovascular regulation in portal hypertensive and cirrhotic rats.

K. Sharkey, S. S. Lee, Y. Zhang, 2001, American journal of physiology. Gastrointestinal and liver physiology.

The role of the endocannabinoid system in the pathophysiology and treatment of irritable bowel syndrome

C. Andrews, M. Storr, K. Sharkey, 2008, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.