C. Verchere

发表

A Multi-Year Analysis of Islet Transplantation Compared With Intensive Medical Therapy on Progression of Complications in Type 1 Diabetes

James D. Johnson, G. Warnock, P. Keown, 2008, Transplantation.

B7-H4 Induces Donor-Specific Tolerance in Mouse Islet Allografts

Lieping Chen, A. Mui, G. Warnock, 2012, Cell transplantation.

Improving Islet Engraftment by Gene Therapy

A. Mui, G. Warnock, C. Verchere, 2011, Journal of transplantation.

IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction

N. Van Rooijen, J. Ehses, G. Soukhatcheva, 2011, The Journal of Immunology.

An Odyssey of Islet Transplantation for Therapy of Type 1 Diabetes

James D. Johnson, David Thompson, G. Warnock, 2007, World Journal of Surgery.

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.

J. Montane, M. Levings, P. Orban, 2011, The Journal of clinical investigation.

Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood.

D. Finegood, C. Verchere, J. Elliott, 2003, The Journal of clinical investigation.

CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance

M. Obach, J. Montane, M. Levings, 2015, Cell transplantation.

Adult stem or progenitor cells in treatment for type 1 diabetes: current progress.

G. Warnock, C. Verchere, Y. Liao, 2007, Canadian journal of surgery. Journal canadien de chirurgie.

Elevated islet prohormone ratios as indicators of insulin dependency in islet transplant recipients

Yi-Chun Chen, M. Bellin, G. Soukhatcheva, 2021, bioRxiv.

Death and Dysfunction of Transplanted β-Cells: Lessons Learned From Type 2 Diabetes?

G. Warnock, C. Verchere, C. Westwell-Roper, 2013, Diabetes.

Role of the TLR signaling molecule TRIF in β-cell function and glucose homeostasis

James D. Johnson, G. Soukhatcheva, C. Verchere, 2010, Islets.

The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts.

R. Korneluk, C. Verchere, P. Liston, 2005, Diabetes.

Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL.

G. Reid, C. Verchere, P. Santamaria, 2004, International immunology.

Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes

Lieping Chen, S. Langermann, A. Mui, 2011, Diabetes.

B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies

Lieping Chen, A. Mui, G. Warnock, 2011, Journal of transplantation.

Islet macrophages are the primary islet source of IGF-1 and improve glucose homeostasis following pancreatic beta-cell death

J. Pospisilik, J. Ehses, C. Verchere, 2018, bioRxiv.

Loss of prohormone convertase 2 promotes beta cell dysfunction in a rodent transplant model expressing human pro-islet amyloid polypeptide

P. Orban, G. Soukhatcheva, C. Verchere, 2017, Diabetologia.

B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation

Lieping Chen, A. Mui, G. Warnock, 2012, PloS one.

Local Expression of B7-H4 by Recombinant Adenovirus Transduction in Mouse Islets Prolongs Allograft Survival

Lieping Chen, A. Mui, G. Warnock, 2009, Transplantation.

Interactions between islets and regulatory immune cells in health and type 1 diabetes

M. Levings, C. Verchere, Matthew A. Budd, 2021, Diabetologia.

Identification of a β-Cell-Specific HLA Class I Restricted Epitope in Type 1 Diabetes

C. Panagiotopoulos, C. Verchere, R. Tan, 2003 .

Identiﬁcation of a (cid:1) -Cell–Speciﬁc HLA Class I Restricted Epitope in Type 1 Diabetes

C. Panagiotopoulos, C. Verchere, R. Tan, 2003 .

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression.

M. Levings, C. Panagiotopoulos, T. Kieffer, 2016, The Journal of clinical investigation.

Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus.

James D. Johnson, D. Al-Adra, G. Warnock, 2005, Archives of surgery.

Eukaryotic translation initiation factor 2 A protects pancreatic beta cells during 1 endoplasmic reticulum stress while rescuing translation inhibition 2 3

James D. Johnson, E. Panzhinskiy, G. Soukhatcheva, 2021 .

Endogenous Expression of B7-H4 Improves Long-term Murine Islet Allograft Survival

Lieping Chen, A. Mui, G. Warnock, 2013, Transplantation.

Identification of a beta-cell-specific HLA class I restricted epitope in type 1 diabetes.

C. Panagiotopoulos, C. Verchere, R. Tan, 2003, Diabetes.

Blockade of both B7-H4 and CTLA-4 co-signaling pathways enhances mouse islet allograft survival

A. Mui, G. Warnock, D. Metzger, 2012, Islets.

XIAP inhibition of β-cell apoptosis reduces the number of islets required to restore euglycemia in a syngeneic islet transplantation model

R. Korneluk, G. Soukhatcheva, C. Verchere, 2010, Islets.

Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver.

Inanc Birol, Yongjun Zhao, Martin Hirst, 2010, Genome research.

Kinetics and genomic profiling of adult human and mouse β-cell maturation

James D. Johnson, J. Piret, G. Warnock, 2011, Islets.

Islet amyloid polypeptide does not suppress pancreatic cancer

James D. Johnson, E. Panzhinskiy, P. Orban, 2023, Molecular metabolism.

Cellular Mechanisms of CCL22-Mediated Attenuation of Autoimmune Diabetes

P. Orban, G. Soukhatcheva, C. Verchere, 2015, The Journal of Immunology.

Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

W. D. de Vos, M. Stahl, M. Nieuwdorp, 2021, bioRxiv.

Strategies for optimizing CITE-seq for human islets and other tissues

J. Murphy, M. Levings, S. Ivison, 2023, Frontiers in Immunology.

Recognition of HLA Class I–Restricted β-Cell Epitopes in Type 1 Diabetes

Q. Ouyang, G. Nepom, C. Panagiotopoulos, 2006, Diabetes.

Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes.

Q. Ouyang, G. Nepom, C. Panagiotopoulos, 2006, Diabetes.

Islet Allograft Rejection Is Independent of Toll-Like Receptor Signaling in Mice

G. Soukhatcheva, C. Verchere, C. Westwell-Roper, 2009, Transplantation.

Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction

B. Tennant, J. Dhillon, B. Hoffman, 2016, Cell Death and Disease.

Inducing an oxidized redox-balance improves anti-tumor CD8+ T cell function

K. Bennewith, Kirsten A. Ward-Hartstonge, C. Verchere, 2023, bioRxiv.

Glycosylphosphatidylinositol‐specific phospholipase D immunoreactivity is present in islet amyloid in type 2 diabetes

C. Verchere, C. Verchere, D. M. Larson, 2004, The Journal of pathology.

Identification of Novel HLA-A*0201–Restricted Epitopes in Recent-Onset Type 1 Diabetic Subjects and Antibody-Positive Relatives

Q. Ouyang, G. Nepom, C. Panagiotopoulos, 2006, Diabetes.

Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts

D. Raleigh, P. Fraser, M. R. Nilsson, 2010, Proceedings of the National Academy of Sciences.

Advances and Challenges in Islet Transplantation: Islet Procurement Rates and Lessons Learned from Suboptimal Islet Transplantation

C. Verchere, A. Plesner, 2011, Journal of transplantation.

Prevention of autoimmune diabetes and islet allograft rejection by beta cell expression of XIAP: Insight into possible mechanisms of local immunomodulation

M. Obach, P. Orban, G. Soukhatcheva, 2018, Molecular and Cellular Endocrinology.

Amyloid Formation in Human Islets Is Enhanced by Heparin and Inhibited by Heparinase

P. Fraser, G. Warnock, J. Oberholzer, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

TRAIL-engineered pancreas-derived mesenchymal stem cells: characterization and cytotoxic effects on pancreatic cancer cells

G. Warnock, L. Dai, Z. Ao, 2012, Cancer Gene Therapy.

Islet Remodeling in Female Mice with Spontaneous Autoimmune and Streptozotocin-Induced Diabetes

C. Verchere, J. T. ten Holder, A. Plesner, 2014, PloS one.

Impaired Proinsulin Processing is a Characteristic of Transplanted Islets

G. Warnock, D. D’Alessio, C. Panagiotopoulos, 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

IAPP and type 1 diabetes: implications for immunity, metabolism and islet transplants.

C. Verchere, C. Verchere, H. Denroche, 2018, Journal of molecular endocrinology.

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance

M. Levings, C. Verchere, C. Verchere, 2015, The Journal of Immunology.

AAV GCG-EGFP, a new tool to identify glucagon-secreting α-cells

James D. Johnson, T. Kieffer, G. Soukhatcheva, 2019, Scientific Reports.

Insulin B peptide-MHC class II-specific chimeric antigen receptor-Tregs prevent autoimmune diabetes

Jason S. Mitchell, M. Levings, P. Orban, 2023, bioRxiv.

A small molecule improves diabetes in mice expressing human islet amyloid polypeptide

C. Verchere, Vriti Bhagat, 2023, Islets.

Different Effects of FK506, Rapamycin, and Mycophenolate Mofetil on Glucose-Stimulated Insulin Release and Apoptosis in Human Islets

James D. Johnson, G. Warnock, L. Dai, 2009, Cell transplantation.

Metabolic stress, IAPP and islet amyloid

J. Montane, C. Verchere, C. Westwell-Roper, 2012, Diabetes, obesity & metabolism.

IAPP and type 1 diabetes: implications for immunity, metabolism and islet transplants.

C. Verchere, H. Denroche, 2018, Journal of molecular endocrinology.

Measurement of Pro-Islet Amyloid Polypeptide (1–48) in Diabetes and Islet Transplants

G. Warnock, Yi-Chun Chen, P. Orban, 2017, The Journal of clinical endocrinology and metabolism.

T cells are present in non-diabetic islets and accumulate during aging

C. Verchere, C. Verchere, S. Miard, 2020, bioRxiv.

Time-resolved studies define the nature of toxic IAPP intermediates, providing insight for anti-amyloidosis therapeutics

D. Raleigh, P. Cao, M. Zanni, 2016, eLife.

SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid deposition

Yi-Chun Chen, T. Willnow, C. Verchere, 2022, bioRxiv.

Rifampicin does not prevent amyloid fibril formation by human islet amyloid polypeptide but does inhibit fibril thioflavin-T interactions: implications for mechanistic studies of beta-cell death.

D. Raleigh, P. Marek, C. Verchere, 2008, Biochemistry.

Tregs with an MHC class II peptide–specific chimeric antigen receptor prevent autoimmune diabetes in mice

Jason S. Mitchell, M. Levings, P. Orban, 2023, The Journal of clinical investigation.

Islet Allograft Rejection Is Independent of Toll-Like Receptor Signaling in Mice

G. Soukhatcheva, C. Verchere, C. Westwell-Roper, 2009, Transplantation.

Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets.

M. Levings, P. Orban, G. Soukhatcheva, 2011, The Journal of clinical investigation.

A human antibody against pathologic IAPP aggregates protects beta cells in type 2 diabetes models

R. Nitsch, M. Donath, J. Kerr-Conte, 2023, Nature communications.

Amyloid inhibitors enhance survival of cultured human islets.

P. Fraser, G. Warnock, M. Lipsett, 2009, Biochimica et biophysica acta.

TITLE: Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing translation inhibition

G. Soukhatcheva, C. Verchere, K. Chu, 2021 .

HumanIslets: An integrated platform for human islet data access and analysis

A. Gloyn, A. Spigelman, C. Verchere, 2024, bioRxiv.

Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic beta cells by Bcl-2 and X-linked inhibitor of apoptosis.

R. Korneluk, D. Metzger, P. Pozzilli, 2005, Human immunology.