D. Elias

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Evaluation of Long-Term Treatment Effect in a Type 1 Diabetes Intervention Trial: Differences After Stimulation With Glucagon or a Mixed Meal

I. Cohen, I. Raz, P. Pozzilli, 2014, Diabetes Care.

Molecular characterization of the diabetes-associated mouse MHC class II protein, I-Ag7.

M Eisenstein, M. Eisenstein, I. Cohen, 1997, International immunology.

Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin.

I. Cohen, Y. Shechter, D. Elias, 1982, Science.

Production and Purification of a Recombinant Human hsp60 Epitope Using the Cellulose-Binding Domain inEscherichia coli

I. Cohen, O. Shoseyov, D. Elias, 1998 .

Production and purification of a recombinant human hsp60 epitope using the cellulose-binding domain in Escherichia coli.

I. Cohen, O. Shoseyov, D. Elias, 1998, Protein expression and purification.

Treatment of new‐onset type 1 diabetes with peptide DiaPep277® is safe and associated with preserved beta‐cell function: extension of a randomized, double‐blind, phase II trial

I. Cohen, I. Raz, M. Metzger, 2007, Diabetes/metabolism research and reviews.

Heat‐shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double‐blind phase II study

M. Phillip, D. Elias, A. Avron, 2007, Diabetes/metabolism research and reviews.

A Human Monoclonal Antibody to Insulin

I. Cohen, Z. Eshhar, J. Sack, 1986, Diabetes.

Mice immunized to insulin develop antibody to the insulin receptor

I. Cohen, Y. Shechter, D. Elias, 1983, Journal of cellular biochemistry.

Immunomodulation with heat shock protein DiaPep277 to preserve beta cell function in type 1 diabetes – an update

R. Bretzel, D. Elias, T. Linn, 2010, Expert opinion on biological therapy.

The pathogenicity of islet‐infiltrating lymphocytes in the non‐obese diabetic (NOD) mouse

I. Cohen, D. Elias, V. Ablamunits, 1999, Clinical and experimental immunology.

Desensitization of the insulin receptor by antireceptor antibodies in vivo is blocked by treatment of mice with beta-adrenergic agonists.

I. Cohen, M. Rapoport, Y. Shechter, 1988, The Journal of clinical investigation.

Chapter 20 – Immunization to Insulin Generates Antiidiotypes That Behave as Antibodies to the Insulin Hormone Receptor and Cause Diabetes Mellitus

I. Cohen, Y. Shechter, D. Elias, 1984 .

A role of Hsp60 in autoimmune diabetes: analysis in a transgenic model.

I. Cohen, D. Douek, O. Birk, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Acceleration of autoimmune diabetes by cyclophosphamide is associated with an enhanced IFN-gamma secretion pathway.

I. Cohen, F. Quintana, D. Elias, 1999, Journal of autoimmunity.

The NOD Mouse: A Model for Autoimmune Insulin-Dependent Diabetes

D. Elias, 1994 .

Immunological efficacy of heat shock protein 60 peptide DiaPep277TM therapy in clinical type I diabetes

I. Cohen, B. Roep, D. Elias, 2008, Clinical and experimental immunology.

NOD mouse diabetes: the ubiquitous mouse hsp60 is a beta-cell target antigen of autoimmune T cells.

I. Cohen, O. Birk, A. Weiss, 1996, Journal of autoimmunity.

Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.

I. Cohen, O. Birk, R. van der Zee, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.

I. Cohen, R. van der Zee, D. Elias, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial.

I. Cohen, I. Raz, M. Metzger, 2001, Lancet.

Neonatal oral administration of DiaPep277, combined with hydrolysed casein diet, protects against Type 1 diabetes in BB-DP rats. An experimental study

D. Elias, N. Bos, F. Klatter, 2004, Diabetologia.

Peptide therapy for diabetes in NOD mice

I. Cohen, D. Elias, Irun R. Cohen, 1994, The Lancet.

DiaPep277® Preserves Endogenous Insulin Production by Immunomodulation in Type 1 Diabetes

I. Raz, D. Elias, A. Avron, 2006, Annals of the New York Academy of Sciences.

Vaccination studies in type 1 diabetes

I. Cohen, I. Raz, D. Elias, 2002, The Lancet.

Treatment of NOD diabetes with a novel peptide of the hsp60 molecule induces Th2-type antibodies.

I. Cohen, D. Elias, J. Bocková, 1997, Journal of autoimmunity.

β-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial

I. Cohen, I. Raz, M. Metzger, 2001, The Lancet.

Insulin-Mimicking Anti-Idiotypic Antibodies in Development of Spontaneous Autoimmune Diabetes in BB/E Rats

I. Cohen, A. Cooke, D. Elias, 1990, Diabetes.

Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. I. Characterization of the antibodies.

I. Cohen, Y. Shechter, D. Elias, 1984, The Journal of biological chemistry.

Mouse antibodies to the insulin receptor developing spontaneously as anti-idiotypes. II. Effects on glucose homeostasis and the insulin receptor.

I. Cohen, D. Elias, R. Maron, 1984, The Journal of biological chemistry.

Production and properties of anti-idiotypic antibodies that recognize insulin receptor.

I. Cohen, M. Rapoport, Y. Shechter, 1989, Methods in enzymology.

T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptides.

H Atlan, I. Cohen, H. Atlan, 1999, Journal of autoimmunity.

Islet T Cells Secreting IFN-γ in NOD Mouse Diabetes: Arrest by p277 Peptide Treatment

Irun R. Cohen, I. Cohen, D. Elias, 1998 .

Islet T cells secreting IFN-gamma in NOD mouse diabetes: arrest by p277 peptide treatment.

I. Cohen, D. Elias, I R Cohen, 1998, Journal of autoimmunity.

A shared TCR CDR3 sequence in NOD mouse autoimmune diabetes.

I. Cohen, D. Elias, A. Friedmann, 1999, International immunology.

Hsp60 Peptide Therapy of NOD Mouse Diabetes Induces a Th2 Cytokine Burst and Downregulates Autoimmunity to Various β-Cell Antigens

Irun R Cohen, I. Cohen, O. Birk, 1997, Diabetes.

Treatment of Recent-Onset Type 1 Diabetic Patients With DiaPep277: Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial

A. Ziegler, I. Cohen, D. Mauricio, 2014, Diabetes Care.

A quantitative model of autoimmune disease and T-cell vaccination: does more mean less?

L. Segel, I. Cohen, D. Elias, 1995, Immunology today.

Regulation of NOD mouse autoimmune diabetes by T cells that recognize a TCR CDR3 peptide.

I. Cohen, D. Elias, G. Frankel, 1999, International immunology.

The 60-kDa heat shock protein modulates allograft rejection.

I. Cohen, O. Birk, D. Altmann, 1999, Proceedings of the National Academy of Sciences of the United States of America.

A Phase II, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study Evaluating the Efficacy and Safety of Alpha-1 Antitrypsin (AAT) (Glassia®) in the Treatment of Recent-Onset Type 1 Diabetes

S. Shalitin, D. Elias, M. Rachmiel, 2019, International journal of molecular sciences.

Treatment of Autoimmune Diabetes and Insulitis in NOD Mice With Heat Shock Protein 60 Peptide p277

I. Cohen, D. Elias, 1995, Diabetes.

Inhibition of diabetes in NOD mice by idiotypic induction of SLE.

I. Cohen, Y. Shoenfeld, B. Gilburd, 1999, Journal of autoimmunity.

Autoimmune Diabetes Induced by the β-cell Toxin STZ: Immunity to the 60-kDa Heat Shock Protein and to Insulin

I. Cohen, A. Lohse, D. Elias, 1994, Diabetes.

The hsp60 Peptide p277 Arrests the Autoimmune Diabetes Induced by the Toxin Streptozotocin

I. Cohen, D. Elias, 1996, Diabetes.

Induction of diabetes in standard mice by immunization with the p277 peptide of a 60‐kDa heat shock protein

I. Cohen, H. Marcus, D. Elias, 1995, European journal of immunology.

Mice Immunized to Insulin Develop Anti-idiotypic Antibody to the Insulin Receptor

I. Cohen, Y. Shechter, D. Elias, 1988 .

Antibodies to Insulin Receptor Followed by Anti-Idiotype: Antibodies to Insulin in Child With Hypoglycemia

I. Cohen, Y. Shechter, D. Elias, 1987, Diabetes.

Autoantibodies to the insulin receptor in juvenile onset insulin-dependent diabetes

B. M. Jongh, I. Cohen, Y. Shechter, 1983, Nature.

Treatment of Recent-Onset Type 1 Diabetic Patients With DiaPep277: Results of a Double-Blind, Placebo-Controlled, Randomized Phase 3 Trial

A. Ziegler, I. Cohen, D. Mauricio, 2014, Diabetes Care.

Treatment of new‐onset type 1 diabetes with peptide DiaPep277® is safe and associated with preserved beta‐cell function: extension of a randomized, double‐blind, phase II trial

I. Cohen, M. Metzger, D. Elias, 2007, Diabetes/metabolism research and reviews.