J. Radziuk

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The Artificial Pancreas

J. Radziuk, 2012, Diabetes.

Splanchnic and systemic absorption of intraperitoneal insulin

D. E. Seigler, J. Radziuk, S. Pye, 1988 .

The Liver, Glucose Homeostasis, and Insulin Action in Type 2 Diabetes Mellitus

J. Radziuk, S. Pye, 2008 .

The Suprachiasmatic Nucleus, Circadian Clocks, and the Liver

J. Radziuk, 2013, Diabetes.

The Effects of Ingested and Intravenous Glucose on Forearm Uptake of Glucose and Glucogenic Substrate in Normal Man

J. Radziuk, R. Inculet, 1983, Diabetes.

The metabolic clearance of glucose: measurement and meaning

J. Radziuk, H. Lickley, 1985, Diabetologia.

The Role of the Liver in Insulin Action and Resistance

J. Radziuk, S. Pye, 1999 .

Galanin Inhibits Insulin Secretion and Induces Hyperglycemia in Dogs

G. Greenberg, V. Mutt, T. McDonald, 1985, Diabetes.

Hyperglucagonemia in liver cirrhosis with portal-systemic venous anastomoses: responses of plasma glucagon and gastric inhibitory polypeptide to oral or intravenous glucose in cirrhotics with normal or elevated fasting plasma glucose levels.

T. McDonald, J. Dupré, J. Radziuk, 1979, Metabolism: clinical and experimental.

Differential Effects of a Graded Selective Suppression of Insulin Secretion with Galanin on Glucose Production and Removal in Dogs

T. McDonald, J. Radziuk, J. Davies, 1994, Pancreas.

The liver and glycogen metabolism.

J. Radziuk, 1991, JPEN. Journal of parenteral and enteral nutrition.

Tracer methods and the metabolic disposal of a carbohydrate load in man.

J. Radziuk, 1987, Diabetes/metabolism reviews.

Hepatic glycogen formation by direct uptake of glucose following oral glucose loading in man.

J. Radziuk, 1979, Canadian journal of physiology and pharmacology.

Substrates and the regulation of hepatic glycogen metabolism.

J. Radziuk, S. Pye, Z. Zhang, 1993, Advances in experimental medicine and biology.

Developments in the tracer measurement of gluconeogenesis and glycogenesis in vivo: an overview.

J. Radziuk, 1982, Federation proceedings.

TheEffect ofSystemic VenousDrainage ofthePancreas on Insulin Sensitivity inDogs

J. Radziuk, H. Najm, P. Barron, 1993 .

Sources of carbon in hepatic glycogen synthesis during absorption of an oral glucose load in humans.

J. Radziuk, 1982, Federation proceedings.

The Effects of an Alpha-Glucoside Hydrolase Inhibitor on Glycemia and the Absorption of Sucrose in Man Determined Using a Tracer Method

M. Vranic, J. Radziuk, T. Morishima, 1984, Diabetes.

Distribution and kinetics of glucose in rats analyzed by noncompartmental and compartmental analysis.

J. Radziuk, G. Hetényi, M. Raman, 1990, The American journal of physiology.

Coordinated regulation of hepatic glycogen formation in perfused rat liver by glucose and lactate.

J. Radziuk, Z. Zhang, 1994, The American journal of physiology.

Measurement of gluconeogenesis and mass isotopomer analysis based on [U-(13)C]glucose.

J. Radziuk, W. P. Lee, W. P. Lee, 1999, The American journal of physiology.

Measurement of gluconeogenesis and mass isotopomer analysis based on [U-13C]glucose.

J. Radziuk, W. P. Lee, W. Lee, 1999, American journal of physiology. Endocrinology and metabolism.

Calculation of the rate of gluconeogenesis from the incorporation of 14C atoms from labelled bicarbonate or acetate.

J. Radziuk, G. Hetényi, C. Ferrarotto, 1982, Canadian journal of physiology and pharmacology.

An integral equation approach to measuring turnover in nonsteady compartmental and distributed systems.

J. Radziuk, 1976, Bulletin of mathematical biology.

Tracer-determined glucose fluxes in health and type 2 diabetes: basal conditions.

J. Radziuk, S. Pye, 2003, Best practice & research. Clinical endocrinology & metabolism.

Measurement using tracers of steady-state turnover and metabolic clearance of insulin in dogs.

C. Bradshaw, J. Radziuk, T. Morishima, 1985, The American journal of physiology.

Comparison of the continuously calculated fractional splanchnic extraction of insulin with its fractional disappearance using a new double-tracer technique.

J. Radziuk, T. Watarai, G. Davies, 1993, Metabolism: clinical and experimental.

Hemipancreatectomy and systemic diversion of pancreatic venous drainage lead to independent alterations in the determinants of glucose tolerance in dogs.

J. Radziuk, S. Pye, J. Davies, 1998, Transplantation proceedings.

Hepatic glycogen in humans. II. Gluconeogenetic formation after oral and intravenous glucose.

J. Radziuk, 1989, The American journal of physiology.

Hepatic glycogen in humans. I. Direct formation after oral and intravenous glucose or after a 24-h fast.

J. Radziuk, 1989, The American journal of physiology.

Insulin-mediated and non-insulin-mediated metabolic effects of gastroenteropancreatic peptides in type I and type II diabetes.

N. Rodger, T. McDonald, J. Dupré, 1985, Advances in experimental medicine and biology.

The Role of Glucagon and Insulin in the Glucoregulatory System, as Assessed by Tracer Methods

M. Vranic, A. Cherrington, J. Radziuk, 1973 .

Production and metabolic clearance of glucose under basal conditions in Type II (non-insulin-dependent) diabetes mellitus

J. Radziuk, S. Pye, 2001, Diabetologia.

Effects of lactate on pathways of glycogen formation in the perfused rat liver.

J. Radziuk, Z. Zhang, 1991, The Biochemical journal.

Physicochemical basis for the rapid time‐action of LysB28ProB29‐insulin: Dissociation of a protein‐ligand complex

J. M. Beals, D. Brems, J. Beals, 1996, Protein science : a publication of the Protein Society.

Insulin sensitivity and its measurement: structural commonalities among the methods.

J. Radziuk, J Radziuk, 2000, The Journal of clinical endocrinology and metabolism.

Sensitivity to insulin and its kinetics

J. Radziuk, 2017, Obesity.

Splanchnic and systemic absorption of intraperitoneal insulin using a new double-tracer method.

J. Skyler, R. Offord, D. E. Seigler, 1994, The American journal of physiology.

Basal activity profiles of NPH and [Nɛ-palmitoyl Lys (B29)] human insulins in subjects with IDDM

L. Vignati, R. DiMarchi, R. Chance, 1998, Diabetologia.

An overview of galanin’s actions on the endocrine pancreas

W. Staines, T. McDonald, J. Radziuk, 1991 .

The numerical solution from measurement data of linear integral equations of the first kind

J. Radziuk, 1977 .

The effect of systemic venous drainage of the pancreas on insulin sensitivity in dogs.

J. Radziuk, H. Najm, J. Davies, 1993, The Journal of clinical investigation.

Preparation of a microcrystalline suspension formulation of Lys(B28)Pro(B29)-human insulin with ultralente properties.

G. D. Smith, J. Radziuk, S. Pye, 1999, Journal of pharmaceutical sciences.

Preparation and characterization of a cocrystalline suspension of [LysB28,ProB29]-human insulin analogue.

J. Radziuk, S. Pye, B. Frank, 1998, Journal of pharmaceutical sciences.

Measurement and validation of nonsteady turnover rates with applications to the inulin and glucose systems.

K. Norwich, M. Vranic, J. Radziuk, 1974, Federation proceedings.

Metformin and its liver targets in the treatment of type 2 diabetes.

J. Yudkin, C. Bailey, J. Radziuk, 2003, Current drug targets. Immune, endocrine and metabolic disorders.

Experimental validation of measurements of glucose turnover in nonsteady state.

K., K H Norwich, K. Norwich, 1978, The American journal of physiology.

Estimating rapid changes in the rates of glucose production from glycogenolysis and recycling through lactate.

M. Vranic, J. Radziuk, 1977, Federation proceedings.

pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus protein induced the expression of

G. Ning, T. Miki, B. Jasmin, 2011 .

Initial splanchnic extraction of ingested glucose in normal man.

T. McDonald, J. Dupré, J. Radziuk, 1978, Metabolism: clinical and experimental.

Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis

J. Radziuk, S Pye, J Radziuk, 2001, Diabetes/metabolism research and reviews.

Effect of acarbose on insulin sensitivity in elderly patients with diabetes.

D. Lau, T. Wolever, E. Ryan, 2000, Diabetes care.

Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia

B. Hoogwerf, E. Suuronen, D. Braun, 2011 .

A qualitative comparison of canine plasma gastroenteropancreatic hormone responses to bombesin and the porcine gastrin-releasing peptide (GRP)

V. Mutt, S. Bloom, T. McDonald, 1981, Regulatory Peptides.

35th Annual meeting of the European Association for the Study of Diabetes. Brussels, Belgium, 28 September-2 October, 1999. Abstracts.

Thomas J. Smith, B. M. Rasmussen, V. C. Phan, 1999, Diabetologia.

KATP channel-deficient pancreatic beta-cells are streptozotocin resistant because of lower GLUT2 activity.

T. Miki, B. Jasmin, J. Radziuk, 2008, American journal of physiology. Endocrinology and metabolism.

Effects of Metformin on Lactate Uptake and Gluconeogenesis in the Perfused Rat Liver

J. Radziuk, N. Wiernsperger, S. Pye, 1997, Diabetes.

Inappropriately high plasma insulin levels in suspected perinatal asphyxia

J. Radziuk, D. Davis, WD Creery, 1999, Acta paediatrica.

An integral equation approach to measuring turnover in nonsteady compartmental and distributed systems

J. Radziuk, 1976 .

Quantitation of basal endogenous glucose production in Type II diabetes: importance of the volume of distribution

J. Radziuk, S. Pye, Radziuk J., 2002, Diabetologia.

Inverse relationship between peripheral insulin removal and action: studies with metformin.

J. Radziuk, Z. Zhang, 2001, American journal of physiology. Endocrinology and metabolism.

Abnormal oral glucose tolerance and glucose malabsorption after vagotomy and pyloroplasty. A tracer method for measuring glucose absorption rates.

J. Radziuk, D. Bondy, 1982, Gastroenterology.

New methods for the analysis of insulin kinetics in vivo: insulin secretion, degradation, systemic dynamics and hepatic extraction.

J. Radziuk, T. Morishima, 1985, Advances in experimental medicine and biology.

Diurnal rhythm in endogenous glucose production is a major contributor to fasting hyperglycaemia in type 2 diabetes. Suprachiasmatic deficit or limit cycle behaviour?

J. Radziuk, S. Pye, 2006, Diabetologia.

Endogenous Glucose Production in Type 2 Diabetes: Basal and Postprandial. Role of Diurnal Rhythms

J. Radziuk, S. Pye, 2004, Journal of Investigative Medicine.

Glucose Production in Health and Type 2 Diabetes: Measurement, Regulation, and Molecular Basis. An Overview

J. Radziuk, 2004, Journal of Investigative Medicine.

Distinguishable substrate pools for muscle glyconeogenesis in lactate-supplemented recovery from exercise.

J. Radziuk, C. Ryan, 1995, The American journal of physiology.

Muscle glyconeogenesis during recovery from a prolonged swim in rats.

J. Radziuk, C. Ryan, 1994, The American journal of physiology.

Homeostastic Model Assessment and Insulin Sensitivity/Resistance

J. Radziuk, 2014, Diabetes.

An adaptive plasma glucose controller based on a nonlinear insulin/glucose model

J. Radziuk, B. Candas, J. Radziuk, 1994, IEEE Transactions on Biomedical Engineering.

Sympathetic nervous dysregulation in the absence of systolic left ventricular dysfunction in a rat model of insulin resistance with hyperglycemia

E. Suuronen, K. Ascah, J. DaSilva, 2011, Cardiovascular diabetology.

The effect of additional insulin on intravenous glucose tolerance and the forearm uptake of glucose compared to that following oral glucose

J. Radziuk, 1984 .

Insulin sensitivity and glucose tolerance following transposition of pancreatic venous drainage to the systemic circulation.

A. Humar, J. Radziuk, J. Davies, 1994, Transplantation proceedings.

HEART RATE, SHEAR STRESS, ATHEROGENESIS AND PLAQUE RUPTURE : IS THERE A LINK ?

R. DiMarchi, R. Chance, J. Radziuk, 1998 .

Posthepatic rate of appearance of insulin: measurement and validation in the nonsteady state.

C. Bradshaw, J. Radziuk, T Morishima, 1992, The American journal of physiology.

Investigations on Insulin Kinetics

D. E. Seigler, J. Radziuk, T. Morishima, 1988 .

A simplified method for metabolic studies in conscious swine.

J. Duff, J. Radziuk, R. Finley, 1986, Laboratory animal science.

Mild acute renal failure potentiates metformin accumulation in the diabetic rat kidney without further impairment of renal function.

J. Radziuk, N. Wiernsperger, M. Barthelmebs, 2003, Diabetes & metabolism.