J. Coutcher

发表

A Selective Aldose Reductase Inhibitor of a New Structural Class Prevents or Reverses Early Retinal Abnormalities in Experimental Diabetic Retinopathy

C. Gerhardinger, M. Lorenzi, Wei Sun, 2006, Diabetes.

SAR and species/stereo-selective metabolism of the sorbitol dehydrogenase inhibitor, CP-470,711.

M. Chu-Moyer, P. Oates, J. Coutcher, 2002, Bioorganic & medicinal chemistry letters.

A sorbitol dehydrogenase inhibitor of exceptional in vivo potency with a long duration of action: 1-(R)-[4-[4-(4,6-dimethyl[1,3,5]triazin-2-yl)- 2R,6S-dimethylpiperazin-1-yl]pyrimidin-2- yl]ethanol.

P. Oates, J. Coutcher, M. O’Gorman, 2002, Journal of medicinal chemistry.

Dietary choline supplementation increases the density of nicotine binding sites in rat brain.

J. Coutcher, L. Wecker, G. Cawley, 1992, The Journal of pharmacology and experimental therapeutics.

Sorbitol dehydrogenase inhibitors (SDIs): a new potent, enantiomeric SDI, 4-[2-1R-hydroxy-ethyl)-pyrimidin-4-yl]piperazine-1-sulfonic acid dimethylamide.

P. Oates, J. Coutcher, D. Beebe, 2001, Journal of medicinal chemistry.

Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines.

M. Chu-Moyer, R. Berger, P. Oates, 2002, Journal of medicinal chemistry.

Design and synthesis of a novel family of triazine-based inhibitors of sorbitol dehydrogenase with oral activity: 1-[4-[3R,5S-dimethyl-4-(4-methyl-[1,3,5]triazin-2-yl)-piperazin-1-yl]-[1,3,5]triazin-2-yl]-(R) ethanol.

P. Oates, J. Coutcher, D. Beebe, 2003, Bioorganic & Medicinal Chemistry.

Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enantiomeric SDI, 4‐[2‐(1R‐Hydroxy‐ethyl)‐pyrimidin‐4‐yl]‐piperazine‐1‐sulfonic Acid Dimethylamide.

P. Oates, J. Coutcher, D. Beebe, 2001 .

A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.

P. Oates, J. Coutcher, M. O’Gorman, 2005, Journal of Medicinal Chemistry.

A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.

P. Oates, J. Coutcher, M. O’Gorman, 2003, Journal of medicinal chemistry.